Background/Aim: Sulphur mineral water is widely used in the treatment of musculoskeletal diseases. Hydrogen sulphide is an important regulator of bone metabolism and its application in the treatment of osteoporosis is intensively researched. The aim of this study was to analyse biochemical and histological effects of H2S containing mineral water of "Mlječanica" spring on ovariectomy-induced experimental osteoporosis in rats. Methods: In this experiment a 14-week-old Wistar female rats were used. The animals undergone bilateral ovariectomy (OVX groups) as an experimental model for oestrogen-deficient osteoporosis. After six weeks, animals were divided into control and the experimental group. Rats from the experimental group treated with H2S (SW group) containing mineral water ad libitum during five weeks. Biochemical parameters for monitoring sulphur water effects were concentration in serum of osteocalcin, alkaline phosphatase, calcium and phosphorus. Histological analyses of the left tibia coloured with haematoxylin-eosin were carried out. Results: Regarding the biochemical parameters, a statistically significant increase was observed in the OVX group for osteocalcin, alkaline phosphatase calcium and phosphorus compared to the sham-operated (CNT) group (p < 0.01). In SW + OVX, alkaline phosphatase was statistically significantly decreased (p < 0.01) and serum osteocalcin and phosphorus increased (p < 0.01). Calcium values were increased without significance. In the OVX + SW group, histological analyses showed numerous osteoblasts along the trabecular endosteum and the growth of young chondrocytes in the central bone zone and their migration to the peripheral parts. Conclusion: Drinking the H2S containing "Mlječanica" mineral water has led to decreased alkaline phosphatase, increased osteocalcin and phosphorus concentration in serum and stimulated the bone reparation in osteoporotic rats.

Plant extracts are widely used as biofungicides and medical bioproducts because of their eco-friendly nature and cost effectiveness. The present investigation focuses on the activity of a solvent based on industrial hemp extracts against two phytopathogenic fungi and five human pathogenic bacteria. The present study suggests the potential of the industrial hemp extracts for the development of novel broad spectrum herbal formulations used in plant protection and medicine.

Technical problems have accrued and we were not able to place abstract here in it's full length. Abstract can we found in the pdf version of the paper attached down below.

Background/Aim: Hypomagnesaemia is one of the most detected electrolyte abnormalities in diabetics. Modulation of numerous cardiovascular pathophysiological processes is a potential goal for anti-diabetic therapy. Magnesium supplementation prevents subclinical tissue magnesium deficiency, thus delaying the onset of metabolic imbalance in diabetes, but long-term effects of magnesium supplementation in chronic diabetes and numerous pathophysiological processes remain unknown. Aim of this study was to determine the effects of subchronic intake of magnesium hydrocarbonate-rich mineral water on cardiometabolic markers and electrolytes in rats with streptozotocin-induced diabetes. Methods: A total of 28 Wistar, male rats, body weight 160 g at start, were divided into four groups of 7 each: two controls, group that drank tap water and received a single ip injection of saline (0.9 % NaCl) (TW-C), group that drank mineral water rich in magnesium hydrocarbonate and received a single ip injection of saline (0.9 % NaCl) (MW-C); and two experimental groups with streptozotocin-induced diabetes, group that drank tap water and received a single ip injection of streptozotocin (100 mg/kg) in saline (0.9 % NaCl, 1 mL) (TW-DM), group that drank mineral water rich in magnesium hydrocarbonate and received a single ip injection of streptozotocin (100 mg/kg) in saline (0.9 % NaCl, 1 mL) (MW-DM). Results: Regarding the biochemical parameters, a decrease was observed in the MW-C group for vitamin B12 and proteins, while triglycerides were higher compared to the TW-C group. By comparing the haemostatic biomarkers between TW-C and MW-C groups, a statistically significant decrease was found for fibrinogen, while the electrolyte analysis showed an increase in phosphates for the MW-C group. Biochemical value comparison between TW-DM and MWDM groups showed that magnesium hydrocarbonate usage in diabetic rats did not significantly reduce glycaemia although the average glycaemic values were lower in the group treated with magnesium hydrocarbonate. Regarding the electrolyte values, a statistically significant decrease was observed for sodium, potassium and phosphate in the MW-DM group. The MW-DM group also showed a significant increase in iron value compared to TW-DM group. Conclusion: Subchronic intake of magnesium hydrocarbonate-rich mineral water, as a form of magnesium supplementation, did not cause a significant improvement in glycaemia or normalisation of diabetes-induced dyslipidaemia. This study showed the reduction of fibrinogen value, thus indicating the possibility of usage of this form of magnesium supplementation in different pro-thrombogenic conditions.

Background/Aim: Optimal intake of magnesium minerals is essential in maintaining the coordinated physiological functions of cells, tissues and organs. The importance of this element is reflected in the fact that it is the fourth most abundant cation in the human body, participating as a cofactor in more than three hundred enzymatic reactions. Its presence is necessary for the proper functioning of a number of vital functions, such as glycaemic control, the work of the heart and the vascular system and it can potentially play a role in the regulation of body weight. Aim of this study was to investigate the effects of subchronic intake of magnesium hydrocarbonate-rich water on changes in body weight, organ weight and cardiovascular variables in rats with streptozotocin-induced diabetes. Methods: Wistar rats (n = 28) were divided into 4 groups: two control groups, on tap water (TW-C, n = 7) and magnesium hydrocarbonate-rich water (MW-C, n = 7); and two experimental groups with streptozotocin-induced diabetes, on tap water (TW-DM, n = 7) and magnesium hydrocarbonate-rich water (MW-DM, n = 7). The values of body weight, organ weight and cardiovascular parameters were compared after 6 weeks between control groups of rats on subchronic treatment with tap water (TW-C) and magnesium hydrocarbonate-rich water (MW-C) and between groups with streptozotocin-induced diabetes on tap water (TW-DM) and with magnesium hydrocarbonate-rich water (MW-DM). Results: By comparing the values of cardiovascular parameters between groups, significant (p < 0.05) positive effects of magnesium hydrocarbonate-rich water were registered on the values of systolic and pulse blood pressure in diabetic rats fed with magnesium hydrocarbonate-rich water (MW-DM) compared to those fed with tap water (TW-DM). In contrast, no significant effect of magnesium hydrocarbonate on changes in body weight and organ weight was observed. Conclusion: Based on the results, the beneficial effects of magnesium hydrocarbonate-rich water in the regulation of blood pressure can be clearly observed. Potential effects on other cardiovascular variables and body weight and organ weight should be further investigated.

Background/Aim: Type 2 diabetes is a common comorbidity in patients with knee osteoarthritis. Bearing in mind that obesity and insulin resistance are risk factors for the development of knee osteoarthritis, physical therapy and balneotherapy containing hydrogen sulphide (H2S) has a positive effect on the functional and metabolic status of these patients. This work was aimed to investigate the effect of sulphate-sulphide-rich mineral baths containing H2S on the level of serum glucose in patients with knee osteoarthritis. Methods: An open prospective randomised clinical trial included patients suffering from stage I and II of the knee osteoarthritis. Patients were divided into two groups of 40 subjects each: control group and experimental group. All subjects underwent inpatient physical treatment consisting of kinesitherapy and transcutaneous electrical nerve stimulation (TENS) 6 days a week. Patients from experimental group, in addition to all the mentioned treatments, also took sulphate-sulphide mineral water baths once a day for 30 minutes for 7 days, unlike the patients from control group who took tap water baths, according to the same schedule. The level of serum glucose was monitored in all patients on admission, after discharge and 6 months after the treatment. The Student t-test was used for statistical data processing and p < 0.05 was considered as statistically significant. Results: Study included 80 patients of both sexes, with an average age of 67.00 ± 5.75 years. All patients had elevated serum glucose values on admission. The initial levels of glycaemia in the control and experimental groups were not significantly different (6.99 ± 1.95 and 7.88 ± 1.90 mmol/L, respectively). At discharge, patients who performed balneotherapy had a statistically significant decrease in serum glucose values compared to patients from the control group (by 1.84 vs 0.26 mmol/L, p < 0.001). This effect did not persist six months after the end of the treatment (p > 0.05). Conclusion: The application of balneotherapy with sulphate-sulphide mineral baths containing H2S as a potent gas transmitter significantly reduces serum glucose levels in patients with knee osteoarthritis.

Protests among citizens of Bosnia and Herzegovina are becoming more frequent. Most often, their aim is to decry the dysfunctionality and opacity of the government, which are the result of the ethno-political structure created by the Dayton Agreement, but also a trend towards democratic regression and autocracy. A number of authors have tackled the ?JMBG? protests of 2013 and the Plenums that emerged from the February 2014 protests, from their particular disciplines. The focus of this paper is the social movement ?Justice for Dzenan,? organized by the Memic family upon the tragic death of Dzenan Memic in Sarajevo in February 2016. An in-depth study was conducted with key actors of the movement, as well as those who follow or in some way support the protests. Particular emphasis in the research was paid to the pragmatic symbiosis of the social movement and one political party. We argue that it is possible to identify a pragmatic symbiosis as a novel form (democratic innovation) of socio-political cooperation that can impede rising autocratization. Through the quest for accountability, social movements are introducing new strategic practices of mobilization and a novel type of alliance-building with external factors (new political parties as well as other social movements). The goal of the paper is to explore how the social movement ?Justice for Dzenan? interacts with political parties and approach the political sphere in BiH. Also, the idea is to examine the possibilities and functionality of this kind of cooperation with the framework of contentious politics.

Using natural and modified Ca-bentonite as an adsorbent to observe a satisfactory trend in the removal of heavy metal ions As(V) and Hg(II) from simulated wastewaters. In this original scientific paper, Ca-bentonite was modified in two ways, thermally activated at a temperature of 300 °C for 3 hours and acid activated with HCl and H2SO4, molar concentrations 0,4 mol/L. Ca-bentonite used in this original scientific work was used from the Shipovo mine (Šipovo mine), Bosnia and Herzegovina and proved to be an excellent bioadsorbent for the removal of present ions from simulated wastewaters. Also this is eco-friendly adsorbent and low costed compared to other expensive adsorbents. Due to its chemical composition in which two oxides predominate, namely SiO2 (48.28 mass %) and Al2O3 (23.04 mass%), it can be concluded that Ca-bentonite from the Shipovo mine (Šipovo mine), Bosnia and Herzegovina belongs to the group of refractory materials. The highest removal efficiency of As(V) ions expressed in % was 75.11 at the initial concentration of 1.5 mg/L and was recorded using HCl acid-activated Ca-bentonite. The efficiency of Hg(II) ion removal was the highest using thermally activated Ca-bentonite and this value was 99.66% at an initial concentration of 1 mg/L.

The research sample consisted of 43 first-year male students at the Faculty of Security Studies Banja Luka. This study was conducted to with the aim of determining the relationship between student self-assessment of motor skill performance and the results of the same obtained based on the application of appropriate tests for the assessment of students' motor status. The assessment of motor skills was performed through a battery of seven tests: maximum number of push-ups in 10 seconds (MSKL) - used to assess the dynamic strength of the arm and shoulder girdle, standing long jump (MSDM) - used to assess the explosive power of the lower extremities, agility with a stick (MOKP) - used to assess coordination, the maximum number of trunk lifts in 30 seconds (MPTR) - used to assess the dynamic strength of the trunk, hand tapping (MTAR) - used to assess the frequency of hand movements, forward roll - backward roll - running (MKNT) - used to assess agility, and the Cooper's 12-minute running test (MKUP) - used to assess aerobic endurance. For the self-assessment of motor skills, a constructed questionnaire with six responses was used: excellent (5), above average (4), average (3), below average (2), poor (1), and very poor (0). The obtained results showed a positive transfer of the Special Physical Education (SPE) curriculum to body coordination, agility, and the dynamic strength of the arm and shoulder girdle. Students' self-assessments of motor skills in the test for the assessment of trunk dynamic strength, dexterity and agility were excellent. The students provided poor self-assessments regarding the test for the assessment of explosive power of the lower extremities, speed, and the frequency of movement, the dynamic strength of the arm and shoulder girdle and body coordination. The students provided overestimated self-assessments in the aerobic endurance test. The obtained results indicate the need to enrich the teaching content of SPE, primarily in the area of motor skills aimed at the development of aerobic endurance, as well as the implementation of the self-assessment method in the same.

The aim of this paper is to review and summarize the theoretical and empirical facts of using the (BMI), (body mass index) in determining the relationship between body constitution and motor skills. Several key circumstances have been identified in which the body mass index can give erroneous information about the actual body composition, and especially about the amount of adipose tissue in the body. Factors such as age, sex, race, health status and muscle mass can influence the connection between(BMI) and body fat. Due to a relatively low coefficient of determination between (BMI)and percentage of body fat, one should be cautious when using (BMI) to evaluate body composition as a predictor of obesity or as a substitution measure in evaluating the influence of body constitution on the efficiency of motor performances. The analysis of the sources indicates that the existence of unexplained facts uses alternative measures of body composition and their limited use in research and direct training practice. Therefore, new concepts and models are necessary in order to explain the influence of body composition on the efficiency of motor performance. Apart from the necessary evaluation of variables of percentages of fatty and muscle tissues, it could be assumed that the application of two component (BMI) = (FFMI+FMI), (Fat Free Mass Index, Fat Mass Index) and/or (MFR) model (Muscle to Fat Ratio) would provide a better comprehension of these relations.