The goal of this Chapter is to review the applications of the Thomson Multitaper analysis (Percival and Walden; 1993b), (Thomson; 1982) for problems encountered in communications (Thomson; 1998; Stoica and Sundin; 1999). In particular we will focus on issues related to channel modelling, estimation and prediction. Sum of Sinusoids (SoS) or Sum of Cisoids (SoC) simulators (Patzold; 2002; SCM Editors; 2006) are popular ways of building channel simulators both in SISO and MIMO case. However, this approach is not a very good option when features of communications systems such as prediction and estimation are to be simulated. Indeed, representation of signals as a sum of coherent components with large prediction horizon (Papoulis; 1991) leads to overly optimistic results. In this Chapter we develop an approach which allows one to avoid this difficulty. The proposed simulator combines a representation of the scattering environment advocated in (SCM Editors; 2006; Almers et al.; 2006; Molisch et al.; 2006; Asplund et al.; 2006; Molish; 2004) and the approach for a single cluster environment used in (Fechtel; 1993; Alcocer et al.; 2005; Kontorovich et al.; 2008) with some important modifications (Yip and Ng; 1997; Xiao et al.; 2005). The problem of estimation and interpolation of a moderately fast fading Rayleigh/Rice channel is important in modern communications. TheWiener filter provides the optimum solution when the channel characteristics are known (van Trees; 2001). However, in real-life applications basis expansions such as Fourier bases and discrete prolate spheroidal sequences (DPSS) have been adopted for such problems (Zemen and Mecklenbrauker; 2005; Alcocer-Ochoa et al.; 2006). If the bases and the channel under investigation occupy the same band, accurate