Introduction: Teachers in Bosnia and Herzegovina had insufficient skills in educational technology but had to lead the introduction of online teaching and adapt all aspects of the educational process to the online environment, which placed a great burden on them. The main objective of this research was to identify the challenges faced by teachers during the lockdown period. The sudden shift to online teaching, lack of preparation, and social isolation resulted in significant changes in job demands, perceived control, and social support in the workplace. Methods: A correlational study was conducted with a sample of 345 employees in the education sector in Bosnia and Herzegovina. Descriptive analysis, multiple regression analysis, and t-tests were performed using SPSS version 20.0. Results: The results indicate that teachers who did not have adequate workspace at home experienced greater workload but remained highly motivated. High job demands and low social support at work are associated with increased stress and decreased psychophysical functioning, while higher social support is associated with higher life satisfaction. In addition, higher job demands and stronger social support were related to greater intrinsic and extrinsic motivation at work. Conclusion: Results show that teachers lacking proper home workspaces reported their work as notably more demanding and stress-inducing, with a reported decline in their overall psychophysical well-being. Moreover, they expressed a reduced sense of control over their work, diminished social support, and lower levels of life satisfaction. These findings provide a valuable foundation for developing recommendations to address crisis situations in education, particularly when teachers transition from physical classrooms to virtual spaces, which is also important for online teaching and learning in typical times.

This paper emphasizes the significance of waqfs in the development of Mostar. Thanks to that institution, Mostar has become one of the largest cultural and economic centers in Eyalet of Bosnia. Special attention was given to the waqf of Babussaade Agha, Ahmed Agha. His waqfiye, which is an integral part of this work, contains information about new buildings, money and other things endowed by the aforementioned Ahmed Agha. It also includes changes to some of his previous waqfiya’s stipulations. His endowments in Istanbul and Mostar are mentioned in the waqfiye. Because little is known about his waqf in Mostar, this work aims to draw attention to the waqfiya’s text. The content of Ahmed Aga’s waqfiye demonstrates the importance of his waqf for cultural life in Mostar and his role in enlightening local imams and students.

In recent years, imaging has become increasingly important to confirm diagnosis, monitor disease activity, and predict disease course and outcome in children with juvenile idiopathic arthritis (JIA). Over the past few decades, great efforts have been made to improve the quality of diagnostic imaging and to reach a consensus on which methods and scoring systems to use. However, there are still some critical issues, and the diagnosis, course, and management of JIA are closely related to clinical assessment. This review discusses the main indications for conventional radiography (XR), musculoskeletal ultrasound (US), and magnetic resonance imaging (MRI), while trying to maintain a clinical perspective. The diagnostic-therapeutic timing at which one or the other method should be used, depending on the disease/patient phenotype, will be assessed, considering the main advantages and disadvantages of each imaging modality according to the currently available literature. Some brief clinical case scenarios on the most frequently and severely involved joints in JIA are also presented.

Background : Acute abdomen (AA) is a synonym for a condition caused by an acute disease of an intra-abdominal organ that requires urgent surgical intervention. The gynecological-obstetrical etiopathogenesis of AA is based on pathological events on the genital organs due to hemorrhagic, inflammatory, and ischemic/obstructive genesis, and is a significant reason for admission to emergency gynecological departments, and emergency surgery. Methods : A retrospective clinical research was performed from 2005 to 2021, from the surgical protocol of the University Department for Gynecology and Obstetrics, Clinical Hospital “Sveti Duh” in Zagreb. In the examined sixteen-year period, 703 patients (4.06%) had surgery with a diagnosis of AA. Results : The largest number of surgeries due to AA was performed in the age group of 21–45 years (74.40%), i.e., in the reproductive age, followed by 106 patients aged 46–52 years (15.07%), then 46 (6.54%) patients in children and adolescent age up to 20 years of age, then from 53–60 years 23 (3.27%) patients, and in the elderly > 60 years old, with 5 (0.71%) patients. The etiopathogenetic factors of AA were: the most common intra-abdominal hemorrhage in 68.14%, followed by inflammation and the most common complications of pelvic inflammatory disease in 25.60%, ischemic-obstructive causes in 2.56% and other causes in 3.7%. Out of the total number of surgeries, 450 (64.01%) were due to ectopic tubal pregnancy. Out of the total number of surgeries, 549 (78.09%) were performed (completed) by laparoscopy procedures, and by laparotomy and/or relaparotomy in 154 cases (21.90%). Regarding laparoscopy, 93.48% was performed in the age group up to 20 years, 83.56% in the age group of 21–45 years, and 62.26% was performed in the age group of 46–52 years. Regarding laparotomy, 69.57% was performed in patients aged 53–60 years, and 100% in the age group of patients > 60 years. A pathological substrate was found for all operated patients, which they undergo for surgery, and we had no cases in which we did not prove a perioperative or pathohistological reason for AA. There were no patients’ deaths in the current study, which had to undergo for surgery for AA. Conclusions : We emphasize the urgent need for proper and continuous education of hospital teams, as well as extra-hospital emergency teams in recognizing AA symptoms of gynecological genesis based on history, clinical palpation examination, and ultrasound examination as a fundamental triad in the diagnosis of this life-threatening condition that requires only surgical treatment.

Introduction: Basal cell carcinoma is the most common non melanoma skin cancer. It accounts for approximately 80% of all skin cancers. Case report: We presented a 62-year-old patient with a giant, deeply infiltrative, destructive lesion of the head which lasted for 15 years. Microbiological analysis showed contamination, computed tomography (CT) scan showed deep infiltration and bone destruction. The risks of operative treatment were numerous. The treatment was more complicated by infection, infiltrative spreading and the patient's comorbidity. Regardless, we decided on a wide surgical resection with pathohistological evaluation of the resection margins. The patient denied oncological treatment. After 10 years, there were no recurrent tumours. Conclusion: Aggressive surgical treatment is the treatment of choice for giant basal cell carcinoma. In the case of giant locally aggressive and advanced neoplasms, when surgery is not appropriate or not possible, medical treatment becomes oncological.

Abstract The servitization literature has explored the role that product modularity plays in supporting service design and delivery. Importantly, product modularity has the potential to aid manufacturers in providing customised solutions on a larger scale, thereby strengthening firm performance. However, despite the prospective benefits of product modularity, manufacturers also need considerable servitization depth, which comprises service orientation, resources, and delivery systems, to provide services in a cost-effective manner. Taking this into account, the study both theoretically articulates and empirically tests relationships among product modularity, servitization depth, service types, and firm performance, employing a moderated mediation model. Using survey data collected from 204 manufacturers in the UK and German, the findings indicate that product modularity exerts a positive influence on firm performance, with servitization depth acting as a mediating factor. The mediation effect of servitization depth on the correlation between product modularity and firm performance was found to fluctuate based on the service types offered by the manufacturer. This study adds to the existing literature on servitization and the role of product modularity and servitization depth in achieving superior firm performance.

Sitagliptin, an anti-diabetic drug, is a dipeptidyl peptidase (DPP)-4/CD26 inhibitor with additional anti-inflammatory and immunomodulatory properties. In this study, we investigated for the first time the effect of sitagliptin on the differentiation and functions of human dendritic cells generated from monocytes (MoDCs) for 4 days using the standard GM-CSF/IL-4 procedure. LPS/IFN-γ treatment for an additional 24 h was used for maturation induction of MoDCs. Sitagliptin was added at the highest non-cytotoxic concentration (500 µg/mL) either at the beginning (sita 0d protocol) or after MoDC differentiation (sita 4d protocol). Sitagliptin impaired differentiation and maturation of MoDCs as judged with the lower expression of CD40, CD83, CD86, NLRP3, and HLA-DR, retention of CD14 expression, and inhibited production of IL-β, IL-12p70, IL-23, and IL-27. In contrast, the expression of CD26, tolerogenic DC markers (ILT4 and IDO1), and production of immunoregulatory cytokines (IL-10 and TGF-β) were increased. Generally, the sita 0d protocol was more efficient. Sitagliptin-treated MoDCs were poorer allostimulators of T-cells in MoDC/T-cell co-culture and inhibited Th1 and Th17 but augmented Th2 and Treg responses. Tolerogenic properties of sitagliptin-treated MoDCs were additionally confirmed by an increased frequency of CD4+CD25+CD127- FoxP3+ Tregs and Tr1 cells (CD4+IL-10+FoxP3-) in MoDC/T-cell co-culture. The differentiation of IL-10+ and TGF-β+ Tregs depended on the sitagliptin protocol used. A Western blot analysis showed that sitagliptin inhibited p65 expression of NF-kB and p38MAPK during the maturation of MoDCs. In conclusion, sitagliptin induces differentiation of tolerogenic DCs, and the effect is important when considering sitagliptin for treating autoimmune diseases and allotransplant rejection.

Recently, the necessity of video testing at the point of reception has become a challenge for video distributors. This paper presents a new system framework for managing the quality of video degradation detection. The system is based on objective video quality assessment metrics and unsupervised machine learning techniques that use the dimensionality reduction of time series. It was demonstrated that it is possible to detect anomalies in the video during video streaming in soft real time. In addition, the model discovers degradations based on the visible correlation between adjacent images in the video sequence regardless the quick or slow change of a scene in the sequence. With additional hardware manipulations on the equipment on the user side, the proposed solution can be used in practical implementations where the need for monitoring possible degradations during video streaming exists.

Insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene is a key component of the Renin-Angiotensin-Aldosterone System (RAAS). It has been proposed as an independent factor for hypertension and other cardiovascular diseases. Consequently, it has been extensively studied in various populations. The aim of this study is to investigate I/D polymorphism of ACE gene and its connection to hypertension in population of Tuzla Canton (Bosnia & Herzegovina). The study included 60 hypertensive subjects and 60 healthy control subjects with no risk factors for hypertension. I/D polymorphism was genotyped by polymerase chain reaction followed by gel electrophoresis and data obtained were statistically analysed using Chi square test. Odd’s ratios were calculated with a 95% confidence interval. P-value < 0.05 was considered significant. Odd’s ratios were calculated with a 95% confidence interval. P-value <0.05 was considered significant. Higher frequency of genotype D/D and allele D was determined in subjects with hypertension compared to control subjects but there is no statistical significance (p>0.05). However, statistically significant association was found in compared groups of subjects with genotypes DD + ID, in regards to genotype I/I (p<0.05). The results indicate the conclusion that ACE I/D polymorphism cannot be considered the main risk factor for development of hypertension, but its influence should be investigated together with other genetic and acquired risk factors that are associated with hypertension. This research contributes to the on-going exploration of molecular-genetic associations with hypertension.

This study investigates the influence of ultraviolet (UV) radiation on the mechanical properties of Fused Deposition Modeling (FDM) 3D printed materials, specifically polycarbonate (PC) and polylactic acid (PLA) specimens. The research involves conducting experiments on five test specimens of each material exposed to UV radiation and comparing their mechanical properties to those of five control specimens that remain unexposed. The results reveal a significant mean difference between the mechanical properties of the control and UV-exposed materials. UV radiation caused a decrease in tensile strength for the PC material, while the PLA material exhibited an increase in tensile strength. The impact of UV radiation on PLA was more substantial compared to PC. Flexural strength testing showed an enhancement in strength for the UV-treated materials, with UV treatment having a greater influence on the flexural strength of PLA compared to PC. The mechanical properties of PLA were more significantly impacted by UV radiation than those of PC. The study findings suggest that PC and PLA materials exhibit different responses to UV exposure, which may have implications for their practical applications. Further research is needed to fully understand the underlying mechanisms governing these divergent responses and to optimize the performance of each material under UV radiation.

For prosthetic hybrid restorations on implants, different combinations of materials are used, from metal alloys, titanium, ceramics, polymers or composites. The aim of this paper is to summarize the char- acteristics and advantages of certain polymers in the production of hybrid restorations, as well as to present the protocol for treating patients with this type of restoration. Polymers based on poly-ether-ether-ketone have gained great popularity and success in the field of implant-prosthetic therapy. Among them, the most famous high-performance polymers developed by Bredent (Bredent group, Senden Germany) are BioHPP (containing 20% ceramic fillers) and breCAM.HIPC (highly cross-linked polymer composite material). Both polymers are machinable and are used to make temporary and permanent resaturations in prosthetics. They are biocompatible and non-allergenic, do not contain metal, oxide and monomer components, and also do not discolor the gingiva. They are characterized by excellent workability and elasticity, which is greater than zirconium ceramics and metal alloys, different shades of color is characteristics for breCAM. HIPC, unlike BioHPP, which is monolithic and monochromatic. Due to their characteristics, these high-per- formance polymers can be exceptional “allies” for the restorations on implants.

This study evaluated the eco-efficiency of rainfed and irrigated maize production in Bosnia and Herzegovina. Environmental impact assessments were performed through energy analysis, carbon footprint, and water scarcity footprint analysis. For economic analysis, gross and net returns and benefit–cost ratios were calculated. Eco-efficiency was measured by the ratio between the net return and environmental criteria. The findings indicate that transition from rainfed to irrigated maize cultivation per unit of land results in a 53.7% higher yield and gross value of production, but also a 69.8% increase in energy input, a 22% rise in greenhouse gas emissions, and a 3.6fold increase in the water scarcity footprint. While a positive link exists in irrigated maize between higher yield and lower carbon footprint per unit of product, rainfed systems outperform in energy efficiency, productivity, profitability, water scarcity footprint, and overall eco-efficiency. Both systems rely heavily on nonrenewable energy sources, with fertilization (energy and carbon footprint), mechanization (carbon footprint), and irrigation (water scarcity) as the main contributors to the negative environmental impacts. The implementation of optimization strategies for these inputs is of paramount importance to reduce environmental impacts and promote sustainability in maize farming in Bosnia and Herzegovina.

Climate change adaptation is paramount, but increasing evidence suggests that adaptation action is subject to a range of constraints. For a realistic assessment of future adaptation prospects, it is crucial to understand the timescales needed to overcome these constraints. Here, we combine data on documented adaptation from the Global Adaptation Mapping Initiative with national macro indicators and assess future changes in adaptation constraints alongside the Shared Socioeconomic Pathways, spanning a wide range of future socio-economic development scenarios. We find that even in the most optimistic scenario, it will take until well after 2050 to overcome key constraints, which will limit adaptation for decades to come particularly in vulnerable countries. The persistence of adaptation constraints calls for stringent mitigation, improved adaptation along with dedicated finance and increasing efforts to address loss and damage. Our approach allows to ground truth indicators that can be further used in climate modelling efforts, improving the representation of adaptation and its risk reduction potential.

Purpose This paper aims to reveal the role of two theories that impact seniors’ entrepreneurial intentions. Both the socioemotional selectivity theory (SST) and the self-determination theory (SDT) re-shape seniors’ intentions to create entrepreneurial opportunities and activities after they retire. Design/methodology/approach This paper uses secondary data resources for developing the research concept, which might leverage seniors’ ultimate goal of creating entrepreneurial activities. A comprehensive past-paper analysis was performed. One hundred papers were initially considered for inclusion in this research. However, after a rigorous synthesisation process, 80 publications were selected for further analysis. Findings This paper presents an investigation of seniors’ entrepreneurship, with a specific emphasis on the SST and the SDT. It suggests potential models that could gauge senior entrepreneurs’ propensity to engage in entrepreneurial endeavours to support the socioeconomic advancement of society. Furthermore, this research discussed the limitations of the enlightening concepts presented to scholars and decision-makers. Originality/value The originality of this paper is illuminated by its idea of integrating two theories (the SST and the SDT), suggesting that these theories can possibly better observe senior entrepreneurs’ intentions in creating an entrepreneurial venture after they retire.