William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, F. Amary, R. Tirabosco, C. Naceur-Lombardelli, Abigail Cristina Sonya Kai-Keen John Daniel Martin Siow-Mi Bunkum Naceur-Lombardelli Hessey Shiu Bridgewater , S. Hessey, K. Shiu, John Bridgewater, D. Hochhauser, Martin D. Forster, Siow-Ming Lee, T. Ahmad, D. Papadatos-Pastos, Sam Janes, Katey S. S. Enfield, N. Mcgranahan, A. Huebner, Sergio Quezada, Stephan Beck, Peter Parker, T. Enver, R. Hynds, D. Pearce, M. Falzon, Ian Proctor, Ron Sinclair, Chi-wah Lok, Zoe Rhodes, David Moore, T. Marafioti, M. Mitchison, P. Ellery, Monica Sivakumar, M. Linch, Sebastian Brandner, A. Rowan, C. Hiley, S. Veeriah, Heather Shaw, Gert Attard, A. Toncheva, Paulina Prymas, T. Watkins, Chris Bailey, Carlos Martinez Ruiz, K. Litchfield, M. Al-Bakir, N. Kanu, S. Ward, E. Lim, J. Reading, B. Chain, Blanca Trujillo Alba, T. Watkins, M. Akay, D. Biswas, O. Pich, M. Dietzen, C. Puttick, Emma C. Colliver, A. Magness, Mihaela Angelova, James Black, Olivia Lucas, William Hill, W. Liu, A. Frankell, Neil Magno, Foteini Athanasopoulou, Roberto Salgado, Claudia Lee, Kristiana Grigoriadis, Othman Al-Sawaf, Takahiro Karasaki, I. Noorani, S. Benafif, Vittorio Barbè, S. Bola, Osvaldas Vainauskas, A. Wingate, Daniel Wetterskog, Mahedi Hasan, Stefano Lise, Gianmarco Leone, A. Jayaram, Constantine Alifrangis, U. McGovern, K. Thol, Samuel Gamble, S. Ung, T. Sahwangarrom, Claudia Peinador Marin, Sophia Wong, Piotr Pawlik, J. Lam, Corentin Richard, R. Vendramin, K. Dijkstra, J. Rane, J. Nicod, Rija Zaidi, F. Gishen, A. Tookman, Paddy Stone, C. Stirling, S. Turajlic, James Larkin, Lisa Pickering, A. Furness, Kate Young, Will Drake, K. Edmonds, N. Hunter, Mary Mangwende, K. Pearce, Lauren Lewis Au, L. Spain, Scott T C Shepherd, Haixi Yan, Ben Shum, Z. Tippu, Brian Hanley, C. Spencer, Max Emmerich, Camille Gerard, Andreas Michael Schmitt, L. Del Rosario, E. Carlyle, Charlotte Lewis, L. Holt, Analyn Lucanas, M. O’Flaherty, Steve Hazell, H. Mudhar, Christina Messiou, A. Latifoltojar, A. Fendler, F. Byrne, Husayn Pallinkonda, Irene Lobon, Alexander Coulton, A. Cattin, Daqi Deng, Geoffrey Hugang Feng, Andew Rowan, N. Yousaf, Sanjay Popat, Olivia Curtis, C. Milner-Watts, Gordon Stamp, E. Nye, Aida Murra, Justine Korteweg, Denise Kelly, L. Terry, Jennifer Biano, Kema Peat, Kayleigh Kelly, Peter Hill, Debra Josephs, Sheeba Irshad, James Spicer, U. Mahadeva, Anna Green, Ruby Stewart, Natasha Wright, Georgina Pulman, R. Mitu, Sherene Phillips-Boyd, D. Enting, Sarah Rudman, Sharmistha Ghosh, Lena Karapagniotou, E. Pintus, A. Tutt, Sarah Howlett, James Brenton, Carlos Caldas, Rebecca Fitzgerald, M. Jimenez-Linan, E. Provenzano, A. Cluroe, Anna Paterson, Sarah Aitken, Kieren Allinson, Grant Stewart, Ultan McDermott, E. Beddowes, Tim Maughan, Olaf Ansorge, Peter Campbell, Patricia Roxburgh, S. Fraser, Kevin G. Blyth, J. Le Quesne, Matthew Krebs, Fiona H. Blackhall, Yvonne Summers, Pedro Oliveira, A. Ortega-Franco, Caroline Dive, Fabio Gomes, Mat Carter, Joanne Dransfield, Anne Thomas, D. Fennell, J. Shaw, Babu Naidu, S. Baijal, B. Tanchel, G. Langman, Andrew Robinson, Martin Collard, P. Cockcroft, C. Ferris, H. Bancroft, A. Kerr, Gary Middleton, J. Webb, S. Kadiri, Peter Colloby, B. Olisemeke, Rodelaine Wilson, Ian Tomlinson, Sanjay Jogai, Samantha Holden, Tania Fernandes, Iain McNeish, B. Hampton, Mairead McKenzie, A. Hackshaw, A. Sharp, Kitty Chan, L. Farrelly, Hayley Bridger, R. Leslie, M. Jamal-Hanjani, Charles Swanton, Simone Zaccaria, Adrienne M. Flanagan, P. van Loo, N. Pillay
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26. 11. 2025.
Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant IDH1 locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.