Introduction/Objective. The purpose of this study was to assess the effectiveness of different approaches in the treatment of metastatic melanoma in daily clinical practice in a situation with limited and late availability of new drugs in a resource-limited country and to compare these parameters with those reported in clinical studies and from other real-world data. Methods. Main methods included assessment of overall survival (OS) and progression-free survival (PFS). Patients were included in the study if they were treated with first or second-line systemic therapy for radiologically/pathologically confirmed metastatic melanoma. Patients were divided into four groups based on the type of therapy they received: chemotherapy (dacarbazin), BRAF inhibitor (vemurafenib), BRAF/MEK inhibitors (vemurafenib/cobimetinib and trametinib/dabrafenib) and anti PD-1 therapy with pembrolizumab. Results. Regardless of the line of therapy, the calculated median OS in chemotherapy and vemurafenib group was nine months. The median OS in the BRAF/MEK inhibitor group was 14 months and 15 months in the pembrolizumab group. Median PFS in the chemotherapy group was four months, seven months for vemurafenib, in the BRAF/MEK inhibitor group nine months and in the pembrolizumab group six months. There was a statistically significant difference in survival between first and second-line therapy in the pembrolizumab group. Conclusion. Our results showed lower median OS and PFS in comparison to reported data from clinical trials. Compared to other real-world data from countries with similar problems related to the late reimbursement of new drugs, our research has shown similar results.

High handgrip strength in men’s artistic gymnastics is crucial, mainly for improving performance and to potentially prevent injuries, as well as for the fact that gymnasts body movements are around immovable apparatuses (pommel horse, rings, parallel bars and high bar) for the extended period of time. Since there are not so many studies that have dealt with this topic and on actual competition, we have aimed to examine the handgrip strength influence on the competition result in elite male artistic gymnasts. The sample of participants were conducted of 37 elite male artistic gymnasts (8–21 years old), from 8 different countries as national team competitors at the International Competition “Laza Krstić and Marica Dželatović” held in Novi Sad, Serbia. Basic anthropometric measurements were included (body height, body weight and Body Mass Index (BMI)), along with training experience and handgrip strength measurement (both dominant and nondominant hand). Kolmogorov-Smirnov Z test (p < 0.05) was used for distribution normality, along with regression analysis with Model 1 (participants age, training experience, body height, body weight and BMI), Model 2 (Model 1 + dominant handgrip strength) and Model 3 (Model 1 + nondominant handgrip strength). SPSS v.20 was used for all statistical analysis. Our study have revealed that there is significant influence of all 3 Models on the parallel bars final result (p = 0.33; p = 0.49; p = 0.31, respectively), in terms of all set of variables, whereas body weight Beta scores (28.6%; 30.3%; 32.7%, respectively) moslty explains the results. Both dominant and nondominant handgrip strength are influential factors only on the parallel bars final result. Since both hands are contributing equally, bilateral training is necessary. In order to expand the knowledge on this topic and completely understand the influential factors, future studies are needed on this sample. Regardless of our main findings, our results should be taken with caution.