The primary aim of the paper is to conduct research on the personality traits and pre-competition anxiety of Esports and sports players, in addition to confirming differences in personality and pre-competition anxiety between the two examined groups. The research has been conducted on 67 (N=67) subjects, 30 of whom are semi-professional or professional gamers who participate in state-level and regional-level competitions. The remaining 37 subjects are the highest-ranked athletes in Bosnia and Herzegovina. The t-test, a type of inferential statistic, has been used to determine statistical differences in disposition between the arithmetic means of the two groups, using BFI-44 (α=0.78) and CSAI-2 (α=0.60) measuring instruments. It has been anticipated that the Esports players are ranked lower at Extraversion (E) and Agreeableness (A) levels, while their Neuroticism (N) level is higher compared to the results of the athletes. The research indicates that all of the three hypotheses regarding the Big Five Model have been confirmed – on the scale of Extraversion (E) with significance levels of p=0.000 (p<0.0001); on the scale of Agreeableness (A) with significance levels of p=0.002 (p<0.01); on the scale of Neuroticism (N) with significance levels of p=0.042 (p<0.05). Furthermore, the fourth and fifth research hypotheses, proposing there is a statistically significant difference in cognitive and somatic anxiety (CSAI-2) in Esports players and athletes, were not confirmed. The sixth research hypothesis was confirmed, showing that there is a statistically significant difference between Esports players and athletes on the self-confidence dimension (CSAI-2) with p=0.030 (p<0.05). Results gathered on this sample could serve as an important part of understanding the differences between Esports players and athletes.

This research focuses on the bacterium Listeria monocytogenes and its occurrence in vegetables, specifically, tomatoes and peppers, and the risks this bacterium poses to health. The research included laboratory analysis of 16 samples of tomatoes and peppers, as well as survey research in the area of the City of Mostar. Based on the survey questionnaire, the respondents showed their knowledge about the occurrence of the bacteria Listeria monocytogenes in food and their general knowledge about listeriosis. Laboratory analysis consists of two parts. The first part refers to the laboratory analysis of the samples conducted in the Federal Agro-Mediterranean Institute laboratory in collaboration with its employees. The second part refers to an additional laboratory analysis conducted in the Veterinary Institute of Herzegovina–Neretva Canton laboratory in Mostar. This laboratory research aimed to establish whether the bacterium Listeria monocytogenes was present in the samples of vegetables examined in the analysis. All the vegetable samples were chosen randomly from four different locations in the area of Mostar. Also, the analysis included the examination of the washed and unwashed tomatoes and peppers. After conducting the laboratory research, it was established that the bacterium Listeria monocytogenes was not found in the samples used, which means all the examination results were negative.

Background and study aim. Group fitness programs are a form of programmed physical exercises with the aim of improving health, aesthetic appearance, satisfying the motivation to preserve health and reduce body weight. The aim of this study was to determine the effects of an experimental cardio fitness program on the morphological status of female subjects aged 21.5 ± 3.5 years. Material and methods. The experimental program was implemented over a period of three months (12 weeks), with a weekly frequency (3 x 20-60 min). Initial and final measurements were performed and Body weight, Body fat percentage, Body fat mass, Free fat mass, Body muscle mass, Body mass index and Basal metabolism rate were analyzed. All test subjects have their doctor's confirmation that they are healthy and can undergo training loads in a planned and clearly defined cardio program. Results. The exercise program on cardio equipment caused changes in all body composition parameters between the initial and final measurements t-test (except for muscle mass). The total average Body weight at the initial-final measurement (66.45 vs. 64.70kg; t= 5.225, p<0.000), which represents a difference of -1.75kg after the program. Conclusions. The assumption is that a controlled and monitored program with a special focus on nutrition would lead to even more precise results on the effects on body composition. Continuous application of the content of this program throughout the entire one-year macrocycle with a higher weekly frequency would certainly give even more significant results.

This article examines women's activism and feminism in Bosnia and Herzegovina, focusing on marginalised women's groups and organisations that are often excluded from academic research and international donor interests. The theoretical section presents the main characteristics of the development of women's organisations in post-war BIH, addressing the problem of NGO-isation of activism and feminism, which marginalises groups of women and organisations that do not belong to prominent liberal feminist organisations that pursue gender mainstreaming. Qualitative research based on in-depth interviews and analysis shows that these organisations mostly focus on the local level to meet diverse, specific, and sometimes urgent needs of women (e.g., Roma women, rural women, impoverished as well as women in small local communities) facing particular challenges while doing so. Although most of them do not clearly profess a feminist identity, they are aware of the patriarchal context, especially in their local communities, and their interpretations are mostly in line with the feminist ethics of care. However, the lack of organisational capacity, sustainable funding, and a clear feminist agenda in their work undermine their critical potential to be triggers for social change.

The negative influence of timber harvesting on the forest environment is reflected through damage to the residual trees, regeneration, and forest soil. Considering that skidding, a popular extraction method, can cause substantial and severe damage to the remaining stand, the aim of this research was to determine damage to residual trees during skidding by an LKT 81T cable skidder, including oxen bunching. The research was conducted in eastern Bosnia and Herzegovina, in an uneven-aged mixed fir (Abies alba Mill.) and spruce (Picea abies L.) forest with pine (Pinus sylvestris L.) on limestone soils. Tree felling was conducted using a Husqvarna 372 XP chainsaw. Extraction operations caused damage to 6.31% of the residual trees in the stand. The most damage was “removed bark” (65.34%) and occurred on the lower parts of the tree, the butt end (55.11%) and root collar (32.39%). The average size of the damage was 197.08 cm2. A statistically significant correlation was found between the damage position and the diameter at the breast height (p < 0.05) and the damage position and damage size (p < 0.01) by Spearman correlation analysis. The conducted analysis by the chi-squared test showed that there is a statistically significant difference in the proportion of damage for trees with different distances to the nearest skid road (p = 0.0487), but the share of damaged trees did not decrease by increasing the distance from the skid road.

Paracetamol/acetaminophen (N-acetyl-p-aminophenol, APAP) overdose is one of the most important causes of drug-induced liver injury worldwide. Hepatotoxicity induced by APAP is mainly caused by the production of N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive intermediate formed predominantly via the cytochrome P450 2E1. Here, we used human studies and in vitro models to demonstrate that NAPQI-derived thiomethyl metabolites identified using high-resolution mass spectrometry could serve to monitor NAPQI detoxification and elimination in patients (after intake at recommended dose or after intoxication), and to study inter-individual variability in NAPQI production. Using in vitro human models, we showed that these thiomethyl metabolites are directly linked to NAPQI detoxification since they are mainly formed after exposure to glutathione-derived conjugates via an overlooked pathway called the thiomethyl shunt. These long-term thiomethyl metabolites have great potential in future clinical studies in order to provide a more reliable history of APAP ingestion in case of acute intoxication or to study underlying causes involved in APAP-induced hepatotoxicity. One Sentence Summary Thiomethyl metabolites are new markers to monitor the elimination of the toxic N-acetyl-p-benzoquinone imine after therapeutic use or intoxication.

Cigarette smoking (CS) and low physical activity levels (PAL) are known to be risk factors for cardiovascular diseases. However, few studies have examined the associations between these factors in population of university students, and, to the best of our knowledge, no study examined this issue in period after the COVID-19 pandemic, despite the detrimental social and health consequences of the pandemic. The aim of this cross-sectional study was to examine associations between sport-participation, PAL and CS among university-level students in the first year after the COVID-19 pandemic. Participants were 761 students (411 females) from three universities in Bosnia and Herzegovina and Croatia, who were tested using semi-structured anonymous questionnaires at the beginning of the 2022/2023 academic year. Questions included queries on sociodemographic characteristics, CS, PAL, and sport-participation. Differences between genders were established by Chi-square test and gender-stratified logistic regressions were calculated to evaluate the associations between sport-participation and PAL, with binomized CS (smoking vs. non-smoking). One third of participants were daily smokers. Logistic regression showed no correlation between PAL and smoking prevalence for total sample (OR = 0.88, 95%CI: 0.75-1.05), males (OR = 0.95, 95%CI: 0.41-1.45), or females (OR = 0.90, 95%CI: 0.54-1.52). In addition, sport participation was not significantly associated with smoking. Results did not prove that sport and physical exercising are a way of reducing the likelihood of smoking; this finding could be a characteristic of the studied sample of participants, but could also be related to the period that was observed (the first year after the COVID-19 pandemic). Further studies examining the associations between PAL/sport participation and other types of substance misuse are warranted.

Goal: Artificial intelligence applied to medical image analysis has been extensively used to develop non-invasive diagnostic and prognostic signatures. However, these imaging biomarkers should be largely validated on multi-center datasets to prove their robustness before they can be introduced into clinical practice. The main challenge is represented by the great and unavoidable image variability which is usually addressed using different pre-processing techniques including spatial, intensity and feature normalization. The purpose of this study is to systematically summarize normalization methods and to evaluate their correlation with the radiomics model performances through meta-analyses. This review is carried out according to the PRISMA statement: 4777 papers were collected, but only 74 were included. Two meta-analyses were carried out according to two clinical aims: characterization and prediction of response. Findings of this review demonstrated that there are some commonly used normalization approaches, but not a commonly agreed pipeline that can allow to improve performance and to bridge the gap between bench and bedside.

Vine-leaved kitaibelia (Kitaibela vitifolia Willd.), also known as balkanmalva or chalice flower, is a critically endangered plant species with a high risk of extinction in the wild. A reason given for this is, among others, a low germination rate primarily caused by dormancy. The present study evaluated the seed germination and seedling growth parameters of vine-leaved kitaibelia in response to eight different pre-sowing treatments. The final germination percentage ranged from 0 % to 55 %, depending on the pre-sowing treatment. The most effective method for breaking dormancy and increasing vine-leaved kitaibelia seed germination was the treatment with seeds soaked in H2SO4 for 5 min. The mechanical scarification of vine-leaved kitaibelia seeds also improved germination as compared to control treatment, while treatments with nitric acid and gibberellic acid were not effective in enhancing seed germination. All evaluated seedling growth parameters were not affected by pre-sowing treatments. Considering that successful germination and seedling establishment are crucial for the regeneration of vine-leaved kitaibelia further studies are required in order to identify other pre-sowing treatments that could further enhance seed germination and, consequently, seedling development.

The inflammatory injury of the mucous membranes lining the digestive tract, from the mouth to the anus, is called mucositis. One of the intriguing and compelling new therapeutic modalities that has emerged in recent decades due to advances in our understanding of this condition’s pathophysiology is probiotics. The purpose of this meta-analysis is to evaluate the efficiency of probiotics in the treatment of chemotherapy-induced mucositis for head and neck malignancies; a literature search was performed on PubMed, Lilacs, and Web of Science, and articles published from 2000 to 31 January 2023 were considered, according to the keywords entered. The term “Probiotics” was combined with “oral mucositis” using the Boolean connector AND; at the end of the research, 189 studies were identified from the search on the three engines. Only three were used to draw up the present systematic study and metanalysis; this meta-analysis showed that the treatment of mucositis with probiotics is an effective method, and the analysis of the results of these studies showed that the use of probiotics promoted a decrease in the severity of mucositis symptoms.

In our study, we investigated the chemical composition and cytotoxic activity of essential oils isolated from Dalmatian sage (Salvia officinalis L.) collected along the Adriatic coast of Croatia. Scanning electron microscopy (SEM) was used to examine the morphology of the stem and leaf surfaces. Essential oil excretory glands were detected on both the leaves and stem surfaces. The essential oils were isolated by hydrodistillation, and their chemical composition was determined by gas chromatography and mass spectrometry (GC-MS). Sage essential oils were mixtures of terpene compounds, among which the most common were: α- and β-thujone, camphor, and 1,8-cineol. Cytotoxic activity was tested using MTS assay on multiple cell lines: normal and immortalized fibroblasts (HF77FA and HDF-Tert), immortalized lung line (BEAS-2B), and breast adenocarcinoma (MDA-MB-231). The growth of treated cells was determined relative to control conditions without treatment. The immortalized lung line was the least resistant to the activity of the essential oils, whereas immortalized fibroblasts were the most resistant. Statistical analysis has connected the cytotoxic effect and chemical composition of the studied essential oils. To the best of our knowledge, this work is the first testing of the cytotoxic activity of S. officinalis EO’s on the BEAS-2B, HF77FA, and HDF-Tert cell lines. The presented data on essential oil chemical composition and cytotoxic effect on 4 types of human cells supports pharmacotherapeutic potential this plant is known to have.

Background: Thiomersal is used as a preservative of some vaccines or as a trace from the pathogen inactivation process in vaccine production. Prophylactic use of paracetamol upon vaccination is still common, even though paracetamol decreases immune response on some vaccines. Considering the cytotoxic and genotoxic potential of thiomersal and paracetamol and possible interaction in vivo, in vitro study was performed. Methods: The genotoxic and cytotoxic effects of thiomersal and paracetamol combination were examined on human lymphocyte cultures by using two methods: analysis of chromosomal aberrations and cytokinesis-block micronucleus cytome assay. Blood samples of three healthy donors were analyzed with the following concentrations of tested substances: thiomersal 1 µg/ml and 0.5 µg/ml, paracetamol 20 µg/ml, thiomersal 0.5 µg/ml with paracetamol 20 µg/ml and thiomersal 1.0 µg/ml with paracetamol 20 µg/ml. Results: The analysis of structural chromosomal aberrations was significantly increased in all treated cultures. In cells treated with the combination of thiomersal 1 µg/ml and 20 µg/ml of paracetamol, the number of aberrations was significantly decreased. Cytokinesis-block micronucleus cytome assay analyses showed significantly increased micronucleus frequency in lymphocytes cultivated with thiomersal 1 µg/ml compared to lymphocytes cultures exposed to thiomersal 0.5 µg/ml. Conclusions: Induction of structural chromosome aberrations and micronucleus is shown as a sign of genotoxicity for the examined concentrations of thiomersal and paracetamol. The suppressing effect of paracetamol on thiomersal genotoxicity in lymphocytes culture treated with thiomersal was shown to be indicative of further examination of paracetamol use in the prevention of genotoxicity.

At the end of 2018, Gazi Husrev-bey library in Sarajevo and the renowned institution for historical research in the Republic of Turkey, Türk Tarih Kurumu, signed a protocol on cooperation on the project of preparing and publishing the regesta of the voluminous manuscript Tārīẖ-i Enveri, History of Muhamed Enveri Kadić. For the next four years, both of these institutions, which kept the first copies of the History, undertook a series of activities in order to realize the signed project. On January 13, 2023, the Gazi Husrev-bey library marked its 486th anniversary by promoting the planned and completed part of the work. The fact that the name and work of this special archivist, copyist, poet, epigrapher and bibliophile was known in detail by a limited number of people outside the fields of Orientalism, Ottoman studies and history, imposes the need to present, in a concise form, his character, work and visions.

BACKGROUND: Critical care medicine is a young branch of medicine, of which the development was much faster in High Income Countries (HICs) than in Low Resources Settings (LRS). Slovenia, as one of the successor states of former Yugoslavia, passed the process of transition and joined the European Union successfully. On the contrary, Bosnia and Herzegovina (B&H) went through the extremely difficult process of transition (four years of civil war), which left a deep scar to the healthcare system, including critical care medicine. OBJECTIVE: To examine the impact of HICs on the development of critical care in LRS. METHOD: This review examined the process of growing up the first modern Medical Intensive Care Unit (MICU) in the Republic of Srpska. RESULTS: The five-year process of transferring critical care knowledge from Slovenia to the health care system of Republic of Srpska has contributed to the existence of modern and state of the art MICU with tremendous social effects. CONCLUSION: The model of using the impact of HICs for improving critical care in LRS can be extrapolated to other similar settings.