This article describes the architecture life cycle effect analysis (ALCEA) method, a structured method for evaluating proposed new architectures for software-intensive systems. The method evaluates a proposed architecture by quantifying its effect on the performance of system life-cycle phases. The method is instantiated by identifying the relevant life-cycle phases of the system under investigation and a set of evaluation functions that capture, in terms of basic factors, the effect of different architectural decisions on key life-cycle PAs, such as revenue, operating resources, and investments. The method results in a transparent cost and revenue structure, documented in a tabular form, based on quantifiable factors from the developing organization. The results of the method can be used directly as part of a business case, and their robustness can be estimated by sensitivity analysis. The ALCEA method is designed for system-level architectural analysis, covering both software and hardware aspects. In this article, we introduce the ALCEA method and provide a detailed example of how to apply it in the evolution of embedded systems. Moreover, we share early experiences of using the method in large-scale industrial settings.

Large peak-to-average power ratio (PAPR) and carrier frequency offset (CFO) are dominant impairments of the orthogonal frequency-division multiplexing (OFDM) symbol transmission that is applied within the state-of-the-art wireless operator networks. In this work, we deal with consequences of the amplitude peak clipping that is commonly used at the transmitter to reduce the PAPR of the OFDM symbol, and thus prevent its non-linear distortion which would otherwise be imposed by the output high-power amplifier (HPA). Accordingly, regardless of the clipping generating mechanism at the transmitter being either inherent (related to the HPA) or deliberate (due to PAPR reduction), the clipped incoming OFDM symbol at the receiver may lead to degraded detection accuracy and transmission performance. However, the methods that have been applied so far at the receiver for compensating non-linear distortion due to clipping, are quite complex and computationally demanding. On the contrary, we propose effective mitigation of the problem to be performed at the receiver, by deriving the closed-form enhanced detection criterion, which requires common measurements of the mean and the rms values, as well as the autocorrelation of the received OFDM symbol comprising both un-clipped and clipped sections. Such improved detection was shown to significantly reduce the side effects of clipping, and restore satisfactory transmission performance – the bit error rate (BER) in particular. The proposed analytical model was preliminarily verified by versatile Monte-Carlo simulations and professional industry-standard vector signal analysis (VSA) test system, as well as by BER testing. The evident convergence of the three methods’ test results leads to the conclusion that the proposed clipped OFDM symbol detection method provides clear improvement with respect to the conventional one.

Every attempt to access to the Internet through a Web browser, email sent, VPN connection, VoIP call, instant message or other use of telecommunications systems involves cryptographic techniques. The most commonly applied technique is asymmetric cryptography, which is generally executed in the background without the user even being aware. It establishes a cryptographic code based on the computational complexity of mathematical problems. However, this type of cryptography, which is widely used in today’s telecommunications systems, is under threat as electronics and computing rapidly develop. The development of fifth-generation cellular networks (5G) is gaining momentum, and given its wide field of application, security requires special attention. This is especially true faced with the development of quantum computers. One solution to this security challenge is to use more advanced techniques to establish cryptographic keys that are not susceptible to attack. An essential part of quantum cryptography, Quantum Key Distribution (QKD) uses the principles of quantum physics to establish and distribute symmetric cryptographic keys between two geographically distant users. QKD establishes information-theoretically secure cryptographic keys that are resistant to eavesdropping when they are created. In this paper, we survey the security challenges and approaches in 5G networks concerning network protocols, interfaces and management organizations. We begin by examining the fundamentals of QKD and discuss the creation of QKD networks and their applications. We then outline QKD network architecture and its components and standards, following with a summary of QKD and post-quantum key distribution techniques and approaches for its integration into existing security frameworks such as VPNs (IPsec and MACsec). We also discuss the requirements, architecture and methods for implementing the FPGA-based encryptors needed to execute cryptographic algorithms with security keys. We discuss the performance and technologies of post-quantum cryptography, and finally, examine reported 5G demonstrations which have used quantum technologies, highlighting future research directions.

To behave in a socially responsible manner and to support the concepts of sustainable development, organizations apply various processes and activities for greening their business. In addition to green marketing, supply and distribution chain, production, packaging and recycling, green human resources management (GHRM) also plays a big role. For this purpose, organizations incorporate a green component into all human resources management (HRM) phases, thereby building a green employer brand. This paper examines the extent to which organizations in Serbia and Bosnia and Herzegovina apply GHRM activities and practices, and whether there are differences in the application of these practices depending on the size and business sector. Empirical research carried out in Serbia and Bosnia and Herzegovina has found that green activities and HRM practices are applied to a small extent, with slightly higher results achieved by small and manufacturing organizations. The findings indicate the need for greater engagement of organizations to strengthen the awareness of the importance of GHRM, support their sustainable development and strengthen the brand in domestic and foreign markets.

Background: Lyme borreliosis is a multisystemic infection caused by the spirochete Borrelia burgdorferi. Erythema migras is the main clinical marker of the disease. Objective: This study aimed was to investigate the frequency and clinical manifestations of European borreliosis on the skin, and to determine the significance of these findings for diagnosis and therapy. Methods: A retrospective-prospective clinical study of outpatients treated and monitored in a private clinic of an infectologist was conducted over nine years from to 2013-2021. The study was clinical, descriptive and analytical in nature. Results: In the investigated period, 509 (30.8%) patients with borreliosis symptoms were treated. EM in our patients occurred under the following conditions: a) ringed redness, b) redness of target cels and d) continuous round or oval redness of different sizes of individual redness, or multiple occurrences with primary dissemination. Skin changes with multiorgan chronic symptoms of borreliosis occurred in 67.7% of cases the including: walking redness of different shapes and sizes, pink borreliosis stretch marks, white borreliosis stretch marks, borreliosis palms and soles, psoriatic changes, Acrodermatitis chronica atrophicans, Scleroderma circumscripta-morphae, Erythema nodosum, Granuloma anulare and Lichen striatus et atrophicans. Of the 509 patients treated for borreliosis, 32.3% with multi-organ symptomatology had no skin changes. Conclusion: The skin manifestations of European borreliosis are multi-layered and Erythema migrans are basic, but not the only markers of the disease. ‘Pink borreliose stretch marks, “white borreliosis striae”, “borreliosis palms or soles”, and intermittent redness accompanied by itching are unique markers for the diagnosis of chronic borreliosis, if they are manifested.

Background: Chordoma is a rare malignant neoplasm that predominantly arises from the axial skeleton, but can also develop in unusual locations. However, there are also rare cases of „NOS“ chordoma involving the oropharyx and epithelial-myoepithelial carcinoma of the parotid gland in the same patient. According to contemporary research, chordoma is a rare malignant neoplasm that arises from the embryonic remnants of the notochord. and typically involves the clivus, sacrococcygeal bones or vertebrae. Studies have shown that the incidence of chordoma has been estimated to be one per one million people per year. Chordoma can occur at any age, but most commonly it is diagnosed in the 40–60 year old age group with the male predominance. Objective: The aim of this article was to review the case of a 74-year-old female patient with epithelial-myoepithelial carcinoma of the parotid gland and a case of „NOS“ chordoma involving the oropharyx. Methods: Diagnostic methods were used to examine a female patient with two primary malignant tumors: CT neck scan, CT of paranasal sinuses, ultrasound examination, scintigraphy and operative finding. Case presentzation: Due to the anatomy complexity, complete resection of the tumor through a transoral-transpharyngeal approach was not possible. Intraoperative palpation of the mass revealed well defined submucosal lesion 20x43x46mm beginning at the level of the oro- and hypopharynx and extending superiorly to the nasopharynx, and posteriorly into the spinal canal and intervertebral foramen causing near complete occlusion of the oro and hypopharynx. The patient also underwent extracapsular dissection of the parotid tumor. Postoperative palliative radiotherapy was performed. Conclusion: Surgical treatment remains the mainstay of treatment for EMC and radiation is imperative for patients who refuse surgery and for those with advanced or inoperable diseases.

Ragweed is a neophyte which inhabits various crops and ruderal habitats. That is the reason why this paper is dedicated to phytocenology and ecological relations of ragweed in such a habitat. Research was carried out in the area of a former railway freight and customs terminal, in the period from 2021 to 2023. Phytocenological image was made and all the parameters were assessed: life form, phytocenological affiliation, floral elements, indicator values, and soil analysis. The aim of the paper is to present the places where ragweed may be found, as well as under what ecological conditions and with what other species it occurs. This research yielded new data on the phytocenology of ragweed, determined in the vegetation of the order Chenopodietalia. A total of 69 species from 23 families were identified. The most numerous is the Asteraceae family. Phytocenologically, the largest number of species belongs to the order Chenopodietalia, and as far as the indicator values are concerned, the most numerous are the representatives of tertiary vegetation. Hemicryptophytes predominate regarding life forms, and concerning the floral elements, 40 different elements from 9 groups were noted. The most numerous group are Eurasian species, and the most numerous individual floral elements are euras-smed and eurassubozean-smed.

During the three-year field research (2019-2022) in the area of the Canton of Sarajevo, we discovered many invasive plant species in localities where they had not been recorded before. Among them, Ailanthus altissima (Mill.) Swingle, Ambrosia artemisiifolia L. and Reynoutria japonica Houtt. stand out in particular due to their abundance and coverage. This study aimed to provide data on the localities where these invasive plants were found, including altitude, longitude and latitude, soil type and their floristic and phytocoenological features. Data from these localities should contribute to the creation of a database that can be used for more a efficient fight against the aforementioned invasive species. In total, 42 new localities were recorded for Ailanthus altissima, 10 for Ambrosia artemisiifolia and 15 for Reynoutria japonica. Due to their abundance and appearance, Ailanthus altissima and Reynoutria japonica have already become a big problem for urban horiculture in Sarajevo, while Ambrosia artemisiifolia poses a health concern, and therefore, urgent measures and necessary to remove them.

Atherosclerosis and endothelial dysfunction are responsible for 80% of cardiovascular diseases. It's important to understand the disease's pathogenesis to determine the best prophylaxis and therapy. Diabetes mellitus contributes to the development of atherosclerosis and endothelial dysfunction, and keeping blood sugar levels in check is crucial. Cardioprotective, nephroprotective, and lipid profile drugs should be preferred to DM treatment. GLP-1 receptor agonists or GLP-1 analogues have cardiorenal benefits and can be used for various indications. The objective of this review is to examine the role of GLP-1 analogues in the treatment of diabetes mellitus (DM), focusing on their cardiovascular benefits as demonstrated by Cardiovascular Outcome Trials (CVOT). Additionally, the review aims to highlight the significance of GLP-1 analogues in the primary and secondary prevention of cardiovascular events. It also proposes the hypothesis that these analogues may benefit patients with heart failure, regardless of whether the systolic function is reduced or preserved. We searched of databases and online libraries, including PubMed, Scopus, and Cochrane, using keywords such as GLP-1 agonist, diabetes mellitus, and cardiovascular diseases. Our search focused on articles published between 2011 and 2023. Antidiabetic drugs have shown a potential impact on cardiovascular risk and benefit. Liraglutide and semaglutide have outperformed placebo, but the mechanisms behind their benefits remain unclear. Prioritizing cardiovascular safety and preventing complications is essential for patients with T2DM when selecting a treatment.