Objectives: Lamivudin has been approved for the treatment of chronic hepatitis B but experience with lamivudin treatment for acute severe hepatitis B is still limited. Fulminant hepatitis develops in 1% of patients with acute hepatitis B. Severe acute hepatitis B in immunocompetent patients may progress to fulminant hepatitis and death. Aim: To evaluate the efficasy of lamivudine for the treatment of acute severe hepatitis B virus infection in imunocompetent adults in Clinic for infectious diseases Banja Luka. Patients and methods: In the period of 2006-2024 years, 12 immunocompetent patients (4 women, 8 men, age 24-77 years) with severe acute hepatitis B were treated with lamivudin. All 12 patients fulfil at least two of the criteria for severe acute hepatitis B infection: 1. hepatic encephalopathy; 2. total bilirubin 210 micromole per litre; and severe coagulopathy (international normalized ratio-INR was 4.5 ± 6.4 or prothrombin time-PT < 40%). All patients had evidence of severe hepatocyte lysis. Nine patients had rapid increase of total bilirubin and contemporary decrease of alanine aminotransferase level, which escalate risk of development of fulminant hepatitis B. All patients received lamivudin at a dose 100 mg per day. Results: Ten patients responded well to the treatment and their biochemical parameters improved rapidly. Within 1-6 months, the HBsAg was undetectable in 10 out of 12 investigated patients. Protective anti-HBs antibodies developed in 10 of them in 1-6 months. The corticosteroid therapy was short-term in 2 of 12 patients. Two patient developed fulminant hepatitis B and died after the lamivudine therapy was initiated. Lamivudine treatment was well tolerated in all patients. Conclusion: Lamivudin induces a prompt clinical, biochemical and serological response in immunocompetent patients with severe acute hepatitis B. Early treatment with lamivudine probably decreases the risk of progression to fulminant hepatitis in patients with severe acute hepatitis B.

PFAS are ubiquitous industrial chemicals with known adverse health effects, particularly on the liver. The liver, being a vital metabolic organ, is susceptible to PFAS-induced metabolic dysregulation, leading to conditions such as hepatotoxicity and metabolic disturbances. In this study, we investigated the phenotypic and metabolic responses of PFAS exposure using two hepatocyte models, HepG2 (male cell line) and HepaRG (female cell line), aiming to define phenotypic alterations, and metabolic disturbances at the metabolite and pathway levels. The PFAS mixture composition was selected based on epidemiological data, covering a broad concentration spectrum observed in diverse human populations. Phenotypic profiling by Cell Painting assay disclosed predominant effects of PFAS exposure on mitochondrial structure and function in both cell models as well as effects on F-actin, Golgi apparatus, and plasma membrane-associated measures. We employed comprehensive metabolic characterization using liquid chromatography combined with high-resolution mass spectrometry (LC-HRMS). We observed dose-dependent changes in the metabolic profiles, particularly in lipid, steroid, amino acid and sugar and carbohydrate metabolism in both cells as well as in cell media, with HepaRG cell line showing a stronger metabolic response. In cells, most of the bile acids, acylcarnitines and free fatty acids showed downregulation, while medium-chain fatty acids and carnosine were upregulated, while the cell media showed different response especially in relation to the bile acids in HepaRG cell media. Importantly, we observed also nonmonotonic response for several phenotypic features and metabolites. On the pathway level, PFAS exposure was also associated with pathways indicating oxidative stress and inflammatory responses. Taken together, our findings on PFAS-induced phenotypic and metabolic disruptions in hepatocytes shed light on potential mechanisms contributing to the broader comprehension of PFAS-related health risks.

Forests play an important role in adapting to and mitigating the negative effects of climate change and environmental degradation through sustainable forest management. In Europe and North America, where private forest ownership dominates, private forest owners play a crucial role in achieving diverse policy objectives. Given the importance of private forest owner cooperation to support the sustainable management and the achievement of policy goals, this paper systematically reviewed the international scientific publication on private forest owners (PFOs) cooperation using bibliometric network analysis complemented with a literature review to examine the development over the last two decades (2000–2021) and to determine where the trend of the research has been heading. The analysis provided a general overview of PFOs cooperation and focus more specifically on two main aspects of PFOs cooperation: “Reasons for joining forest owners’ organizations” and “Factors influencing PFOs cooperation”. The data was retrieved from the Scopus database and analysed using the VOSviewer software. The results showed that the number of publications on PFOs’ cooperation is more or less constant and that the most prolific authors’ institutions in this topic area come from the United States, Finland, Sweden and Germany. The keyword cluster analysis showed that there are three topic oriented clusters for both aspects of PFOs’ cooperation – “Reasons for joining forest owners’ organizations” and “Factors influencing PFOs cooperation”, while the trend of keywords showed a change in the perspective of PFOs’ cooperation over time: from cooperation for “timber production and supplying to the market” to cooperation for “multifunctional and sustainable forest management”, “biodiversity conservation” and “climate change mitigation”. The results also showed the influence of forest policy on PFOs cooperation.

We discuss the general theory of radicals of paragraded rings, establish that the ADS-Theorem holds, and characterize paragraded normal radicals. It is known that any special radical of a ring can be described by the appropriate class of modules over that ring. In this note we show that all special paragraded radicals of paragraded rings can be described by the appropriate class of their paragraded modules. * This paper was presented at the International Scientific Conference Graded structures in algebra and their applications, dedicated to the memory of Prof. Marc Krasner, IUCDubrovnik, Croatia, September, 22-24, 2016.

In this paper we prove that there exist paragraded rings which are not graded and we discuss prime and Jacobson radicals of paragraded rings. In particular, we prove that paragraded counterparts of prime and Jacobson radicals are the largest paragraded ideals contained in them. * This paper was presented at the International Scientific Conference Graded structures in algebra and their applications, dedicated to the memory of Prof. Marc Krasner, IUCDubrovnik, Croatia, September, 22-24, 2016.

Background and Objectives: Cancer is associated with an increased risk of acute ischemic stroke (AIS) and venous thromboembolism. The role of a cardiac right-to-left shunt (RLS) as a surrogate parameter for paradoxical embolism in cancer-related strokes is uncertain. We sought to investigate the relationship between the presence of an RLS and cancer in AIS patients. Methods: We included consecutive AIS patients hospitalized at our tertiary stroke center between January 2015 and December 2020 with available RLS status as detected on transesophageal echocardiography (TEE). Active cancers were retrospectively identified and the association with RLS was assessed with multivariable logistic regression and inverse probability of treatment weighting to minimize the ascertainment bias of having a TEE obtained. Results: Of the 2236 AIS patients included, 103 (4.6%) had active cancer, of whom 24 (23%) were diagnosed with RLS. An RLS was present in 774 out of the 2133 AIS patients without active cancer (36%). After adjustment and weighting, the absence of RLS was associated with active cancer (adjusted odds ratio (aOR) 2.29; 95% confidence interval (CI), 1.14–4.58). When analysis was restricted to patients younger than 60 years of age or those with a high-risk RLS (Risk of Paradoxical Embolism Score ⩾ 6), there was no association between RLS and cancer (aOR, 3.07; 95% CI, 0.79–11.88 and aOR, 0.56; 95% CI, 0.10–3.10, respectively). Conclusion: RLS was diagnosed less frequently in AIS patients with cancer than in cancer-free patients, suggesting that arterial sources may play a larger role in cancer-related strokes than paradoxical venous embolization. Future studies are needed to validate these findings and evaluate potential therapeutic implications, such as the general indication, or lack thereof, for patent foramen ovale (PFO) closure in this patient population.

<p>Ovaj rad poja&scaron;njava primjenu novih proizvoda informacionih &nbsp;tehnologija u nastavi Tjelesnog i&nbsp;<br />zdravstvenog odgoja kroz primjer aplikacije &bdquo;Lesson Study Analyst for Physical Education&ldquo; u&nbsp;<br />svrhu analize časa Tjelesnog i zdravstvenog odgoja, održanog u srednjoj &scaron;koli u Brezi, a u sklopu&nbsp;<br />online treninga JICA &ldquo;Quality Physical Education&ldquo;. Održani čas je snimljen potom analiziran&nbsp;<br />aplikacijom &nbsp;&bdquo;LSA &nbsp;for &nbsp;PE&ldquo;, &nbsp;uz &nbsp;prethodnu &nbsp;suglasnost &nbsp;roditelja &nbsp;učenika &nbsp;odjeljenja. &nbsp;Aplikacija,&nbsp;<br />primjenjiva na iOS uređajima, identifikovala je trajanje i analizu časa prema prostoru utjecaja&nbsp;<br />kao i interakciju i pona&scaron;anje nastavnika. Kroz primjere primjene aplikacije u eksperimentalnim&nbsp;<br />istraživanjima, može se uočiti njena značajnost primjene u edukaciji nastavnika razredne nastave,&nbsp;<br />nastavnika &nbsp;i &nbsp;profesora &nbsp;tjelesnog &nbsp;odgoja, &nbsp;te &nbsp;u &nbsp;kontinuiranom &nbsp;procesu &nbsp;pobolj&scaron;anja &nbsp;stručnih &nbsp;i&nbsp;<br />profesionalnih kompetencija pedagoga tjelesnog odgoja.&nbsp;</p>

<p>The &nbsp;current &nbsp;practice &nbsp;within &nbsp;the &nbsp;Bosnian-Herzegovinian &nbsp;educational &nbsp;system &nbsp;indicates&nbsp;<br />inconsistencies in implementing intercultural and &nbsp;intracultural educational practices. They are&nbsp;<br />not even differentiated but rather equated. However, for the preservation of all the values that&nbsp;<br />Bosnia &nbsp;and &nbsp;Herzegovina &nbsp;embodies, &nbsp;it &nbsp;is &nbsp;necessary &nbsp;to &nbsp;preserve &nbsp;the &nbsp;unique &nbsp;BosnianHerzegovinian &nbsp;habitus, &nbsp;composed &nbsp;of &nbsp;all &nbsp;cultural &nbsp;traditions &nbsp;(Bosniak, &nbsp;Croatian, &nbsp;Serbian,&nbsp;<br />Jewish, Roma, and others), and this can only be achieved through intracultural education.&nbsp;<br />What needs to be done within the educational system is the introduction of the subject of course&nbsp;<br />&ldquo;Intracultural &nbsp;education&rdquo; &nbsp;in &nbsp;primary &nbsp;and &nbsp;secondary &nbsp;schools &nbsp;and &nbsp;the &nbsp;implementation &nbsp;of&nbsp;<br />intracultural &nbsp;policies &nbsp;through &nbsp;the &nbsp;ministries &nbsp;of &nbsp;education &nbsp;at &nbsp;the &nbsp;state, &nbsp;entity, &nbsp;and &nbsp;cantonal&nbsp;<br />levels, as well as intracultural education across all segments of society. This paper highl ights&nbsp;<br />the differences between intercultural and intracultural education and provides guidelines on&nbsp;<br />how to implement the necessary intracultural education policy. As a paradigm, some positive&nbsp;<br />practices within Bosnian-Herzegovinian culture and literature are presented, which can serve&nbsp;<br />as a good foundation for further action.</p>

<p>U ovom radu ćemo pomoću planarnih grafova napraviti klasifikaciju pravilnih poledara i vidjeti&nbsp;<br />jo&scaron; neke mogućnosti primjene grafova u geometriji.</p>

ntroduction: The thyroid hormone secretion disorders may be hyperthyroidism (reduced TSH levels and increased levels of FT3 and FT4) and subclinical hyperthyroidism (decreased concentration of TSH with normal FT3 and FT4).Aim: To investigate levels of thyroid hormones (TSH, FT3, and FT4) in patients with hyperthyroidism or subclinical hyperthyroidism treated at Tuzla Blue Clinic.Materials and methods:The study included 120 patients divided into three groups: a control group, groups with respondents who have hyperthyroidism, and a group of patients with subclinical hyperthyroidism. The concentrations of the hormones TSH, FT3, and FT4 were analyzed. The determination was carried out on the device IMMULITE 1 Siemens using the immunochemistry method. Results:TSH between our group investigated the existence of significant statistical differences between the control group and the group with hyperthyroidism (p<0.0001) and between the control group and the group withsubclinical hyperthyroidism (p=0.0001), and the parameter FT3 showed that a statistically significant difference exists between the control group and the group with hyperthyroidism (p<0.0001), and between patients with hyperthyroidism andsubclinical hyperthyroidism (p<0.0001). For FT4, we found a statistically significant difference between the control group and the group with hyperthyroidism (p<0.0001) and between groups with hyperthyroidism and subclinical hyperthyroidism (p <0.0001).Conclusions: The concentration of TSH is reduced in both hyperthyroidism and subclinical hyperthyroidism. The serum concentrations of FT3 and FT4 are elevated in hyperthyroidism, while in subclinical hyperthyroidism, the serum concentrations of FT3 and FT4 stand in the reference area.Keywords:Thyrotropin, thyroxine, TSH, FT3, FT4, hyperthyroidism

Introduction: Vaccines for protection against 10 infectious diseases are available in the Program of Regular Immunization in the Federation of Bosnia and Herzegovina. These vaccines save the lives of up to 3 million people worldwide every year. The latest report of the Institute of Public Health of the Federation of Bosnia and Herzegovina on regular immunization carried out during 2020 shows that the rate of vaccination of children during the 2019 coronavirus disease (COVID-19) pandemic with regular vaccines has decreased compared to previous years. Such a situation in the health system leads to a potential risk of outbreaks of infectious diseases that are prevented by vaccination.Objective: To examine the impact of the COVID-19 pandemic on the regular immunization of children in the Mostar Health Center.Materials and methods: A retrospective cross-sectional epidemiological study was conducted. Data on regular immunization of children from theMostar Health Center, Herzegovina-Neretva County in the Federation of Bosnia and Herzegovina from 2017, 2018, 2021 and 2022 were used.Results: A statistically significant difference was obtained in vaccination against measles, mumps and rubella during a period of four years. Vaccination with the mentioned vaccines was significantly higher in 2017 and 2018 than in 2021 and 2022.Conclusion: It was shown that the COVID-19 pandemic affected the regular immunization of children in the Mostar Health Center.Keywords: regular immunization of children, COVID 19 pandemic, MMR vaccine, Mostar

Simple Summary This study explores hypoxia-inducible factors (HIFs) in glioblastoma development, progression, and treatment. Reviewing 104 relevant studies, it highlights diverse global contributions, with China leading at 23.1%. The most productive year was 2019, contributing 11.5% of the studies. Key factors studied included HIF1α, HIF2α, osteopontin, and cavolin-1, involving pathways such as GLUT1, GLUT3, VEGF, PI3K-Akt-mTOR, and ROS. HIF expression correlates with glioblastoma progression, survival, neovascularization, glucose metabolism, migration, and invasion. Overcoming treatment resistance and the lack of biomarkers is crucial for integrating HIF-related therapies into glioblastoma treatment to improve patient outcomes. Abstract Background: The study aims to investigate the role of hypoxia-inducible factors (HIFs) in the development, progression, and therapeutic potential of glioblastomas. Methodology: The study, following PRISMA guidelines, systematically examined hypoxia and HIFs in glioblastoma using MEDLINE (PubMed), Web of Science, and Scopus. A total of 104 relevant studies underwent data extraction. Results: Among the 104 studies, global contributions were diverse, with China leading at 23.1%. The most productive year was 2019, accounting for 11.5%. Hypoxia-inducible factor 1 alpha (HIF1α) was frequently studied, followed by hypoxia-inducible factor 2 alpha (HIF2α), osteopontin, and cavolin-1. Commonly associated factors and pathways include glucose transporter 1 (GLUT1) and glucose transporter 3 (GLUT3) receptors, vascular endothelial growth factor (VEGF), phosphoinositide 3-kinase (PI3K)-Akt-mechanistic target of rapamycin (mTOR) pathway, and reactive oxygen species (ROS). HIF expression correlates with various glioblastoma hallmarks, including progression, survival, neovascularization, glucose metabolism, migration, and invasion. Conclusion: Overcoming challenges such as treatment resistance and the absence of biomarkers is critical for the effective integration of HIF-related therapies into the treatment of glioblastoma with the aim of optimizing patient outcomes.