Abstract Objectives To develop two ethical checklists to evaluate (i) management of ethical concerns in research projects and (ii) awareness of ethical conduct of healthcare laboratory professionals. Methods Comprehensive discussion among the members of IFCC Task Force on Ethics based on pertinent literature. Results This Checklist for Clinical Research Projects should be useful to evaluate research proposals from an ethical perspective before submitting it to an IRB or its equivalent, thereby diminishing rejection rates and resulting in more time-effective projects. The checklist designed to evaluate the ethical conduct in laboratory medicine could be useful for self evaluation (internal audits) and for certification/accreditation processes performed by third parties. Conclusions These checklists are simple but powerful tools useful to guide professionals to adhere to ethical principles in their practice, especially in developing countries where accredited ethics committees may be difficult to find.

To investigate a robot’s role in children’s welfare and safety, we conducted interviews with 8 Subject Matter Experts and Professionals (SMEs) across the disciplines of robotics, child technology, psychology, and psychiatry disciplines. Through qualitative analysis, we synthesize the challenges of safeguarding, compounding limitations, and potential solutions for involving robots in safeguarding as broadly defined in SME interviews. While they agree robots should not be responsible for making judgement calls, the experts also identified the ways robots can be a valuable addition to the safeguarding team. However, more conversations spanning disciplines need to occur to inform policy and legal frameworks that will better establish a robot’s role in intimate spaces in children’s lives. While this line of inquiry is specific to robots in safeguarding, many of the themes reflect the nuances of finding appropriate places for child-robot interactions in the context of children’s welfare.

Background Type 1 diabetes mellitus (T1DM) management in children and adolescents requires intensive supervision and monitoring to prevent acute and late diabetes complications and to improve quality of life. Digital health interventions, in particular diabetes mobile health apps (mHealth apps) can facilitate specialized T1DM care in this population. This study evaluated the initial usability of and satisfaction with the m-Health intervention Diabetes: M app, and the ease of use of various app features in supporting T1DM care in rural and remote areas of Bosnia-Herzegovina with limited access to specialized diabetes care. Methods This cross-sectional study, performed in February–March 2023, evaluated T1DM pediatric patients who used the Diabetes: M app in a 3-month mHealth-based T1DM management program, along with their parents and healthcare providers (HCPs). All participants completed self-administered online questionnaires at the end of the 3-month period. Data were analyzed by descriptive statistics. Results The study population included 50 T1DM patients (children/parents and adolescents) and nine HCPs. The mean ± SD age of the T1DM patients was 14 ± 4.54 years, with 26 (52%) being female. The mean ± SD age of the HCPs was 43.4 ± 7.76 years; all (100%) were women, with a mean ± SD professional experience of 17.8 ± 8.81 years. The app was reported usable in the domains of ease-of-use and satisfaction by the T1DM children/parents (5.82/7.0), T1DM adolescents/young adults (5.68/7.0), and HCPs (5.22/7.0). Various app features, as well as the overall app experience, were rated positively by the participants. Conclusion The results strongly support the usability of mHealth-based interventions in T1DM care, especially in overcoming care shortage and improving diabetes management and communications between HCPs and patients. Further studies are needed to compare the effectiveness of apps used to support T1DM management with routine care.

Purpose The present study aimed to investigate a) the associations between bilateral performance utilizing countermovement jump (CMJ), squat jump (SJ), speed and unilateral CMJ, isokinetic peak torque in knee extension and flexion with angular velocities of 60°/s and 180°/s and tensiomyography (TMG) parameters; b) whether the asymmetries derived from unilateral tests are associated with bilateral CMJ, SJ and speed in elite female soccer players. Methods Thirty-five elite female soccer players (average age: 20 ± 5 years) completed CMJ, SJ, speed, isokinetic muscle strength and TMG tests. Results Compared to the non-dominant leg, the dominant leg demonstrated greater peak torque output in both knee flexion (7.4%) and knee extension (5.6%) isokinetic tasks, as well as m. vastus medialis contraction time (7.6%), and soccer-specific agility test (4.1%). Conversely, the hamstring to quadriceps peak torque ratio at 180°/s (8.5%) was significantly greater in the non-dominant leg. The associations between CMJ, SJ and speed performance were positive and ranged from weak (r = 0.350) to high (r = 0.710). For speed and TMG-derived variables, correlations were negative and ranged from weak (r = −0.345, p = 0.042, for vastus medialis contraction time) to moderate (r = −0.530, p = 0.001, for biceps femoris contraction time). Furthermore, both bilateral CMJ and SJ negatively correlated with TMG-derived variables, ranging from weak (r = −0.350, p = 0.039, for vastus lateralis contraction time) to moderate (r = −0.537, p = 0.003, for rectus femoris contraction time). Conclusion The overall significant, albeit inconsistent, correlations between the diverse performance scores obtained highlight the necessity for a multifaceted and thorough diagnostic strategy in female soccer players.

Introduction: Acute lymphoblastic leukemia (ALL) is the most frequent pediatric leukemia; it can be defined according to chromosomic and genomic data. Cytogenetic analyses and determination of chromosomal numbers (such as hypo- or hyperdiploidy) and/or specific chromosomal rearrangements are basic for ALL classification and treatment. Even though cure rates of childhood ALL are at ~95%, pharmacogenetic aspects are of raising importance. Material and Methods: We have analyzed the literature for ALL subtypes, corresponding therapy options, and pharmacogenetic implications. Results: Data for ALL subtypes such as B-ALL, T-ALL, Ph-like ALL, DS-ALL, ETP-ALL, BCR-ABL1-like ALL are presented here. The gene polymorphism which lead to metabolizability of 6-MP are ITPA variants (94C>A) and IVS2+21A>C, in conjunction with TPMT (238G>C, TPMT*3B 460G>A and *3C 719A>G and NUDT15 (415C>T). For methotrexate metabolism gene polymorphisms are found for gene MTHFR as C677T and A1298C. Conclusion: In the last decade in many hospital laboratories, pharmacogenetic aspects gain more and more importance. Application of many molecular biology methods provided progress in treatment and diagnosis of ALL patients. Combination therapy is proposed as an alternative to single drug treatments.

Background: Recent findings point to the key role of cathepsin S (CTSS) in the survival of malignant cells, as well as the significance of the anti-apoptotic properties of high-density lipoprotein (HDL) that contribute to enhanced cell survival. The purpose of this study is to analyze CTSS as a potential biomarker in lymphoma. Also, in order to better understand the role of CTSS in the origin and development of lymphoma, its association with cystatin C (Cys C), lipids, and inflammatory markers was analyzed.  Methods: The study included 90 subjects: 11 Hodgkin (HL) and 44 B-cell non-Hodgkin lymphoma (NHL) patients, and 35 healthy subjects. CTSS was determined using the Invitrogen ELISA kit (Thermo Fisher Scientific, Inc., Waltham, MA, USA). Results: The level of CTSS was significantly higher in NHL patients than in control subjects: 12.20 (9.75-14.57) vs 9.97 (8.44-10.99), P<0.001. In NHL patients, there was a positive correlation between CTSS and the proportions of HDL3a, HDL3b, and the sum of the HDL3 subclasses (r=0.506, P<0.001; r=0.411, P=0.006, r=0.335, P=0.026, respectively). In addition, the area under the receiver operating characteristic curve (AUC curve) of CTSS was 0.766 (CI: 0.655-0.856). Conclusions CTSS is significantly elevated in patients with NHL and has the potential to be a new diagnostic biomarker. Moreover, demonstrating a correlation between CTSS levels and the proportion of anti-apoptotic HDL3a and HDL3b subclasses improves understanding of NHL, as well as contributes to the development of new therapeutic strategies for this cancer.

Background Among many genes which have been analyzed to understand obesity and related metabolic traits among children and adolescents, not many studies are conducted on LGALS3 gene, especially in population of children. A positive correlation of circulating galectin 3 serum levels with impaired blood glucose, high blood pressure and higher values of serum lipids and was found in general population. The aim was to investigate possible association of rs4644 with body mass index, glycaemia, and lipid profile in Serbian adolescents. Methods The study included 72 boys and 79 girls, 14-15 years of age. Among boys 51 (67.1%) had normal values of BMI, 11 (14.5%) were overweight, and 14 (18.4%) were obese. Among girls, 53 (63.9%) had normal BMI, 16 (19.3%) were overweight, and 14 (16.9%) were obese. Diabetes type 1 or 2, genetic syndromes, generalized inflammation, cardiovascular and malignant diseases were criteria for exclusion. Genotyping was performed by Real time PCR.

This study aimed to investigate the reliability, validity, and sensitivity of spatiotemporal parameters, during sprint skating, of bandy players. Thirty-two well-trained male bandy players (age: 17.8 ± 1.2 years; height: 1.80 ± 0.06 m; body mass: 75.7 ± 1.2 kg) participated in this study. They performed two 80 m linear skating sprints. To calculate the velocities and obtain glide-by-glide spatiotemporal variables, nine timing gates and two skate-mounted inertial measurement units (IMUs) were synchronized and used. The spatiotemporal variables at each step included the glide time, glide length, double support time, double support length, step length, and step frequency. All the spatiotemporal variables were analyzed separately: averaged over 80 m, during the acceleration, and the maximal steady-state phases. The relative and absolute reliability of the spatiotemporal parameters were good (ICC > 0.70; CV < 10%), except for the step frequency during the steady-state phase. The spatiotemporal parameters showed “good” to “satisfactory” sensitivity during the acceleration phase and whole sprint, and “marginal” sensitivity during the steady-state phase. Content validity was confirmed by a low percentage of the shared variance (17.9–34.3%) between the spatiotemporal parameters obtained during the acceleration and steady-state phases. A “stepwise” regression significantly predicted the steady-state skating velocity from the spatiotemporal metrics obtained during the acceleration [F(5,26) = 8.34, p < 0.001, adj. R2 = 0.62] and steady-state phases [F(5,26) = 13.6, p < 0.01, R2 = 0.67]. Only the step frequency obtained in the acceleration phase significantly predicted the maximal skating velocity (p < 0.01), while the glide length and step frequency derived during the steady-state phase significantly added to the prediction (p < 0.01). In conclusion, the spatiotemporal parameters, obtained by two skate-mounted IMUs, were shown to be reliable and sensitive measures of sprint skating, and they could be used to provide independent information for the different skating phases. The maximal skating velocity could be predicted from the spatiotemporal parameters, with longer gliding and more frequent steps as the most significant determinants.

This article examines the ways in which the media in Bosnia and Herzegovina in times of crisis relate to the already existing social polarization and the ways in which they further strengthen it. Theories of social polarization were used, with a special emphasis on interpretive polarization, in which the media play a crucial role. The focus of the research is reporting on the Ukrainian crisis, in order to consider the patterns that have developed in media reporting, especially when it comes to different approaches in the Federation of Bosnia and Herzegovina and the Republika Srpska. The research is based on the method of content analysis and in-depth structured interviews with journalists, editors and political analysts. The sample consists of the 7 most read web portals from BiH: 4 from the Federation of BiH and 3 from the RS, and the corpus totals 50 texts. A search used the keywords: Ukraine, Russia, aggression, attack, invasion, war, and the analyzed period is seven days from the beginning of the attack on Ukraine (from February 24, 2022) and seven days from the date of the first anniversary of the attack on Ukraine (from February 24 .2023). Indicators for analysis are: how the media decide what is newsworthy, how the media choose sources, how the media verify information and how the media shape the story (with special reference to how they shape it in relation to the agenda they set and the public opinion they shape). The goal is to question how much the Ukrainian crisis was used by the media to further polarize B&H society, and the general conclusion is that media reporting only partially fulfills the key roles of providing comprehensive, clear information, contextualizing events and educating the public. The interpretation of the events is selective and in accordance with the dominant narratives and, as such, does not contribute to a complete understanding of the events, and even less to a high-quality social dialogue. As a post-conflict society, Bosnia and Herzegovina should have a much greater sensitivity to the events in Ukraine, and the media should approach this topic with much more attention, responsibility and public interest. This applies equally to the quantity and quality of information available to citizens.

Gender equality is a democratic and civilizational standard, and mechanisms to implement gender mainstreaming have been established in many countries around the world, including Bosnia and Herzegovina. International mechanisms and women's civil society organizations are the main carriers of these changes, but the real impact of gender mainstreaming depends on the ability of institutions and the commitment of policy makers to move gender from the margins to the center in setting public policy at all levels of government. Unfortunately, across globally, the norm and practice diverge, especially at the local level. In the countries of the Western Balkans, these problems are even more pronounced and insufficiently articulated in academic research. Therefore, this paper analyzes the results of a survey conducted in local communities in Bosnia and Herzegovina. The research included an analysis of legal provisions at the local level and interviews with relevant stakeholders (women activists and members of local equality commissions). The analysis shows that gender equality is addressed in a fragmented and inconsistent manner, that it is not adequately addressed in local documents, and that local gender mechanisms (commissions for gender equality) have been formed to fulfill a formal obligation. In communities with no profiled women's organizations, the situation is even worse when it comes to the possibility of monitoring and improving the work of these mechanisms.

Telepresence robots, designed to bridge physical distances, have unique capabilities and inherent limitations when deployed in classroom environments. This study examines these aspects, focusing on how telepresence robots facilitate or hinder classroom accessibility and inclusivity. Based on field study results from participatory observations, surveys and interviews with 22 participants, we present and catalogue the operational capabilities of telepresence robots, such as mobility and interaction potential, alongside their limitations in areas like sensory perception and social presence. Our findings reveal a nuanced landscape where telepresence robots act as both enablers and barriers in the classroom. This duality raises the question of whether these robots can be considered “disabled” in certain contexts and how this perceived disability impacts remote students’ inclusion in classroom dynamics. Finally, we present use recommendations to improve classroom experience and telepresence design.

Robot motion planning is a challenging domain as it involves dealing with high-dimensional and continuous search space. In past decades, a wide variety of planning algorithms have been developed to tackle this problem, sometimes in isolation without comparing to each other. In this study, we benchmark two such prominent types of algorithms: OMPL's sampling-based RRT-Connect and SMPL's search-based ARA* with motion primitives. To compare these two fundamentally different approaches fairly, we adapt them to ensure the same planning conditions and benchmark them on the same set of planning scenarios. Our findings suggest that sampling-based planners like RRT-Connect show more consistent performance across the board in high-dimensional spaces, whereas search-based planners like ARA* have the capacity to perform significantly better when used with a suitable action-space sampling scheme. Through this study, we hope to showcase the effort required to properly benchmark motion planners from different paradigms thereby contributing to a more nuanced understanding of their capabilities and limitations. The code is available at https://github.com/gsotirchos/benchmarking_planners

PurposeTo understand how three features of online consumer reviews - the strength of persuasiveness in online consumer reviews (argument quality), the number of online consumer reviews (volume of reviews), and source credibility – are related to the behavioural intentions in the movie consumption context. Besides, the present study aims to explore intergenerational differences (X, Y, and Z) in the patterns of association between three characteristics of online consumer reviews (argument quality, volume of reviews, and source credibility) and an individual’s choice of a movie intended to be watched.Design/methodology/approachThe study sample (n = 518) was recruited from a population of users of IMDb living in Bosnia and Herzegovina. Structural equation modelling and multi-group analysis were used to test the proposed hypotheses.FindingsThe results revealed that argument quality, the volume of reviews, and source credibility of movie-related online consumer reviews are positively related to the intention to watch a movie for all three generational cohorts (X, Y, and Z). Regarding biases in processing information cues, our findings indicate that movie viewers from all three generations (X, Y, and Z) make inferences between source credibility and argument quality. However, biases in the relation between the volume of reviews and the argument quality were found only among X-ers and Y-ers but not among Z-ers.Originality/valueThe present study contributes to the eWOM research stream by examining the role of different characteristics of online consumer reviews (argument quality, the volume of reviews, and the source credibility) in movie consumption. Moreover, it sheds light on how argument quality, the volume reviews and the source credibility interact with the behavioural intentions of different generations and whether these interactions exhibit similarities or differences across three distinct generation cohorts: X-ers, Y-ers, and Z-ers.

<p class="KEYWORDS">Architectural designers are currently faced with many challenges&mdash;technological changes, environmental and economic impacts, necessity to innovate and raise the bar in building performance, and the paradigm shift in architecture with the wider adoption of advanced computational design and fabrication techniques. This paper focuses on innovations in architecture, relationships between scientific research and design, and advanced building technologies. Several research projects are presented, including use of virtual and augmented reality for design, smart facade systems for generating heating/cooling and electricity, and regenerated buildings with improved performance.</p>