INTRODUCTION/OBJECTIVE Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain. We evaluated the safety of IVT combined with conservative versus aggressive intraprocedural APT in patients requiring stenting during EVT. METHODS This multicenter RESISTANT registry subanalysis (2016-2023) included 823 adults. APT was categorized as conservative (aspirin +/- oral P2Y12) or aggressive (including GPIIb/IIIa inhibitors or cangrelor). The primary outcome was a composite of symptomatic intracranial hemorrhage (sICH) and parenchymal hematoma (PH1/PH2). Multivariable logistic regression assessed associations and interactions between IVT and APT. RESULTS A total of 823 patients were included: 44 (5.3%) received IVT + conservative APT, 130 (15.8%) No IVT + conservative APT, 145 (17.6%) IVT + aggressive APT, and 504 (61.2%) No IVT + aggressive APT. Frequencies of sICH-PH1-PH2 were 9.3% with IVT + conservative APT, 10.7% with IVT + aggressive APT, 3.2% with No IVT + conservative APT, and 9.9% with No IVT + aggressive APT. In multivariable analysis without interaction terms, neither IVT (aOR 1.18, 95% CI 0.58-2.27; p = 0.64) nor aggressive APT (aOR 2.10, 95% CI 0.92-5.69; p = 0.10) was independently associated with increased risk of sICH-PH1-PH2. However, in the interaction model, IVT within the conservative-APT stratum (aOR 5.84, 95% CI 1.07-43.92; p = 0.05) and aggressive APT within the no-IVT stratum (aOR 4.81, 95% CI 1.41-30.22; p = 0.03) were each associated with higher odds of sICH-PH1-PH2, while the IVT-by-APT interaction term was < 1 (aOR 0.15, 95% CI 0.02-0.94; p = 0.05), indicating attenuation of the joint effect on the multiplicative odds scale. CONCLUSION Among patients requiring intracranial stenting during EVT, we found no evidence that IVT and aggressive intraprocedural APT act synergistically to increase hemorrhagic risk. Rather, the negative IVT-by-APT interaction suggested attenuation of the joint effect on the multiplicative odds scale, although patients receiving both therapies remained at increased hemorrhagic risk relative to the reference group.

Conversational commerce agents that personalize assistance based on a user’s transactional state (cart contents, checkout progress, order completion) must model that state correctly, or downstream adaptive behavior will be misaligned with the user’s actual journey. We call mismatches between an agent’s claims and the observable event history journey hallucinations, and study a lightweight verification framework that reconstructs a minimal transactional user model from execution logs and checks agent claims against deterministic invariants. On 90 real sessions across four foundation models, trace-aware prompting reaches 99.5–100% user-state accuracy at 84–99% coverage, while unconstrained prompting produces unsupported state assertions at rates up to 8.5%. In a between-subjects user study (N = 42), verified responses were judged more trustworthy (p =.008, r =.43), better at reflecting journey understanding (p =.039, r =.32), and more often factually correct (p <.001, r =.56). The framework provides a practical reliability layer for transactional user-state modeling, helping personalization and dialog policies operate on verified, not hallucinated, user states.

Group Recommender Systems (GRSys) are designed to recommend items that address the needs of groups of people. Compared to individual users, groups are dynamic entities where interpersonal relationships, group dynamics, emotional contagion, etc., substantially affect the group’s needs. Nevertheless, these characteristics are often poorly defined or overlooked in system modeling. The fifth GMAP workshop brought together a community of scholars focused on group modeling, adaptation, and personalization. The event was dedicated to exploring the challenges and opportunities of supporting collective decision-making, fostering interdisciplinary dialogue, and forging new collaborations. The three presented papers covered a diverse range of topics, revisiting assumptions about similarity, task definitions, and fairness perception in particular scenarios within the realm of group modeling, adaptation, and personalization.

Adaptive and personalized systems increasingly mediate everyday digital experiences, and recent advances in LLMs, NLP, and Generative AI have amplified their reach, from intelligent user interfaces and conversational agents to AR/immersive interactions and autonomous assistants. These methods now support applications in health and well-being, behavior change and persuasion, e-learning and educational games, and group modeling for collaboration and team formation, all of which require increasingly rich and dynamic user models. At the same time, modern pipelines based on data mining, knowledge graphs/linked data, semantic representations, and affective computing raise urgent questions about transparency, privacy, fairness, accountability, and user understanding, reinforced by regulatory expectations such as the GDPR right to explanation. Yet research often optimizes personalization performance without comparable attention to interpretability and human comprehension. This workshop provides a forum for theoretical, methodological, and empirical work that bridges effectiveness and explainability, with emphasis on robust human-centered evaluation and reproducible practices, including benchmarks, datasets, and shared challenges that advance trustworthy personalization in an era of increasingly autonomous AI.

Abstract Introduction Transthoracic echocardiography (TTE) identifies a hypercontractile phenotype (HP) in chronic coronary syndromes (CCS), characterized by elevated resting left ventricular (LV) elastance (force = systolic blood pressure/end-systolic volume). To evaluate the prognostic significance and functional correlates of HP. Methods In a prospective multicentre study, 10 677 patients with CCS underwent resting TTE to assess LV ejection fraction (EF), stroke volume, and force by quantitative volumetric echocardiography. All patients were followed for the endpoint of all-cause mortality. In a subset of 5834 patients, stress echocardiography (exercise or dobutamine) was performed for LV contractile reserve and heart rate reserve. Results Patients were stratified into Force quintiles (Q1–Q5). Patients with hypercontractile phenotype exhibited lower stroke volume at rest (Q5 = 34.8 ± 12.3 vs Q1–Q4 = 57.4 ± 19.1 mL; P < .01) and higher EF at rest (Q5 = 64.8 ± 6.9% vs Q1–Q4 = 58.1 ± 8.7%, P < .01). During a median follow-up of 24 months (interquartile range = 12–40 months), 509 deaths occurred. The exposure-adjusted death rate was lowest in Q3 (3.53–4.51 mmHg/mL; 1.03 per 100 person/years) and higher in Q1 (≤2.62 mmHg/mL, 2.88), Q2 (2.63–3.52 mmHg/mL, 1.86), Q4 (4.52–6.11 mmHg/mL, 1.56), and Q5 (HP, >6.11 mmHg/mL; 1.88; P < .0001 vs Q1 and Q3). Multivariable analysis identified HP (Q5; HR 1.531 vs Q3, 95% CI 1.116–2.099; P = .006) and EF (HR 0.963, 95% CI 0.953–0.972; P < .0001) as independent predictors of death. During exercise or dobutamine stress, HP showed reduced LV contractile reserve (ΔEF: Q5 = 4.3 ± 9.4% vs Q1–Q4 = 7.0 ± 9.3%; P < .001) and blunted heart rate reserve (Q5 = 1.77 ± 0.33 vs Q1–Q4 = 1.85 ± 0.39; P < .01). All patients with force-based LV contractile reserve >4.1 (present in 185, 3.2% of the population) survived. Conclusion Patients with CCS with HP assessed by resting TTE demonstrate higher mortality and multilayered functional impairment, including reduced LV contractile and chronotropic reserves. Hypercontractile phenotype improved the prediction of mortality by EF. A ‘stronger’ heart is, in fact, functionally and prognostically weaker.

Effective early warning systems for aquatic contamination require monitoring strategies capable of detecting subtle, long-term shifts in mixture-driven biological activity. Suspended particulate matter (SPM) serves as a carrier and reservoir for complex contaminant mixtures, facilitating their transport and persistence in aquatic systems, yet systematic toxicological time series for archived SPM remain scarce. Regulatory monitoring predominantly targets Priority Substances and River Basin Specific Pollutants, leaving the temporal trends of particle-associated mixture toxicity largely unresolved. Leveraging 18 years (2005-2022) of cryogenically archived annual SPM composites from the Rhine River, we conducted a spatiotemporal effect-based assessment integrating receptor-mediated effects, oxidative stress analysis and untargeted Cell Painting phenomics. This integrated toolbox enabled evaluation of pathway-specific responses and multi-compartment cellular perturbations associated with particle-bound contaminant mixtures. Polar SPM-associated chemicals elicited oxidative stress response and caused endocrine disruption through estrogen receptor α (ERα) activation and androgen receptor inhibition (anti-AR). Trend analysis showed spatiotemporal variation along the river, with statistically increasing trends of oxidative stress and anti-AR activity over time at Koblenz, driven by polar chemicals. Both polar and non-polar SPM extracts activated the aryl hydrocarbon receptor (AhR), indicating presence of compounds capable of triggering xenobiotic response pathways. Several subcellular compartments were affected, with mitochondrial features being among the most affected. These findings demonstrate that SPM-associated chemicals elicit diverse toxicological effects by acting on several receptors and impacting diverse cellular structures. Combining targeted and phenomics-based effect approaches provided comprehensive mechanistic insights and valuable information to support the early warning systems for chemical contamination in aquatic environments.

This systematic review synthesizes 38 peer-reviewed empirical studies (January 2010-December 2025) on microcontroller use in physics education, following preferred reporting items for systematic reviews and meta-analyses procedures and searches in Scopus and ERIC. It describes how platforms such as Arduino, ESP32, Atmega328, and Micro:bit potentially support development of laboratory skills and may facilitate learning of mechanics, thermodynamics, electromagnetism and optics. These low-cost programmable devices most often facilitate learning through automated, high-frequency data collection and real-time visualization, allowing students to observe transient phenomena and connect measurements to conceptual models. Instructions are typically inquiry and project-based, with students building sensor systems, troubleshooting, and developing computational and experimental reasoning. Across studies, motivation and engagement frequently improve, and some report gains in conceptual understanding and laboratory problem-solving. Different barriers include limited teacher training, time constraints, calibration/debugging difficulties, and resource and maintenance demands. Future studies should prioritize longitudinal research and scalable teaching models to support sustained classroom integration.

This scoping review maps the scope, characteristics, and emerging patterns of empirical research on doomscrolling. Guided by PRISMA-ScR recommendations, searches were conducted in Scopus and Web of Science, and 50 empirical studies met the inclusion criteria. The findings indicate that doomscrolling is generally conceptualized as repetitive, prolonged, and difficult-to-stop consumption of negative digital news, often driven by uncertainty, informational needs, and emotional discomfort. Research on doomscrolling has expanded rapidly since 2020, with a focus on pandemic-related contexts and growing attention to climate change, natural disasters, geopolitical conflicts, and other crises. Methodologically, the field is dominated by cross-sectional quantitative studies, while longitudinal, experimental, qualitative, and intervention-oriented studies remain limited. Across the reviewed studies, doomscrolling was frequently associated with adverse psychological outcomes, including anxiety, depression, stress, psychological distress, and reduced well-being. Emerging evidence also suggests social and occupational implications, including distraction, reduced productivity, and altered risk perceptions. Key individual-level factors associated with doomscrolling include fear of missing out, intolerance of uncertainty, emotional vulnerability, and low self-regulation. Despite growing scholarly interest, the literature remains fragmented in terms of definitions, measurement tools, research designs, and contextual coverage. This review highlights the need for standardized, cross-culturally validated measures; broader populations and crisis contexts; and stronger longitudinal, experimental, and intervention-based evidence. Overall, the findings position doomscrolling as a multidimensional phenomenon at the intersection of digital media use, crisis communication, and mental health, with important implications for future interdisciplinary research and digital well-being initiatives.

This research aims to investigate the concept of industrial symbiosis as a change agent in the Circular Economy, with its consequent effects on the economy, the environment, and society in terms of sustainable development. This study employs qualitative research with quantitative support from a structured survey of 152 IS project experts, researchers, and practitioners, utilizing a questionnaire comprising Likert-type and multiple-choice questions. Data were aggregated into composite indicators and analyzed by using a log-log multiple regression model. Empirical results reveal that economic benefits are the most significant positive drivers. The actors’ involvement also contributes positively, highlighting the importance of multi-stakeholder collaboration. Conversely, barriers have the strongest and the highest negative scale impact on perceived IS synergies. Broader economic and social conditions moderately enhance synergies, while awareness and training show a weaker but positive effect. IS is both economically viable and environmentally necessary, but its expansion depends on reducing financial, regulatory, and infrastructural barriers. Certain economic policy-driven interventions, such as fiscal incentives, regulatory clarity, and investment, enable infrastructure to scale up the adoption of IS.

A central promise of topological quantum computing is that increasing the excitation gap improves device performance significantly. Here, we experimentally validate this principle in an InAs--Pb tetron device via interferometric single-shot parity measurements. By replacing aluminum with the higher-gap superconductor lead in our superconductor-semiconductor hybrid devices, we have improved the robustness of our topological phase. In addition, to enable fast and precise bring-up at scale, we have developed an rf measurement technique that resolves low-energy wire-end states and directly measures their energy splitting with $\mu\text{eV}$ precision. We employ this technique to bring up a device in a multi-tetron array and perform parity measurements of one of the tetron's hybrid nanowires (NWs). By controllably switching the wire parity, we observe $h/2e$-periodic bimodal shifts in the quantum capacitance of a quantum dot coupled to the hybrid nanowire in an interference loop. Further time-resolved measurements reveal a characteristic parity switching time of $\sim 20$ s with some instances reaching minute-scale. Such extremely long parity lifetimes are orders of magnitude longer than typical qubit operation times, which are on the order of $\mu\text{s}$. Finally, we discuss potential implications for the fidelity of Pauli measurements.

Background and Objectives: Vitamin D signaling plays critical roles in immune regulation, bone metabolism, and cellular differentiation across multiple tissues. However, the spatial and temporal expression patterns of key vitamin D signaling components—the vitamin D receptor (VDR) and the enzyme 1α-hydroxylase (encoded by CYP27B1)—during human nephrogenesis have not been mapped at the protein level. The primary objective of this study was to characterize VDR and 1α-hydroxylase expression across critical stages of human kidney development, complementing prior transcriptomic and single-cell descriptions, and to contextualize these developmental observations against the dysregulation of vitamin D pathway genes in adult renal and urothelial malignancies. Materials and Methods: Immunofluorescence analysis was performed on FFPE kidney tissue from 12 specimens (3 per stage) at 10, 22 and 38 gestational weeks and postnatally at 1.5 years. For each specimen, at least three non-adjacent sections were stained and 6 non-overlapping cortical fields were imaged at ×40 (18 fields per stage). Fluorescence-area percentages were quantified in ImageJ 1.54g, and group differences were assessed by one-way ANOVA with Tukey’s post hoc test at both field- and specimen-level. An accompanying bioinformatic analysis evaluated the differential expression of VDR, CYP27B1, and CYP24A1 in adult renal and urothelial malignancies (TCGA cohorts: KICH, KIRC, KIRP, BLCA) using unpaired Welch’s t-test, with Benjamini–Hochberg FDR correction applied across all 16 tumor-versus-normal comparisons (12 gene-wise + 4 post hoc log2(CYP24A1/CYP27B1) ratios). Results: VDR showed its highest mean fluorescence area at 10 weeks (3.40% (95% CI 3.24–3.56); field-level Tukey p < 0.0001 versus other stages) and its lowest at 22 weeks (0.69% (0.64–0.74)). 1α-hydroxylase was also highest at 10 weeks (5.44% (5.29–5.60); p < 0.0001) and stabilized at lower levels thereafter (3.04–4.26%). Co-expression of both proteins was observed throughout development except in 22-week glomeruli. In TCGA, all 12 significant gene-wise comparisons retained significance after BH FDR correction (q < 0.05). VDR showed cohort-specific dysregulation: reduced in KICH (q = 2 × 10−4) but increased in KIRC and KIRP (q = 2 × 10−4 for both). CYP24A1 was reduced in all three renal cohorts (q ≤ 0.029) and unchanged in BLCA. CYP27B1 showed cohort-specific direction (reduced in KIRC; increased in KICH, KIRP, and BLCA). Conclusions: This study provides an initial immunofluorescence-based spatial description of VDR and 1α-hydroxylase across human kidney development, revealing a coordinated redistribution from immature glomeruli at 10 weeks to mature tubular segments at later stages. The TCGA analysis demonstrates that vitamin D pathway dysregulation in renal carcinoma is cohort-specific and is not abolished by multiple-testing correction. Together, these results indicate that the developmentally engaged vitamin D pathway retains kidney-specific functional relevance in adult renal pathology and provide a baseline reference for future mechanistic studies.

This study aimed to examine the influence of effective playing time (EPT) on match running performance (MRP) in elite soccer players competing in the UEFA Champions League (UCL), while controlling for contextual factors. In total, 1371 individual observations, involving 437 outfield players, participating in 32 teams, were collected from 122 matches using an optical tracking system. The MRP variables included total distance (TD), low- (LIR), moderate- (MIR), and high-intensity running (HIR). Linear mixed models were applied, with match outcome, match location, and opponent quality included as fixed effects, and player and team identity as random effects. The results showed that EPT significantly influenced TD (f=5.01–14.20, all p<0.01) and LIR (f=3.23–21.93, all p<0.05) across most playing positions, with players covering 9–10% greater distances in matches with very long EPT compared to very short EPT. In contrast, no significant effects of EPT were observed for MIR and HIR across any playing position. These findings indicated that longer EPT primarily increased overall activity, mainly through low-intensity activities, while moderate- and high-intensity activities remained relatively stable. Importantly, this pattern was consistent across players from multiple national contexts. From a practical perspective, EPT should be considered when planning and monitoring overall load, whereas moderate- and high-intensity activities should be systematically developed and maintained through training independent of EPT.