During the early months of the COVID-19 pandemic, treatment protocols varied substantially among countries and even between hospitals. This study compared the clinical characteristics, management strategies, and outcomes of hospitalized COVID-19 patients treated in tertiary centers in Türkiye and Bosnia and Herzegovina. We retrospectively analyzed 1338 adults hospitalized with laboratory-confirmed SARS-CoV-2 infection: 657 patients in Tuzla (Bosnia and Herzegovina, June–December 2020) and 681 in İstanbul (Turkiye, April–May 2020). Demographic, clinical, and laboratory data, treatment details (including favipiravir use), need for invasive or non-invasive mechanical ventilation, and in-hospital mortality were extracted from medical records. Patients in Bosnia and Herzegovina were older (61.6 ± 14.4 vs. 56.9 ± 15.8 years; p < 0.001) and had longer hospital stays (9.0 ± 5.5 vs. 7.7 ± 6.1 days; p < 0.001). In the Bosnian cohort, leukocyte, neutrophil, platelet, ferritin, CRP, troponin, creatinine, AST, and ALT levels were significantly higher, whereas hemoglobin and D-dimer levels were lower. The need for ventilatory support was greater in Bosnia and Herzegovina (15.1% vs. 12.2%, p < 0.001), and overall mortality was higher (25.7% vs. 9.3%, p < 0.001). No mortality difference was observed between patients treated and not treated with favipiravir. Despite similar inclusion criteria, patients in Bosnia and Herzegovina exhibited more severe disease, greater organ involvement, and higher mortality than those in Turkiye. Favipiravir use did not influence survival. Inter-country comparisons highlight how differing patient profiles and treatment protocols may impact COVID-19 outcomes; however, interpretation should consider that the two centers contributed data from different phases of the 2020 pandemic, and that country-level differences in circulating variants, healthcare capacity, hospital strain, and evolving clinical guidelines may also have influenced the observed patterns.

The primary objective of external fixation is to stabilize bone fractures, with the mechanical characteristics of the fixation system playing a critical role in shaping the biomechanical environment of the fracture and, consequently, the healing process. This study presents an experimental investigation of the stability of eight unilateral external fixation configurations applied to an open tibial fracture. The stiffness of each configuration was evaluated under axial compression, anterior–posterior (AP) bending, medial–lateral (ML) bending, and torsional loading. In addition, the effects of structural parameters—such as the number of half-pins, planarity of the configuration, and interfragmentary distance—on fixator stiffness and generated stresses were examined. The results revealed a linear relationship between applied load and both bone segment displacement and principal stresses. Biomechanical tests demonstrated that biplanar configurations provide sufficient stability for open tibial fractures, while simultaneously offering an optimal structural design for the fixation system. Moreover, the number of half-pins was identified as a statistically significant factor influencing configuration stiffness under axial loading and torsion, with biplanar configurations proving particularly effective in torsional scenarios. However, in AP and ML bending tests, neither configuration type nor any individual parameter produced statistically significant differences in bending stiffness. Interestingly, interfragmentary distance did not exert a statistically significant effect on configuration stiffness under any loading condition. Furthermore, neither configuration type nor the analyzed parameters had a notable influence on the principal stresses measured at the control points.

In this research, the impact of applications on improving urban logistics was examined using the example of the company EX, with an emphasis on the sustainability of its business. To conduct this research, expert decision-making was used. The model used ten criteria and eight applications. To incorporate uncertainty into this research, an intuitionistic fuzzy approach was used. Based on the obtained CC values, the criteria weights were determined using the SiWeC (Simple Weight Calculation) method, while the WASPAS (Weighted Aggregated Sum Product Assessment) method ranked the applications. The results showed that “Security and data protection” and “System reliability and stability” were the most important criteria, while Application 1 achieved the best results. These results were confirmed by the consistency analysis of the WASPAS method and the sensitivity analysis, which considered 30 scenarios.

OBJECTIVE To report two additional cases of glycogen-rich clear cell carcinoma (GRCC) of the breast - detailing their clinicopathologic features, immunophenotypes, and follow-up - and to provide an updated literature review since 2020. CASE REPORTS Two patients (66 and 52 years old) had GRCC confirmed morphologically and histochemically. Case 1 was ER-positive/HER2- positive (luminal B/HER2-positive) and was managed with surgery, followed by adjuvant chemotherapy, endocrine therapy, and anti-HER2 therapy (trastuzumab). Case 2 was triple-negative and received neoadjuvant chemoimmunotherapy (pembrolizumab- based) with marked pathologic tumor regression at resection. Both patients were disease-free at one and 12 months, respectively. CONCLUSIONS GRCC is heterogeneous and should not be regarded as a single clinicopathologic entity within invasive breast carcinoma of no special type or assumed to have a uniform prognosis. Management should be biomarker-guided, as illustrated by these cases. The role of targeted and immune therapies in GRCC warrants multi-institutional studies.

Grammatical aspect informs us about the internal temporal contours of a situa tion. In other words, aspect provides information as to how the verbal action is to be regarded, whether it is complete, continuous, or iterative. Bosnian grammati calizes the binary system characteristic of Slavic languages that entails that verbs are marked for the perfective or the imperfective aspect. English, on the other hand, grammaticalizes the perfect and the progressive, which do not entirely cor respond to the perfective/imperfective aspectual opposition. Grammatical aspect is an obligatory category in Bosnian, whilst in English, verbs need not be mor phologically marked for aspect. Expectedly, studies report different processing patterns in sentences with aspectual violations in these two languages. It has been shown that native speakers of English do not show electrophysiological responses to violations of aspect, while native speakers of Bosnian show a clear sensitivity to aspectual violations immediately at the verb. Even though they detect aspectual violations already at the point of the verb in Bosnian, their L1, in this study we investigate whether university students of English process aspectual violations in English, their L2. More precisely, we conducted a self-paced reading study to ex plore whether Bosnian university students of English detect aspectual violations at the position of the verb or in adjacent positions during incremental sentence processing. Our results are in line with the previous findings on L1 processing of English aspect – English aspectual violations are not detected online during sen tence comprehension in L2 processing. However, there is an important difference. Unlike native speakers of English, Bosnian university students of English do not detect aspectual violations even after the sentence has been processed. Such re sults provide evidence for the Shallow Structure Hypothesis in L2 processing. We, therefore, compare our findings with other studies on grammatical aspect, con trast L1 and L2 processing, and discuss English and Bosnian grammatical aspect.

This paper explores both theoretical and practical dimensions of peacebuilding in post-conflict societies, with a specific focus on Bosnia and Herzegovina and the role of the High Representative, established by Annex 10 of the General Framework Agreement for Peace (Dayton Peace Agreement). By analysing the functioning of the Office of the High Representative (OHR), the study investigates the scope and limitations of the liberal institutionalist approach to peacebuilding, which dominated international intervention strategies in Bosnia and Herzegovina after 1995. The paper argues that classical institutional models failed to adequately respond to the fragmented political landscape and deep ethno-political divisions in Bosnia and Herzegovina, leading to a gradual transformation of the High Representative’s mandate from a coordinating body to a politically active institution with significant executive powers. The aim of this study is to examine the institutional evolution of the OHR and assess its contribution to state-building and peace preservation in Bosnia and Herzegovina, while also critically engaging with broader debates on the effectiveness of international peacebuilding in complex post-conflict environments. The research employs a qualitative methodology, including the analysis of primary documents (Annex 10, decisions of the OHR, legal acts), secondary sources (academic literature, international reports), and a case study approach based on a chronological review of the actions taken by High Representatives from 1995 to 2021. The analysis focuses on three core areas where the intervention of the High Representative had a decisive impact: (1) the imposition of binding decisions and laws in cases where domestic political actors failed to reach consensus; (2) judicial reforms and the annulment of rulings by domestic courts that were seen as contrary to the peace agreement; and (3) the dismissal of political officials deemed to be violating the Dayton Agreement or undermining the constitutional order. Findings indicate that this form of international tutelage contributed to short-term stabilization and institutional functionality but also raised concerns over democratic legitimacy and the limited ownership of domestic actors in the reform process. The theoretical framework links traditional liberal peacebuilding approaches with more recent critiques that emphasize the need for deeper local participation, long-term capacity-building, and context-sensitive governance. In this regard, the Bosnia and Herzegovina case illustrates the ambivalence of international interventions—balancing between ensuring stability and respecting sovereignty, and between delivering quick institutional fixes and fostering sustainable domestic governance. Scholarly and political critiques of the OHR’s role vary widely—from accusations of autocratic governance to acknowledgments of its necessity—thus exposing the ongoing tension between efficiency and legitimacy in international administration. The paper concludes that while the institution of the High Representative has played a critical role in maintaining peace and facilitating institutional development in Bosnia and Herzegovina, long-term sustainability requires a shift from external supervision to internal political consensus. The contribution of this research lies in its systematic analysis of the institutional trajectory of the OHR and its theoretical interpretation within broader debates on post-conflict international governance. The findings offer valuable insights for future peacebuilding missions in similarly complex environments.

Efficient and consistent string processing is critical in the exponentially growing genomic data era. Locally Consistent Parsing (LCP) addresses this need by partitioning an input genome string into short, exactly matching substrings (e.g.,"cores"), ensuring consistency across partitions. Labeling the cores of an input string consistently not only provides a compact representation of the input but also enables the reapplication of LCP to refine the cores over multiple iterations, providing a progressively longer and more informative set of substrings for downstream analyses. We present the first iterative implementation of LCP with Lcptools and demonstrate its effectiveness in identifying cores with minimal collisions. Experimental results show that the number of cores at the i^th iteration is O(n/c^i) for c ~ 2.34, while the average length and the average distance between consecutive cores are O(c^i). Compared to the popular sketching techniques, LCP produces significantly fewer cores, enabling a more compact representation and faster analyses. To demonstrate the advantages of LCP in genomic string processing in terms of computation and memory efficiency, we also introduce LCPan, an efficient variation graph constructor. We show that LCPan generates variation graphs>10x faster than vg, while using>13x less memory.

We study strong-field ionization by quantum lights with emphasis on high-order above-threshold ionization and the intensity-dependent enhancements in the photoelectron spectra. We find that the length of the plateau in the photoelectron energy spectrum generated by such quantum lights can be extended by an order of magnitude in comparison with that generated by the classical coherent laser light and that within this plateau resonantly enhanced groups of sharp peaks appear at energies which are integer multiple of the photon energy. We relate the observed intensity-dependent enhancements to the channel closing effect. Our results are particularly interesting in the context of the recent interplay and merging of quantum optics with strong-field physics and attoscience.

BACKGROUND The value of intravenous thrombolysis (IVT) prior to endovascular therapy (EVT) with emergent stenting for intracranial atherosclerotic disease (ICAD)-large vessel occlusion (LVO) is unknown. We aimed to investigate the safety and efficacy of IVT among patients with adjuvant intracranial stenting after EVT. METHODS RESISTANT is a study of consecutive acute ischemic stroke patients who underwent EVT and intracranial stenting from 36 comprehensive stroke centres in 7 countries across 3 continents. The primary outcome of interest was ordinal shift of the modified Rankin Scale (mRS) score at 90-days after the intervention. Secondary outcomes were excellent outcome (mRS 0-1) and functional independence (mRS 0-2) at 90-days. Safety outcomes were rates of symptomatic intracranial hemorrhage (sICH) at 24-hours and 90-day mortality. Adjusted multivariate ordinal and logistic regressions were performed for all outcomes. RESULTS Of 828 patients (median age 67 years, IQR 59-77; 65% male), 23% have received IVT. In the adjusted analysis, receiving IVT was not associated with mRS ordinal shift (aOR 0.8, 95%CI 0.6 -1.1), nor with functional independence (aOR 1.1, 95% 0.7 - 1.7). However, there was a positive association with excellent outcome (aOR 1.6, 95%CI 1.0 - 2.7). There were no differences in sICH rates at 24-hours (aOR 1.5, 95%CI 0.8 - 2.9), nor 90-day mortality (aOR 0.8, 95% 0.5-1.3). CONCLUSION In this multi-center study of patients who underwent EVT with emergent intracranial stenting, IVT was associated with excellent clinical outcome, possibly due to indication bias, and there were no safety concerns. Receiving IVT should not be a criterion for deferring acute stenting among patients with ICAD-associated LVO and IVT should not be routinely withheld in suspected ICAD cases.

This longitudinal study aimed to examine the in-season variations in morphological, cardiorespiratory, muscular, and motor fitness components in junior male basketball players during an 8-month competitive season. Eighteen male basketball players (16.56 ± 0.90 years) were tested at three time points (T1, T2, T3). Assessed variables included body fat (BF), fat-free mass (FFM), muscle mass (MM), total body water (TBW), maximal oxygen uptake (VO2max), final running speed in the 30-15 Intermittent Fitness Test (VIFT), maximum and average heart rate (HRmax, HRavg), squat jump (SJ), countermovement jump with arm swing (CMJmax), drop jump (DJ), 20 m sprint with 5 m and 10 m splits, T-test (TT), and Lane Agility Drill (LAD). Significant improvements were observed in body mass (T1–T3, p = 0.002; T2–T3, p = 0.039), along with reductions in BF (T1–T2 and T1–T3, p < 0.05) and increases in FFM and MM (especially T2–T3, p < 0.05). VO2max increased significantly from T1 to T2 and T3 (p < 0.01), while HRaverage decreased across all intervals (p < 0.001), and HRmax declined slightly from T1 to T3 (p = 0.031). VIFT improved significantly between T1 and both T2 and T3 (p < 0.001). Measures of explosive strength (SJ, CMJmax, DJ) and agility (TT, LAD) showed consistent improvement across the season (p < 0.001), with moderate gains from T2 to T3 (p < 0.01 for SJ). These findings suggest meaningful physical and physiological adaptations during the competitive season, highlighting the importance of structured and continuous training throughout critical phases of athletic development in junior basketball players.

Magnetic resonance imaging is a non-invasive method that does not use ionizing radiation to produce images, which is its greatest advantage for visualizing fetal pathology. Fetal magnetic resonance imaging is used to visualize pathologies of the central nervous system, abdomen, thoracic organs, and heart, particularly when ultrasound examination is insufficient. FCMR  allows detailed visualization of the fetal heart and surrounding structures during pregnancy. It is particularly useful in diagnosing congenital heart defects and assessing fetal circulation, especially when other methods such as ultrasound are inconclusive.

Fennel (Foeniculum vulgare), a culinary and folk medicinal plant used worldwide in infantile colic, bloating, and indigestion, has scarce scientific evidence.