N-(4-hydroxyphenyl) acetamide or paracetamol is an acylated aromatic amide used as analgesic and antipyretic to relieve pain and reduce body temperature. In medicinal chemistry, there is a growing interest in the development of drugs based on metal complexes, which are of great importance in therapeutic and diagnostic possibilities. Selected metals, magnesium and copper are elements that are extremely important for the human body. In this research, complexes of Mg(II) and Cu(II)-ions with N-(4-hydroxyphenyl) acetamide were synthesized and confirmed with FTIR, UV and MS spectroscopy. The results of the analysis of the synthesized complexes spectra indicate interactions between N-(4-hydroxyphenyl) acetamide and metal Mg(II)-ions and Cu (II)-ions via O-donor and N-donor atoms.  

Fexofenadine hydrochloride (FFN), (±)-4-[1-hydroxy-4[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl] α,α-dimethylbenzeneacetic acid hydrochloride, is a second-generation antihistamine that is used to treat allergies. The drug is highly hydrophobic and slightly soluble in water. Cyclodextrins are widely used to improve the physicochemical and pharmaceutical properties such as solubility, stability, and bioavailability of poorly soluble drug molecules.Cyclodextrins can molecularly encapsulate various drugs into their hydrophobic cavity without forming any covalent bonds. Cyclodextrin (CDs), especially ß-Cyclodextrin (ß-CD), are widely used in the pharmaceutical field due to its ability to stabilize drug molecules and taste masking purposes. The phase solubility study was performed according to the method of Higuchi and Connors by adding the fexofenadine hydrochloride in excess to different concentrations of cyclodextrin solutions. Phase solubility study records show that the stability constant and complex stoichiometry of FFN-CD complexes increases linearly with CD concentration. Also, an increase in the concentration of β-cyclodextrin leads to an increase in the aqueous solubility of FFN. Complexes were analyzed by UV-VIS spectroscopy using the calibration curve of FFN. Also, UV-VIS spectra indicate a bathochromic shift which proves that complex formation has occurred.Solid inclusion complexes of fexofenadine/β-cyclodextrin and its derivatives were prepared at the molar ratios of 1:1 by the physical mixing method. Characterization of the complexes was performed by using infrared spectroscopy. 

Lignit je mrki ugalj koji u svom sastavu sadrži huminsku kiselinu. Izolacija huminskih kiselina je vrsena iz prethodno oksidovanog i osusenog lignita nakon cega je vrseno preciscavanje. Identifikacija tako dobivenih huminskih kiselina vrsena je FTIR spektroskopijom, a njena karakterizacija UV analizom gde je određivana opticka gustina izolovane huminske kiseline i izvrsena njena kompleksacija sa metalnim katjonima. Podaci dobiveni FTIR spektro­skop­skom analizom za izolovanu huminsku kiselinu ne pokazuju znacajnu strukturnu i hemijsku razliku u odnosu na spektar dobiven za standardnu huminsku kiselinu (Sigma–Aldrich). UV analizom je utvrđeno da izolovana i standardna huminska kiselina imaju E 4 /E 6 odnos u odgovarajucem opsegu od 3–5, sto indicira prisustvo veceg broja alifatskih struktura. Na osnovu stepena humifikacije utvrđeno je da izolovane huminske kiseline pripadaju tipu B dok standardne huminske kiseline pripadaju tipu A. Kompleksacija huminskih kiselina je vrsena rastvorima razlicitih koncentracija nitratnih soli metala i pri razlicitim pH vrednos­tima. Kolicina slobodnog metala merena je metodom ICP-OES. Podaci su analizirani i ANOVA statistickom metodom. Rezultati su pokazali da se povecanjem pH vrednosti sma­njuje koncentracija metalnog jona adsorbovanog na huminsku kiselinu dok se povecanjem koncentracije metala i kolicine huminske kiseline ta moc povecava. Istraživanjem je utvr­đen sledeci niz vezivanja metala za huminsku kiselinu Pb>Zn>Ni>Cu.