Abstract Cancer of the cervix has a progressive character and is one of the most significant public health problems in many countries. Our research aimed to translate EORTC QLQ CX 24 (European Organization for Research and Treatment of Cancer; Quality of life questionnaire-cervical cancer 24) from English to Serbian, to create essential cultural adaptations and to analyze psychometric properties of the translation in a model of female inpatients with cancer of the cervix. The QLQ CX 24 was translated and adapted according to internationally established guidelines, and then tested on a sample of 100 Serbian females with cancer of the cervix. The testing was repeated three times on the same patients. We calculated the internal consistency (Cronbach’s alpha), criterion validity, convergent validity, and discriminative validity of the QLQ CX 24. We used factor analysis to discover the original construct. The Serbian translation of QLQ CX 24 showed good internal consistency, showed satisfactory reliability, and temporal stability. In the first, when was rated by the investigators Cronbach’s alpha was 0.607, and one month later when the questionnaire also was rated by investigators Cronbach’s alpha was 0.696. When the scale was rated by females themselves Cronbach’s alpha was 0.802. Divergent as well as convergent validity tests had good results. The factorial analysis exposed six domains. The Serbian translation of QLQ CX 24 is a trustworthy and appropriate specific instrument for measuring the quality of life in females with cervical cancer.

Uvod: Mišićno-koštani poremećaji uzrokovani radom (engl. Work-Related Musculoskeletal Disorders – WRMSDs) najčešća su oboljenja povezana s radom, a opisuju širok dijapazon degenerativnih i upalnih stanja. WRMSDs pogađaju milione radnika na području cijele Evrope i svijeta, a sami poslodavci zbog njihovih posljedica troše milijarde eura. Zdravstvo kao poseban sektor ima jednu od najvećih prevalenci radom uzrokovanih mišićno-koštanih poremećaja (MKP) u svijetu daleko ispred građevinarstva, rudarstva i proizvodnje. Ispitanici i metode: U istraživanje bilo je uključeno 177 zdravstvenih profesionalca oba spola koji su svojim radom aktivno uključeni u pružanje zdravstvenih usluga, kategorizirani prema životnoj dobi i vrsti radnih zadataka koje obavljaju u različitim položajima tijela u okviru svojih stručnih službi. Instrumenti koji su se koristili u istraživanju su standardizirani holandski upitnik za MKP (Dutch Musculoskeletal Discomfort Questionnaire – DMQ), standardizirani upitnik za procjenu indeksa radne sposobnosti (Work Ability Index – WAI) i ergonomski interventni program. Istraživanje je trajalo od januara 2021. do oktobra 2021. godine. Rezultati: Najveća učestalost MKP povezanih s radom kod zdravstvenih profesionalaca prije i poslije provođenja ergonomskog interventnog programa bila je u području vrata (83,1% prije, 64,9% poslije), u regiji gornjeg dijela leđa (71,8% prije, 56,5% poslije) te u regiji donjeg dijela leđa (68,4% prije, 55,9% poslije). Prosječna vrijednost indeksa radne sposobnosti prije uvođenja ergonomskog interventnog programa iznosila je 35,44±8,59, dok se poslije provedenog ergonomskog interventnog programa statistički signifikantno povećala i iznosila je 38,40±7,30. Zaključak: Ergonomski interventni program je utjecao na smanjenje učestalosti MKP uzrokovanih radom, i povećanje radne sposobnost zdravstvenih profesionalaca.

Cardiovascular diseases (CVDs) are a group of diseases with a very high rate of morbidity and mortality. The clinical presentation of CVDs can vary from asymptomatic to classic symptoms such as chest pain in patients with myocardial infarction. Current therapeutics for CVDs mainly target disease symptoms. The most common CVDs are coronary artery disease, acute myocardial infarction, atrial fibrillation, chronic heart failure, arterial hypertension, and valvular heart disease. In their treatment, conventional therapies and pharmacological therapies are used. However, the use of herbal medicines in the therapy of these diseases has also been reported in the literature, resulting in a need for critical evaluation of advances related to their use. Therefore, we carried out a narrative review of pharmacological and herbal therapeutic effects reported for these diseases. Data for this comprehensive review were obtained from electronic databases such as MedLine, PubMed, Web of Science, Scopus, and Google Scholar. Conventional therapy requires an individual approach to the patients, as when patients do not respond well, this often causes allergic effects or various other unwanted effects. Nowadays, medicinal plants as therapeutics are frequently used in different parts of the world. Preclinical/clinical pharmacology studies have confirmed that some bioactive compounds may have beneficial therapeutic effects in some common CVDs. The natural products analyzed in this review are promising phytochemicals for adjuvant and complementary drug candidates in CVDs pharmacotherapy, and some of them have already been approved by the FDA. There are insufficient clinical studies to compare the effectiveness of natural products compared to approved therapeutics for the treatment of CVDs. Further long-term studies are needed to accelerate the potential of using natural products for these diseases. Despite this undoubted beneficence on CVDs, there are no strong breakthroughs supporting the implementation of natural products in clinical practice. Nevertheless, they are promising agents in the supplementation and co-therapy of CVDs.

This paper investigates the application of Adaptive Fuzzy PID Control in the context of car control using a bilateral teleoperator. A bilateral teleoperator allows the operator to operate a remote car using his own controls and at the same time receive feedback on the car’s condition. The goal of the research is the analysis and comparison of different control methods, including PID controller, Adaptive Fuzzy PID controller, and the use of energy and wave variables of the bilateral teleoperator. The paper presents a car control model by means of a bilateral teleoperator, which was implemented in a simulation environment. Then performance comparisons of different control methods were made. The PID controller was used as the basic method, while the Adaptive Fuzzy PID controller was additionally included to achieve system adaptivity. Also, the use of energy and wave variables of the bilateral teleoperator was additionally investigated. The results of the comparison show that the use of bilateral teleoperator wave variables gave the best response of the control system. The analysis of signal waveforms and frequencies enabled more precise monitoring of the car’s condition and the detection of possible problems or instability in the system. This knowledge can be of great importance for improving the performance of car control by means of a bilateral teleoperator.

Museum development is a side effect of tourism development since museums are significant components of cultural and tourist infrastructure, and tourism encourages infrastructure development in general. In Bosnia and Herzegovina, where tourism is a critical sector of the economy with a decades-long flow, the pattern of comparative development of tourism and museums has been recognized. The study provides a comparative review of the country's tourism and museum development, showcasing the multiple benefits of tourism and museums. Museums are one of the most important socio-cultural benefits of tourism because they preserve and present heritage, improve science, education, and cultural profiling, encourage employment and visitation, provide a better stay, generate income, and contribute to environmental urbanization and higher living standards. The identification of museums and museum resources revealed that, during the past three decades, approximately thirty museums of a predominantly thematic character have been established, particularly in the country's most visited destination (Sarajevo). Furthermore, an open-air museum (ethno-village) trend has begun. Museum visitation is increasing in tandem with tourist trips to the country, despite a lack of adequate monitoring (incomplete figures that are inconsistent with the situation in the field). Despite the fact that the global crisis disrupted tourism and museum development (COVID-19), both areas are key drivers of economic revitalization, as evidenced by new ideas and projects in this field. However, in addition to the benefits of increased museum activity, the study highlighted certain issues (e.g., lower engagement of professional staff and women etc.), which will encourage future research to provide more sustainable strategies for museum development.

Drug-induced nephrotoxicity is still a significant obstacle in pharmacotherapy of various diseases and it accounts for around 25 % of serious side-effects reported after drug administration. Furthermore, some groups of drugs such as nonsteroidal anti-inflammatory drugs, antibiotics, antiviral drugs, antifungal drugs, immunosuppressants, and chemotherapeutic drugs have the "preference" for damaging the kidney and are often referred to as the kidney's "silent killer". Clinically, the onset of acute kidney injury associated with drug administration is registered in approximately 20 % of patients and many of them develop chronic kidney disease vulnerability. However, current knowledge about the mechanisms underlying this dangerous phenomenon is still insufficient with many unknowns. Hence, the valuable use of these drugs in clinical practice is significantly limited. The main aim of this study is to draw attention to commonly prescribed nephrotoxic drugs by clinicians or drugs bought over the counter. In addition, the complex relationship between immunological, vascular and inflammatory events that promote kidney damage is discussed. The practical use of this knowledge could be implemented in the engineering of novel biomarkers for early detection of drug-associated kidney damage such as Kidney Injury Molecule (KIM-1), lipocalin associated with neutrophil gelatinase (NGAL) and various microRNAs. In addition, the utilization of artificial intelligence (AI) for the development of computer algorithms that could detect kidney damage at an early stage should be further explored. Therefore, this comprehensive review provides a new outlook on drug nephrotoxicity that opens the door for further clinical research of novel potential drugs or natural products for the prevention of drug-induced nephrotoxicity and accessible education.

Large-scale incorporation of new energy generation units based on renewable sources, such as wind and photovoltaic power, drastically alters the structure of the power system. Because of the intermittent nature of these sources, switching in grids (connection and disconnection) occurs much more frequently than with conventional sources. As a result, the power system will inevitably experience a large number of transients, which raises questions about the stability of the system and the quality of the electrical energy. Therefore, measuring various types of transients in power system is crucial for stability, power quality, fault analysis, protection design, and insulation design. Transient recorders that are currently used are generally expensive and only suitable for particular locations in power systems. The number of installed transient recorders is insufficient for a comprehensive analysis of problems that may occur. Hence, it is important to have inexpensive and efficient transient recorders that can be installed at multiple points in the power system on various types of objects. It is also essential to have a transient record database with open access, which can be used by researchers to develop new analysis techniques based on artificial intelligence. This paper proposes an inexpensive measurement and acquisition system designed to record transient phenomena on different objects within the power system. The system is designed to use autonomous power, a standardized data acquisition module, a low-budget system for transmitting recorded transient events to the server via mobile network, and a sensor system adapted to the object where transients are recorded. The proposed system is designed to be used for all types of objects in the power system where transients may occur, such as power lines, transmission towers, surge arresters, and transformers. All components of the system are described, and the system is tested under laboratory conditions. The modular nature of the system allows customization to the specifics of the location in power system by choosing appropriate components. The calibration method of the custom designed Rogowski coil is described. The cost analysis of the proposed system and power consumption analysis are performed. The results show that the system’s performance meets application requirements at a low cost.

The work represents the continuation of the research of the maximum bending stress force of a wooden beam up to the moment of failure, which is defined experimentally and with a corresponding mathematical model. The goal was to confirm the accuracy of the mathematical model of the breaking force using numerical simulation and the Solid Works software. Five different types of wood and five different beam thicknesses were used as input parameters whose influence was monitored trough the simulation. The stress deformation state and deflection for the calculated fracture forces were analysed separately for each variant. The breaking force model, which is defined depending on the density of the wood and the thickness of the board, proved to be adequate for defining the maximum stresses and deflections when bending beams.

In order to determine the bending strength of wood or wood-based panels, an experimental method is typically used to test samples of different sizes that involves bending or compression. However, such tests are expensive and time-consuming, so mathematical models are often applied that allow predicting the bending strength based on a smaller number of obtained test results. One such model is the Lagrange interpolation polynomial. The study discusses Lagrange’s interpolation model. Using the results of tests done on plywood of various thicknesses, approximates the bending strength of plywood for values that could not be tested directly and provides an estimate of strength for particular values.

Educational institutions record an increase in behavioral disorders in children and adolescents every day, with severe symptoms that result in hospitalization or the imposition of criminal sanctions for juvenile delinquents. Behavioral disorders of children and young people stand out as one of the primary problems of today's society. The purpose of this paper is to give a detailed insight into the state of emotional and behavioral disorders, from those that are hidden such as withdrawal, apprehension, fear,anxiety to behavior that children and young people come into conflict with others, even committing acts that are legally recordable as punishable. It has been proven in various studies that early diagnosis and preventive interventions in working with children give the best results. The hypothesis that behavioral disorders and emotional problems among children and young people in primary and secondary schools are present and require the application of appropriate preventive and treatment programs has been confirmed. Through the presentation of modern approaches to the detection, prevention and diagnosis of behavioral problems, this work shows the relationship between biological factors, parental qualities, education, the influence of peers, school and socialnorms, and the way in which they become risky for the development of problematic behavior. Detecting risk factors and stopping the action of risk processes, which have been proven to have a positive correlation with the occurrence of aggressive behavior in children, leads to a decrease in the rate of its occurrence. It has been observed that there are several successful ways of working with children that result in a reduction in the rate of behavioral disorders, even in provoking situations. Communication and problem-solving skills training can successfully reduce inappropriate child behaviors. Teaching social-emotional skills, in addition to reducing behavioral disorders, also results in higher self-esteem and more positive attitudes in children.Schoolshave a need for continuous implementation of science-based prevention programs that include interventions aimed at children and work with parents Keywords: Behavioral disorders, interventions, children, adolescents, parents, prevention programs

This paper brings the introduction of the analysis of foundation solution for the noise protection walls on the reinforced earth along the Highway Corridor Vc, a road and rail transport corridor that connects Hungary, Croatia and Bosnia and Herzegovina, included in the network of Pan-European transport corridors. A solution with pile foundations made of steel IPE profiles is presented in detail. During the design and modelling, as well as the calculation of the structural foundation, the modern software program PLAXIS was used, and the calculation was made in accordance with EN 1997 Eurocode 7, Geotechnical Design. Special attention is devoted to the analysis of the impact of driving IPE steel profiles, as foundation piles, on reinforced earth. The presented solution was then verified by an additional control calculation and a field test of the impact of the horizontal load on the bearing capacity of the IPE steel profile driven into the reinforced slope. Based on the conducted analyses and testing, it has been proven that it is possible to build noise protection walls on the reinforced earth without disturbing the internal stability and functionality of the reinforced earth.

The objective of this research was to investigate impulsivity among children with dyslexia and comorbid dyslexia/ADHD. Children with these disorders, along with a non-ADHD/dyslexia sample, completed a self-report on impulsivity. Additionally, a specific impulsivity scale was completed by the children's parents and teachers. The analysis revealed a main effect for groups, indicating that children with dyslexia and comorbid dyslexia/ADHD reported more symptoms of impulsivity than normally achieving children. Furthermore, differences were identified between children with dyslexia and those in the comorbid dyslexia/ADHD group. Specifically, children with comorbid dyslexia/ADHD exhibited more impulsive behavior than children with dyslexia alone. Notably, there was a high level of consensus in ratingsof impulsivity between children and their teachers and parents.Keywords:dyslexia, ADHD, impulsivity

Modeling flow in open channels is essential for determining channel capacity and predicting flood events. The key segment for creating flood hazard and risk maps is a high-quality hydraulic model of the flow in the main bed with its tributaries. Several software packages have been developed for hydrodynamic simulations of flood events. In addition to the geometric characteristics of the watercourse, the equations of a one-dimensional flow model include a parameter that connects all influences that provide resistance to the flow of water. Determining the roughness of a natural channel is one of the most demanding procedures for the development of hydraulic models. Therefore, it is necessary to calibrate and validate the Manning coefficients of the channel roughness using simulation models. In the present study, the estimation of channel and floodplain roughness for the Veseočica River in Bosnia and Herzegovina was performed using the HEC-RAS hydrodynamic model. After calibration and verification of the model, flood hazard maps were created for flood waves with return periods of 20, 100, and 500 years. ArcGIS and HEC-GeoRAS software tools were used to create the flood risk maps.

Preschool wheezing and childhood asthma create a heavy disease burden which is only exacerbated by the complexity of the conditions. Preschool wheezing exhibits both “curricular” and “aetiological” heterogeneity: that is, heterogeneity across patients both in the time‐course of its development and in its underpinning pathological mechanisms. Since these are not fully understood, but clinical presentations across patients may nonetheless be similar, current diagnostic labels are imprecise—not mapping cleanly onto underlying disease mechanisms—and prognoses uncertain. These uncertainties also make a identifying new targets for therapeutic intervention difficult. In the past few decades, carefully designed birth cohort studies have collected “big data” on a large scale, incorporating not only a wealth of longitudinal clinical data, but also detailed information from modalities as varied as imaging, multiomics, and blood biomarkers. The profusion of big data has seen the proliferation of what we term “modern data approaches” (MDAs)—grouping together machine learning, artificial intelligence, and data science—to make sense and make use of this data. In this review, we survey applications of MDAs (with an emphasis on machine learning) in childhood wheeze and asthma, highlighting the extent of their successes in providing tools for prognosis, unpicking the curricular heterogeneity of these conditions, clarifying the limitations of current diagnostic criteria, and indicating directions of research for uncovering the etiology of the diseases underlying these conditions. Specifically, we focus on the trajectories of childhood wheeze phenotypes. Further, we provide an explainer of the nature and potential use of MDAs and emphasize the scope of what we can hope to achieve with them.

Timber structures have been a popular choice for construction due to their natural and aesthetic appeal. However, with the increasing focus on sustainability and eco-friendliness, alternative building materials are gaining popularity. One such material that has gained attention is coconut wood. Coconut wood is a by-product of the coconut industry and has several unique properties that make it an excellent choice for timber structures. This paper reviews the properties and applications of coconut wood in timber structures and discusses its advantages, limitations, and challenges. We discussed the physical and chemical properties and durability of coconut wood. The average density of coconut palm wood ranges from 0.41-1.11g/cm3, while its moisture content ranges from 50% to 400%. Coconut wood has low shrinkage and swelling rates, reducing the risk of cracking or warping. The holocellulose content is about 67% while the lignin content is approximately 25%. Chemical and natural products, are effective in protecting coconut wood against decay and insect attack. Understanding such characteristics of coconut wood is critical for its optimal utilization in various industries. By employing appropriate preservation techniques and utilizing this versatile and sustainable resource, coconut wood can continue to provide significant benefits for communities and industries around the world.