Background: Neurogenic stuttering is a subtype of acquired stuttering, and it is characterized by disfluencies associated with acquired brain damage. Objective: To provide an insight into pathophysiology, symptomatology, differential diagnosis, assessment, and treatment of neurogenic stuttering through a critical review of the literature. Methods: Studies published during the past and recent years were searched and analyzed on neurogenic stuttering. Results: Neurogenic stuttering is a complex disorder. The pathophysiological mechanism of neurogenic stuttering is not yet fully understood. It appears with several neurological diseases and conditions, and the use of some drugs. Differential diagnosis of neurogenic and psychogenic stuttering is a challenge for clinicians. Treatment usually requires a joint effort from speech therapists and doctors, most often neurologists Conclusion: Although research on neurogenic stuttering can be found in the literature, the complexity of this disorder still requires detailed monitoring and studying to provide the best treatment for patients.

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Healthy and controlled immune response in COVID-19 is crucial for mild forms of the disease. Although CD8+ T cells play important role in this response, there is still a lack of studies showing the gene expression profiles in those cells at the beginning of the disease as potential predictors of more severe forms after the first week. We investigated a proportion of different subpopulations of CD8+ T cells and their gene expression patterns for cytotoxic proteins (perforin-1 (PRF1), granulysin (GNLY), granzyme B (GZMB), granzyme A (GZMA), granzyme K (GZMK)), cytokine interferon-γ (IFN-γ), and apoptotic protein Fas ligand (FASL) in CD8+ T cells from peripheral blood in first weeks of SARS-CoV-2 infection. Sixteen COVID-19 patients and nine healthy controls were included. The absolute counts of total lymphocytes (p = 0.007), CD3+ (p = 0.05), and CD8+ T cells (p = 0.01) in COVID-19 patients were significantly decreased compared to healthy controls. In COVID-19 patients in CD8+ T cell compartment, we observed lower frequency effector memory 1 (EM1) (p = 0.06) and effector memory 4 (EM4) (p < 0.001) CD8+ T cells. Higher mRNA expression of PRF1 (p = 0.05) and lower mRNA expression of FASL (p = 0.05) at the fifth day of the disease were found in COVID-19 patients compared to healthy controls. mRNA expression of PRF1 (p < 0.001) and IFN-γ (p < 0.001) was significantly downregulated in the first week of disease in COVID-19 patients who progressed to moderate and severe forms after the first week, compared to patients with mild symptoms during the entire disease course. GZMK (p < 0.01) and FASL (p < 0.01) mRNA expression was downregulated in all COVID-19 patients compared to healthy controls. Our results can lead to a better understanding of the inappropriate immune response of CD8+ T cells in SARS-CoV2 with the faster progression of the disease.

Abstract The main aim of this paper is to explore the factors determining Microfinance institutions (MFIs) self-sufficiency. The data on selected variables for this research were obtained from the public MIX Market Database and cover the year of 2017. The empirical model is constructed with application of a Principal Component Analysis (PCA) and Logistic regression analysis. Sample is consisted of 342 MFIs from all around the world, with 21 independent variables grouped into eight factors/components, and OSS (operational self-sufficiency) as dependent variable. The obtained results suggest that higher revenue and MFIs profitability combined with decrease of credit risk lead to higher probability of MFI to be self-sufficient. These results also confirm widespread belief that MFIs will not be able to achieve their social goals without achieving sustainable profitability. In addition, results also confirm importance of MFIs core mission as with increase in outreach, probability of MFIs achieving self-sustainability also increases.

Abstract This paper explores the role of knowledge visualization in facilitating decision-making in cultural heritage management. The paper addresses the issue in the specific context of stećci - the tombstones from medieval Bosnia inscribed on the UNESCO world heritage list. Grounded in the distant reading paradigm, the paper introduces a series of visualizations of spatial, temporal, architectural, iconographical, epigraphical, and impact analyses of stećci data. Together, these visualizations should enable decision-makers to gain an enhanced understanding and knowledge of this important cultural heritage. In turn, this should help them make better decisions regarding their protection and promotion.

Abstract The electricity supplier, having direct contact with end consumers, has significant potential for contributing to the achievement of country’s strategic goals related to increasing the share of electricity production from renewable energy sources and promoting efficient use of electricity. This paper presents the concept of conducted analyses of energy efficiency at the customers of JP Elektroprivreda BH d.d. Sarajevo for the purpose of identifying consumers where it would be useful to apply some of the energy efficiency measures and/or peak load management, all for reducing electricity costs. The results of the analysis are presented in the paper. Special attention is given to the techno-economic analysis of the application of measures used to improve the energy efficiency. The results of the analyses show that the shortest payback period is achievable by adequate waste heat recovery in compressors and refrigeration systems, reactive power compensation, control of motor drives of pumps and fans, and the replacement of motors with a higher efficiency class.

Zbog svojih jedinstvenih i rijetkih kolekcija, Specijalne zbirke Nacionalne i univerzitetske biblioteke Bosne i Hercegovine (NUBBiH) su nezamjenjiv izvor za mnogostruke istraživačke projekte i naučne radove. Već dugi niz godina NUBBiH ulaže napor da putem svojih projekata naučnoj zajednici pobliže predstavi vrijedne kolekcije Specijalnih zbirki. Da bi se korisnicima osigurao brži i lakši pristup građi, a ujedno i zaštitili originalni dokumenti od njihovog daljeg propadanja, građa koja je obuhvaćena projektima digitalizira se i prezentira kroz Digitalne kolekcije NUBBiH. U ovom radu predstavit ćemo jedan takav projekt, a to je projekt zaštite i prezentacije Arhiva poljičkih isprava iz Zbirke Aleksandra Poljanića te ćemo prikazati dosadašnje rezultate, kao i krajnje ciljeve ovoga projekta. = The Special Collections of the National and University Library of Bosnia and Herzegovina (NULBIH) are an irreplaceable source for multiple research projects and scientific papers. For many years, NULBIH has been strengthening efforts to present values of Special Collections to the scientific community through its projects. To provide users with faster and easier access to the material, and at the same time to protect the original documents from their further deterioration, the materials covered by the projects are digitized and presented through the Digital Collections portal of the National and University Library of BIH. In this article, we will present the ongoing project “Protection and presentation of the Poljica Documents Archive from the Collection of Aleksandar Poljanić” and so far, the results and ultimate goals of this project.

The main goal of this paper is to determine the level of independence in performing daily activities in children and youth with cerebral palsy who are included in the regular education and rehabilitation program and to see their progress in relation to children and youth with cerebral palsy who are occasionally included or not included in the education and rehabilitation program. The research was conducted in the Center for Children with Multiple Disabilities "Koraci Nade (eng. Steps of Hope)" in Tuzla as well as in practice with the mobile team of the Centre. Total of 40 respondents were included. Respondents were divided into two groups: respondents who were included in the program and respondents who were occasionally or not at all included in the program. The results of the research indicate that the respondents who were included in the regular program of education and rehabilitation achieve better results in performing activities of everyday life in relation to the respondents who are occasionally or not at all included in the program. Key words: cerebral palsy, motor functioning, daily life activities, treatment

Cotoneaster integerrimus represents a multiploid and facultative apomictic system of widely distributed mountain populations. We used flow cytometry to determine genome size, ploidy level, and reproduction mode variation of the Balkan populations, supplemented by analysis of nuclear microsatellites in order to address: (i) geographic distribution and variation of cytotypes among the populations; (ii) variation of reproduction mode and the frequency of sexuality; (iii) pathways of endosperm formation among the sampled polyploids and their endosperm balance requirements; (iv) genotypic diversity and geographic distribution of clonal lineages of polyploids. The prevalence of apomictic tetraploid cytotype followed by sexual diploids and extremely rare triploids was demonstrated. This prevalence of tetraploids affected the populations’ structure composed from clonal genotypes with varying proportions. The co-occurrence of diploids and tetraploids generated higher cytotype, reproductive mode, and genotypic diversity, but mixed-ploidy sites were extremely rare. The endosperm imbalance facilitates the development and the occurrence of intermediate triploids in mixed-ploidy populations, but also different tetraploid lineages elsewhere with unbalanced endosperm. All these results showed that the South European populations of C. integerrimus have higher levels of cytotype and reproductive diversity compared to the Central European ones. Therefore, the South European populations can be considered as a potential reservoir of regional and global diversity for this species.

OBJECTIVES To test the influence of a bleaching procedure using 16% carbamide peroxide (CP) on the colour of composite materials and their consecutive subjection to discolouration in beverages. MATERIALS AND METHODS Nanocomposite Z550 (3M ESPE) and the microhybrid Z250 (3M ESPE) composite materials were selected for the research. 16% CP was applied to composite plates (15 samples each material) for seven hours a day for 14 days simulating at-home nightguard vital bleaching. The test samples were then divided randomly into three sub-groups and submerged in instant coffee, green tea and Coca Cola for 30 days. The control group (N=5) samples were kept in deionized water. Determination of the L*a*b* dimensions of colour of the polymerized discs was performed by calibrated spectrophotometer 24 hours later, after the bleaching procedure, and on days 7, 15 and 30 after immersion in the beverages. RESULTS After application of 16% CP, there were perceptible changes in the colour of both test materials, which did not exceed the boundaries of acceptability (ΔE<3.48). Coca-Cola did not cause discolouration of the tested composites, but coffee and tea changed their colour above the level of perceptibility already seven days after immersion. A statistically significant difference in the change in colour was established between the materials when they were immersed in coffee (P<0.05). CONCLUSIONS 16% CP does not affect the basic colour of the composites. Immersion in a beverage led to an unacceptable change in the colour of both test materials in coffee and tea, primarily towards black. The greatest discolouration after bleaching was shown by Z550 when immersed in coffee.

INTRODUCTION Pregnancy is a unique experience accompanied by significant physiological, biochemical, and psychological changes that may affect a woman's mental health status. With the development of a holistic approach, midwives have become continuous support during pregnancy and childbirth. Childbirth education is an intervention that affects delivery outcomes and the experience of childbirth. Music therapy has been proven to be a safe and effective non - pharmacological method to gain in pregnancy and puerperium. The study aimed to prove the impact of educating pregnant women and listening to classical music on the experience of childbirth pains and the occurrence of psychological symptoms during puerperium. METHODS A prospective randomized controlled trial (n=198) was conducted. The experimental group of pregnant women was educated during pregnancy and listened to classical music the rest of the pregnancy, while the control group received the usual care. The VAS scale was used to assess pain, and the 90 - point scale was used to assess the incidence of psychological symptoms. RESULTS The difference in pain assessment between the experimental and control groups was significant (p<0.001). The experimental group rated their childbirth pain as moderate (M=5.98), while the control group experienced severe pain (M=8.42). A significant difference in the incidence of psychological symptoms between groups was found in the dimensions of interpersonal sensitivity, hostility, phobic anxiety, and paranoid ideations (p=0.042; p=0.014; p=0.013; p=0.008). CONCLUSION This study demonstrated the impact of midwifery education and listening to classical music on the perception of childbirth pain and mental health in the puerperium. The experimental group rated childbirth pain significantly lower compared to the control group and had significantly fewer psychological symptoms 6 weeks after delivery.

Kampus Sveučilišta Jurja Dobrile u Puli karakteriziraju istaknute arhitektonske vrijednosti i vrijednosti otvorenog prostora. Otvoreni prostori čine više od 50% površine kampusa i uvelike određuju njegovu estetiku. Kartiranje dendroflore i kategorizacija zelenih površina kampusa provedeno je s ciljem pružanja temeljnih znanja za učinkovitije i isplativije upravljanje zelenim površinama kampusa. Poticanje zelenih otvorenih površina napravili su studenti Pejzažne arhitekture na Univerzitetu u Sarajevu – Šumarski fakultet tokom međunarodne studentske radionice CAMPULA u listopadu 2019. Studija je rezultirala jasnim informacijama o funkcionalnim svojstvima zelenih elemenata u Kampusu. Na području kampusa kartirana je ukupno 301 jedinka (203 zimzelena stabla, 80 listopadnih stabala, 9 zimzelenih grmova, 6 listopadnih grmova i 3 zimzelene palme) . Ukupno su kartirana 32 taksona (20 zimzelenih i 12 listopadnih). Poboljšano upravljanje zelenim otvorenim prostorom pulskog kampusa može rezultirati iznimno vrijednim ekološkim, društvenim i estetskim akademskim zelenim prostorom.

Many recent research has focused on graphic design and shape of the packaging, and their effects on the customer's decision-making process as two separate categories. Since the shape of the packaging along with the graphic design plays an important role in the visual appearance of the packaging and attracts the customer's attention, the main objective of this research was to find out which packaging shapes and graphic elements customers find most attractive, as well as to understand the general opinion of customers about the influence of packaging aesthetics on their decision-making process when purchasing a product. Methodology of this research was conducted in two stages, from which the first one included creating three different graphic design solutions combined with three shape categories, and three variations of added value, for the same food packaging. The second part of the research covered an online questionnaire, in which a group of 50 people participated. This questionnaire focused on three variables: graphic design of the packaging, packaging shape and it’s added value. These variables were evaluated using the Likert scale. Through the questionnaire, participants were asked to answer general questions about the impact of the packaging visual appearance and added value, on their decision-making process when buying a product, as well as to choose the most appealing packaging between the given options. The research results showed that customers preferred non-standard packaging shapes and simple graphic design, as well as packaging with added value. The results of this research prove that the aesthetics of packaging has an impact on the customer's perception of a product, which means that packaging plays an important role in product marketing.

Abstract – Traffic safety should always be prioritized in all traffic systems. As the railway is a high-level complex technical and technological system, many factors affect its safety. Two factors that are the subject of research in this paper are train stopping distance and overlap. Keywords – Railway Traffic Safety, Train Stopping Distance, Overlap.