Este artigo investiga como o idoso está contemplado como sujeito de direitos na Convenção Interamericana sobre a Proteção dos Direitos Humanos dos Idosos e objetiva compreender a maneira como as diretrizes internacionais têm tratado a proteção dos direitos humanos na velhice. Foi realizada uma pesquisa documental quanti-qualitativa que analisa o conteúdo da Convenção Interamericana de forma exploratória e descritiva. Verificou-se que a Convenção rechaça a homogeneização e os estereótipos da velhice, sendo fortalecedora do reconhecimento da alteridade e observou-se que o idoso é contemplado como sujeito de direitos que merece proteção e cuidado, não sendo encarado como sinônimo de vulnerabilidade.

The Dinaride Ophiolite Belt formed from the Jurassic part of the Neotethys. The investigated Ozren ophiolite complex in Bosnia and Herzegovina consists of peridotites, plagioclase peridotites, plagiogranites, troctolites and other gabbroic rocks, and fewer basalts. Lherzolites and harzburgites contain corroded ortho- and clinopyroxene1 porphyroclasts enclosed in the olivine matrix. The boundaries between olivine aggregates and pyroxene1 and spinel1 are infilled by medium-grained undeformed aggregates of clinopyroxene2, less orthopyroxene2, spinel2, and often clinopyroxene3-spinel3 symplectites. These textures indicate the final crystallization of peridotite in subsolidus conditions. Partial dissolution of deformed pyroxene1 porphyroclasts and coarse-grained spinel1 most likely occurred due to their reaction with the rest melt present in the grain boundaries. The Al decrease from pyroxene1 to pyroxene2 and 3, or the Cr decrease and Al increase from spinel1 to spinel2 and 3 is characteristic. Peridotites are associated with inferred remnants of a gabbro-dolerite layer, whereas basalts and radiolarites occur as rare dm-size fragments in an ophiolitic breccia. Troctolites display interstitial crystallization of plagioclase, clinopyroxene, less Na-Ti-rich amphiboles, and phlogopite in the olivine-spinel matrix, indicating the replacive character of impregnating melt within the dunite layers. Clinopyroxene-plagioclase-ilmenite-±amphibole gabbroic and fewer basaltic dykes in peridotites formed due to subridge extension, mantle thinning, and the deeper mantle melting. Iron-enriched olivines occur in the peridotite-dyke interfaces and troctolites. Hydrated ultramafics and mafics contain amphiboles, biotite, phlogopite, clinozoisite, epidote, and chlorite aggregates. Estimated magmatic to subsolidus T from peridotite two-pyroxene thermometry are 1000–850 °C, for the spinel facies. Ca-in-orthopyroxene1 thermometry provided T of 1028–1068 °C, and Ca-in-orthopyroxene2 thermometry gave 909–961 °C at estimated P of 1.1–0.9 GPa. However, the gabbroic dyke magmatic crystallization T was constrained to 1200–1100 °C at P of 0.45–0.15 GPa by single clinopyroxene thermobarometry. The obtained P–T conditions constrained the deeper mantle environment for the formation of peridotites than troctolites and crosscutting dykes. The ophiolitic thrust-sheet hanging wall conditions in an obduction-related accretionary wedge were estimated from amphibolites at 620 °C and 0.85 GPa by Ti-in-amphibole thermometry and amphibole-plagioclase thermobarometry. 300 °C and 0.5 GPa were determined from an exhumation shear zone using a combination of chlorite thermometry and Si-in-phengite barometry.

Standalone hybrid systems based on renewable energy sources may represent a convenient and cost effective option for powering isolated consumers located far from the existing grid. In this study the focus is on particular photovoltaic-wind-diesel-battery systems which supply mobile telephony base stations. In the study, both the consumption of telecommunication electronic equipment and the consumption of cooling devices are taken into account. Nine characteristic locations across Europe with different climatic conditions were selected for comparative techno-economic assessment. For each location, a comprehensive simulation and optimization routine was performed, in order to find the optimal system configuration and the minimum amount of total annualized costs. The obtained results are discussed and some conclusions regarding system sizing at different locations are drawn.

water quality; pollination of nearby crops; recreation and and of timber; raw materials other than timber; medicinal resources; supplying ornamental resources; or religious values; well-being and health; inspiring artistic outputs; cultural and historical values; peace and stability; biodiversity; education; nature conservation; knowledge values; soil maintenance; mitigation of and disease Data analyses performed

Glucocorticoids prevent or suppress the full inflammatory response to the infectious, immunological or physical agents by inhibiting early inflammatory events such as edema or cell exudation. The main effect of glucocorticoids on the inflammatory process is the inhibition or recruitment of neutrophils and monocytes. In this study, the effect of the glucocorticoid betamethasone on the hematological parameters of rats of the species Rattus norvegicus Berkenhout 1769 was examined in vivo. Betamethasone has been shown to affect the values of hematological parameters four hours after application and leads to a significant decrease in the prevalence of lymphocytes and monocytes, but also leads to a statistically significant increase in erythrocyte count, hemoglobin concentration and hematocrit values.

Despite the fact that technology is improving day by day and that the medical devices (MDs) are being constantly upgraded, their malfunction is not a rare occurrence. The aim of this research is to develop an expert system that can predict whether the device will satisfy functional and safety requirements during a regular inspection. This expert system can be seen as part of Industry 4.0 that is revolutionizing medical device management. In order to develop the system, five machine learning algorithms that are representative of each classifier group, were used: (1) Random Forest, (2) Decision Tree, (3) Support Vector Machine, (4) Naive Bayes, (5) k-Nearest Neighbour. The Decision Tree outperformed other classifiers achieving the classification accuracy of 100% with and without attribute selection applied on the dataset. This study showed that machine learning algorithms can be used in order to predict MDs performance and potential failures in order to make the process of maintenance of medical devices more convenient and sophisticated and it is one step in modernizing medical device management systems by utilizing artificial intelligence.

Simple Summary Penalties in judo (shido) have been previously associated with match outcomes and increased the likelihood of being defeated, particularly in heavier weight categories. Each 1-min increase in match duration and further athlete proceeds in competition increases the possibility of receiving a penalty. Penalties have also been associated with the occurrence of injuries, especially with grip fighting and other illegal moves and therefore, have a substantial effect on athletes’ health. The main findings highlighted that the leading penalties in all weight categories for both genders on Judo World Championships (WC) were Non-combativity, Avoid Grip and False Attack. Additionally, a new trend in heavyweight athletes with a lower number of penalties is noted. Abstract Background: This research aimed to compare individual penalties by gender and weight categories in judo from the Judo World Championships (WC): Budapest—2017, Baku—2018, Tokyo—2019 and Budapest—2021 in all individual weight categories for females and males. Methods: Data were collected by notational analysis of 2041 penalty videos for females and 3473 penalty videos for males (total n = 5514). All individual penalties—Shido 1, 2, 3 and Hansoku Make (direct disqualification) were analysed by the Pearson chi-square test at the level of statistical significance of 5%. Results: Significant differences were noted in the assigned individual penalties between individual categories (p < 0.001) in both genders. The significant difference was contributed mainly by the weight category +78 kg with penalties Non-combativity (5.3) and Avoid Grip (−3.4) in females, while in males it impacted by the +100 kg weight category and the Non-combativity (4.2) and Avoid Grip (−4.0) penalties. For females, the most dominant individual penalties were Non-combativity (41.6%), Avoid Grip (16.2%) and False Attack (15.0%), and were Non-combativity (40.3%), Avoid Grip (19.5%) and False Attack (16.4%) for males. The largest number of penalties in females were in −52 kg (16.7%), −57 kg (15.9%) and +78 kg (15.2%) categories, while in males, they were −66 kg (17.2%), −73 kg (16.1%) and −90 kg (15.6%). Conclusions: The findings of this study highlight the leading penalties in all weight categories for both genders on WC to be Non-combativity, Avoid Grip and False Attack. Additionally, a new trend in heavyweight athletes with a lower number of penalties is noted. The obtained results indicate the need to pay more attention to working with competitors of all ages and genders on education to implement tactical variants, forms and means to use penalties to athletes’ advantage, especially after a possible rule change and to lower the occurrence of injuries.

In order to fill in a decade-long information gap regarding the biological, serological and molecular data for plum tree viruses in Bosnia and Herzegovina, a three-phase study combining symptom evaluation, and serological and molecular assays with high-throughput sequencing (HTS) technology was conducted. The most frequently observed symptoms were discolorations in the form of ring patterns, bands and irregular shapes, as well as vein banding. Sharka-associated symptoms in the form of ring patterns and semicircles were prevalent. A total of 468 plum tree samples were tested by ELISA for the presence of PPV, ApMV, PDV, PNRSV, PBNSPaV, ACLSV and MLRSV. An overall infection incidence of 51.9% was detected, with PPV being the most prevalent (48.7%), followed by PDV (2.99%), PNRSV (0.21%) and mixed infections of PPV+PDV (1.71%). RT-PCR-assisted strain typing in 45 samples revealed PPV-D as the most common strain (22.22%), followed by PPV-REC (6.66%). Mixed infections of PPV-D+PPV-REC were detected (6.66%). HTS enabled the recovery of a 9743 nts long sequence of PPV-D (PPV_O7/80, MW412433), which shared the highest nucleotide and amino acid identities with isolates S13 (LC375131) from Serbia, SVN1 (LC375132) from Slovenia and N9 (LC375129) from Bulgaria. The phylogenetic analysis of the whole genome placed the isolate of the D strain in a distinctive group with the Slovenian isolate SVN1 (LC375132). In addition, the (Cter)NIb/(Nter)CP fragment of a PPV-REC isolate (MW412434) obtained in this survey formed a separate group with previously known isolates from Bosnia and Herzegovina (BOS64Pl and BOS257Pl).

Objective Using a short-form specific questionnaire, we sought to quantify specific and generic benefits of surgery for chronic otitis media (COM) while adjusting for expectancy (placebo) bias. Study Design A prospective observational pretreatment/posttreatment study. Setting A national tertiary referral center. Patients Consecutive adult COM patients were enrolled for 1 year. Of 246 patients, 205 were recommended for surgery, and 167 were operated on the (more) affected ear. Intervention(s) All patients filled out two questionnaires, one specific (Chronic Otitis Media Questionaire-12) and one generic (Short Form-36) at baseline, and then again 6 and 12 months after surgery. Main Outcome Measures Factor-based scores of questionnaires, standardized response means (SRMs) for treatment effects, with multiple linear regression for implementing bias adjustment. Results All but one (generic Short Form-36 “mental” scale) of the seven considered measures gave very highly significant (p < 0.001) improvements. Unadjusted SRMs were large (1.0–2.0 standard deviation units) for audiometry, symptoms of ear discharge, reported hearing, and aggregate specific quality of life, but only moderate for the less specific activity/healthcare. The proposed bias adjustment reduced SRM magnitudes for most measures by about a third, for activity/healthcare and ear discharge by only a tenth to a fifth, and for audiometry not at all. Conclusion Most scores of the specific questionnaire displayed definite placebo-like biases; this demands caution in interpreting improvement after COM surgery. With bias adjustments, credible and worthwhile magnitudes of improvements remained for Chronic Otitis Media Questionnaire-12 total and subscores (0.5–1.09 standard deviation SRM), but not for generic quality of life.

The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome biogenesis and mutation of ribosomal proteins. The ribosome represents an attractive anti-cancer therapy target and several strategies are used to identify specific drugs. Here we review the role of different drugs that may decrease ribosome biogenesis and cancer cell proliferation.

Abstract Background DIALOG+ is a digital psychosocial intervention aimed at making routine meetings between patients and clinicians therapeutically effective. This study aimed to evaluate the cost-effectiveness of implementing DIALOG+ treatment for patients with psychotic disorders in five low- and middle-income countries in Southeast Europe alongside a cluster randomised trial. Methods Resource use and quality of life data were collected alongside the multi-country cluster randomised trial of 468 participants with psychotic disorders. Due to COVID-19 interruptions of the trial’s original 12-month intervention period, adjusted costs and quality-adjusted life years (QALYs) were estimated at the participant level using a mixed-effects model over the first 6 months only. We estimated the incremental cost-effectiveness ratio (ICER) with uncertainty presented using a cost-effectiveness plane and a cost-effectiveness acceptability curve. Seven sensitivity analyses were conducted to check the robustness of the findings. Results The average cost of delivering DIALOG+ was €91.11 per participant. DIALOG+ was associated with an incremental health gain of 0.0032 QALYs (95% CI –0.0015, 0.0079), incremental costs of €84.17 (95% CI –8.18, 176.52), and an estimated ICER of €26,347.61. The probability of DIALOG+ being cost-effective against three times the weighted gross domestic product (GDP) per capita for the five participating countries was 18.9%. Conclusion Evidence from the cost-effectiveness analyses in this study suggested that DIALOG+ involved relatively low costs. However, it is not likely to be cost-effective in the five participating countries compared with standard care against a willingness-to-pay threshold of three times the weighted GDP per capita per QALY gained.

Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic encephalopathic state, manifesting clinical symptoms of headache, altered consciousness, visual disturbances, and seizures. Although several diseases have been identified as causative of PRES, the underlying mechanism remains unclear. Song et al recently published “Posterior reversible encephalopathy syndrome (PRES) in a patient with metastatic breast cancer: A case report“ in the World Journal of Clinical Cases, highlighting and discussing the role of hypercalcemia in PRES as related to uncontrolled hypertension. To build upon this case description, we provide further insight into the possible underlying mechanisms of PRES through this commentary.