Introduction: Sexual satisfaction is the pleasure an individual feels both physically and psychologically, and is the result of erotic experiences, thoughts, dreams, and autoeroticism. Purpose: The purpose of the study is to present the determinants of sexual satisfaction among Bosnian and Herzegovinian women. Methods: The survey was conducted on 387 Bosnian and Herzegovinian women via online questionnaire that consisted of demographic data and 17 statements. The validated questionnaire was used with some adaptations and contained a 5-point Likert scale for each statement, ranging from “not at all satisfied” to “extremely satisfied.” The inclusion criteria were: (a) Age 18–60 years; and (b) completion of the questionnaire as personal consent. Data were analyzed using SPSS 26.0 statistical software. Results: Data collection was conducted from July 2020 to September 2020. The realization rate of the sample was 24.19%. Most of the participants have a high school diploma, most are between 18 and 24 years old and most are currently married. Thirty-five percent of women sometimes experience pain during intercourse (less than half the time). The lower half of the vagina (from the vaginal entrance to the half of the vagina) and the lower part of the abdomen are usually most affected. A relationship was found between the number of children and sexual satisfaction. Women without children were the most satisfied with their sexual life, followed by women who had only one or two children. Conclusions: Every woman has the right to feel sexual satisfaction. The complexity of sexual satisfaction is reflected in many determinants and factors that can influence it positively and negatively.

The main objective of the study is to empirically investigate the impact of the Conventional stock market index on the Islamic stock market index and the comparative performance of the two stock market indexes. For the purpose of the study, daily observations of Dow Jones Islamic Market US Titans 50 (DJUS50) and Dow Jones Composite Index (DJA) spanning a period from January 2015 until December 2021 are obtained from the Investing.com database. Risk-adjusted performance, VAR model, granger-causality test, generalized impulse response functions, and Johansen cointegration tests are used to investigate the behavior and performance of the Islamic market index empirically. Results based on risk-adjusted performance indicate that the Islamic market index performs better than the Conventional market index. Furthermore, the results suggest no long-run association between the indexes, while there is short-run bidirectional causality. This study will contribute both to the literature and practice. It will contribute to the already existing literature through the usage of the newest data, while the practical implication will help investors to better understand the behavior of the Islamic stock market index.

– This paper considers controlled scalar systems relying on a lossy wireless feedback channel. In contrast with the existing literature, the focus is not on the system controller but on the wireless transmit power controller that is implemented at the system side for reporting the state to the controller. Such a problem may be of interest, e.g. , for the remote control of drones, where communication costs may have to be considered. Determining the power control policy that minimizes the combination of the dynamical system cost and the wireless transmission energy is shown to be a non-trivial optimization problem. It turns out that the recursive structure of the problem can be exploited to determine the optimal power control policy. As illustrated in the numerical performance analysis, in the scenario of a dynamics without perturbations, the optimal power control policy consists in decreasing the transmit power at the right pace. This allows a significant performance gain compared to conventional policies such as the full transmit power policy or the open-loop policy.

We report that implanting argon ions into a film of uniform atomic layer deposition (ALD)-grown SiOx enables electroforming and switching within films that previously failed to electroform at voltages <15 V. We note an implantation dose dependence of electroforming success rate: electroforming can be eliminated when the dosage is high enough. Our devices are capable of multi-level switching during both set and reset operations, and multiple resistance states can be retained for more than 30,000 s under ambient conditions. High endurance of more than 7 million (7.9 × 106) cycles is achieved alongside low switching voltages (±1 V). Comparing SiOx fabricated by this approach with sputtered SiOx we find similar conduction mechanisms between the two materials. Our results show that intrinsic SiOx switching can be achieved with defects created solely by argon bombardment; in contrast to defects generated during deposition, implantation generated defects are potentially more controllable. In the future, noble ion implantation into silicon oxide may allow optimization of already excellent resistance switching devices.

Background: The aim of the study was to find out what happens to erythrocytes and their forms during life and after death as a result of high water temperature.Methods: Heat stress was used on a rat model.to investigate the effects of different temperature intensities (37°C and 44°C) and exposure time (20 min and until the time of death) on erythrocyte morphology. Total of 23 Wistar rats were divided into two groups: 37°C as control group and 44°C as trial groups. The trial groups were classified into antemortem the exposure time of 20 min and postmortem groups exposure time until fatal outcome. The anaesthetised rats were exposed to preheated water using the water bath. May-Grünwald-Giemsa colouring technique was applied on blood samples taken from the abdominal aorta. Results: Exposure of Wistar rats to water temperature in groups KG37 and G44 led to a significant changes in core temperature. In the control group, the thermoregulatory mechanism established normothermia, and in G44 hyperthermia was detected during 20 minutes of exposure. The frequency of heat stroke in group G44 was 43.8%. Target cells and anulocytes were predominant in antemortem group at 44°C, while anulocytes and spherocytes in postmortem groups 44°C, respectively. Dacryocytes with spherocytes were significantly higher in postmortem group 44°C than in antemortem group 44°C (p=0.002, p=0.017, respectively).Conclusions: Poikilocytosis is associated with the exposure length and temperature intensity. Following a fatal outcome dacryocytes with spherocytes at 44°C were significantly more than in corresponding antemortem groups.

Denial of Service attacks and the distributed variant of this type of attack called DDoS are attack types which are easy to start but hard to stop especially in the DDoS case. The significance of this type of attack is that attackers use a large number of packets usually created with programs and scripts for creating specially crafted types of packets for different types of attack such as SYN flood, ICMP smurf, etc. These packets have similar or identical attributes such as length of packets, interval time, destination port, TCP flags etc. Skilled engineers and researchers use these packet attributes as indicators to detect anomalous packets in network traffic. For fast detection of anomalous packets in legitimate traffic we proposed Interactive Data Extraction and Analysis with Newcombe-Benford power law which is able to detect matching first occurrences of leading digits – size of each packet that indicate usage of automated scripts for attack purposes. Power law can be used to detect the same first two, three, or second digits, last one or two digits in data set etc. We used own data set, and real devices.

Since viral infectious diseases continue to be a global health threat, new antiviral drugs are urgently needed. A unique class of therapeutic compounds are antimicrobial peptides (AMPs). They can be found in humans, bacteria and plants. Plants express a wide variety of such defense peptides as part of their innate immune system to protect from invading pathogens. Cyclotides are non-classical AMPs that share a similar structure. Their unique topology consists of a circular peptide backbone and disulfide bonds. In previous studies they have been attributed to a wide range of biological activities. To identify novel cyclotides with antiviral activity, we established a library of plant extracts largely consisting of cyclotide-rich species and screened them as inhibitors of HIV-1 infection. Subsequent extraction and fractionation revealed four cyclotide-containing subfractions from Viola tricolor with antiviral activity. These subfractions inhibited HIV-1 infection with IC50 values between 0.6 and 11.2 μg/ml, and selectivity indices of up to 8.1. The identification and characterization of antiviral cyclotides and the determination of the antiviral mechanisms may allow to develop novel agents to combat viral infections. Therefore, cyclotides represent a natural source of bioactive molecules with prospects for development as therapeutics.

In this paper we proved the existence and local stability of prime period-two solutions for the equation 𝐱𝐧􀬾𝟏 􀵌 𝛂𝐱𝐧 𝟐 􀬾𝛃𝐱𝐧􀬾𝛄𝐱𝐧􀰷𝟏 𝐀𝐱𝐧 𝟐 􀬾𝐁𝐱𝐧􀬾𝐂𝐱𝐧􀰷𝟏 , for certain values of parameters ,,,A,B,C0, where ++>0 , A+B+C>0, and where the initial conditions x₋₁, x₀>0 are arbitrary real numbers such that at least one is strictly positive. For the obtained periodic solutions, it is possible to be locally asymptotically stable, saddle points or nonhyperbolic points. The existence of repeller points is not possible.

Pomegranate peel extract (PoPEx) has been shown to have antioxidant and anti-inflammatory properties, but its effect on the adaptive immune system has not been sufficiently investigated. In this study, the treatment of human peripheral blood mononuclear cells (PBMC) with PoPEx (range 6.25–400 µg/mL) resulted in cytotoxicity at concentrations of 100 µg/mL and higher, due to the induction of apoptosis and oxidative stress, whereas autophagy was reduced. At non-cytotoxic concentrations, the opposite effect on these processes was observed simultaneously with the inhibition of PHA-induced PBMC proliferation and a significant decrease in the expression of CD4. PoPEx differently modulated the expression of activation markers (CD69, CD25, ICOS) and PD1 (inhibitory marker), depending on the dose and T-cell subsets. PoPEx (starting from 12.5 µg/mL) suppressed the production of Th1 (IFN-γ), Th17 (IL-17A, IL-17F, and IL-22), Th9 (IL-9), and proinflammatory cytokines (TNF-α and IL-6) in culture supernatants. Lower concentrations upregulated Th2 (IL-5 and IL-13) and Treg (IL-10) responses as well as CD4+CD25hiFoxp3+ cell frequency. Higher concentrations of PoPEx increased the frequency of IL-10- and TGF-β-producing T-cells (much higher in the CD4+ subset). In conclusion, our study suggested for the first time complex immunoregulatory effects of PoPEx on T cells, which could assist in the suppression of chronic inflammatory and autoimmune diseases.

Rare flavour-changing neutral-current transitions b → sμ+μ− probe higher energy scales than what is directly accessible at the LHC. Therefore, the presence of new physics in such transitions, as suggested by the present-day LHCb anomalies, would have a major impact on the motivation and planning of future high-energy colliders. The two most prominent options currently debated are a proton-proton collider at 100 TeV (FCC-hh) and a multi-TeV muon collider (MuC). In this work, we compare the discovery prospects at these colliders on benchmark new physics models indirectly detectable in b → sμ+μ− decays but beyond the reach of the high-pT searches at the HL-LHC. We consider a comprehensive set of scenarios: semileptonic contact interactions, Z′ from a gauged U1B3−Lμ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \textrm{U}{(1)}_{B_3-{L}_{\mu }} $$\end{document} and U1Lμ−Lτ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \textrm{U}{(1)}_{L_{\mu }-{L}_{\tau }} $$\end{document}, the scalar leptoquark S3, and the vector leptoquark U1. We find that a 3 TeV MuC has a sensitivity reach comparable to the one of the FCC-hh. However, for a heavy enough mediator, the new physics effects at a 3 TeV MuC are only observed indirectly via deviations in the highest energy bin, while the FCC-hh has a greater potential for the discovery of a resonance. Finally, to completely cover the parameter space suggested by the bsμμ anomalies, among the proposed future colliders, only a MuC of 10 TeV (or higher) can meet the challenge.

Abstract Objectives To investigate the influence of maternal level of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) one by one or in combination on incidence of gestational hypertension and preeclampsia. Methods The study included pregnant women (n=107) hospitalized in the period from July 1, 2020 to October 10, 2021 at the Department of Pathology of Pregnancy of the University Clinic of Obstetrics and Gynecology, University Clinical Center Sarajevo (UCCS) (Bosnia and Herzegovina), due to hypertensive disorder in pregnancy without symptoms of impaired thyroid function. In all patients fulfilling inclusion criteria TSH, FT3, and FT4 using electrochemiluminescence immunoassay (ECLIA, Roche Diagnostics, Basel, Switzerland) were checked. There were two groups of patients: one with gestational hypertension (G1) and the other with preeclampsia (G2). The programs SPSS for Windows 25.0, SPSS Inc, Chicago, IL, USA and Microsoft Excel 11, Microsoft Corporation, Redmond, WA, USA were used for statistical analysis using nonparametric Mann-Whitney U test because the distribution of the data was not normal. The result was considered statistically significant if p<0.05. Results Gestational age at delivery (G2 36.86 ± 3.79 vs. G1 38.94 ± 2.15; p=0.002) and birth weight (G2 2,841.36 ± 1,006.39 vs. G2 3,290.73 ± 745.6; p=0,032) were significantly different between the investigated groups. The difference between the peak systolic (p=0.002), peak diastolic blood pressure (p=0.007), TSH (p=0.044), and FT3 (p=0.045) were statistically significant. Impaired thyroid function was observed more often in G2 than in G1. Conclusions Thyroid function was more often affected adversely in pregnancies complicated with preeclampsia than with gestational hypertension. Based on the results of our study it might be prudent to check thyroid hormones in all asymptomatic pregnancies with preeclampsia or gestational hypertension. These findings need confirmation in larger better designed prospective studies.