U radu su razmatrana trenutna i konsolidacijska slijeganja kvadratnog temelja za dvije različite geomehaničke sredine. Prvi slučaj je pjeskovito tlo ispod kojeg se nalazi sloj gline, a druga geomehanička sredina je pjeskovito tlo u mješavini sa šljunkom te ojačano cementnim prahom (30%) i staklenim vlaknima (1%) ispod kojeg se nalazi glina. Dobiveni rezultati slijeganja pokazuju dobru stabilizaciju tla i povoljne geomehaničke karakteristike ojačanog tla koji se ogledaju u manjoj vrijednosti ukupnog slijeganja temelja koja zadovoljava maksimalnu dopuštenu vrijednost definiranu Eurocode-om. U radu su prikazana slijeganja kroz vremensko razdoblje od 120 dana, prikazano je konačno, dugoročno slijeganje ispod temelja kao i diferencijalni omjer (δ/L) slijeganja temelja. Proračun trenutnog slijeganja vršen je prema teoriji elastičnosti odnosno konsolidacijsko slijeganje prema Terzaghi-ju.

Evaluation of the performance of teleoperation systems plays an important role in assessing the efficacy and reliability of such systems. The evaluation is usually performed based on factors such as stability, transparency, and user satisfaction. However, very few studies have addressed the numerical evaluation of transparency in teleoperation systems so far. This letter presents a novel method to numerically assess the transparency of teleoperation systems based on representing recorded experimental data algebraically by fitting parametric curves using Elliptic Fourier Descriptors (EFD). The EFD coefficients are used to compute the Hybrid Matrix of the teleoperation system, which provides a metric for judging how transparent a teleoperation system is. This letter validates the proposed method using real experimental position and force data for teleoperation systems with and without time delay, as well as providing an analysis of the effect of the number of harmonics on the calculation of the Hybrid Matrix.

We analyze the high-order above-threshold ionization (HATI) process of a small polyatomic molecule with C3 symmetry, which is induced by a bicircular strong laser field. This field consists of two coplanar, counter-rotating, circularly polarized components with frequencies rω and sω where r and s are integers. In our study, we use an improved molecular strong-field approximation to obtain electron energy-angle-resolved and momentum spectra of the BF3 molecule. We analyze the contributions of individual atoms as well as the impact of molecular symmetries on these spectra. We find that these spectra are significantly affected by the characteristics of the molecule and the laser-field parameters. Furthermore, we observe pronounced interference minima in the HATI spectra. We demonstrate that these minima result from the destructive interference of rescattered wave packets from different atomic centers, and we determine the conditions under which they occur, including two-, three-, and four-center interference.

Summary The rapid rise of 3D printing, both in industrial and home settings, presents emerging health and environmental risks. While 3D printing enhances sustainability by reducing waste and optimizing resource use, its impact on human health remains poorly understood. The use of metals and polymers linked to health risks, coupled with the release of inhalable particles and volatile organic compounds, raises concerns about respiratory and systemic effects. The absence of clear guidelines creates high public demand for information and limits safe implementation, particularly in schools and homes where millions of 3D printers are expected by 2030. Additionally, improper disposal of 3D printing polymer materials may exacerbate plastic pollution. This article proposes the perspective of a structured risk assessment framework set on particle emissions from industrial 3D printing. It will offer a practical tool to bridge current knowledge gaps and to inform safe practice and policy development, because immediate action is necessary to balance innovation with safety.

Introduction. Sentinel lymph node biopsy (SLNB) has significantly advanced axillary staging in clinically node-negative breast cancer, offering lower morbidity compared to traditional axillary lymph node dissection (ALND). Nonetheless, precise prediction of non-sentinel lymph node (non-SLN) involvement remains essential for optimizing surgical decisions and preventing unnecessary ALND. Methods. A retrospective cohort analysis was performed on 176 patients with clinically node-negative breast cancer who underwent SLNB. Clinicopathological data were reviewed to evaluate associations between various predictive factors and non-SLN involvement. Variables analyzed included tumor size, histological grade, lymphovascular invasion (LVI), Ki-67 proliferation index, and sentinel lymph node characteristics. Results. Multivariable logistic regression identified the type of SLN metastasis (OR=21.4; 95% CI 1.7–43.6; p=0.01), the number of positive SLNs (OR=5.66; 95% CI 1.18–36.6; p=0.03), and the number of negative SLNs (OR=0.04; 95% CI 0.006–0.27; p=0.001) as independent predictors of non-SLN metastases. The predictive model demonstrated excellent discriminatory power, with an area under the receiver operating characteristic curve (AUC) of 0.91. Conclusion. Specific clinical and histopathological variables reliably predict non-SLN involvement in SLN-positive breast cancer patients. Incorporation of these predictors into clinical practice may enhance individualized axillary management and reduce unnecessary ALND procedures. Further validation through larger prospective studies is warranted. Key words: Breast Neoplasms, Sentinel Lymph Node Biopsy, Axillary Lymph Nodes, Lymph Node Dissection, Neoplasm Staging.

Background Non-ST-elevation myocardial infarction (NSTEMI) is frequently associated with systemic inflammation and metabolic dysregulation. Indices derived from routine laboratory tests that reflect systemic inflammatory and lipid-inflammatory status may offer better prognostic insight. This study aimed to evaluate the association between selected indices and short-term major adverse cardiovascular events (MACE) and all-cause mortality in patients with NSTEMI treated with dual antiplatelet therapy (DAPT) and statin. The selected indices reflect key mechanisms involved in NSTEMI pathophysiology, including insulin resistance, atherogenic dyslipidemia, and inflammation. Materials and methods This prospective observational study included 171 patients with NSTEMI admitted to the Intensive Care Unit of the Clinic for Internal Medicine at the University Clinical Centre Tuzla between February 1, 2022, and January 31, 2023. Blood samples were collected upon admission and 24 hours subsequently. The following indices were calculated: triglyceride-glucose index (TyG), triglyceride-to-high-density lipoprotein ratio (TG/HDL), atherogenic index of plasma (AIP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and pan-immune-inflammation value (PIV). Outcomes were tracked during hospitalization and up to three months post-discharge. MACE was defined as cardiovascular death, reinfarction, stroke, or unplanned revascularization. All patients underwent coronary angiography; revascularization was performed when clinically indicated. Exclusion criteria included active malignancy, infection, or inflammatory disease. Logistic regression was adjusted for age, diabetes, and other clinical variables. Missing data were handled using the pairwise deletion method. Results High levels of TyG at admission were independently associated with MACE (odds ratio (OR) 1.7; 95% confidence interval (CI) 1.0-2.8; p = 0.037). All-cause mortality occurred in 14.6% of patients (n = 25), while MACE occurred in 60 patients. Independent predictors of mortality included elevated TyG at admission (OR 2.2; 95% CI 1.1-4.4; p = 0.034), TG/HDL at 24 hours (OR 1.4; 95% CI 1.1-1.7; p = 0.007), AIP at 24 hours (OR 5.7; 95% CI 1.1-28.9; p = 0.035), and NLR at 24 hours (OR 1.1; 95% CI 1.0-1.2; p = 0.002). PLR and PIV at 24 hours were also significantly associated with mortality. Optimal cut-off values were TyG ≥ 8.9, AIP ≥ 0.35, and NLR ≥ 4.5. NLR had the highest estimated area under the curve (AUC ≈ 0.78). Conclusion In NSTEMI patients treated with DAPT and statin, several inflammatory and lipid-inflammatory indices were independently associated with short-term mortality. Indices measured at 24 hours had a stronger prognostic value than baseline values. Serial monitoring may aid early risk stratification. Outcomes were assessed during hospitalization and via structured follow-up up to three months post-discharge.

This work proposes a motion planning algorithm for robotic manipulators that combines sampling-based and search-based planning methods. The core contribution of the proposed approach is the usage of burs of free configuration space ($\mathcal{C}$-space) as adaptive motion primitives within the graph search algorithm. Due to their feature to adaptively expand in free $\mathcal{C}$-space, burs enable more efficient exploration of the configuration space compared to fixed-sized motion primitives, significantly reducing the time to find a valid path and the number of required expansions. The algorithm is implemented within the existing SMPL (Search-Based Motion Planning Library) library and evaluated through a series of different scenarios involving manipulators with varying number of degrees-of-freedom (DoF) and environment complexity. Results demonstrate that the bur-based approach outperforms fixed-primitive planning in complex scenarios, particularly for high DoF manipulators, while achieving comparable performance in simpler scenarios.

Narrative review synthesizes the most current literature on the SARS-CoV-2 XEC variant, focusing on its genomic evolution, immune evasion characteristics, epidemiological dynamics, and public health implications. To achieve this, we conducted a structured search of the literature of peer-reviewed articles, preprints, and official surveillance data from 2023 to early 2025, prioritizing virological, clinical, and immunological reports related to XEC and its parent lineages. Defined by the distinctive spike protein mutations, T22N and Q493E, XEC exhibits modest reductions in neutralization in vitro, although current evidence suggests that mRNA booster vaccines, including those targeting JN.1 and KP.2, retain cross-protective efficacy against symptomatic and severe disease. The XEC strain of SARS-CoV-2 has drawn particular attention due to its increasing prevalence in multiple regions and its potential to displace other Omicron subvariants, although direct evidence of enhanced replicative fitness is currently lacking. Preliminary analyses also indicated that glycosylation changes at the N-terminal domain enhance infectivity and immunological evasion, which is expected to underpin the increasing prevalence of XEC. The XEC variant, while still emerging, is marked by a unique recombination pattern and a set of spike protein mutations (T22N and Q493E) that collectively demonstrate increased immune evasion potential and epidemiological expansion across Europe and North America. Current evidence does not conclusively associate XEC with greater disease severity, although additional research is required to determine its clinical relevance. Key knowledge gaps include the precise role of recombination events in XEC evolution and the duration of cross-protective T-cell responses. New research priorities include genomic surveillance in undersampled regions, updated vaccine formulations against novel spike epitopes, and long-term longitudinal studies to monitor post-acute sequelae. These efforts can be augmented by computational modeling and the One Health approach, which combines human and veterinary sciences. Recent computational findings (GISAID, 2024) point to the potential of XEC for further mutations in under-surveilled reservoirs, enhancing containment challenges and risks. Addressing the potential risks associated with the XEC variant is expected to benefit from interdisciplinary coordination, particularly in regions where genomic surveillance indicates a measurable increase in prevalence.

This study investigated the potential of high-voltage electrical discharge (HVED), as a green, non-thermal extraction technology, for recovering polyphenols from winter savory (Satureja montana L.). Key process parameters, including frequency (40, 70, 100 Hz) and extraction time (1, 5, 15, 30, 45 min), were optimized, using water as a solvent and maintaining a constant solid-to-liquid ratio of 1:100 g/mL. The extracts were characterized for total polyphenol content (TPC), total flavonoid content (TFC), and antioxidant activity (DPPH, ABTS, FRAP), while individual phenolics were quantified via HPLC-DAD. Multivariate chemometric analyses, including Pearson correlation, heatmap clustering, and principal component analysis (PCA), were employed to reveal relationships between extraction conditions, polyphenolic profiles, and antioxidant activities. The results showed strong correlations between TPC, TFC, and antioxidant activity, with compounds such as quercetin-3-D-galactoside, procyanidin A2, and rutin identified as key contributors. Among the tested conditions, extraction at 70 Hz for 45 min provided the highest polyphenol yield and bioactivity. The application of HVED demonstrated its potential as an efficient and environmentally friendly technique for obtaining phenolic-rich extracts. In addition, the use of chemometric tools provided useful insights for optimizing extraction conditions and understanding the contributions of specific compounds to bioactivity. These results support future applications in clean-label product development and contribute to broader efforts in sustainable ingredient production for the food, cosmetic, and nutraceutical sectors.

Insular cortex (i.e., insula; Latin for “island”), also known as the Island of Riel, represents a still poorly researched part of neural circuitry consisting of anterior and posterior areas divided by the insular central sulcus and surrounded by the peri-insular sulcus. Insula is involved in a variety of functions including gustatory and sensorimotor processing, somatic processing, as well as risk-reward behavior. Insula has been shown to play a major role in socio-emotional processes, such as emotional experience and introspection. Recent comprehensive meta-analysis studies suggest that lesion of the insular cortex can lead to significant psychiatric and neurological disorders as it plays a vital role in human motivation and emotional perception. Therefore, there is a growing interest in the medical community regarding this mostly unknown part of the human brain and the role of insular cortex in the pathogenesis of psychiatric disorders. Keywords: insula, neocortex, mental disorders.

This scientific research work investigates the social and legal protection of unaccompanied and separated children from the population of migrants, refugees and asylum seekers in the municipality of Velika Kladušafrom 2019 to 2022. The research is based on data collected from government records, reports from non-governmental organizations and interviews with key actors, including social workers, lawyers and representatives of civil society organizations. The research reveals that unaccompanied and separated children in Velika Kladuša face significant challenges in accessing social and legal protection. Many of these children experience trauma, violence and exploitation during the journey, but also in Bosnia and Herzegovina, and continue to face significant risks and vulnerabilities upon arrival. Despite the established legal and political frameworks for the protection of these children, the ability of institutions and services to respond to their needs is limited, and many children fall through gaps in the system.The research highlights the need for increased resources, funding and training for institutions and service providers working with unaccompanied and separated children. It also highlights the importance of a holistic, child-centred approach to social and legal protection, which takes into account the specific needs and vulnerabilities of this population. Ultimately, this research provides important insights and recommendations for improving the social and legal protection of unaccompanied and separated children in the municipality, and contributes to broader efforts to ensure the rights and well-being of all children on the move. Key words: unaccompanied and separated children, migrants, refugees, asylum seekers, social and legal protection, risks, vulnerabilities, institutions, services, capacities, child-centred approach, resources, policy frameworks, recommendations.

The aim of this research was to determine differences in the levels of anxiety, depression, perceived stress, and quality of life among parents of children with different developmental difficulties (intellectual disabilities, autism spectrum disorder, and cerebral palsy). The sample consisted of 104 parents, the majority of whom were female (85.6%). Most parents reported that their child had an autism spectrum disorder (45.2%), while the rest reported Down syndrome (29.8%) and cerebral palsy (25.0%). The following instruments were used for the purposes of the research: Demographic Data Questionnaire, Perceived Stress Scale (PSS), Family Quality of Life Scale (FQoL), Generalized Anxiety Disorder Scale (GAD-7), and the Patient Health Questionnaire (PHQ-9). Statistical data analysis was conducted using univariate analysis of variance (ANOVA). The results showed that parents of children with cerebral palsy exhibit statistically significantly higher levels of anxiety, depression, and perceived stress compared to parents of children with autism and Down syndrome. These findings confirm previous research on the impact of the complexity of motor impairments on the psychological state of parents and highlight the need for targeted psychosocial support for this population. On the other hand, the study did not show statistically significant differences in the perception of overall quality of life among parents, regardless of the type of their child's difficulty. This result implies that factors such as family support, adopted coping mechanisms, and the degree of acceptance of the situation may play a key role in maintaining the subjective sense of life homeostasis. Keywords:parents, developmental difficulties, anxiety, depression, quality of life.

The paper aims to identify and analyze effective strategies aimed at managing autistic behaviorand learning barriers. A qualitative analysis of the relevant scientific and professional literature published in the last decade was carried out, and after screening, 41 papers were included in thematic analysis. Strategies are divided into six categories: Behavioral interventions and behavior management, Education of children and youth with ASD and the empowerment of educators, Teaching social skills, Sensory integration therapies, Digital and assistive technologies, and Transition support. All included strategies are evidence-based practices (EBPs). The literature review confirms that there is no universal approach in working with children and youth with ASD. Still, successful intervention is based on the application of a combination of strategies adapted to the individual needs of students, the educational environment, and developmental goals. Despite the multitude of strategies at a given setting's disposal effective implementation of EBPs is often thwarted by system, school, and individual factors suchas limited resources, training, as well as consistency across environments. By addressing these challenges in a comprehensive manner—through inclusive pedagogy, adaptive technology, and collaborative support systems—we can bridge the research-practice gapand provide rich, enabling learning experiences for students with autism spectrum disorders. Key words: autism, learning strategies, behavior management, learning barriers

It can be stated that quality is an integral part of our daily life. All people constantly insist on quality in certain areas of life, which indicates that quality can be found in all segments in which a person work. The main objective of this study is to examine the satisfaction of clients/users with the services of spa centers. The basic research methods used are: synthesis, analysis, induction and deduction, comparative and statistical methods. The collection of primary data was carried out through an online survey, which contains a standardized scale (SERVQUAL). The correlation analysis confirms the general objective, so it can be concluded that the Pearson coefficient is -0.158, from which it follows that there is a very weak negative correlation between these two variables. It is concluded that sociodemographic factors do not at all influence the attitude of respondents about the quality of service of spa resorts. But, Pearson coefficient indicates a high degree of correlation between respondents' satisfaction with the quality of service in sparesorts and other factors. There is a very high degree of correlation between respondents' satisfaction with service quality and other factors -81%, which have an impact on the respondents' satisfaction with thequality of service in the spa: the first contact in the spa, the reason for coming to the spa, the distance from home to the spa, travel time and the manner the therapy is introduced. Key words: Quality, safety of services, spa resorts, Bosnia and Herzegovina