Background: Chronic periodontitis is a biofilm-induced inflammatory disease leading to progressive destruction of periodontal supporting tissues. Mechanical debridement by scaling and root planing (SRP) remains the gold standard of therapy; however, complete elimination of pathogenic microorganisms from deep periodontal pockets is challenging. Adjunctive laser therapy has been proposed to enhance clinical outcomes. Objective: To compare the clinical effectiveness of two diode laser wavelengths (980 nm and 445 nm) as adjuncts to subgingival curettage/SRP in the treatment of periodontal pockets, and to evaluate their outcomes relative to SRP alone. Materials and Methods: Comparative analysis of two independent prospective studies with identical methodology were analyzed. The first study included 24 subjects (1,164 periodontal pockets) treated with SRP + 980 nm diode laser (SmilePro 980, Biolitec, Germany). The second study included a same number of subjects and a comparable number of periodontal pockets were treated (862 periodontal pockets) with SRP + 445 nm diode laser (SiroLaser Blue, Dentsply Sirona, Germany). Control groups received SRP alone. Clinical parameters included Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL), assessed at baseline and 1 month post-therapy. Results: Both laser groups demonstrated statistically significant reductions in PI, GI, BOP, and PPD compared with baseline (p < 0.05). When compared to SRP alone, both adjunctive laser therapies showed significantly greater improvement in PPD reduction and CAL gain (p < 0.05). No statistically significant difference was observed between the 980 nm and 445 nm laser groups in overall clinical outcomes (p > 0.05). Conclusion: Both diode laser wavelengths (980 nm and 445 nm) significantly enhance short-term clinical outcomes when used adjunctively with SRP compared to SRP alone. No clear superiority of one wavelength over the other was demonstrated under the applied clinical conditions.

RRI, ethical standards, the Nagoya and Cartagena Protocols, and IP frameworks influence natural products R&D&I and the bioeconomy, providing a foundation for sustainable and equitable resource use while promoting innovation and growth.

This paper presents a production-oriented evaluation framework for entity resolution that operates without traditional ground truth data. We address the challenge of evaluating ER quality in production environments where ground truth data are unavailable, by combining continuous monitoring, domain constraints, and synthetic data generation. Our experiments show that the system has very high precision (0.99). However, the recall is low (0.41), many true matches are missed, resulting in an F-measure of 0.58. Our approach combines string similarity function optimization, adaptive blocking key design, and domain constraint validation to improve recall while maintaining high precision. The framework has been validated in a large-scale production environment processing millions of entity records daily, demonstrating practical applicability for industrial ER systems.

In this study, the fruit quality of June-bearing (‘Aprica’ and ‘Brilla’) and everbearing (‘Irma’ and ‘Monterey’) strawberry cultivars was evaluated across different harvest periods (beginning, middle, and end). June-bearing cultivars produced larger fruits, particularly in the later harvests, whereas everbearing cultivars showed a higher proportion of large fruits at the beginning and middle of the harvest period. Fruit dimensions and shape index generally decreased toward the end of the harvest. Soluble solids content was higher in June-bearing (7.47 and 8.20 °Brix) compared to everbearing (6.03 and 6.60 °Brix) cultivars. Fruit firmness was highest in ‘Monterey’ (2.28 N), while color parameters (L*, a*, b*) were highest in fruits harvested in the middle of the period, regardless of cultivar, resulting in lighter, intensely red, and visually more attractive fruits. These findings highlight the importance of harvest timing and cultivar selection in optimizing strawberry fruit quality traits for the fresh market.

Background: Diverticula of the gastrointestinal tract are common in older adults, most often affecting the colon. While typically asymptomatic, acute diverticulitis represents the most frequent complication and may lead to severe outcomes, including perforation, abscess formation, and diffuse peritonitis. Duodenal diverticula on the other hand is a rare clinical entity, and is frequently detected incidentally during proximal endoscopy. While most cases are asymptomatic, inflammation of periampullary duodenal diverticula may result in serious complications. Acute pancreatitis secondary to duodenal diverticulitis is exceedingly rare and has been described almost exclusively in isolated case reports. Clinical obesity, particularly increased visceral adiposity, has been associated with more severe inflammatory responses in complicated diverticular disease and may influence disease progression and outcomes. Objective: The aim of this article was to present a case of severe acute pancreatitis with peripancreatic fat necrosis caused by acute duodenal diverticulitis in a patient with clinical obesity. Case presentation: A patient presented with diffuse abdominal pain and was diagnosed with severe acute pancreatitis based on laboratory findings and radiological imaging. Comprehensive diagnostic evaluation, including radiological studies, proximal endoscopy, and endoscopic ultrasound (EUS), excluded common etiology. Further assessment identified a markedly enlarged periampullary duodenal diverticulum as the most likely trigger, associated with peripancreatic visceral fat necrosis and with signs of multiorgan dysfunction. Subsequent anthropometric and body composition assessment confirmed clinical obesity with increased visceral fat area, which was considered a contributing factor to disease severity. Targeted pharmacological therapy combined with individualized nutritional intervention resulted in complete clinical remission. Conclusion: Complicated diverticular disease has been shown to be associated with obesity and increased visceral adipose tissue. Periampullary duodenal diverticulitis complicated by peripancreatic fat necrosis in patients with clinical obesity and increased visceral fat area is rarely described in the literature. Appropriate pharmacological treatment combined with a targeted dietary regimen aimed at reducing visceral adiposity may result in complete remission of severe acute pancreatitis. In patients with acute pancreatitis of unknown etiology and concomitant clinical obesity, duodenal diverticulitis and peripancreatic fat necrosis should be considered as potential underlying causes.

As part of many national energy transition strategies, solar photovoltaic (PV) capacity is expected to increase significantly because PV deployment represents a key pathway for decarbonizing the energy sector. Alongside utility-scale installations, distributed PV systems connected to near-end users are becoming increasingly common in distribution networks. However, integrating intermittent sources without demand-matching capabilities introduces challenges related to operational network constraints. Consequently, distribution system operators (DSOs) limit PV integration to an acceptable level, referred to as hosting capacity (HC). Moreover, with increasing PV penetration, the curtailment of production becomes necessary during certain periods. Although curtailment has traditionally been avoided owing to the associated loss of clean energy, techno-economic studies show that shifting toward curtailment management can increase both HC and profitability. Curtailment management can be achieved through flexible PV power control, energy-storage integration, demand-side management, and flexible network regulation devices. This study specifically focuses on the techno-economic performance of flexible PV power control and compares it with the conventional approach without curtailment management, energy storage-based solutions, and their combination. The analysis was conducted on a modified IEEE 33-node test network, and key network constraints were incorporated. Using sequential Monte Carlo simulations with correlated stochastic time-series data for PV production, load profiles, and electricity prices over the years, the optimal PV and/or energy storage capacities were determined for various configurations. The results demonstrate that flexible curtailment management can increase both PV HC and expected profit, providing DSOs with boundary HC values while offering investors insight into the profitability of further PV integration.

The distribution of services across heterogeneous edge and cloud infrastructures in Beyond 5G (B5G) and Sixth-Generation (6G) networks increases operational complexity, while existing MANagement and Orchestration (MANO) solutions remain single-domain and lack unified telemetry or autonomous cross-domain decision mechanisms. Prior work proposes cross-domain orchestration concepts, but most validations rely on simulation and overlook interoperability issues, non-stationary latency, and inconsistent Key Performance Indicator (KPI) models in real Network Function Virtualization Infrastructure (NFVI) deployments. This paper introduces a modular, technology-agnostic Zero-touch Network and Service Management (ZSM) framework that provides unified NFVI abstraction and a multi-criteria decision engine that jointly considers latency, compute load, and energy consumption for autonomous service placement, scaling, and dynamic resource provisioning. Evaluation in a real-world deployment across geographically distributed testbeds demonstrates that our ZSM framework mitigates latency spikes by up to 96%, reduces overloaded-node latency by 36%, and maintains stable performance under variable load. These results confirm the practicality and effectiveness of zero-touch, multi-domain orchestration for future 6G compute-continuum environments.

Introduction: Regular physical activity reduces the risk of cardiovascular diseases (CVD). The aim of this study was to examine the association of physical activity with the severity of carotid disease. Materials and methods: This cross-sectional study involved 506 patients from the Vascular Surgery Clinic at the Institute for Cardiovascular Diseases "Dedinje", who underwent carotid endarterectomy from 2012 - 2017 . The severity of carotid disease was assessed based on the degree of carotid stenosis, plaque type, and patients' symptomatic status before surgery. Patient physical activity data were collected using the standardized Baecke questionnaire. Univariate and multivariate logistic regressions were performed to examine the association between physical activity and the severity of carotid disease. Results: According to univariate analysis, there was no statistically significant association between any form of physical activity (occupational, sports, or recreational) and the degree of carotid stenosis, nor with other characteristics. Also, physical activity was not associated with complicated carotid plaque. The only characteristic associated with complicated carotid plaque was the use of oral anticoagulants in therapy (OR=2.91; 95% CI=1.12-7.52; p=0.028). The relationship between physical activity and symptomatic carotid disease was not observed, but according to multivariate analysis, the following factors were associated with symptomatic status: age (OR=0.97; 95% CI 0.94-0.99; p=0.016), gender (OR=0.64; 95% CI 0.44-0.99; p=0.028), family history of CVD (OR=0.63; 95%CI 0.43-0.94; p=0.022), use of clopidogrel (OR 1.79; 95% CI 1.18-2.71; p=0.006) and ACEIs in therapy (OR=1.60; 95% CI 1.02-2.53; p=0.041). Conclusion: Physical activity was not associated with carotid disease severity.

Objective: Ergonomics in dental practice plays a crucial role in maintaining professional health, as prolonged static postures and repetitive movements significantly increase the risk of work-related musculoskeletal disorders among dental professionals. Understanding ergonomic risk factors and their impact on musculoskeletal health is essential for identifying vulnerable groups and developing effective preventive strategies in dental practice. Aim: The aim of this study was to assess the occurrence of musculoskeletal pain as a manifestation of work-related musculoskeletal disorders among dentists and to analyze its association with demographic characteristics, work habits, and dental specialization. Materials and Methods: This cross-sectional study included 130 dentists from various dental specialties. Data were collected using a structured questionnaire addressing demographic variables, work habits, ergonomic conditions, and the presence of musculoskeletal pain. Descriptive statistical methods were applied, and chi-square tests were used to analyze associations between categorical variables, with statistical significance set at p < 0.05. Results: The results indicated that the majority of participants experienced work-related musculoskeletal disorders, with prevalence increasing with age and length of professional experience. Occupational factors such as prolonged sitting or standing, improper working posture, lack of ergonomic chairs, and insufficient physical activity were significantly associated with the occurrence of work-related musculoskeletal disorders (p < 0.05). A statistically significant association was also observed between dental specialty and the presence of work-related musculoskeletal disorders (χ²(9) = 25.83; p < 0.01). The highest prevalence was reported among specialists in prosthodontics, pediatric dentistry, orthodontics, and endodontics, while lower prevalence was observed among oral surgeons, general dental practitioners, and periodontists. Conclusion: These findings emphasize the importance of implementing ergonomic interventions, regular physical activity, and preventive strategies in dental practice to reduce the occupational risk of work-related musculoskeletal disorders.

Background: Artificial intelligence (AI) is applied in numerous areas of society and has also led to significant changes in the field of medicine. Medicine is a branch of science of exceptional importance, and it is therefore necessary to ensure a high level of patient protection. The quality of healthcare has significantly improved through the use of artificial intelligence in various stages of the medical process, from the analysis of medical data and diagnostics, through therapy planning, to patient monitoring and the management of healthcare systems. Objective: The aim of this paper is to analyze the civil law aspects of artificial intelligence in medicine, with a particular focus on questions of liability for damage resulting from the use of such systems. Methods: The paper will first present the basic characteristics and areas of application of artificial intelligence in medicine, and then examine potential sources of damage and the legal basis for the liability of various stakeholders, including AI system manufacturers, software developers and data providers, healthcare institutions, and healthcare professionals. Special attention will be given to the challenges of proving causation and allocating liability in situations where decisions are made or supported by autonomous algorithmic systems. Results and Discussion: However, at the same time, numerous legal issues arise, particularly in the field of civil liability in cases where the application of artificial intelligence results in harm to a patient. Given the great importance of medicine and the need to ensure a high level of patient protection, the application of artificial intelligence must be accompanied by appropriate legal protection. The paper gives answers to a number of questions, with particular emphasis on the question of who may be held liable for damage caused by the use of artificial intelligence in medicine, as well as under which regulations and in what manner such liability is determined. Conclusion: Artificial intelligence has the potential to significantly enhance medical practice, its application must be accompanied by appropriate legal mechanisms that ensure patient protection and clearly define the responsibility of all participants in the system. Future legal development in this area will likely focus on further adapting existing civil law institutions to the specificities of artificial intelligence, while simultaneously strengthening preventive risk management mechanisms and transparency of AI systems in medicine.

This year the journal “Medical Archives” celebrates 80th anniversary of the establishiment (1947-2026). With the name “Medicinski Arhiv” this journal was founded in the year 1947 as official journal of the Society of physicians of Bosnia and Herzegovina (B&H). The first Editorial board was consisted of professors of the Faculty of Medicine of the University in Sarajevo opened in November 16th 1947: Vladimir Čavka, Blagoje Kovačević, Bogdan Zimonjić and Ibro Brkić. “Medical Archives” journal was a key milestone that helped in education of all academic and professional staff that became the foundation of Bosnian and Herzegovinian medicine, as a science and health care as a profession. The oldest medical journal in B&H was “Jahrbuch des Bosnisch-Herzegowinischen Landesspitales in Sarajevo” (“Annual of the National Hospital in Sarajevo”) which was established in 1897 and printed in German language in the period from 1897 until 1900. From the year 1950 “Medicinski Arhiv” was included in the most influential and important index database MEDLINE, as one of oldest medical journals in Souut-Eastern Europe. The first aim of journal was to give a opportunity to young researchers from B&H to present their scientific and research work to wider community. The tradition of publishing of “Medical Archives” as the most recognizable journal in B&H, was kept by Editor of Professor Izet Masic in 1993 who in extraordinary and difficult occasions (during wartime in BiH from 1992 until 1995) re-established journal and continued printing of the war issues. Hopefully the MEDLINE did not stop to continue receiving “Medicinski arhiv” journal and did not stop accept of published articles of “Medicinski Arhiv” in Medline/PubMed, SCOPUS, EMBASE, HINARI, EBSCO, and a lot of other indexed databases. From the year 2013 articles published in “Medical Archives” were included in PubMed Central with full papers (in extenso). Today “Medical Archives” belong to the most cited journals in former Yugoslavia countries with h-Index 38 in SCImago rank, it means 38 published papers in “Medical Archives” were cited 38 times in other indexed scientific journals worldwide, with SJR 0.33 and Q3 in the year 2024.