ABSTRACT The application of microsatellite simple sequence repeat (SSR) markers has proven to be highly effective in genetically characterising the origins of various fruit species. Bosnia and Herzegovina boast abundant cornelian cherry (Cornus mas L.) germplasm within its natural habitats. This study focuses on three geographically distant regions in Bosnia and Herzegovina–Drvar, Mostar and Zenica–comprising a sample of 60 cornelian cherry genotypes. The genetic analysis of cornelian cherry utilised eight microsatellite primers to characterise the genetic makeup of the 60 genotypes. Notably, all observed loci in the three populations demonstrated 100% polymorphism. The total genetic differentiation is 0.042, which is also confirmed by the analysis of molecular variance (AMOVA), which indicates that 3% of the total genetic variation is between groups, 8% between individuals and 89% within individuals. The results of pairwise Fst analysis (pFst) indicate that the greatest differentiation is between the populations of Mostar and Zenica (0.037), between Drvar and Zenica (0.026) and between Drvar and Mostar (0.025). The results of the genetic distance according to Nei confirm these results. Also, the largest difference was observed between the populations of Mostar and Zenica (0.316), then between Drvar and Zenica (0.285), and the smallest between Drvar and Mostar (0.251). This research contributes valuable insights into the genetic diversity and characterisation of cornelian cherry populations in different regions of Bosnia and Herzegovina.

Whether recreational or professional, sport is an integral part of human life, so its daily impact on society is undeniable. It is, therefore, important to recognise the role of moral values and ethics in sport, which can help to ensure fairness and preserve the integrity of professional sports. In recent years, there has been a growing awareness of the importance of implementing these values in professional sport, as it is crucial to enable physical performance without compromising the very essence of sport. However, using prohibited substances and methods in professional sports today has become an increasingly worrying ethical issue, particularly in sports medicine. The primary aim of sports science, especially sports physiology, is to help athletes improve their performance and prevent and overcome injuries, while the primary goal of sports management and some athletes is often to win, which can lead to unethical means to achieve this goal. This behaviour raises many ethical doubts and highlights the need for a framework to address these contemporary challenges increasingly facing professional sport today. Bioethics can effectively address these challenges by examining medical and scientific advances’ ethical, social, moral, and legal implications. By considering the values, principles, and norms underlying medical and scientific practices, bioethics in the context of sport can provide guidance and recommendations for bioethical decision-making concerning (bio)ethical doubts or controversies that may arise, such as the use of performance-enhancing drugs, non-therapeutic use of gene therapy and ethical considerations related to using new technologies. This paper, therefore, aims to emphasise the importance of bioethics as a bridging science in sport in the context of the (bio)ethical challenges that increasingly characterise the professional practice of sport today.

This study examines the correlation between vitamin D levels and the severity of symptoms and quality of life in patients with benign prostatic hyperplasia (BPH). A total of 125 participants were categorized based on their prostate symptoms (mild, moderate, and severe) and vitamin D levels (deficient, insufficient, and optimal). Among those with mild symptoms (n=60), 37.93% were vitamin D deficient, 44.11% had insufficient vitamin D, and 54.83% had optimal levels. For moderate symptoms (n=55), 44.82% were deficient, 47.05% had insufficient, and 41.93% had optimal vitamin D levels. In severe cases (n=10), 17.04% were deficient, 8.82% had insufficient, and 3.22% had optimal vitamin D levels. Overall, 23.02% of participants were deficient, 27.02% had insufficient, and 49.6% had optimal vitamin D levels. Quality of life assessments revealed that 56.8% of participants reported a good quality of life, with 46.66% of these being vitamin D deficient, 57.57% insufficient, and 61.29% optimal. An indifferent quality of life was noted by 29.6% of participants, with 28.57% deficient, 27.27% insufficient, and 29.03% optimal vitamin D levels. A very poor quality of life was reported by 13.6% of participants, with 21.42% deficient, 15.15% insufficient, and 9.67% optimal vitamin D levels. These results indicate a potential association between higher vitamin D levels and improved prostate symptoms and quality of life in BPH patients. Further research is needed to establish causality and underlying mechanisms.

The roadmap is organized into several thematic sections, outlining current computing challenges, discussing the neuromorphic computing approach, analyzing mature and currently utilized technologies, providing an overview of emerging technologies, addressing material challenges, exploring novel computing concepts, and finally examining the maturity level of emerging technologies while determining the next essential steps for their advancement.

Improved molecular strong-field approximation theory is used to calculate the ionisation probability for the high-order above-threshold ionisation process induced by a few-cycle pulse with two carrier frequencies and one envelope. The asymmetry in the photoelectron momentum distribution is due to the ultrashort nature of the driving pulse and due to the relative orientation of the molecule with respect to the laser field. We introduce the generalised asymmetry parameter, which can be used to quantitatively measure the asymmetry between the photoelectron spectra along arbitrarily many selected directions. We investigate the difference between the asymmetry parameters calculated for atomic and molecular targets and show that the contributions to the asymmetry strongly depend on the type of the employed driving pulse. For the driving pulse with components that are linearly polarised with mutually orthogonal polarisations, we find that the main source of the asymmetry, especially in the high-energy part of the spectrum, is the ultrashort nature of the pulse. The relative orientation of the molecule with respect to the laser pulse only affects the low- and medium-energy parts of the spectrum. On the other hand, for the driving pulse with circularly polarised counterrotating components, the asymmetry introduced by molecular orientation is more pronounced. We also analyse the influence of the characteristics of molecular orbitals on the asymmetries using the examples of N2 and O2 molecules.

The eternal 1-secure set, strategically protects graphical structures against attacks by placing sentinels within dominating sets. This study adapts this concept to real-world scenarios, like emergency response systems, by addressing challenges such as roadblocks and traffic congestion. We introduce the secure set and the eternal 1-secure set for fuzzy graphs based on edge membership levels J. Our analysis examines the relationship between the security number of a fuzzy graph G at level J and the domination number of its spanning subgraph at level J, demonstrating the potential of the eternal 1-secure set to enhance security measures in dynamic environments.

We present the first single-stage optimization of islands in finite-$\beta$ stellarator equilibria. Stellarator optimization is traditionally performed as a two-stage process; in the first stage, an optimal equilibrium is calculated which balances a set of competing constraints, and in the second stage a set of coils is found that supports said equilibrium. Stage one is generally performed using a representation for the equilibrium that assumes nestedness of flux surfaces, even though this is not warranted and occasionally undesired. The second stage optimization of coils is never perfect, and the mismatch leads to worse performing equilibria, and further deteriorates if additional constraints such as force minimization, coil torsion or port access are included. The higher fidelity of single-stage optimization is especially important for the optimization of islands as these are incredibly sensitive to changes in the field. In this paper we demonstrate an optimization scheme capable of optimizing islands in finite $\beta$ stellarator equilibria directly from coils. We furthermore develop and demonstrate a method to reduce the dimensionality of the single-stage optimization problem to that of the first stage in the two-stage approach.

Introduction. The development of the coronavirus disease 2019 (COVID-19) vaccine marked the beginning of the end of the pandemic and the understanding of the disease as something that is part of clinical practice. The aim of this study was to investigate, assess, and demonstrate the signifi cance of vaccination on the outcome of severely ill patients treated in intensive care units. Methods. A retrospective study was conducted on a sample of patients hospitalized at the Clinic for Infectious Diseases of the Clinical Center of the University of Sarajevo during 2022. Results. Participants who were vaccinated against COVID-19 had a lower mortality rate and a higher chance of survival compared to unvaccinated participants. Additionally, disease outcomes were signifi cantly infl uenced by oxygen saturation and platelet count at admission. Conclusion. COVID-19 vaccination signifi cantly reduced the mortality rate, with vaccinated par-ticipants having a higher chance of survival compared to unvaccinated participants.

Case summary A 1-year-old domestic shorthair queen with five neonates was referred for umbilical cord entwinement in three kittens 24 h after parturition. The owner noticed the kittens were stuck to each other 3 h before admission. Despite a conservative treatment approach, prolonged ischaemia led to dry gangrenous changes in one of the kitten’s metatarsi. Relevance and novel information This and other neonatal complications in cats are rarely reported. Primiparity is a known factor contributing to postpartum complications. Furthermore, inexperienced owners require more assistance in mitigating these challenges. Therefore, further research and collaboration among breeders, owners and veterinary professionals are imperative in order to accurately determine the prevalence of this condition in kittens and develop effective strategies to address it.

The paper explores the evolving role of Artificial Intelligence (AI) in perinatal medicine and hu-man reproduction, highlighting its potential to transform clinical practices. AI technologies are being utilized to improve diagnostic accuracy, personalize treatment, and enhance patient care, particularly in areas like perinatal ultrasound, fetal heart rate monitoring, and fetal neurology. The Kurjak Antenatal Neurodevelopmental Test (KANET) exemplifies how AI can aid early detection of neurodevelopmental disorders. However, the integration of AI presents challenges such as data quality concerns, algorithmic bias, ethical concerns, and the need for robust regulatory frameworks. The authors argue that while AI offers significant opportunities, its implementation must be carefully managed to avoid over-reliance on technology and ensure equitable healthcare access. The paper concludes that the current state of AI in this field marks not an endpoint but a critical phase of growth and development, necessitating a balanced approach that combines innovation with ethical and practical considerations.

This paper presents a full degrees-of-freedom (DOFs) robust control design for a nonlinear quadrotor unmanned aerial vehicle (UAV) operating under bounded disturbances. Second-order sliding modes controllers (SOSMCs) are designed so that the quadrotor UAV can follow a 3D trajectory in the presence of model uncertainties, underactuation, as well as external disturbances that may be matched or mismatched, and vanishing or nonvanishing. The stability analysis of the closed-loop system is presented via the Lyapunov method, showing the finite-time convergence of the system trajectories to the sliding surfaces, as well as the finite-time convergence of the quadrotor position and attitude to their reference values. The high-gain adaptation (HGA) method is adopted in the SOSMC technique, called SOSMC-HGA, to alleviate the chattering phenomenon. Simulation studies in different scenarios demonstrate that the SOSMC technique exhibits superior tracking performance and robustness properties compared to concurrent control methods for tracking reference trajectories of quadrotor UAVs. The simulation results confirm that SOSMC-HGA significantly attenuates the chattering phenomenon in control signals and system states, which is an important improvement, as it increases the safety of UAVs and reduces power consumption.

In this case report, we describe the diagnostic modality of sinus of Valsalva aneurysm (SOVA) in combination with congenital cardiac defect, aortic valve involvement, and conduction abnormality in a 19-year-old patient. Aim of article was to understand the importance of clinicians being cautious about SOVA presenting in young patients, despite cases being rare, and that SOVA requires a thorough SOVA diagnostic approach. We further provide a review of literature highlighting and comparing the treatment options for both unruptured and ruptured SOVAs. The patient presented for examination due to tachycardia and palpitations. A murmur was heard, and the patient was found to have an atrioventricular nodal reentry tachycardia. Echocardiographic evaluation, magnetic resonance imaging, and computed tomography angiography confirmed an aneurysmally dilated aortic root, aortic regurgitation, and ventricular septal defect. Surgical intervention was indicated; however, the patient refused to undergo surgery.