Starting from the emergence of 1st Generation network (1G), wireless mobile communications have been undergoing an evolution - from 2nd Generation (2G), 3rd Generation (3G), 4th Generation (4G) networks to 5th Generation network (5G) at present. The fifth era is only a continuation of the ongoing evolution as it is still in the research phase and is also the basis for further development of industries and the society in general. The paper presents and compares the fourth and fifth generation of wireless mobile communications, focusing on the differences and progress in terms of data transmission rate, capacity, architecture, technology and applied multiple-technique approaches and services provided.

Abstract Introduction Professional drivers’ knowledge about driving-impairing medications is not satisfactory. The aim of this study was to develop and test the reliability and validity of the questionnaires designed to measure the knowledge and attitude of professional drivers about the influence of various medications on driving ability. Methods The questionnaires for assessing professional driver’s knowledge (performance-based) and attitudes about influence of various medications on driving abilities were developed by creating the item pool, testing reliability and validity, and factor analysis. The study was conducted as a multicenter, cross-sectional study in Serbia and Bosnia and Herzegovina. The study population consisted of professional drivers, who filled out both questionnaires in three time intervals. Results Both questionnaires showed great internal consistency and temporal stability. Cronbach’s Alpha for the first questionnaire was 0.984 and for the second it was 0.944. The Kaiser–Meyer–Olkin test for the first questionnaire confirmed sampling adequacy with its value of 0.964 and for the second questionnaire it was 0.933. Exploratory factor analysis of the questionnaire showed that three factors were revealed after rotation for the first questionnaire and they explained 78.0% of variance. Both questionnaires showed high degree of correlation between scores after the first and repeated administration, Spearman’s rho coefficient of correlation for was 0.962 and 0.980. Conclusion Based on the results of this study, we believe that both questionnaires are useful tools for testing professional drivers’ knowledge and attitudes about the influence of medications on driving ability.

Monitoring of the lineages SARS-CoV-2 is equally important in a fight against COVID-19 epidemics, as is regular RT - PCR testing. Ion AmpliSeq Library kit plus is a robust and validated protocol for library preparation, but certain optimizations for better sequencing results were required. Clinical SARS-CoV-2 samples were transported in three different viral transport mediums (VTM), on arrival at the testing lab, samples were stored on -20OC. Viral RNA isolation was done on an automatic extractor using a magnetic beads-based protocol. Screening for positive SARS-CoV-2 samples was performed on RT–PCR with IVD certified detection kit. This study aims to present results as follows: impact of first PCR cycle variation on library quantity, comparison of VTMs with a quantified library, maximum storage time of virus and correlation between used cDNA synthesis kit with generated target base coverage. Our results confirmed the adequacy of the three tested VTMs for SARS-CoV-2 whole-genome sequencing. Tested cDNA synthesis kits are valid for NGS library preparation and all kits give good quality cDNA uniformed in viral sequence coverage. Results of this report are useful for applicative scientists who work on SARS-CoV-2 whole-genome sequencing to compare and apply good laboratory practice for optimal preparation of the NGS library.

Globalization has led to the spread of English, which has become the world’s international language. As a result of its importance in social, economic, and political spheres, many countries have introduced English language learning in their school curricula. However, despite its importance many learners still seem to struggle with English second language (L2) motivation, which is an important element of L2 learning success. The aim of this study was to analyse the relationship between several phases of learners’ motivation, including learners’ attributions of past English L2 learning success, current motivational characteristics, and motivation to learn English in the future. Using the L2 Motivational Self System (L2MSS) as a framework, it was found that past learning experiences did not have a significant effect on current learner motivational dispositions. However, elements of the L2MSS had an effect on learners’ intentions to exert effort into future English language learning. In other words, Croatian university students’ L2 motivation was based on their visions for the future rather than on past learning experiences. Moreover, it appears that the ideal L2 self plays a much stronger role in learners’ motivation compared to the ought-to L2 self, and this motivation is tied to utilitarian motives for learning English. In addition, the results showed that other motivational components, such as interest, as well as L2 anxiety, are important elements of learners’ motivation, suggesting cognitive as well as affective aspects in this motivational profile. The complexity of motivation as shown in this study suggests the need for further investigations in various contexts.

Abstract Rare diseases (RD) are serious chronic diseases affecting small number of people compared to the general population. There are between 6000 and 8000 RDs, which affect about 400 million people worldwide. Drugs used for causal treatment of RDs are called orphan drugs. RDs bear great clinical and economic burden for patients, their families, healthcare systems and society overall. There are at least two reasons for the high cost of treatment of RDs. First, there is no causal therapy for majority of RDs, so exacerbations, complications, and hospitalizations in those patients are common. The second reason is high price of available orphan drugs, which are not cost-effective when traditional pharmacoeconomic evaluation is employed. The pharmacoeconomic aspect of the treatment of RDs is especially important in the field of neurology, since at least one fifth of all RDs is composed of neurological conditions. The aim of this paper was to provide a concise overview of the pathophysiological, epidemiological and clinical characteristics of some of the most important and common rare neurological diseases, with special reference to their impact on society and economy.

The quality level of corporate governance can be defined as the degree of compliance with set corporate governance standards defined at the international and national institutional levels. Guided by previous theoretical and empirical findings, Bosnia and Herzegovina has characteristics of a closed corporate governance system in both entities and, for this reason, the models that measure corporate governance in countries with typical closed corporate governance systems are selected as the basis for developing a model for measuring the level of corporate governance. Measuring the quality of corporate governance provides a clear picture of the internal strengths and weaknesses of the corporate governance system in corporations in Bosnia and Herzegovina. The quality of corporate governance is one of the non-financial indicators of business operations and shows the degree of compliance with international standards of corporate governance. A significant number of studies show that corporations that achieve higher standards and better practices of corporate governance also have better financial results and thereby higher value in the capital market. This means that corporations with a higher level of corporate governance also have a better financial result of business operations, easier access to financial capital and higher value in the capital market. The subject of the study is to determine the relationship between the quality of corporate governance and profitability of business operations of corporations, and considering that this is historical data, the study will determine whether corporations that had good corporate governance also had greater business profitability and vice versa. The mean objective of the study is to determine the relationship between the quality of corporate governance and business profitability indicators and the direction of this relationship.

Aim To assess the impact of the COVID-19 pandemic on admissions of patients with acute coronary syndromes (ACS) and primary percutaneous coronary intervention (PPCI) in countries participating in the Stent-Save a Life (SSL) global initiative. Methods and Results We conducted a multicenter observational survey to collect data on patient admissions for ACS, ST-elevation myocardial infarction (STEMI) and PPCI in participating SSL member countries through a period during the COVID-19 outbreak (March and April 2020) compared with the equivalent period in 2019. Of the 32 member countries of the SSL global initiative, 17 agreed to participate in the survey (three in Africa, five in Asia, six in Europe and three in Latin America). Overall reductions of 27.5% and 20.0% were observed in admissions for ACS and STEMI, respectively. The decrease in PPCI was 26.7%. This trend was observed in all except two countries. In these two, the pandemic peaked later than in the other countries. Conclusions This survey shows that the COVID-19 outbreak was associated with a significant reduction in hospital admissions for ACS and STEMI as well as a reduction in PPCI, which can be explained by both patient- and system-related factors.

Purpose: to determine the most significant kinematic indicators in the sports selection of beginner shot putters. Material and Methods: This study was carried out on a sample of 9 students at the fourth stage of the competition in Division 1, which took place in the 2017/2018 academic year at the Faculty of Physical Education of Maysan University. The following kinematic (biomechanical) parameters were analyzed: the angle of release of the nucleus, the velocity of release, the height of the point of ejection of the nucleus and the speed of swing. The correlation coefficients were determined between the kinematic indicators and the result in the shot put, as well as the regression equation for the dependence of the result in the shot put on the knematic indicators. The data obtained in the study were presented in the form of the arithmetic mean, standard deviation, median, skewness coefficient, Pearson's correlation coefficient, analysis of variance and linear regression, which included the contribution coefficients of each analyzed indicator, standard error, reliability of the regression equation as a whole, and reliability of the coefficients contribution to the shot put result of each kinematic exponent. Results. It has been shown that the swing speed has the greatest influence on the result in the shot put among beginner athletes. The swing speed, shot angle, shot speed and shot height have significant relationships with the shot put result. The multiple regression equation for the dependence of the shot put result on the swing speed, shot angle, shot height and shot point turned out to be reliable in general. However, only the swing speed has a reliable coefficient of the regression equation. The shot angle tends to be the determining factor in the shot put result. The release rate and the height of the release point have significant correlations with the shot put result, although in the regression equation they have unreliable indicators of influence on the shot put result. Conclusions. When teaching beginner shot putters, the greatest attention should be paid to the pushing swing technique, namely the swing speed. The second most important indicator is the angle of the shot put, it is recommended to use the basic prediction equation, which determines the expected results in the selection of young athletes in shot put, with high reliability of the results obtained. These characteristics are recommended to be used for evaluating young athletes, as well as in the process of training and preparing athletes for competitions.  

Purpose: The aim of the study was to determine the differences between football players and basketball players in the mean absolute values ​​of maximum torque flexors and extensors, ratio of maximum hamstring torque to maximum quadriceps torque dominant (DOM) non-dominant (ND) leg and differences in bilateral imbalance of flexor muscles and knee extensors. Material and methods: The research included a sample of 39 professional athletes. The first subsample included 19 professional basketball players while the second subsample included 20 professional soccer players. Results: Based on the results of the torques of the extensors in the knee joint of the DOM and ND legs, it was established that there is no statistically significant difference between basketball players and football players. However, a statistically significant difference was found in the torque flexors of the knee joint DOM (p≤0.01) and ND (p≤0.00) of the leg between basketball players and football players. On the other hand, the results of the research indicate that the difference between basketball players and football players in the ratio of Hamstrings peak torque to Quadriceps peak torque was recorded only in the ND leg (p≤0.02), while the difference in the DOM leg is not statistically significant. The results of our study indicate that basketball players have a higher percentage of imbalances compared to football players, especially in m. hamstrings. Conclusion: This study provides normative data on populations specific to soccer and basketball, but does not provide evidence of the ability of the isokinetic assessment of lower extremity muscle strength to predict injuries to football players and basketball players.

Rhetoric in Ancient Rome was a very specific type of discourse construction used to shape, present, and interpret specific works of individuals and then present them to critics. Depending on the perspective of the orator, defense counsel, or plaintiff, discourse strategies were aimed at legitimizing or delegitimizing a specific act. Words and wise acts of a skillful orator, which Cicero was renowned for, were often as powerful as weapons; they not only uncovered the intentions and objectives of participants in a given situation, but they reflected the social and political image of Rome, including the context of the event. The paper presents one of the possible methods of analyzing Cicero’s speeches made for the defense of Milo, a notable Roman charged for the murder of aristocrat Clodius Pulcher. It is based on the discourse-historical approach of R. Wodak and M. Reisigl. It is a qualitative analysis focused on the linguistic construction of the defense of the defendant at a trial. The analysis will show the discourse constructions produced under the influence of a set of specific social factors, in this case, the political environment in Rome, the ideological affiliation of speakers, and the main discussion participants – Milo and Pulcher, their political roles, and the degree of formality. The paper’s theoretical framework is a critical analysis of the discourse.

The aim of this study was to study the impact of crop load on the yield and grape quality of ‘Merlot’ and ‘Vranac’ (Vitis vinifera L.) in Trebinje vineyard. The crop load levels studied in this trial were 9 buds (V1) and 12 buds (V2) per vine at each variety trained on Lenz-Moser bilateral cordon system. The impact was determined by measurements of yield per vine and grape quality characterized by the contents of total soluble solids, titratable acidity, total phenolics, total flavonoids and by total antioxidant capacity. The measured parameters of grape quality of ‘Merlot’ and ‘Vranac’ were not influenced significantly by crop load levels. V2, compared to the V1, showed the potential for increasing grape yield only for Merlot variety under experimental conditions. The results of this study also showed a positive correlation between total phenolics/flavonoids and total antioxidant capacity of grape berries in both varieties, regardless of crop loads applied.

Most pharmaceutical and nutritional compounds are marketed as enzyme inhibitors, and such inhibitors show their specific action in inhibiting enzymes within cells. Since their discovery, corticosteroid treatment has been one of the most used and effective treatments for various inflammatory and autoimmune disorders. Corticosteroids have anti-inflammatory and immunosuppressive effects, so it is hypothesized that these corticosteroids will have an inhibitory effect on the enzyme catalase. This study aimed to examine the effect of the corticosteroid’s betamethasone dipropionate and prednisone on catalase activity in vitro. A spectrophotometric method was used based on the reaction between hydrogen peroxide, enzymes, and corticosteroids. After incubation at 37°C with the addition of ammonium heptamolybdate, a stable complex was formed, and the absorbances were analysed. The obtained results indicate an uncompetitive type of inhibition in betamethasone dipropionate, while prednisone acts as a partial competitive agent.

During one hundred years of the development of archaeology in southeast Europe, one of the dominant issues was the origin of communities that were recognized by former researchers as a homogenous component named the Illyrians. The issue of their origin was observed through different interpretations of wethnogenetic processes which numerous researchers tried to use to create different developmental phases of creating communities named after the Illyrians. By combining the most recent interpretations of concepts of myths and legends of the past communities, written data containing live memories of these myths during the past two centuries, as well as archaeological and historical data, the relationship and complexities of the oldest myths and legends, such as the one of Cadmus and Harmonia, are reimposed as they suggest the origin of the entire term of the Illyrians as a geographic and religious concept entirely dichotomous compared to, seemingly, misinterpretations of the wider ethnic context of the prehistoric Balkans.

This paper reviews a state-of-the-art zero emission propulsion system for a battery-powered small craft. The main aspects considered are the available propulsion systems, energy storage, and dock battery charging. This underlying activity is part of the KISS project, a research and development program in the frame of the EU-funded “Piano Operativo Regionale CALABRIA FESR-FSE 2014–2020 ASSE I–PROMOZIONEDELLA RICERCA E DELL’INNOVAZIONE”, which is aimed at designing and building a physical prototype. Its hull form is based on previous research conducted by the authors, and the powering performances were preliminarily predicted by CFD simulation. The KISS project represents a successful example of an electric small craft with performances and a mission profile comparable to competitors with conventional propulsion. Such a target has been achieved by a concurrent design that considers the hull form, engine, propulsion system, and energy storage onboard. Safety issues and the regulatory frame are also highlighted.