W. Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, A. Rocha, Tom Lesluyes, F. Amary, R. Tirabosco, C. Naceur-Lombardelli, Abigail Cristina Sonya Kai-Keen John Daniel Martin Siow-Mi Bunkum Naceur-Lombardelli Hessey Shiu Bridgewater , S. Hessey, K. Shiu, J. Bridgewater, D. Hochhauser, Martin D. Forster, Siow-Ming Lee, T. Ahmad, D. Papadatos-Pastos, Sam Janes, Katey S. S. Enfield, N. Mcgranahan, A. Huebner, Sergio Quezada, Stephan Beck, Peter Parker, T. Enver, R. Hynds, D. Pearce, M. Falzon, Ian Proctor, Ron Sinclair, Chi-wah Lok, Zoe Rhodes, D. Moore, T. Marafioti, M. Mitchison, P. Ellery, Monica Sivakumar, M. Linch, Sebastian Brandner, A. Rowan, C. Hiley, S. Veeriah, H. Shaw, G. Attard, A. Toncheva, Paulina Prymas, T. Watkins, Chris Bailey, Carlos Martinez Ruiz, K. Litchfield, M. Al-Bakir, N. Kanu, S. Ward, E. Lim, J. Reading, B. Chain, Blanca Trujillo Alba, T. Watkins, M. Akay, D. Biswas, O. Pich, M. Dietzen, C. Puttick, E. Colliver, A. Magness, M. Angelova, James R. M. Black, O. Lucas, William Hill, W. Liu, A. Frankell, Neil Magno, Foteini Athanasopoulou, R. Salgado, Claudia Lee, Kristiana Grigoriadis, O. Al-Sawaf, Takahiro Karasaki, I. Noorani, S. Benafif, Vittorio Barbè, S. Bola, O. Vainauskas, A. Wingate, Daniel Wetterskog, M. Hasan, S. Lise, Gianmarco Leone, A. Jayaram, C. Alifrangis, U. McGovern, K. Thol, Samuel Gamble, S. Ung, T. Sahwangarrom, Claudia Peinador Marin, S. Wong, Piotr Pawlik, J. Lam, Corentin Richard, R. Vendramin, K. Dijkstra, J. Rane, J. Nicod, Rija Zaidi, F. Gishen, A. Tookman, P. Stone, C. Stirling, S. Turajlic, James Larkin, Lisa Pickering, A. Furness, Kate Young, W. Drake, K. Edmonds, N. Hunter, Mary Mangwende, K. Pearce, L. Au, L. Spain, Scott T C Shepherd, Haixi Yan, B. Shum, Z. Tippu, Brian Hanley, C. Spencer, Max Emmerich, Camille L. Gerard, Andreas M. Schmitt, L. Del Rosario, E. Carlyle, C. Lewis, L. Holt, Analyn Lucanas, M. OFlaherty, S. Hazell, H. Mudhar, Christina Messiou, A. Latifoltojar, A. Fendler, F. Byrne, Husayn Pallinkonda, Irene Lobon, Alexander Coulton, A. Cattin, Daqi Deng, Geoffrey Hugang Feng, Andew Rowan, N. Yousaf, Sanjay Popat, O. Curtis, C. Milner-Watts, Gordon Stamp, E. Nye, A. Murra, Justine Korteweg, Denise Kelly, L. Terry, Jennifer Biano, Kema Peat, Kayleigh Kelly, Peter Hill, D. Josephs, Sheeba Irshad, James Spicer, U. Mahadeva, A. Gréen, Ruby Stewart, N. Wright, Georgina Pulman, R. Mitu, Sherene Phillips-Boyd, D. Enting, Sarah Rudman, Sharmistha Ghosh, Lena Karapagniotou, E. Pintus, A. Tutt, Sarah Howlett, James Brenton, Carlos Caldas, Rebecca Fitzgerald, M. Jimenez-Linan, E. Provenzano, A. Cluroe, Anna Paterson, Sarah J. Aitken, K. Allinson, G. Stewart, U. McDermott, E. Beddowes, Tim Maughan, Olaf Ansorge, Peter Campbell, P. Roxburgh, S. Fraser, Kevin G. Blyth, J. Le Quesne, Matthew Krebs, Fiona H. Blackhall, Y. Summers, P. Oliveira, A. Ortega-Franco, C. Dive, Fabio Gomes, M. Carter, Joanne Dransfield, Anne Thomas, D. Fennell, J. Shaw, Babu Naidu, S. Baijal, B. Tanchel, G. Langman, Andrew Robinson, Martin Collard, P. Cockcroft, C. Ferris, H. Bancroft, A. Kerr, Gary Middleton, J. Webb, S. Kadiri, P. Colloby, B. Olisemeke, Rodelaine Wilson, I. Tomlinson, Sanjay Jogai, Samantha Holden, Tania Fernandes, Iain McNeish, B. Hampton, Mairead McKenzie, A. Hackshaw, A. Sharp, Kitty Chan, L. Farrelly, Hayley Bridger, R. Leslie, M. Jamal-Hanjani, Charles Swanton, Simone Zaccaria, Adrienne M. Flanagan, P. van Loo, N. Pillay
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26. 11. 2025.
Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant IDH1 locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.