BackgroundSevere mental illness (SMI) presents a major burden to societies worldwide. Low- and middle-income countries (LMICs) often do not have sufficient financial resources and qualified staff to provide extensive specialised services for outpatients with SMI. Our research therefore aims to explore and test low-cost interventions that use existing resources in routine patient-clinician meetings, families and communities.MethodsIn Bosnia-Herzegovina, Colombia and Uganda, three psychosocial interventions will be tested, i.e. making patient-clinician meetings therapeutically effective through DIALOG+, family involvement in multi-family group meetings, and support for patients in befriending schemes with volunteers. All interventions will be provided to patients with SMI, delivered over a six-month period and evaluated with assessments at baseline and after six and 12 months. We will conduct nine trials including non-controlled trials, non-randomised controlled trials and randomised controlled trials (RCTs). Core outcome criteria will be used across all studies. However, details of study delivery and additional outcome criteria vary to accommodate local contexts, interests and priorities. The studies will be analysed separately, but with the option to compare and combine findings.DiscussionThe approach provides the opportunity to learn from commonalities and differences in the results and experiences across the three resource-oriented approaches and the three countries. If successfully implemented the studies can lead to more extensive research and are expected to inform health policies and clinical practice of community care for patients with SMI in the three participating countries and other LMICs.Trial registrationAll RCTs were registered prospectively and non-randomised trials retrospectively within the ISRCTN Registry.DIALOG+ in Uganda: ISRCTN25146122 (Date of Registration: 20/11/2018, prospective); DIALOG+ in Colombia: ISRCTN83333181 (Date of Registration: 20/11/2018, prospective); DIALOG+ in Bosnia-Herzegovina: ISRCTN13347129 (Date of Registration: 20/11/2018, prospective); Volunteer Support in Uganda: ISRCTN86689958 (Date of Registration: 04/03/2019, retrospective); Volunteer Support in Colombia: ISRCTN72241383 (Date of Registration: 04/03/2019, retrospective);Volunteer Support in Bosnia-Herzegovina: ISRCTN51290984 (Date of Registration: 20/11/2018, prospective); Family Involvement in Uganda: ISRCTN78948497 (Date of Registration: 04/03/2019, retrospective); Family Involvement in Colombia: ISRCTN11440755 (Date of Registration: 04/03/2019, retrospective); Family Involvement in Bosnia-Herzegovina: ISRCTN13347355 (Date of Registration: 20/11/2018, prospective).

The purpose of the present study was to examine the effectiveness of 23 different synthesized ionic liquids (ILs) on Fusarium culmorum and Fusarium oxysporum growth rate. The strategy of IL synthesis was a structural modification of ionic liquids through changing the polarity of imidazolium and pycolinium cations and replacing halide anions with well known antifungal anions (cinnamate, caffeate and mandelate). The findings clearly suggest that the type of alkyl chain on the cation is the most determining factor for IL toxicity. In order to examine how IL structure affects their toxicity towards Fusarium genus, lipophilic descriptor A log P is calculated from density functional theory and correlated with Fusarium growth rate. All these results demonstrate the high level of the interdependency of lipophilicity and toxicity for investigated ILs towards the Fusarium genus. The data collected in this research suggest that the inhibitory influence of ILs is more pronounced in the case of F. oxysporum.

Presently, almost all human activities (agriculture, transport, industry, construction sector, etc.) have an adverse impact on the environment. The construction sector in the EU alone accounts for a big part of the total energy consumption and emission of CO2. Two-thirds of the energy used in the construction sector in Europe goes to housing. As the number of residents grows, the requirements for new housing increase, causing an additional increase in energy consumption and new CO2 emissions for construction, maintenance, lighting, ventilation, cooling, and heating. Benefits of detailed planning of sustainable development of the construction sector are manifold. The most important benefits are sustainable use of resources, economic and social development of communities, increasing employment rates, improvements of living conditions and protection of the environment. Two scenarios for the development of an energy-efficient construction sector in Bosnia and Herzegovina with a focus on housing facilities are developed, in order to address the needs and benefits of detailed planning. Both scenarios analyze the effects on job creation, the impact of used construction materials on the environment and eco balance of local products. The difference in the solutions confirms the benefits of an interdisciplinary approach to the planning of sustainable systems so that not only technical, but also economic and social benefits can be evaluated thanks to the combination of methods used.

Magnesium is an essential element and the intracellular divalent cation involved in many biochemical functions. People with magnesium deficiency must increase their intake of magnesium, usually in the form of various supplements. A common form of magnesium supplement widely available in pharmacies is magnesium oxide (MgO). In this work, the content of MgO was determined in pharmaceutical supplementations using spectrophotometry, based on the reaction between magnesium ions and eriochrome black T at a wavelength of 535 nm. The analysed content of MgO ranged from 360.5 to 386.5 mg MgO, which corresponds to the daily Mg recommended values (300 to 400 mg).

Bosnia and Herzegovina is a place of meeting of different peoples and religions, which has contributed, according to the religious and cultural heritage, to be one of the richest countries in Europe. Four large religious communities in Bosnia and Herzegovina have significant shrines that are visited by tourists from all over the world, although neither the entities nor the states have a strategy for promoting religious tourism. In this paper we will present the representation of religious objects and manifestations of West Herzegovina tourism-geographic region, their tourist valorization and proposal in order to improve this specific form of tourism.

In a continuous system of production in open-cast coal mining, in addition to the basic machinery which consists of highly productive machines (bucket-wheel excavators, bucket-chain excavators, spreaders, conveyor-belt transporters, etc.) that provide an uninterrupted exploitation of mineral ores, the usage of auxiliary machinery is also necessary. The auxiliary machinery provides the possibility of using the capacities of basic machinery adequately and timely. Further, it must be mentioned that the auxiliary machinery generates up to 20% of the total mining expenses. Dozers are the most commonly used machines. Choosing the adequate dozer of the right type and manufacturer is of great importance and can be made easier by carrying out an analysis of the existent operational-exploitative parameters. In this paper, the method of grading the operational-exploitative parameters of dozer is defined. The choice of the optimal type of dozer was conducted by using the analytical hierarchy process (AHP).

The freedom of services by correspondence should be one of the most important market freedoms in the EU legislative politics and the CJEU jurisprudence. The announcement of the establishment of a fifth market freedom on data flow is directly addressed by the freedom of services by correspondence. The growing importance of the freedom of services in general is in line with the rise of the EU service sector as the main contributor to growth and employment in the EU, accounting for about two thirds of both EU employment and value added. In addition, since 2015 the Digital Single Market is one of European Commission’s political priority that aims at providing free access to online services. Online services are in most part services by correspondence, where neither provider nor recipient travels cross border. The truth is that the freedom of services by correspondence is barely ever mentioned explicitly neither by EU legislator nor by the CJEU. The EU legislator has rather chosen a sectoral approach to the Digital Single Market, fragmenting the fifth market freedom to several narrow pieces of legislation. The paper deals with the question why the freedom of services by correspondence has not acquired the same position as the freedom of goods. The analysis will focus on answering this question on the grounds of the theory of convergence of market freedoms and its limits.

Resistive Random Access Memory (RRAM) is a promising technology for power efficient hardware in applications of artificial intelligence (AI) and machine learning (ML) implemented in non-von Neumann architectures. However, there is an unanswered question if the device non-idealities preclude the use of RRAM devices in this potentially disruptive technology. Here we investigate the question for the case of inference. Using experimental results from silicon oxide (SiOx) RRAM devices, that we use as proxies for physical weights, we demonstrate that acceptable accuracies in classification of handwritten digits (MNIST data set) can be achieved using non-ideal devices. We find that, for this test, the ratio of the high- and low-resistance device states is a crucial determinant of classification accuracy, with ~96.8% accuracy achievable for ratios >3, compared to ~97.3% accuracy achieved with ideal weights. Further, we investigate the effects of a finite number of discrete resistance states, sub-100% device yield, devices stuck at one of the resistance states, current/voltage non-linearities, programming non-linearities and device-to-device variability. Detailed analysis of the effects of the non-idealities will better inform the need for the optimization of particular device properties.

For many years, the computer industry has relied on steady progress in the exponential rate of scaling MOSFETs in integrated circuits. The usual expectation, based on Moore's law, is that the number of transistors able to be packed on a chip doubles roughly every 18 months. Sustaining this pace requires aggressive research into the numerous bottlenecks that threaten to slow it down. Much research has gone into the photolithography needed to produce such dense circuits, device structures that would allow smaller channel lengths, and a plethora of other materials and device advances that help sustain the present rate of scaling. In the past decade, however, another issue has emerged that threatens to impose an absolute limit on how many transistors can be packed onto a die. This is the issue of heat dissipation.

Summary Background: During reproductive life of women, adenosine causes both contraction (with low concentrations) of fallopian tubes and inhibition of their spontaneous motor activity (with high concentrations). Objective: The aim of this study was to investigate effects of natural agonists of adenosine, P2X and P2Y receptors on motility of isolated fallopian tubes taken from postmenopausal women. Materials and Methods: Isolated preparations of isthmus and ampoule were made from fallopian tubes of 21 women in post-menopause, and then tested for reactivity on increasing concentrations of adenosine and P2X/P2Y selective agonists. Results: Adenosine showed concentration-dependent inhibitory effect on spontaneous contraction of both isthmic and ampullary segments of fallopian tubes, while P2X and P2Y agonists (adenosine-5-diphosphate, adenosine-5-triphosphate, uridine-5-diphosphate, and uridine-5-triphosphate) did not influence motility of the isolated preparations. Contractile effect of adenosine was not observed throughout the concentration range used in the experiments. Conclusions: Fallopian tubes of postmenopausal women are unresponsive to P2X and P2Y agonists, unlike those of women in reproductive period. Only an inhibitory effect of adenosine on spontaneous contractions of fallopian tubes is maintained in post-menopause, while a contractile effect is observed in younger women at low concentrations is lost.