In early 2020, the world faced a pandemic of the COVID-19 disease that suddenly changed the way we learn, live and work. It was necessary to ensure the continuity of teaching and learning literally overnight. The university management, teachers and academic staff, students and all administrative services had to adapt to the new situation.Although the impact of the pandemic on higher education institutions was stressful and in most cases there was no contingency plan, higher education systems ensured continuity of the educational process. The system required the reorganization of teaching and learning, significant teacher involvement and additional time, advanced organization and continuous training of teachers.The lessons learned so far should serve as a guide for the future development of education as a whole and through the analysis and application of good solutions to put in the forefront a recovery program and increase investment in education. At the same time, digital transformation is becoming one of the strategic goals of the development strategy of most universities. Paper will present what necessary steps should be taken to achieve digital transformation in education, why continuous teacher training is important and what are the trends and further steps of development.

RNA-binding proteins contain intrinsically disordered regions whose functions in RNA recognition are poorly understood. The RNA chaperone Hfq is a homohexamer that contains six flexible C-terminal domains (CTDs). The effect of the CTDs on Hfq’s integrity and RNA binding has been challenging to study because of their sequence identity and inherent disorder. We used native mass spectrometry (nMS) coupled with surface-induced dissociation (SID) and molecular dynamics (MD) simulations to disentangle the arrangement of the CTDs and their impact on the stability of E. coli Hfq with and without RNA. The results show that the CTDs stabilize the Hfq hexamer through multiple interactions with the core and between CTDs. RNA binding perturbs this network of CTD interactions, destabilizing the Hfq ring. This destabilization is partially compensated by binding of RNAs that contact multiple surfaces of Hfq. By contrast, binding of short RNAs that only contact one or two subunits results in net destabilization of the complex. Together, the results show that a network of intrinsically disordered interactions integrate RNA contacts with the six subunits of Hfq. We propose that this CTD network raises the selectivity of RNA binding. Significance Statement Hfq is a protein hexamer necessary for gene regulation by non-coding RNA in bacteria, during infection or under stress. In the cell, Hfq must distinguish its RNA partners from many similar nucleic acids. Mass spectrometry dissociation patterns, together with molecular dynamics simulations, showed that flexible extensions of each Hfq subunit form a dense network that interconnects the entire hexamer. This network is disrupted by RNA binding, but the lost interactions are compensated by RNAs that contact multiple Hfq subunits. By measuring interactions that are too irregular to be counted by other methods, mass spectrometry shows how flexible protein extensions help chaperones like Hfq recognize their RNA partners in the messy interior of the cell.

Accessibility is a key for the social and economic development of persons with disabilities. In the digital age, digital or ICT accessibility is imperative, which includes identifying and eliminating obstacles and barriers that persons with disabilities face in using ICT.The purpose of this article is to give a short introduction to the UN Convention on the Rights of Persons with Disabilities, universal design principles, assistive technology, accessibility, and relevant EU directives and standards.Additionally, the Internet Society in Bosnia and Herzegovina’s activities in empowering blind persons through computer training will be presented. Acquiring ICT skills is a necessary condition for access to the opportunities offered by the Internet, which is in line with the Internet Society mission - Internet for All.

As imagens, sejam elas em movimento ou sem movimento, estão presentes no nosso cotidiano nas mais diversas situações, como em jornais, revistas, redes sociais, filmes, novelas, entre outros meios. Na escola essa situação não é diferente, pois, durante o Ensino de Ciências, as imagens sem movimento estão presentes de forma significativa no decorrer das aulas, principalmente nos materiais e livros didáticos. Diante disto, o presente artigo pretende analisar a imagem Pneus depositados na costa de Fort Lauderdale de Steve Spring, através da proposta de Leitura de Imagem Interdisciplinar – LI² com enfoque CTS, a fim de mostrar a potencialidade da imagem para abordar assuntos de Ciência-Tecnologia-Sociedade.

Given the doping profiles available in different CMOS technologies, different single-photon avalanche diode (SPAD) structures could be designed. A good insight into the effect of various doping profiles on the electric field distribution within the device is crucial for optimizing the photodetection performance. In this paper, we present an experimental and simulation characterization of the photon detection probability (PDP) for two reach-through SPADs with different doping profiles, and study the effect of the electric field distribution on the PDP performance. We use a comprehensive model to evaluate the PDP up to an excess bias voltage of 13.2V. In addition, it is shown that the SPAD with a thicker high-field region, despite having the lower maximum value of the electric field, shows higher carrier avalanche triggering probabilities and, consequently, a higher PDP (67% at 13.2 V excess bias and a wavelength of 642 nm). The PDP at the wavelength of the absolute transmission maximum of the isolation and passivation stack at 665 nm is even 84% at 13.2 V excess bias. The presented results and discussions can offer a better insight to the designer to achieve higher PDP for other SPAD structures by optimizing the electric field profile using doping modifications.

The 5th edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems contains relevant revisions and introduces a group of molecularly defined renal tumour subtypes. Herein we present the World Health Organization (WHO) 2022 perspectives on papillary and chromophobe renal cell carcinoma with emphasis on their evolving classification, differential diagnosis, and emerging entities. The WHO 2022 classification eliminated the type 1/2 papillary renal cell carcinoma (pRCC) subcategorization, given the recognition of frequent mixed tumour phenotypes and the existence of entities with a different molecular background within the type 2 pRCC category. Additionally, emerging entities such as biphasic squamoid alveolar RCC, biphasic hyalinising psammomatous RCC, papillary renal neoplasm with reverse polarity, and Warthin‐like pRCC are included as part of the pRCC spectrum, while additional morphological and molecular data are being gathered. In addition to oncocytomas and chromophobe renal cell carcinoma (chRCC), a category of ‘other oncocytic tumours’ with oncocytoma/chRCC‐like features has been introduced, including emerging entities, most with TSC/mTOR pathway alterations (eosinophilic vacuolated tumour and so‐called ‘low‐grade’ oncocytic tumour), deserving additional research. Eosinophilic solid and cystic RCC was accepted as a new and independent tumour entity. Finally, a highly reproducible and clinically relevant universal grading system for chRCC is still missing and is another niche of ongoing investigation. This review discusses these developments and highlights emerging morphological and molecular data relevant for the classification of renal cell carcinoma.

Many consumer studies have confirmed that in different international settings ethnocentric consumers mostly prefer domestic products. Consequently, consumer ethnocentrism has been considered as a prominent informal barrier for international trade. Even though an ethnocentrism as a personal trait has been a subject of international management studies, ethnocentrism was rarely observed within a context of managers’ or owners’ decisions that affect business orientations. The purpose of this study was to explore a link among consumer ethnocentrism and ethnocentric business orientations of graduate students as future managers and business owners. The main goal was to and derive implications relevant for consumer and organizational marketing in international environment. The main motivation behind the study was to explore potential extension of consumer ethnocentrism on managerial ethnocentric decision making, and consequently, on ethnocentric business orientation. Research was conducted on a convenience sample of 219 business economics graduates from the University of Rijeka, Croatia and from the University of Mostar, Bosnia and Herzegovina. Multi-Group Structural Equation Modeling has been employed to explore a linkage among observed concepts. Empirical results indicated a differences among sub-samples from two countries in level of consumer ethnocentrism and its impacts on preferences towards domestic products. However, significant positive relation has been found between consumer ethnocentrism and ethnocentric business orientation in case of both observed groups. Consumer ethnocentrism has been confirmed as predictor of ethnocentric tendencies towards domestic products as well as predictor of ethnocentric business orientations of youth as a future managers and business owners. Research results confirmed that consumer ethnocentrism can be extended from consumer preferences and orientation towards domestic products to managers’ ethnocentric decision making, providing ethnocentric business orientation.

The paper investigates the empirical verification of the efficacy of investment diversification using the main stock exchange indices in the Eurozone countries and Bitcoin. The paper also investigates whether and to what extent it is desirable for institutional investors, in addition to traditional financial instruments, to invest in Bitcoin. The aim of the research is to examine whether it is justified and to what extent to include Bitcoin in the portfolio of an institutional investor. Through this research, an attempt is made to find an answer to the research question: “What share of Bitcoin in the portfolio structure is justified, taking into account the ratio of return and risk”? The analysis includes data on the daily movement of selected action indices as well as the movement of Bitcoin. The methodology involves the analysis of high-frequency data, given that daily trading data were used. The results show that it is justified to include Bitcoin in the portfolio structure. Also, the results show which share of Bitcoin in the portfolio is justified from the aspect of institutional investors. The data used in the analysis cover the period from 2019 and 2020. Two portfolios have been created, one without Bitcoin and the other with Bitcoin. The goal in optimization for both portfolios is to minimize risk. The observed period of the analysis is characterized by the crisis caused by the coronary virus pandemic and the period of active bitcoin trading. The results of the research show that Bitcoin is a good source of diversification in a portfolio that contains traditional financial instruments, both for an investor who is not prone to risk, and for those investors who have a greater appetite for risk. The conclusion is that the rational behavior of institutional investors requires consideration of investing in Bitcoin using the Markowitz model. However, given the high degree of volatility, investors should be careful when making decisions about including Bitcoin in their investment portfolio. Bitcoin is an extremely volatile instrument. Given that it is a speculative and highly volatile financial instrument, investors have different views on Bitcoin. First in terms of defining this cryptocurrency and then in terms of including this instrument in the investment portfolio. By including Bitcoin in the investment portfolio, the goal of diversification has been achieved. This is to reduce the risk of the institutional investor to a minimum. In practice, this means that it is possible to create a portfolio that carries an acceptable level of risk with the desired level of return. Given that Bitcoin is an extremely volatile and consequently - risky instrument, the expected return is also - high. The results of the research show that the cryptocurrency Bitcoin can serve as a desirable instrument for diversification of the investment portfolio when looking at a portfolio that includes stock indices. The results suggest that it is desirable to include in the structure of the portfolio a certain share of Bitcoin, about 6%.

This paper aims to describe lexicographic strategies for treating loanwords from Arabic, Persian, and Turkish in a productive bilingual Bosnian-German dictionary. In terms of number, stylistic and cultural features, those words significantly characterize the Bosnian language. In lexicography, they have the status of cultural-bound words with a high degree of anisomorphism. We will look into their description in existing monolingual and bilingual dictionaries as well as into their equivalents in literary translations to propose more suitable equivalents. In this paper, we focus in particular on lexicographic treatment strategies of partial and zero equivalence, taking into account the deep cultural embeddedness of Arabic, Turkish and Persian loanwords in the Bosnian language. It will be shown that specific concepts such as “tekija”, for which the German language has no word, and the existing bilingual dictionary provides an equivalent „Muslim monastery“ (Jakić & Hurm 1992: 1053), can be treated by combined strategies to obtain more suitable equivalents, such as the incorporation of the source item into the target language with an additional explanation as well as an explanatory equivalent.

The play in numerous philosophical, literary-theoretical, and artistic texts is recognized as a constituent part of life and as one of the vital determinations of a human being. This Paper perceives the play as a fundamental principle that permeates all levels of the texts in the selected examples in the literature for children and youth of Ljubica Ostojić. We will show how Ljubica Ostojić takes the play and artistic creation as a thematic-conceptual base of her texts, focusing on structural, semantic, and language aspects of its presence in the text. The analyzed texts of Ljubica Ostojić are a helpful example of the accomplished correlation of the reality between the child and the world with elements of a fantastic discourse. In the parallel existence of realistic and fantastic, deconstructing the traditional children's literature, the author writes various types of texts for children and youth, which share the seeming disharmony and complexity of the structure.

Correspondence as a source for the study of literary, cultural, and political circumstances and events in Bosnia has not received an appropriate place in the humanities and social sciences because the letters are treated exclusively in the field of privacy. However, letters are sometimes a first-class source for presenting an image of a particular period or event, especially if it is interesting to determine how a particular person or group understands events or processes in society and culture. Studying the letters would open a different perspective on some events since it is often about an "informal" form of communication. In the framework of Bosnian studies, the so-called "letters from the border/krajišnička pisma" (Muhamed Nezirović and Lejla Nakaš) have been the most comprehensively studied, with slightly fewer letters in oriental languages (Sabaheta Gačanin), while letters from the 20th century (Hamid Dizdar, Munir Šahinović, Alija Nametak, for example), unfortunately, did not receive proper valorization. In this paper, the correspondence of Alija Nametak between the two world wars will be presented. Considering the dispersed thematic content of the letters, they are grouped into several thematic units. Letters about Safvet-beg Bašagić, letters about political censorship of articles and literary and artistic works, and correspondence with Slavists throughout Europe especially stand out. The letters were linked to other texts (co-text) that were in the broadest sense related to the topics of the letters. We tried to present as much as possible the events to which the letters referred. We also pay attention to the need to renew the study of Bosnian archival and documentary material, especially in the study of the history of literature.

The rule of law is, along with democracy, one of the main concepts of the 21st century, while Islam is, along with Christianity, the most populous religion. On the other hand, Muslim states face the problem of accepting the rule of law as a concept that originated in the West. The paper discusses the compatibility of the rule of law and Islam as well as the reason why the rule of law is not developed in Muslim countries. The authors investigate whether the underdevelopment of the rule of law in Muslim countries is inherently related to Islam or to the socio-economic circumstances that led to it. The authors of the paper put forward the thesis that the cause of the underdevelopment of the rule of law in Muslim countries is primarily caused by socio-economic circumstances, and not because of the very concept of Islam as a religion.