Transportation occupies one-third of the amount in the logistics costs, and accordingly transportation systems largely influence the performance of the logistics system. This work presents an adaptive data-driven innovative modular approach for solving the real-world vehicle routing problems (VRPs) in the field of logistics. The work consists of two basic units: (i) an innovative multistep algorithm for successful and entirely feasible solving of the VRPs in logistics and (ii) an adaptive approach for adjusting and setting up parameters and constants of the proposed algorithm. The proposed algorithm combines several data transformation approaches, heuristics, and Tabu search. Moreover, as the performance of the algorithm depends on the set of control parameters and constants, a predictive model that adaptively adjusts these parameters and constants according to historical data is proposed. A comparison of the acquired results has been made using the decision support system with predictive models: generalized linear models (GLMs) and support vector machine (SVM). The algorithm, along with the control parameters, which uses the prediction method, was acquired and was incorporated into a web-based enterprise system, which is in use in several big distribution companies in Bosnia and Herzegovina. The results of the proposed algorithm were compared with a set of benchmark instances and validated over real benchmark instances as well. The successful feasibility of the given routes, in a real environment, is also presented.

The European Economic and Monetary Union (EMU) and the euro and euro area to which it gave birth have often been presented as the definitive and irreversible outcome of European integration, or even as a historical necessity at a crucial time of major changes in world politics. Today, however, the story of deeper integration and unification through the single currency is being called into question.

Security, freedom, stability and prosperity create the conditions for people to maintain economic and personal relationships with one another, to express themselves freely and to profess their beliefs, to be free from violence and to be protected from disproportionate risk. That is, in brief, the meaning of a democratic and social legal state.

The previous chapter discussed the existing forms of variation within the internal market. The remainder of this book discusses forms of variation that fall both within and outside the current framework of European Union Treaty law. This chapter connects the various dots to reveal a broad range of variation options.

Primary Extra‐mammary Paget's disease (EMPD) is a very rare cutaneous adenocarcinoma affecting anogenital or axillary regions. It is characterized by a prolonged course with recurrences and eventually distant metastatic spread for which no specific therapy is known.

This research aimed at testing multiple Þ tness hypothesis of attraction, investigating relationship between male facial characteristic and female students’ reported readiness to engage in various social relations. A total of 27 male photos were evaluated on Þ ve dimensions on a seven-point Likert-type scale ranging from -3 to 3, by convenient sample of 90 female students of University of Sarajevo. The dimensions were: desirable to date – not desirable to date; desirable to marry – not desirable to marry; desirable to have sex with – not desirable to have sex with; desirable to be a friend – not desirable to be a friend; attractive not attractive. Facial metric measurements of facial features such as distance between the eyes, smile width and height were performed using AutoCad. The results indicate that only smile width positively correlates with desirability of establishing friendship, whilst none of the other characteristics correlates with any of the other dimensions. This leads to the conclusion that motivation to establish various social relations cannot be reduced to mere physical appearance, mainly facial features, but many other variables yet to be investigated.

ABSTRACT Democracy is backsliding throughout Southeast Europe but there are no signs of full democratic breakdown. Instead, political parties and their leaders incrementally undermine challenges to governmental authority while keeping electoral contest largely intact. This article introduces a special issue that aims to examine and explain democratic decline by looking at the prevalence of illiberal politics across countries and issues. In order to overcome the limitations of fixed regime classification we adopt a procedural lens and look into governing practices that gradually tilt the electoral playing field. Utilizing the concept of Illiberal politics allows us to examine sets of policies enacted by political parties in government with the aim to remain in power indefinitely. By tracing democratic decline in Serbia, North Macedonia, Montenegro, Bosnia and Herzegovina, Kosovo, Albania, and Croatia we observe different patterns of weakness, but also common causes arising from weak institutions and inherited governance practices that preserve executive dominance, patronage, and informality.

ABSTRACT Purpose: The purpose of this study was to determine the reliability, validity, and usefulness of 30–15 Intermittent Fitness Test (30-15IFT) in female basketball players. Methods: Nineteen female basketball players (17.82 ± 1.94 yr, 175.4 ± 7.3 cm, 67.9 ± 7.7 kg) competing in the National Croatian League performed one trial of a continuous treadmill running test and two trials of the 30-15IFT. The 30-15IFT involves 30-s runs across a 40-m course interspersed with 15 s of walking, with running speed increasing every 45 s. The continuous treadmill running test was used as the criterion for validation. Results: High to very high reliability across test–retest trials were observed for maximal oxygen uptake (VO2max) (CV = 4.9%, ICC = 0.85), the 30-15IFT end-running velocity (VIFT) (CV = 6.0%, ICC = 0.85), and maximal heart rate (HRmax) (CV = 4.8%, ICC = 0.96). Criterion validity was supported for the 30-15IFT with strong to very strong relationships with VO2max (r =0.69), VIFT (r =0.74), and HRmax (r =0.73) attained during the continuous treadmill running test. The typical error (TE) of the 30-15IFT was greater than the smallest worthwhile change for VO2max (1.16 > 0.42 ml/kg/min), VIFT (0.56 > 0.20 km/h), and HRmax (2.15 > 1.89 bpm) adjudging usefulness of the test as marginal. The TE of 0.56 km/h (90% CI = 0.44–0.77 km/h) demonstrates changes in the performance of one to two stages (0.5–1.0 km/h) are meaningful. Conclusions: The 30-15IFT possesses acceptable reliability and validity to assess maximal aerobic fitness capacity in female basketball players. While the usefulness of the 30-15IFT was marginal, meaningful changes in performance consisted of only one to two stages. The present findings support the 30-15IFT as a practical testing option for basketball practitioners to assess fitness capacities in female players.

Parental separation is a major adverse childhood experience. Parental separation is generally preceded by conflict, which is itself a risk factor for child problem behavior. Whether parental separation independent of conflict has negative effects on child problem behavior is unclear. This study was embedded in Generation R, a population-based cohort followed from fetal life until age 9 years. Information on family conflict was obtained from 5,808 mothers and fathers. The 4-way decomposition method was used to apportion the effects of prenatal family conflict and parental separation on child problem behavior into 4 nonoverlapping components. Structural equation modeling was used to test bidirectional effects of child problem behavior and family conflict over time. Family conflict from pregnancy onward and parental separation each strongly predicted child problem behavior up to preadolescence according to maternal and paternal ratings. Using the 4-way decomposition method, we found evidence for a strong direct effect of prenatal family conflict on child problem behavior, for reference interaction, and for mediated interaction. The evidence for interaction implies that prenatal family conflict increased the children’s vulnerability to the harmful effect of parental separation. There was no evidence of a pure indirect effect of parental separation on child problem behavior. Overall, results indicated that if parental separation occurs in families with low levels of conflict, parental separation does not predict more child problem behavior. Moreover, the bidirectional pattern suggested that child problem behavior influences the persistence of family conflict.

ABSTRACT Introduction There are positive aspects regarding the prescribing of fixed dose combinations (FDCs) versus prescribing the medicines separately. However, these have to be balanced against concerns including increased costs and their irrationality in some cases. Consequently, there is a need to review their value among lower- and middle-income countries (LMICs) which have the greatest prevalence of both infectious and noninfectious diseases and issues of affordability. Areas covered Review of potential advantages, disadvantages, cost-effectiveness, and availability of FDCs in high priority disease areas in LMICs and possible initiatives to enhance the prescribing of valued FDCs and limit their use where there are concerns with their value. Expert commentary FDCs are valued across LMICs. Advantages include potentially improved response rates, reduced adverse reactions, increased adherence rates, and reduced costs. Concerns include increased chances of drug:drug interactions, reduced effectiveness, potential for imprecise diagnoses and higher unjustified prices. Overall certain FDCs including those for malaria, tuberculosis, and hypertension are valued and listed in the country’s essential medicine lists, with initiatives needed to enhance their prescribing where currently low prescribing rates. Proposed initiatives include robust clinical and economic data to address the current paucity of pharmacoeconomic data. Irrational FDCs persists in some countries which are being addressed.

Abstract Cadmium is a heavy metal, toxic even in trace amounts and its biological function in the human body has not been described to date. It is assumed that cadmium manifests in dose-dependent genotoxic and cytotoxic effects on many organs and tissue types. In this study, we have analyzed the biochemical parameters in the serum of Japanese quails (Coturnix japonica) after chronic in vivo exposure to cadmium. Adult animals were exposed to cadmium in the form of CdCl2 dissolved in water (0.20 mg/L) for 20 days. Significant differences between controls and exposed animals were found in 12 out of 13 analyzed biochemical parameters. Total bilirubin concentrations did not show any significant differences between the two groups. Exposure to cadmium has resulted in a significant increase in lactate dehydrogenase activity, sodium and chloride concentration, as well as significant reductions in total proteins, albumins, globulins, glucose, triglycerides, cholesterol, calcium concentration, and alkaline phosphatase activity. In this sense, chronic in vivo exposure to low doses of cadmium has induced severe changes in the levels of observed biochemical parameters and enzyme activity. Additionally, evident cytogenetic changes in the liver were also noted, where hepatocyte damage and even lack of organized nuclei, including nuclear fragmentation, clearly indicated ongoing apoptotic processes.