Angiogenesis is the process of forming new blood capillaries from pre-existing vessels. Even though it is essential during normal development, it plays a major role in cancer progression. Neratinib is a pan-human epidermal growth factor receptor (HER) inhibitor that has recently been approved for the treatment of HER2-positive breast cancer. However, its effects on angiogenesis and embryogenesis remain unknown. This study examined the antiangiogenic effects of neratinib using the chorioallantoic membrane (CAM) of chicken embryos. We also evaluated neratinib’s toxicity during the early stages of normal development using the chicken embryos, primary embryonic fibroblasts (EFBs), and human umbilical vein endothelial cells (HUVEC). Our findings revealed that neratinib significantly inhibited the CAM angiogenesis compared to controls by reducing vessel percentage area and the average vessel length. Furthermore, neratinib downregulated vascular endothelial growth factor (VEGF), a key mediator of angiogenesis. At lower concentrations, neratinib was well-tolerated during early stages of normal development. Additionally, EFBs treated with neratinib showed no morphological or viability changes when compared to controls. However, at the highest concentration tested, neratinib treatment reduced HUVEC cell viability. This effect may be associated with the dysregulation of key apoptotic genes, including caspase-3, caspase-8, caspase-9, and the B-cell lymphoma 2 (Bcl2) gene. Our findings indicate a novel potential application of neratinib as an antiangiogenic agent, exhibiting tolerable toxicity in the early stages of embryogenesis.

Bosnia and Herzegovina (BiH), a country rich in history and culture, has for centuries been at the crossroads between the West and the East, which has resulted in quite a mixture of cross-cultural elements that pose many obstacles for translators. As the issues of tourism-language translation have been relatively underexplored in BiH, this article attempts to investigate the extent to which the translators of tourism-related content available online succeeded in making the local color of architecture-related terms accessible to foreign visitors. The article also examines whether the issue of accessibility of local color was addressed adequately by local translators. Many formal and informal online sources were used for the selection of prominent cultural terms and their English translations, which were analyzed in terms of lexis and semantics. We identified many examples where the cultural content was made accessible to the target audience, as well as examples where the transfer of the cultural content was done less successfully. In cases where translators experienced difficulty while transferring cultural terms, we attempted to draw prospective translators’ attention to potential pitfalls in the process of cultural mediation in translation from BiH’s official languages into English. Keywords: Bosnia and Herzegovina, tourism online, mediation, (in)accessibility, local color, translation, architecture

<p>Diabetic retinopathy (DR) is a chronic microvascular complication of diabetes. Due to the dramatic increase in the number of diabetes cases, the prevalence of DR has also risen, making it the leading cause of blindness among the working-age population worldwide, despite the availability of screenings and modern therapeutic options. Risk factors for the development and progression of DR (duration of diabetes, hypertension, hyperglycemia, dyslipidemia, and genetic factors) have been investigated in numerous epidemiological studies and clinical researches, but the research results were not consistent. In recent years, there has been considerable interest in the study of dyslipidemia in diabetes as one of the factors that could influence the onset and progression of DR, as well as apolipoproteins as potentially better biomarkers for DR. The results of our research also point in that direction. Identifying the risk factors for DR is crucial for enabling adequate prevention and raising awareness among individuals with diabetes about the importance of taking appropriate measures to prevent this microvascular complication.</p>

Introduction: A bone fracture is a break in the continuity of bone tissue, caused by the action of an external or internal force on the bone. Ankle sprains are one of the most common injuries among athletes. Physically active people who participate in activities that require jumping, changing direction, and turning have an increased risk of ankle sprains. Ankle sprains and the repetitive trauma often associated with this condition can lead to long-term disability, lost time from activity, and financial burdens for athletes. Methods: The work is non-experimental (qualitative research), i.e. a review of scientific literature. The search included an overview of the relevant databases: Medline, PubMed, Google Scholar, Research Gate. The literature review includes 4 randomized clinical trials and 1 randomized single-blind trial. The mentioned databases were searched with the help of keywords: athletes, injury, ankle joint, rehabilitation. Results: Through a scientific review of the literature, the results of the significance and productivity of the application of rehabilitation in athletes with an ankle injury are presented. The results include the presentation and analysis of five published scientific papers in the period 2018-2020. The studies used for this review were published in India, Saudi Arabia, Iran, United States, Austria. Conclusion: By reviewing the scientific literature, it can be concluded that there are improvements in the quality of life of athletes after an ankle injury. The greatest improvements were noted in strength, balance and functional task performance. The application of the rehabilitation program plays an important role in reducing pain and stabilizing the knee joint.

This study was conducted to investigate the relationship between vertical jump height and negative block performance of elite male volleyball players in the positions of spiker and middle player. Twenty-two players, 10 middle players and 12 spikers, aged 25-30 years, playing in professional volleyball league in Turkey participated in the study. During 15 training matches, vertical jump distances were recorded with VERT belt and negative block performances (-) ineffective block and (=) erroneous block percentages) were recorded with Data Volley4 software. Since the data did not show normal distribution as a result of normality analysis performed in SPSS 25 program, the relationship between the variables was determined by Spearman correlation analysis. As a result of the analysis, there was no correlation between the average jump height of the middle players and their block error percentages, while there was a strong positive significant correlation in ineffective block percentages. There was a strong positive correlation between the vertical jump height of the spikers and their ineffective block percentage, while there was a strong negative correlation in their block error percentage. As the vertical jump height of the middle players and spikers increased, ineffective block percentage increased. It can be said that as the vertical jump height of the spikers increases, the block error percentage decreases, while the vertical jump height of the middle players does not affect the block error percentage.

Introduction: Anterior cruciate ligament injury is an injury that occurs in both sexes and in the population of all ages. The anterior cruciate ligament (ACL) is a very strong internal ligament of the knee, whose injuries occur frequently in athletes (professional and recreational) and after which the recovery is very long and complicated. The aim of this study is to determine the effectiveness of a standardized rehabilitation program after anterior cruciate ligament reconstruction based on the time required for rehabilitation in athletes and recreational athletes. Methods: Research is designed as prospective study. The research was conducted in Polyclinic FM Sarajevo over a period of 10 months, starting in June 2018 and ending in March 2019. The collection of data required for the study was carried out using a form prepared for the analysis of patients included in the study. Results: Thirty-six people participated in the study, divided into two groups. In the first group, 52.8% belonged to recreational athletes, while in the second group, 47.2% belonged to athletes. At the end of the study, the flexion value in both studied groups was 120º. At the end of the study, the percentage of subjects with correct extension of the injured limb was 94.7% of recreational athletes and 64.7% of athletes. Of the total number of respondents included in this study, 33% were soccer players, 14% were basketball players, and 53% were recreational athletes. Conclusion: Based on the research results, it was confirmed that early rehabilitation after the established rehabilitation treatment program is shorter in recreational athletes than in professional athletes.

Radiation and nuclear security and safety represent regulated and controlled area. First of all, because of the common importance for humanity. Bosnia and Herzegovina has an established legal, i.e. institutional framework, but due to the decentralized complex system, it is unclear whether CBRN teams have been formed, what tasks and roles they perform and whether the procedure is uniform. In this research, the main focus is on the analysis of the complexity of the system, and the role of the State Regulatory Agency for Radiation and Nuclear Safety as a central authority and the Federal Administration of Civil Protection as a lower entity body in training and equipping teams for incident situations related to CBRN materials. The research is of empirical character and qualitative design. With this research we will show the level of equipment of the institutions of Bosnia and Herzegovina including measures and activities that are undertaken to prevent events and incidents in the broadest view, which will indicate recommendations for improving the preparedness and performance of institutions in preventing extraordinary events and incident situations.

Osvrt na knjigu The Height of Prophet Adam: At the Crossroads of Science & Scripture Muntasira Zamana

<p>Bacterial resistance to antibiotics is a problem that arose simultaneously with the beginning of their use and on a global level represents one of the biggest threats to public health. At the beginning of the twenty-first century, the emphasis of the medical and pharmaceutical public is on Gram-negative bacteria, especially enterobacteria, which show resistance to most, and some to all, available antibiotics. Treatment of infections caused by multiresistant bacteria is a big challenge for clinicians. Although bacterial resistance to antibiotics is a global problem, resistance rates vary significantly from country to country, and when it comes to hospital pathogens, from institution to institution. Monitoring antibiotic resistance in one&rsquo;s own environment is one of the first steps in the prevention and control of infections caused by multiresistant bacteria.</p>

The aim of the study was to use a multi-criteria decisionmaking method to make a rational choice for a new location for the distribution centre of agricultural products in the northeastern part of Bosnia and Herzegovina, specifically in five populated areas. The required criteria were selected based on experiences from previous research in this field, and decision-makers involved in the selection were engineers and technologists from the company in question. The results indicate that the criteria of construction cost and market connectivity gained the greatest importance, and Brčko was chosen as the location for the future distribution centre among the five populated areas. Additionally, the successful application of the used multi-criteria decision-making method, in this case, the CoCoSo method, was demonstrated. This could lead to improvements in making future business decisions within this economic sector.

Background: Data suggest that food allergies greatly impact a child’s health and growth due to inadequate nutrient intake. Our study aimed to establish the long-term outcome of children with food allergies compared to a control group. Methods: This study was a retrospective cohort study with longitudinal follow-up with a mean period of 4.85 years from the diagnosis to the last study visit. The patients’ nutritional intake was assessed using a three-day food diary and analysed by a dietitian. Patients (61 boys and 33 girls, mean age 6.9 years) had a single food allergy including 21 patients with cow’s milk, 34 with egg, and 39 with peanut allergies. The control group included 36 children (19 boys and 17 girls, mean age 8.03 years). Blood analysis was performed on all participants. Results: Data from our study showed that patients with cow’s milk, egg or peanut allergies had normal growth and achieved catch-up growth from the diagnosis until the last study visit. In the cow’s milk allergy group, the allergy was shown to affect calcium intake (p < 0.05), while egg and peanut allergies did not impact the dietary intake of nutrients. None of the investigated food allergies affected blood results (p < 0.05). Conclusions: In the present study, we showed that single food allergies do not compromise growth in children if they are provided with appropriate support and that the affected children reach catch-up growth from the diagnosis.

By critically analyzing the status and differentiation of bodies and their lives, the author expands the vision of governmentality beyond the West in order to define the body beyond the pacified techno-promises of their emancipation through fragmentation, calculability and programmability. By elaborating the nature, power, and promises of dominant digital technologies and technobodies, the author conceptualizes them in relation to the shift between bio- and necropolitics/power and in relation to violence, (digital) coloniality, and racialization to which bodies are exposed. It is about the normality of violence against the Other, also in relation to the principle of separation of virtual bodies and “surplus flesh,” which increases exponentially with technological development. The author seeks to understand how we have come to the point where techno-objects are humanized, given agency, while the body and life of the Other are dehumanized, deprived of any rights. The article contextualizes and re-politicizes the shifting relations between subject and object, particularly within our forensic contemporaneity.