Rhegmatogenous retinal detachment (RRD) is a vision-threatening retinal disorder in which successful anatomical reattachment does not always result in satisfactory functional visual recovery. Optical coherence tomography (OCT) has become an essential non-invasive imaging modality for evaluating retinal microstructure and identifying biomarkers associated with postoperative visual outcomes. This narrative review summarizes and critically evaluates current evidence regarding the prognostic significance of OCT biomarkers following RRD repair. Available studies indicate that primary outer retinal biomarkers, particularly the integrity of the ellipsoid zone (EZ) and external limiting membrane (ELM), are the most reliable predictors of postoperative best-corrected visual acuity. Preservation of these structures reflects photoreceptor viability and is strongly associated with improved visual recovery. Secondary biomarkers, including hyperreflective foci, intraretinal cystic changes, retinal folds, persistent subretinal fluid, and preretinal hyperreflective dots, provide complementary information regarding inflammatory activity, retinal remodeling, and postoperative complications such as epiretinal membrane formation. Although these biomarkers have considerable clinical value for prognostication, patient counseling, and postoperative monitoring, their interpretation is limited by heterogeneity among studies, differences in imaging protocols, and the lack of standardized assessment criteria. Future large-scale prospective studies are needed to validate OCT biomarkers and establish standardized approaches for their integration into routine clinical practice.

BACKGROUND Tuberculosis (TB) is the leading global cause of death from a single infectious agent. Recent reductions in global health funding have threatened TB control, making comprehensive assessment of TB, HIV-related TB, and drug-resistant TB burdens before these disruptions essential for shaping effective responses. The WHO End TB Strategy sets targets of a 95% reduction in TB deaths and a 90% reduction in TB incidence between 2015 and 2035. Using results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023, this study aims to assess the burden of TB and multidrug-resistant TB (MDR-TB) across 204 countries and territories, and to evaluate progress towards the WHO End TB incidence and mortality targets. METHODS We quantified TB mortality using the Cause of Death Ensemble modelling platform with global vital registration, surveillance, verbal autopsy, and minimally invasive tissue sampling data. For TB morbidity estimation, we simultaneously modelled incidence, prevalence, and mortality by age and sex using DisMod-MR 2.1. A population attributable fraction (PAF) approach was applied to stratify morbidity and mortality estimates by HIV and drug-resistance status. We also calculated disability-adjusted life-years (DALYs) as the sum of years of life lost and years lived with disability. For the risk factor analysis, a comparative risk assessment framework was used and PAFs were derived for alcohol use, smoking, and high fasting plasma glucose to determine the proportion of TB burden associated with these risk factors. FINDINGS In 2023, there were an estimated 9·11 million (95% uncertainty interval 8·04-10·3) incident cases of all-form TB, 1·22 million (0·98-1·49) deaths, and 54·6 million (43·8-65·5) DALYs globally. HIV-related TB comprised 781 000 (690 000-879 000) incident cases and 210 000 (142 000-279 000) deaths, contributing 11·0 million (7·56-14·3) DALYs. MDR-TB accounted for 466 000 (198 000-1 080 000) incident cases, 102 000 (31 700-238 000) deaths, and 3·96 million (1·31-9·01) DALYs. From 2015 to 2023, global all-form TB incidence rates declined by 19·2% (17·8-20·5) and deaths declined by 22·6% (4·7-35·7); declines were larger for drug-susceptible TB than for MDR-TB. Sub-Saharan Africa and south Asia had the highest mortality burdens in 2023; reductions in all-form TB incidence and mortality were uneven between 2000 and 2023, with limited progress in both measures in Latin America and the Caribbean. Removing smoking, alcohol use, and high fasting plasma glucose would reduce global TB deaths to 768 000 (592 000-970 000) and DALYs to 34·9 million (27·8-43·8) in 2023; MDR-TB deaths would decrease to 77 200 (23 400-183 000) and DALYs to 3·12 million (1·03-7·29). INTERPRETATION Global progress towards WHO End TB targets is disparate and fragile. Although many regions achieved meaningful gains, others have stagnated in recent years. The complexity of TB prevention is amplified by divergent MDR-TB trends, the persistent burden of HIV, and growing exposure to modifiable risk factors. Recent volatility in global health financing threatens to further destabilise this vulnerable epidemiological landscape; concerted action is urgently needed to temper disruptions and preserve progress. FUNDING Gates Foundation.

Cerebral visual impairment (CVI) is a complex neurological disorder that significantly affects the visual functioning of school-age children, often unrecognized within educational settings. The aim of this study was to determine the presence and frequency of specific visual behaviors associated with the risk of CVI in lower primary school students, and to examine differences in their recognition between parents and teachers. The study included 112 students from grades three through five, with data collectedusing an abbreviated version of the Screening for Cerebral Visual Impairmentquestionnaire. The results indicated that parents recognize specific visual behaviors considerably more often than teachers. Although this difference did not reach statistical significance, a borderline trend was observed. The findings suggest a need for enhanced teacher training, strengthened collaboration with parents, and the introduction of systematic screening procedures to enable timely identification of children at risk forCVI.Keywords:cerebral visual impairment, specific visual behaviors, visual difficulties

The introductory section defines the concepts of graphomotor skills and hearing impairment.The aim of this study was to examine the characteristics of graphomotor skills in children with hearing impairments compared to hearing children. Additionally, one of the objectives was to investigate whether there are differences in graphomotor skills depending on the quality of hearing, as well as to identify the factors that influence these skills.For assessment purposes, the Diagnostic Set for Testing Speech, Language, Reading, and Writing Abilities in Children –Diagnostic Material for Identifying Specific Difficulties in Reading and Writing wasused, focusing on variables related to graphomotor skills. Descriptive statistics, optimal scaling regression analysis, and linear regression analysis were employed for statistical data processing.The study revealed that hearing participants achieved statistically significantly better results in graphomotor skills compared to participants with hearing impairments.The degree of hearing impairment affects the graphomotor skills of children with hearing impairment, while educational conditions and gender did not show any influence on these skills. Age also impacts the graphomotor skills of children with hearing impairment.These findings provide insight into the specific needs of children with hearing impairments and emphasize the importance of individualized education, taking into account the unique characteristics of each child with hearing impairment.Keywords: graphomotor skills, graphomotor development, children with hearing impairment

Digital narratives, particularly animated films, are increasingly recognized as powerful educational tools capable of fostering empathy and promoting inclusive values among school-age children. This study examined how viewing the animated film Jonathan from Seagull Mountaincontributes to the development of empathy and understanding of diversity among primary school students in Bosnia and Herzegovina. A mixed-methods design was employed, integrating quantitative and qualitative data collection and analysis.The sample comprised 214 students aged 9 to 15 years from four cities (Tuzla, Sarajevo, Zenica, and Mostar), while a purposive subsample of 32 students participated in four focus groups. Data were collected through a structured post-viewing questionnaire and semi-structured focus group discussions. Quantitative data were analyzed using descriptive statistics, while qualitative data from focus group transcripts were analyzed through thematic analysis. Results indicate that the film elicited positive emotional responses in the majority of participants, with 78.6% expressing a desire to help the protagonist and 78.0% reporting increased motivation to support peers who are different from them. Girls demonstrated markedly higher levels of affective empathy than boys, with the most pronounced difference recorded on the item relating to sadness over the protagonist's exclusion (86.5% vs. 53.6%). Thematic analysis identified five main themes: emotional experience of the narrative, development of empathy and acceptance of diversity, peer support and moral responsibility, symbolic elements, and student recommendations for more inclusive school practices. The findings confirm the potential of digital narratives as a pedagogical tool for developing empathy and inclusive attitudes among primary school students. Keywords:digital narratives, empathy, inclusion, animated film, primary school students

Indoor air quality may be compromised by elevated radon levels, a naturally occurring radioactive gas. Prolonged exposure to increased radon levels can adversely affect human health. This paper presents the results of indoor radon activity concentration measurements conducted at 20 locations using a passive method. CR-39-based radon detectors were deployed over three different exposure periods, from January to April. The aim of the study was to compare and analyse average indoor radon activity concentrations obtained over different detector exposure periods, and to determine whether reliable information on indoor air quality can be obtained using shorter exposure durations. The measured indoor radon activity concentrations ranged from 6.0 to 727 Bq/m 3 , 10.1 to 561 Bq/m 3 , and 15.1 to 480 Bq/m 3 for the three-month, two-month, and one-month exposure periods, respectively. Comparative analysis of the results showed that the mean ratio of radon activity concentrations for one-month to two-month, two-month to three-month, and one-month to two-month exposure periods were 1.24, 1.57, and 1.85, respectively. To establish the relationship between radon activity concentrations obtained for different exposure periods, linear regression analysis was performed. The analysis of the estimated relative percentage differences showed that the results for different exposure periods agreed within ±20% at approximately 53% of the locations.

In this research, a rapid seismic assessment of the I Gymnasium in Sarajevo (Bosnia and Herzegovina) was conducted. The structural information was obtained from original designs, visual inspection, which was supported by the usage of a drone, and infrared thermography. The vulnerability of the structure was assessed by implementing the Vulnerability Index Method (VIM). Once the mean damage grades were obtained for various seismic intensities (EMS 98 scale applied) vulnerability curve was constructed, enabling the quantification of risk for various seismic scenarios. The structure would experience no to minor damage if exposed to weaker earthquakes (IV–V). The most interesting intensities for Sarajevo are VII and VIII, indicating moderate damage. For earthquakes of higher intensities (X–XII), there is a significant increase in heavy and severe damage, leading to the complete collapse in the case of XII intensity level. The paper further discussed the effects that have a direct impact on the degradation of masonry material, leading to a reduction of its resilience. An aspect of inadequate strengthening is emphasized, together with the importance of regular maintenance for prolonging the life of these types of structures.

<p>The aim of this work was to examine the possibility of stabilizing red mud with a natural mineral, namely pyrophyllite shale, to the extent that it is not harmful to the environment, as well as the use of such a stabilized composite for the production of building materials such as bricks, in order to ultimately achieve a complete circular economy, where on the one hand there would be the utilization of waste material, the preservation of the environment and natural resources, and on the other hand, the production of products of the same quality.</p> <p>Based on the set goal, the results for the composition of red mud and pyrophyllite shale as well as the stabilized composite before and after thermal treatment at 900 &deg;C are presented in the work, and they show that there is a decrease in the proportion of all oxides present in the mixture except silicon, because it is over 63% in pyrophyllite shale. Based on the stabilized composite, building block samples were formed. After the firing process, the samples cracked, and as such they could not be analyzed further. Based on this, it could be concluded that only stabilized composite cannot be used to make bricks.</p>

<p>Nifuroxazide is an antimicrobial drug from the nitrofuran group, which is used in the treatment of acute bacterial intestinal infections. Its mechanism of action is based on the reduction of the nitro group in bacterial cells, which produces reactive metabolites that permanently damage enzymes and the genetic material of microorganisms. Enzymes of redox metabolism are particularly sensitive, among which lactate dehydrogenase (LDH) stands out. In this work, an electrochemical method (cyclic voltammetry and chronoamperometry) was used to determine kinetic constants. The enzyme LDH (biosensor) was immobilized on a GC electrode and the effect of nifuroxazide on enzyme activity was monitored. The results show that nifuroxazide binds non-competitively to the enzyme and thus changes the enzyme conformation. This process leads to permanent blockade of key metabolic reactions, disruption of the redox balance and death of the bacterial cell.</p>

A comprehensive understanding of fundamental physical laws is essential for effectively using modern medical devices and comprehending the biological processes of organisms. This underscores the necessity of physics as a mandatory course in medical and healthcare studies. However, there is a lack of research regarding medical students’ motivation to learn physics and their awareness of its importance in healthcare, particularly among students in radiology and physiotherapy programmes. Therefore, the aim of this study is to assess students’ motivations for enrolling in healthcare programmes, their opinions about physics, and their perceived value of physics education for future career competencies. The sample comprised 157 undergraduate students from the physiotherapy and radiologic technology programmes at the Faculty of Health Studies, University of Rijeka, Croatia. Data were collected using a standardised questionnaire and analysed using the non-parametric Mann–Whitney U test and Kruskal–Wallis test. The research findings indicate that most students are enthusiastic about learning physics when they see its practical applications, especially in therapeutic and diagnostic procedures. Additionally, students are primarily motivated by a desire to help others, positive high school experiences, career aspirations, and family influence. Final-year students particularly recognise the significance of physics in diagnostics and therapies. Furthermore, professors’ professionalism and the curriculum’s relevance to future job skills are keymotivators. These findings can be used to develop diverse teaching strategies to enhance student interest, ultimately cultivating experts who can advance healthcare and improve disease diagnosis and treatment. 

<p>Estmating the risk to pulic health from heavy metals can help solve the basic questions about the potential dangers of exposure to them. This is the first study&nbsp; aimed to assess the health risk for the residents of the municipality of Zenica, on the land closest to the steel industry by examining the heavy metals Zn, Ni, Pb, Cd, Cr and Cu in the soil and plant cultivars corn and chard that could be used for the potential remediation of such soil. With the calculated data for HQ and HI, the non-carcinogenic and carcinogenic risk for adults and children were estimated, based on heavy metals in the selected topsoil and plants, which are usually grown in the area of interest, through different ways of their intake. The results showed that there is an unacceptable risk for children and adults due to long-term consumption of investigated plant cultivars from soil contaminated with heavy metals. Constant monitoring and measures to reducing the heavy metal pollution, primarily Cd, Pb and Cr, are necessary in the lands of ​​the municipality of Zenica. Special caution is required for residents who intend to grow plant cultivars near steel industry</p>

Monitoring vehicle movements at roundabouts and determining their operational throughput traditionally relies on tracking individual turning movements, a process that is technically demanding, labour-intensive and often impractical for complex multi-leg roundabouts. This study proposes a simplified approach to data collection and the determination of roundabout flow parameters. Two data collection techniques were examined: simplified manual counting of vehicles at entry legs and automated licence plate recognition. For roundabout flow parameters, determining the key methodological contribution is applying the roundabout investigation model (MIKR). Model MIKR enables capacity and turning-movement estimation using only entry and exit counts, thereby substantially reducing the scope of required field observations compared with conventional trajectory-based methods. The results show that licence plate recognition can determine turning flows with an accuracy of approximately 90%. The MIKR model reliably estimates roundabout capacity without requiring vehicle trajectory tracking. These findings confirm the practical value of the MIKR approach and highlight its potential for more efficient and cost-effective traffic-flow analysis at roundabouts.

Background Large language models (LLMs) are increasingly being studied as potentially valuable support tools in oncology practice including clinical decision support. Yet, their real-world utility in melanoma treatment decision-making is still not sufficiently considered, especially in resource-limited settings. Accordingly, this study evaluated the performance of four LLMs against real-world treatment decisions of a melanoma multidisciplinary tumor board (MDT). Methods This retrospective single-center study included 151 consecutive patients with newly diagnosed cutaneous melanoma discussed at the MDT at the University Clinical Center Tuzla, Bosnia and Herzegovina, between 2020 and 2024. Melanoma treatment recommendations generated by four LLMs, ChatGPT-4o, ChatGPT-5 Thinking, Gemini 2.5 Pro and DeepSeek-V3.2, were evaluated by four board-certified oncologists against the actual MDT treatment decisions. Additionally, the LLM-generated recommendations were also rated across five pre-specified domains: clarity, clinical applicability, coverage, explanation and support with evidence, and guideline concordance. Results In this study, inter-rater reliability was acceptable to good, supporting the consistency of expert evaluation. ChatGPT-5 Thinking showed the strongest and most consistent overall performance, followed by ChatGPT-4o, while Gemini 2.5 Pro and DeepSeek-V3.2 were rated less favorably. Differences between LLMs were statistically significant across all evaluated domains. Performance differences appeared most clinically relevant in more complex scenarios, particularly when consideration of adjuvant or systemic treatment strategies was required. Conclusion The findings of this study suggest that selected LLMs may have a supportive role in everyday melanoma MDT practice particularly in oncology centers with limited resources. However, the current results do not support the use of LLM-generated recommendations as independent treatment decisions, and further prospective studies are required before LLM-assisted treatment recommendations can be safely integrated into the MDT workflow.

A comprehensive book review of the recently published two-volume study, "Russia and the Eastern Question: Challenges of De-Ottomanization and Balkan Responses", authored by the distinguished historian Dr. Safet Bandžović and published by the Institute for History, University of Sarajevo.