Aim To assess morphological characteristics of carotid blood vessels in uremic patients before to the initiation of the dialysis treatment, and corelate data with various dialysis therapy modules. Methods The study included 30 patients with end-stage renal disease (ERDS) prior to commencing dialysis, 30 patients treated with haemodialysis and 30 patients treated with continuous ambulatory peritoneal dialysis. The control group consisted of 15 subjects with normal kidney function (eGFR>60ml/min). Carotid intima-media thickness (CIMT), as well as lipid status values (cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), apolipoprotein A, apolipoprotein B) were evaluated. Results The significant difference in CIMT was detected between the control and haemodialysis groups (p<0.001), and between the control and the peritoneal dialysis group (p=0.004). In patients in the predialysis group, CIMT was influenced by cholesterol (p=0.013), HDL (p=0.044), LDL (p=0.001) and ApoB (p=0.042) values. A significant difference in CIMT was proved between the haemodialysis and predialysis group of patients (p<0.001). The only variable from the patient's lipometabolic profile significantly associated with the change in IMT in uremic patients was HDL. A significant difference was found in the average value for systolic blood pressure (p<0.001) and diastolic blood pressure (p=0.018) in patients before starting the dialysis treatment compared to patients treated with other dialysis methods. Conclusion Patients on haemodialysis treatment had a significantly greater CIMT, which is in relation with a higher cardiovascular risk.

- The influence of multi-hole orifice flow meter geometry parameters on the parameters of Newtonian fluid through multi-hole orifice meters was investigated using computational fluid dynamics as well as the effect of contamination in front of the MHO flow meter. The air flow was steady, three-dimensional, and turbulent. Analysed Newtonian fluid was air and physical properties that were considered were density and dynamic viscosity. The numerical method was finite volume method, and standard k-ε turbulence model was used for turbulence modelling. Multi-hole orifice meter with thre e different β parameters 0.5 5, 0.6 and 0.7, was observed and Reynold’s number was 10 5 . The pressure drop and discharge coefficient were analysed. Numerical simulations were performed using commercial software the STAR-CCM+ 2019.2. It was found that increase in 𝛽𝛽 parameter results with the decrease in pressure drop and increase in discharge coefficient. Also, it was found that that the influence of 𝛽𝛽 parameter is much higher when analyzing pressure drop rather than discharge coefficient values. Numerical simulations were also performed to investigate the effect of contaminations in front of the MHO plate with 𝛽𝛽 = 0.5, on the discharge coefficients. It was found that as the contamination angle is increased the discharge coefficient tends to increase.

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Partial or complete dentures are constructed from thermoplastic resins that are thermally processed and molded. This review examines the presently available evidence for the cytotoxicity of thermoplasticized denture base resins on human gingival epithelial cells, adipose cells, and fibroblasts; human amnion fibroblasts; and mouse fibroblasts. Electronic searches were performed on PubMed, Scopus, Web of Science, and Google Scholar databases to identify relevant articles to be included in the review until September 2022. Clinical, in vivo, and in vitro studies in English language were searched for. The quality of the studies was assessed using the Toxicological data Reliability Assessment tool (ToxRTool) developed by the European Commission’s Joint Research Centre. GRADE assessment was used to evaluate the certainty of evidence. Seven in vitro studies were included in the review. The overall risk of bias was determined to be high, with the majority of studies assessed found to be reliable with restrictions or not reliable. Only two studies were considered reliable without restrictions based on ToxRTool assessment. The effect of thermoplastic denture base resins on viability and cell adherence of human gingival or amnion fibroblasts and mouse fibroblasts (L929s) is not significant. Conditioned media from unpolished specimens of resins were significantly more toxic to cultured cells than those from polished specimens. This may be of concern in cases of poor post-processing of dentures. Based on the limited evidence available, there is low-certainty evidence that thermoplastic denture base resins appear to be biocompatible and show insignificant cytotoxicity. Further well-designed trials adhering to standard reporting guidelines and using objective measures are necessary before outlining universal guidelines for best practice. Long-term in vivo and clinical assessment is necessary to corroborate laboratory findings with clinical outcomes. Denture base resins are in constant contact with oral tissues, and cytotoxic components released by the resins may irritate or inflame the tissues or provoke an allergic response.

This paper examines the relationship between herbivores and plants with a strong Allee effect. When the plant reaches a particular size, the herbivore attacks it. We use the logistic equation to model plant growth and analyze its behavior without herbivores before investigating their interactions. Our study investigates the equilibrium points and their stability, discovering that different fixed points can become unstable due to various bifurcations such as transcritical, saddle-node, period-doubling, and Neimark–Sacker bifurcations. We have identified the Allee threshold, which, if exceeded, can cause both populations to become extinct below that level. However, we have discovered a coexistence equilibrium that is locally asymptotically stable for a range of parameter values above that threshold. Our additional numerical simulations suggest that this area of stability can be expanded. Our results indicate that this system is highly responsive to its parameters. We compare our findings to those of a system without strong Allee effects and conduct numerical simulations to verify our results. By including the Allee effect in the plant population, we enrich the local and global dynamics of the system.

Aim To investigate morphometric determinants of lumbar canal in patients treated in Cantonal Hospital Zenica, and their variation according to gender. Methods Morphometry of lumbar spinal canal was assessed in 52 patients treated at the Department of Neurosurgery of Cantonal Hospital Zenica in the period between September 2022 and November 2022. Data were collected retrospectively: anteroposterior and transverse diameter of lumbar vertebrae and intervertebral discs, as well as anteroposterior diameter of the spinal canal. Results Gender appeared to be an important morphometric determinant, since it significantly differed when it comes to lumbar vertebral anteroposterior and transverse diameter, being mostly larger in males. Conclusion This study increases anatomical knowledge of the vertebras and spinal canal of the lumbar region. Therefore, the measured dimensions of the lumbar vertebrae and spinal canal could be used as a baseline point for evaluation of patients presenting with low back pain and potential spinal canal stenosis.

Entre os vários problemas ambientais da contemporaneidade, a falta do reconhecimento da importância da botânica no nosso cotidiano, a ausência de sensibilização e a interação com a natureza são assuntos que a sociedade deve discutir. O presente trabalho, a fim de buscar e implantar possibilidades dentro da Educação Ambiental (EA), traz a proposta de formatação de uma trilha interpretativa conduzida e/ou autoconduzida de uma forma didático-pedagógica no campus da Universidade Estadual de Santa Cruz (UESC). A metodologia propõe uma dupla análise ao utilizar os métodos de Indicadores de Atratividades de Pontos Interpretativos (IAPI) e o Valor Turístico (Vtur). Foram realizadas visitas ao Horto Florestal da UESC e, com o auxílio do GPS Garmin etrex 10x e do aplicativo de celular TCpGPS, propomos um novo trajeto da trilha de 1.047 metros, com design circular e 10 pontos interpretativos. Diante disso, é possível afirmar que as metodologias utilizadas na proposta atingiram seu escopo ao possibilitar o conhecimento da flora local, das relações ecológicas, da acessibilidade, bem como do desenvolvimento de atitudes e valores diante do meio ambiente, de forma prática e sistematizada.

A sociedade experimenta uma forma de economia calcada em tecnologias de vigilância, que influenciou na conflagração de dados em camadas incomensuráveis. Nesse contexto, aparelha-se um desafio para a pesquisa científica, que deve acontecer obedecendo os padrões nacionais de proteção de dados pessoais. Para tanto, o presente trabalho objetiva estabelecer os padrões da LGPD para pesquisa científica, o contexto histórico que fundamenta a importância da ética na pesquisa e os perigos de uma regulamentação rígida da pesquisa através da LGPD que pode ferir direitos fundamentais. O método utilizado é o hipotético-dedutivo, com utilização de recursos bibliográficos e documentais. Em conclusão, a LGPD revela uma nova realidade para a pesquisa científica, transformando o pesquisador ou órgão de pesquisa em agentes de tratamento, com devidas responsabilidades no tratamento de dados pessoais dos humanos envolvidos na pesquisa científica. 

Aim This is the first research in Bosnia and Herzegovina presenting minimally invasive coronary artery bypass grafting surgery (MICS CABG) experience, advantages, and outcomes as compared to conventional surgery (OPEN CABG). Methods This retrospective cross-sectional study was conducted between January 2019 and November 2022 and included patients with indication for surgical revascularization. Results Among 237 patients, males predominated, 182 (76.7%), with a mean body mass index (BMI) of 28.4±3.9, median The Society of Thoracic Surgery Risk (STS) score of 1.55 (0.8, 4.0), short term STS score of 11.2 (6.8, 23.7), mean age of 64.8±8.7 (ranging 41-83) years, 122 (51.4%) underwent OPEN CABG and 115 (48.6%) MICS CABG. MICS CABG took less time (p<0.001; OPEN 3.5±0.8h; MICS 2.8±0.8h) and needed less mechanical ventilation (p<0.001, OPEN 17.3±11.9h; MICS 13.0±12.5h) than OPEN CABG. Even though there was no difference in hospitalization length between groups (OPEN (7.5±3.2), MICS (7.1±4.0)), patients receiving MICS (2.9±1.5) spent less time in the ICU (p=0.0013) than OPEN CABG (3.6±2.8). OPEN CABG used also more blood derivatives, red blood cells (OPEN 292 vs MICS 55), plasma (OPEN 270 vs MICS 86) and platelets (OPEN 71 vs MICS 28). Conclusion Patients undergoing MICS CABG in Bosnia and Herzegovina had less mechanical ventilation hours and less ICU duration compared to OPEN CABG even though the hospitalization duration was very similar. MICS CABG takes less time to be conducted, has fewer CPRs postoperatively, uses less blood derivatives including red blood cells, plasma and platelets.