This paper presents a semi-automated approach for detecting conflicts and inconsistencies between architecture solutions. Inconsistencies occur when two or more architecture solutions rely on each other but cannot be satisfied, and conflicts when there are contradictions within one single decision specification, such as contradictory variable range and value. The proposed approach comprises a set of checks followed by transformations of architecture solutions specified according to a domain-specific-language, also created in the context of this work, into state machines. The semi-automated approach is implemented as a plugin for the MagicDraw modeling tool, and was evaluated in a project from the automotive domain.

This study delves into the herding and bubble detection in the volatility domain of a capital market underlying. Furthermore, it focuses on creating heuristics, so that common investors find it relatively easy to understand the state of the market volatility. Hence, it can be termed that this study is focused on the specific financial innovation regarding bubble and herding detection coupled with investor awareness. The traces of possible volatility bubble emerge when it is positioned against its own lags (both lag1 and lag2). The volatility trigger indicated clear traces of herding and an embedded parabola function. Continuous and repetitive parabola function hinted at a subtle presence of “fractals”. Firstly, the detrended fluctuation analysis has been used with its multifractal variant. Secondly, the regularized form of Hurst calculation and analysis have been used. Both tests reveal the traces of nascent bubble formation owing to prominent herding in CNX Nifty HFT environment. They also indicate a clear link with Hausdorff topological patterns. These patterns would help to create heuristics, enabling investors to be aware of possible bubble and herd situations.

We present a new class of totally positive Toeplitz matrices composed of recently introduced hyperfibonacci numbers of the r -th generation. As a consequence, we obtain that all sequences F n ( r ) of hyperfibonacci numbers of r -th generation are log-concave for r  ≥ 1 and large enough n .

Cadmium is a heavy metal classified as an environmental hazard, and its toxicity is subject to extensive research. Japanese quails were exposed to cadmium chloride (CdCl2) ad libitum for 20 days. Bone marrow, peripheral blood and liver were analyzed following the exposure. Moreover, we have provided the very first explanation of hematopoietic lines in Japanese quail. Following CdCl2 exposure, changes in the number, size and morphology of blood cells were observed in both peripheral blood and bone marrow. Alterations included severe erythrocyte damage, monocytosis and lymphopenia. In the liver of Cd-exposed animals we observed necrotic cells, absence of hematopoietic regions and cytogenetic changes of hepatocytes. Alterations in the bone marrow were also noted, as well as giant phagocytic cells, most likely macrophages. In vivo, CdCl2 exposure caused swift and destructive changes in the hematopoietic niche, liver and other tissues responsible for the detoxification cycle of cadmium and its compounds.

The research in this article aimed at determining the importance of occupational safety and health (OSH) factors at work as criteria for development of the OSH climate. Based on the views of 28 responsible persons of the OSH management system, the significance of the criteria was determined using the rough step-wise weight assessment ratio analysis method. The obtained results show that development of the OSH climate in organizations primarily depends on the factors of the work environment and the commitment of the management to the OSH system. The results also point out that education of employees in the field of safety at work has a significant impact. A comparison of the obtained results was made in the sensitivity analysis using the full consistency method. The specific dimensions of the safety climate at work were determined and ranking of the OSH factors was performed.

Yoga and mindfulness improve the blood circulation and thereby reduces the causes of hypertension hearth attack or stroke. Complete yoga breathing has the role in oxygenating the blood and therefore assists fresh nutrients to reach all peripheral vessels and capillaries. Yoga helps to prevent various circulatory ailments and illnesses such as high blood pressure, shallow breathing, muscle tension and coronary heart disease. During moderate to intense yoga exercise hearth rate increases and as a result hearth pumps more blood, systolic blood pressure rise and blood volume increases. It provides better circulation and formation of new capillaries. The purpose of this review is to investigate the efficacy of yoga exercise on circulatory system, pulse and hearth rate, systolic and diastolic blood pressure and cardiovascular function. A review of literature was conducted from Pubmed, Research Gate, Medline and Google Scholar.

Numerous reports assigning (Z)-ligustilide (1) the role of a major bioactive principle in Apiaceae botanicals are called into question by the recurrent demonstrations of 1 being an unstable, rapidly degrading compound, ultimately leading to dynamic Residual Complexity. While Angelica sinensis is recognized for its therapeutic value in (peri-)menopausal symptom management, its purported active principle, ligustilide, represents a typical example for the instability-bioactivity chasm of botanicals. To help bridge the gap, this study used both the essential oil and purified 1 obtained from A. sinensis to investigate the factors that influence the chemical transformation of 1, the products formed, and the rationale for monitoring 1 in natural product preparations. Countercurrent separation was used to purify 1 from a supercritical fluid extract of A. sinensis, achieving 93.4% purity in a single step. Subsequent purification by preparative HPLC afforded 1 with a 98.0% purity. Providing a mass balance setting, we monitored chemical changes occurring to highly purified 1 under various conditions and at different time points, in sealed NMR tubes by quantitative 1H NMR (qHNMR). The non-destructive nature of NMR enabled a comprehensive assessment of degradation products. Moreover, in being a mole-based determination, the total intensity (integral) of all NMR signals intrinsically represent the theoretical mass balance within the sample solution. The results demonstrated that 1 is most stable while within the original plant material. Exposure to light had a profound impact on the chemical transformation of 1 leading to the formation of ligustilide dimers and trimers, as verified by both NMR and LC-HRMS studies. Moreover, the results shown for 1, augmented by other recent outcomes, have serious implications for the meaningful biological evaluation of NPs which exhibit instability/reactivity, while having a plethora of “promising” bioactivities reported in the literature and being frequently associated with unsubstantiated health claims.

Clearances between rotating and stationary parts in a screw compressor are set to ensure the efficient operation and allow for thermal deformation without unwanted contacts. The change in clearances is caused by both pressure and temperature changes within the machine. If clearances are too large, the increased leakage flows will reduce efficiency. However, if the nominal clearances are too small, contacts between the rotating and stationary parts can occur as a consequence of rotor and casing deformations. In order to determine the operational clearances, a numerical analysis of deformation of screw compressor rotors and casing has to be performed. This paper discusses how the temperature of rotor and casing surfaces calculated from the one-dimensional chamber model in the SCORG could be used as a boundary conditions for a steady state thermal and structural analysis of a screw compressor solid parts. Deformations of rotors and casing under temperature load were calculated using a commercial Finite Element Analysis code ANSYS. Operational clearance are estimated from these deformations and some recommendations for further work are proposed.

The aims of this study were to determine improved kineticparameters in five kinetic models for oxidation of n-butane intomaleic anhydride in an industrial fixed-bed reactor, and tosimulate the reactor performance. On the basis of the measuredprocess parameters, inlet and outlet concentrations of n-butanewere calculated and then used to fit the kinetic models. Theindustrial fixed-bed reactor was approximated by 10 continuousstirred tank reactors (CSTR) connected in series. Based on thecalculated outlet concentration of n-butane from the industrialreactor, the outlet concentration of n-butane from thepenultimate reactor was calculated. Then the concentrations ofn-butane were calculated until the inlet concentration of nbutanein the first reactor was obtained. Kinetic parameterswere determined by comparing the inlet concentrations of nbutanein the first reactor with the inlet concentration of nbutaneobtained on the basis of the measured processparameters in the industrial fixed-bed reactor. Kinetic modelswith improved kinetic parameters showed better simulationresults compared to kinetic models with the existing kineticparameters. The best agreement of simulation results andmeasured values was achieved with application of the kineticmodel 2 (Equations (2a-c)). The smallest deviations ofnumerical simulation in comparison with measured values of theoutlet pressure of reaction mixture were 0.45, 0.75 and 0.75%for application of the kinetic model 3 (Equations (3a-c)). Thepercentage deviations of numerical simulation with improvedkinetic parameters and the existing kinetic parameters incomparison with measured values of inside reactor temperaturewere in the range 0.90-5.36% and in the range 4.17-9.78%(kinetic model 2, Equations (2a-c)), respectively.

Abstract Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate, K2[B3O3F4OH] (boroxine) was previously shown to be very effective in inhibition of several carcinoma cell lines, including the skin cancer. Here, we investigated its antimicrobial potential by targeting the multidrug-resistant opportunistic pathogens associated with skin and wound infections. The antimicrobial testing against eleven bacterial and four fungal species revealed good activity of boroxine against pathogenic filamentous fungi Penicillium funiculosum and Aspergillus niger (MIC50 64 and 128 µg/ml), and a moderate bioactivity against the yeast Candida albicans (MIC50 512 µg/ml). Among the tested multidrug-resistant bacteria, the best antibacterial effect, stable over a 24-h period, was observed against the methicillin-resistant Staphylococcus aureus strain (MRSA) at MIC of 1024 µg/ml. The atomic force microscopy (AFM) used to investigate the morphology of S. aureus cells revealed indentations on its cell envelope after the boroxine exposure. These results show that in addition to the antitumor effect, boroxine exerts wide spectrum antimicrobial activity, thus may help preventing the development of skin and wound-related opportunistic infections.

The aim of this paper is to determine the opinions of deaf workers on their labor capacity and the opinions of their hearing co-workers about the labor capacities of the deaf. The sample consisted of 247 respondents, of whom 127 were deaf and 120 were hearing workers. Qualitative and quantitative analysis were used in processing the results. Testing was performed by Wilks' Lambda, tested significance in discriminant analysis was done by F test, at the statistical significance of 0.01. It was found that the sub-sample of respondents had a statistically significant difference in views on claims regarding the exploitation of deaf workers by employers, the employment of deaf people in low-paid simple occupations, and the equally successful but insignificant productivity of deaf workers. The statistical differences found indicate that there are differences in the assessment of the labor capacity of deaf workers in the hearing work environment. Qualitative analysis found that hearing impairment and the subjective attitudes of colleagues without hearing impairment have the greatest impact on the assessment of the labor capacity of deaf workers.