Background: In the year 2024 Bosnia and Herzegovina celebrates anniversaty of three important healthcare institutions: the Vaqf's hospital in Tuzla established in 1874, Regional hospital in Sarajevo (Landesspital) established in 1894 and the first Faculty of Medicine in Bosnia and Herzegovina established in Sarajevo in 1944. Objective: The aim of this article was to describe historical facts how mentioned institutions were founded and what was importance of functioning all of them during history of health care education and healthcarte protection. Methods: The author searched important historical facts about establishing and works Hastahana in Tuzla, Landesspital in Sarajevo and Medical faculty in Sarajevo, writen in the books and articles deposited in indexed databases PubMed Central, Scopus, Hinari, Embase, etc. Results and Discussion: The first hospital (hastahanas, named as Waqf's hospitals, besides other 4 - established in Tuzla, Mostar, Travnik and Banja Luka) has been founded in Sarajevo in 1866, which was founded by Governor Serif Osman Topal Pasha and doctor Jozef Kecet. These hastahanas were definitely the embryo of an organized health services in Bosnia and Herzegovina, which have had enormous hystorical significance. Vakuf's hospital in Tuzla (Hastahana) founded by doctor Mehmed Serbic Sami, the first Muslim physician, graduated in Instanbul, Turkey at Lecole de Medicine in 1873. The first official hospital established during Austrian-Hungarian period was Regional (Landesspital) hospital opened in the July 1st 1894 and had 303 hospital beds in 4 departments: the first Internal department with diseases of the throat and nose (not the ear) with 45-50 beds, the Second - Surgical Department with ophtalmology (for ear surgery) with 45-50 beds, the Third - Dermatology and Venerology ward with 70-80 beds and the fourth - Gynaecology-obstetrics department with 70-80 beds. It will be a good basis for training future teachers pioneers of medicine, which will be opened in Sarajevo in November 22nd 1944 as a part of Medical Faculty in Zagreb. An generation of medical students attend the first year of study in Sarajevo. True, most students of this generation will be mobilized during the war, some will move on to medical faculties in other cities, and some other faculties in Sarajevo. The first Faculty of Medicine in Bosnia and Herzegovina officialy established in November 16th 1946. Conclusion: All institutions described in this article played important role in the history of healthcare education and healthcare protection in Bosnia and Herzegovina.

Background. The novel SARS-CoV-2 virus initiated one of humanity’s biggest pandemics, swiftly spreading worldwide and inducing significant health issues. This virus prompted widespread changes, with initial inadequate immune response and a lack of effective drug therapies. Consequently, every organ, particularly the respiratory and nervous systems, was susceptible to infection. The Covid-19 pandemic ended in 2023, but ongoing symptoms led to the term Long Covid and chronic manifestations. Objective: The aim of this article was to describe the important role of health professionals, especially family physicians and their teams when and how to identify common neurological symptoms and clinical conditions during pandemic and post-pandemic period. Methods. A systematic review gathered data on neurological symptoms and complications in Covid-19 patients, ranging from mild, like headache, to severe, such as encephalitis and stroke. Results and Discussion. Analysis revealed a significant proportion of Covid-19 patients experiencing neurological manifestations, with about one-third exhibiting symptoms. Epidemiological data showed ongoing Long Covid symptoms alongside acute manifestations. Many of cases with Long Covid related neurological complications were presented. Common neurological manifestations included chronic fatigue, changes in smell and taste, brain fog, headaches, fibromyalgia, cognitive impairment, and mood disorders. Severe Covid-19 cases were more likely to exhibit neurological complications, such as ischemic brain vasculitis and thromboembolic events, associated with higher mortality rates. Neurological complications of Covid-19 are frequent and diverse, necessitating a multidisciplinary approach in diagnosis and treatment, coordinated by primary care physicians. In practice, it is necessary to monitor the patient’s immune status over a longer period, and coagulation disorders (D-dimer) for adequate therapy and rehabilitation. Very important is to recognize the immune response after an acute infection. Due to the epidemic occurrence of Long Covid, it is necessary to introduce the above-mentioned procedures also in case of clinical signs of Long Covid. There are several hypotheses for the causes of Long COVID symptoms, including immune disorders, persistence of the virus in various organs, and microvascular coagulation changes. Within primary healthcare as the first line of defense it is necessary to address stress caused by COVID-19, try to recognize the affected other organ systems. Conclusion: The family doctor with his communication skills can make connection with the secondary and tertiary levels and the consulting services of immunologists, microbiologists, nutritionists, pharmacist, physiatrist and infectiologist. The family medicine team plays a key role in prevention, random detection and adequate medical procedures. The main interventions at the primary level should include education, emotional support, specific nutrition interventions and lifestyle modifications.

This publication has always been a cornerstone of our community, providing valuable insights, updates, and a platform for sharing the incredible work of our members. It was initiated during the EFMI presidency of Catherine Chronaki (Belgium, Greece), with our enthusiastic colleague, Izet Masic (Bosnia Herzegovina), serving as the first Editor-in-Chief. The past year has been a period of reflection and rejuvenation for our team. We took this time to evaluate how best to serve you, our esteemed members, and ensure that our newsletter remains a vital resource in our professional journey together. We continue the traditional general content of previous editions, introducing a structural organization by sections, each coordinated by a guest editor. Additionally, we have expanded the range of topics, introducing articles on opinions as well as including some highlights from our previous meetings. This edition features three special sections.

Background: Autoimmune limbic encephalitis (ALE) is an inflammatory brain process involving a group of diseases with antibodies against neuronal synaptic and cellular antigens. Diagnosis is based on clinical examination, neurological functional tests, cerebrospinal fluid analysis, immunological testing, and radiological findings. Objective: This case report aims to present the case of a 68-year-old patient initially hospitalized for intermittent neurological deficits in the form of cognitive disorders of consciousness, which was initially declared as dementia without physical neurological deficit. Case presentation: Initial brain MRI (SIEMENS Magnetom Avanto, 1.5 T, Erlangen, Germany) showed changes differentially diagnosed characterised as glial neoplasm of mixed-grade astrocytoma or inflammatory process of unilateral autoimmune encephalitis. Since the neurosurgical opinion suggested a higher-grade glioma with proposed surgical treatment, the patient was referred for repeated MRI with MR spectroscopy in order to exhaust all diagnostic possibilities before surgery. MRI with MR spectroscopy (SIEMENS Magnetom Lumina, 3 T, Erlangen, Germany) revealed radiologically altered findings, in the right hippocampus and parahippocampal gyrus, which primarily corresponded to changes due to unilateral autoimmune encephalitis,due to its morphology characteristics and spectroscopy profile, making the primary glial neoplasm of lower grade less likely. Since the neurological mosaic IIFT result showed a positive LGI1 antibody finding, therapy for autoimmune encephalitis was initiated, leading to significant improvement in cognitive functions and the return of short-term memory. Conclusion: Although the detection of antibodies against onconeural, cellular, and synaptic proteins represents a significant advancement in diagnosing autoimmune limbic encephalitis, the role of conventional diagnostic tools such as MRI, EEG, and cerebrospinal fluid analysis should not be overlooked, where the application of new functional imaging techniques such as MR spectroscopy can be beneficial and should be considered.

Introduction: Doping which includes veterinary drugs as irrational human medicine after the infection with COVID 19 still leaves the field open from the aspect of vascular surgery and angiology of the iliac segment. Reflection of the effect of the COVID 19 virus on the sports performance of athletes in various sports after the corona virus is still present. Some athletes have had a hard time individually coping with the clinical consequences after a long illness of the COVID 19 virus. Even though covert doping is part of the everyday life of an elite athlete, it still remains an unresolved topic in the form of a solution for post-COVID 19 symptoms or switching to or taking some other masked substances that are impossible to detect in the blood, as well as a potential reflection on the morphological changes of the arteries. Although consequences of the corona virus for the cardiorespiratory system have been reported, a question arises as to the connection between the development of iliac syndrome and pathomorphological arterial iliac changes in athletes with suspicion of potential correlation with underground doping substances of pharmacologically untested origin in the Balkan population. Widespread global COVID 19 pandemic and the isolation factor have forced numerous athletes to switch their normal training routine and protocols to alternatives such as cycling with or without abusing illegal substance. Increased intima-media thickness, the first structural change detected in atherosclerosis, is an important surrogate marker in atherosclerosis can be connected with high intensity endurance cyclists, running and triathlon competitive athletes affecting their poor performance status and professional doping levels. In some cases, amateur and recreational athletes are also affected especially if they were exposed to COVID 19 infection and doping. Goals: The primary focus of the present study is to determine the initial progression of the disease during and after the COVID 19 pandemic, starting from morphological changes and obstructive arteriopathy of the external iliac artery on account of measuring intima media thickness and the possibility of outset of kinking and obstructive arterial disease of the external iliac artery after 3 years. The secondary focus of the study is to examine the influence of doping on the pathomorphological changes of the external iliac artery during 3 years of research. Subjects and Methods: two groups of were observed (recreational and amateur cyclist). In total 63 selected subjects in the demographic area of ​​former Yugoslavia without cardiovascular disease were observed during the January 2021 and January 2024 period (3 years). Results: Changes in intima-media thickness of iliac artery from baseline 3 years were observed between the standard exercise amateur group and recreational control group. However, intensity exercise under 9000km per year were no significant developing progression of intima-media thickness of iliac artery during 3 years in recreational control group, but minimal progression of intima-media thickness of iliac artery were significant in amateur cycling group due to the potential effect of doping. Conclusion: The application of doping itself is indisputable, but the missing link that would confirm this claim is scientifically limited. We cannot confirm with certainty what is the trigger for the progression of pathomorphological changes and whether the consequences of overcoming the COVID 19 infection or doping. But there are many scientific facts and studies that confirm the connection between progressive atherosclerosis and illegal underground doping substances of pharmacologically untested origin. The consequences may result with a tendency for a futuristic vascular invasive patch or bypass surgical treatment.

Background/Aim: To evaluate the effect of curing light parameters (intensity, duration, and distance of curing tip) on the depth of cure of conventional resin-based composite. Material and methods: Cylindrical specimens made of nanohybride resin-based composite are cured with 12 different curing protocols, combined with 3 different light intensities (300, 650, and 1100 mW/cm²), 2 distances of curing tip (0 and 8 mm), and 2 exposure times (20 and 40 seconds). The specimens were measured after scraping the uncured composite material according to the ISO 4049 standard. The depth of cure was calculated by dividing the length of the remaining composite by 2. Data were analyzed using: Levene's test and Multivariate Analysis-of-variance (MANOVA). The level of significance was set at P<0.05. Results: The highest depth of cure (3.332 mm) was observed for curing protocol 1100mW/cm²/0mm/40s. The lowest depth of cure had specimens cured with curing protocol 300 mW/cm²/8mm/20s (2.034mm). MANOVA showed a significant influence of the distance of the curing tip (P=0.014; P=0.001) regardless of light intensity and duration of exposure time. Exposure time was a significant factor (P=0.009) when cured from different distances. Although higher light intensity produced a higher depth of cure, light intensity was not a significant factor. Conclusions: The depth of cure can be increased by reducing the distance of the curing tip, when it is possible. At a distance of 8 mm, the depth of cure can be increased by a longer exposure time, regardless of curing light intensity.

Background: In aim to promote HPV vaccination among children and youth, the Institute for Public Health of the Federation of BiH in 2023 developed an HPV immunization program, furtherly accepted by the Federal Ministry of Health. In collaboration with WHO and UNFPA country offices, the Institute for Public Health of the Federation of BiH initiated education to emphasize the importance of improving the knowledge and skills for over 280 health professionals in effective communication with parents in the promotion of HPV vaccination. Methods and materials: Paper presents an analysis of results of the pre and post testing of the health professionals directly involved in the HPV vaccination process in the Federation of BiH, regarding their self-confidence in communication with parents about HPV vaccination. For data collection was used the questionnaire as a part of the WHO document "Communicating with caregivers about HPV vaccination: facilitator's guide" published in 2023. The questionnaire was created in Google Forms for health professionals who participated on training. For descriptive and inferential statistics of collected data used IBM SPSS20 package. Results: The data showed an increase in self-confidence of health professionals in communication with parents after completed training. Before training 32.5% of health professionals confirmed self-confidence in talking to parents about HPV vaccination while 68.0% of them after training. Self-confidence about adverse reactions after HPV vaccination is confirmed by 27.4% health professionals before training and by 64.4% of them after training. Conclusions: A systematic approach in improving the communication knowledge and skills of health professionals is significant support for increasement of the coverage and promotion of HPV vaccination.

The article presents an approach to the automatic derivation of conceptual database models from heterogeneous source artifacts. The approach is based on the integration of conceptual database models that are derived from source artifacts of one single type by already existing tools, whereby those models possess limited certainty given their limited completeness and correctness. The uncertainty of the automatically derived models from specific source artifacts is expressed and managed through the effectiveness measure of the generation of specific concepts of the input conceptual database models. The approach is implemented by the DBomnia tool - the first online web-based tool enabling automatic derivation of conceptual database models from heterogeneous source artifacts (business process models and textual specifications). DBomnia employs other pre-existing tools to derive conceptual models from sources of the same type and then integrates those models. The case study-based evaluation proves that the implemented approach enables effective automatic derivation of the conceptual database model from a set of heterogeneous source artifacts. Moreover, the automatic derivation of the conceptual database model from a set of heterogeneous source artifacts is more effective than each independent automatic derivation of the conceptual database model from sources of one single type only.

Background. Endoscopic Retrograde Cholangiopancreatography (ERCP) is an essential procedure for diagnosing and treating biliary and pancreatic disorders but carries the risk of significant complications, particularly in patients with pre-existing conditions. The most critical complications include acute pancreatitis, bleeding, perforation, and cholangitis. Early detection and comprehensive therapeutic interventions are key factors in patient recovery and require seamless communication among healthcare professionals at all levels of care. Close collaboration between medical staff ensures a well-coordinated treatment strategy, even at the primary care level. Objective: This article aims to present a case of a patient who developed multiple severe complications following ERCP, including ulcer perforation with pneumoperitoneum, acute pancreatitis, cholangitis, and cardiac decompensation, all of which were successfully managed within an outpatient and family medicine setting. Methods and Design: The patient’s clinical history, laboratory findings, radiological imaging, and endoscopic evaluations were carefully analyzed and described to outline the approach to diagnosis and management. Case Presentation: An 86-year-old male with a known history of peptic ulcer disease opted for outpatient treatment after undergoing an ERCP procedure. The patient subsequently developed a series of severe complications, including ulcer perforation, pneumoperitoneum, acute pancreatitis, and cholangitis, along with cardiac decompensation. However, through meticulous outpatient management and primary care follow-up, the patient achieved a favorable recovery. Conclusion: This case report highlights that comprehensive outpatient management can effectively address complex complications following ERCP, even in patients with pre-existing conditions. Coordinated care at the primary healthcare level plays a vital role in ensuring positive outcomes.

In order to remove harmful microorganisms, textile materials are subjected to various types of antimicrobial treatments. Skin infections represent a permanent diagnostic and therapeutic challenge, and can be caused by bacteria, viruses, fungi and parasites. In this paper, the impact of printing insoles with alginate paste, modified bentonites and Picea omorika plant extract on their antimicrobial, dielectric and sorption properties was investigated. It was found that the printed insoles show a certain antimicrobial effect on the bacteria Staphylococcus aureus and Escherichia coli and the yeast Candida albicans. The obtained values of specific conductivity are in agreement with the tested parameter of the sorption properties of the insoles.