Catheter ablation for atrial fibrillation (AF) is one of the most commonly performed electrophysiology procedures. Despite significant advances in our understanding of AF mechanisms in the last years, ablation outcomes remain suboptimal for many patients, particularly those with persistent or long-standing AF. A possible reason is that ablation techniques mainly focus on anatomic, rather than patient-specific functional targets for ablation. The identification of such ablation targets remains challenging. The purpose of this study is to investigate a novel approach based on directed networks, which allow the automatic detection of important arrhythmia mechanisms, that can be convenient for guiding the ablation strategy. The networks are generated by processing unipolar electrograms (EGMs) collected by the catheters positioned at the different regions of the atria. Network vertices represent the locations of the recordings and edges are determined using cross-covariance time-delay estimation method. The algorithm identifies rotational activity, spreading from vertex to vertex creating a cycle. This work is a simulation study and it uses a highly detailed computational 3D model of human atria in which sustained rotor activation of the atria was achieved. Virtual electrodes were placed on the endocardial surface, and EGMs were calculated at each of these electrodes. The propagation of the electric wave fronts in the atrial myocardium during AF is very complex, so in order to properly capture wave propagation patterns, we split EGMs into multiple short time frames. Then, a specific network for each of these time frames was generated, and the cycles repeating in consecutive networks point us to the stable rotor's location. The respective atrial voltage map served as reference. By detecting a cycle between the same 3 nodes in 19 out of 58 networks, where 10 of these networks were in consecutive time frames, a stable rotor was successfully located.

UDK: 630*9:502.1(234.422 Vranica) Nature conservation and sustainable management of forest resources become more important in Bosnia and Herzegovina, driven by the accession process toward the European Union as well as other international processes directed toward responsible management of forest resources. The forest certification has been widely adopted in the forestry sector and it implies meeting the sustainable forest management standard, whereas identification and proper management of high conservation value forests are one of the basic requirements. The NATURA 2000 ecological network is to become an important driver of reforms in the field of nature protection and forestry sector, due to the designation of new sites in forest area, which are under the responsibility of forestry institutions. This paper illustrates the scientific understanding of identification and management processes related to high conservation value forests that were proposed within potential NATURA 2000 habitats. The paper is based on analysis of main guiding principles for site designation and the role of the cross-sectoral approach applied identification and management of sites with high conservation value attributes. The case study research design was selected focusing on the Vranica Mountain due to recent activities implemented in this site. The in-depth face-to-face interviewing was used to collect qualitative data containing the key stakeholders' attitudes regarding the harmonization of NATURA 2000 habitats with the high conservation value forests – (HCVF), as well as the involvement of stakeholders in the processes of cross-sectoral cooperation. Results of this paper can be useful for the key forest and nature protection policy-makers, as well as to those responsible for managing of protected areas, or other stakeholders directly or indirectly involved in the process of identification and management of HCVFs and NATURA 2000 sites. Harmonisation of guiding principles and cross-sectoral cooperation during the identification and management of HCVFs and NATURA 2000 forest habitats enables the proper implementation of conservation and management measures based on sustainable forest management activities.

Simple Summary The contamination of feed with mycotoxins is a global concern, resulting in adverse effects on productivity and animal health and, therefore, a great economic loss. Ochratoxin A and T-2 mycotoxins are among the mycotoxins that contaminate animal feed. These mycotoxins could adversely affect the health of broilers, and the most effective method to mitigate the toxic effects of mycotoxins is the use of detoxifying agents. In the present experiment, broiler chickens were allotted into five groups. Group 1 received a non-contaminated diet; group 2 received a non-contaminated diet + 3 g/kg of a mycotoxin binder (MMDA); group 3 received a non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin; group 4 received a non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin + 1 g/kg MMDA; and group 5 received a non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin + 3 g/kg MMDA for 35 days. The results revealed that OTA and T-2 toxin negatively affected the productive parameters and some blood and carcass characteristics of broiler chickens. The addition of the detoxifying agent (MMDA at 1 or 3 g/kg feed) to contaminated diets alleviated the adverse effects observed on productivity and the broilers heath related parameters. Abstract The present study was conducted to evaluate the efficacy of the feed additive, a novel multicomponent mycotoxin detoxifying agent (MMDA) containing modified zeolite (clinoptilolite), Bacillus subtilis, B. licheniformis, Saccharomyces cerevisiae cell walls, and silymarin, as detoxifiers of 0.5 mg/kg (0.5 ppm) ochratoxin A (OTA) and 1 mg/kg (1 ppm) T-2 toxin on broiler chickens. A total of 240 1-old broiler chickens (Ross 308) were randomly distributed into five different dietary treatments: (1) control (non-contaminated diet); (2) non contaminated diet + 3 g/kg of MMDA; (3) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin; (4) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin + 1 g/kg MMDA; and (5) non-contaminated diet + 0.5 mg/kg OTA + 1 g/kg T-2 toxin + 3 g/kg MMDA. The results showed that, in the starter period, from 1 to 10 days, the presence of OTA and T-2 mycotoxins reduced the consumption of feed and the growth of the broilers, and no effects of the detoxifying product were observed in the productivity of the chickens, at any of the doses tested, compared to the contaminated control (treatment 3). However, in the growing period, the same negative effect of mycotoxins was registered, but a recovery was observed in the consumption of feed and in the weight of the broilers that consumed 3 g/kg of the MMDA mycotoxin binder, reaching similar values to those of chickens fed uncontaminated control diets. The presence of mycotoxins in feed led to a reduction in the concentration of total proteins and albumin in blood compared to controls, and the presence of the detoxifying product partially reversed this effect. The breast yield of the chickens fed with mycotoxins was lower than that of the animals fed with the control feed and was not affected by the presence of the product tested, at 1 or 3 g/kg. The weight of the different organs (liver, gizzard, kidneys, or spleen), the intestinal pH, the histology of the small intestine, and oral lesions were not affected by the experimental treatments. In summary, the productive parameters and some blood and carcass characteristics of broiler chickens were impaired by the dietary presence of OTA and T-2 toxin. The tested product included at 1 or 3 g/kg feed in contaminated diets improved performance and seems to be effective in partly counteracting the deleterious effects of the tested mycotoxins.

Aktualna globalna pozicija Bosne i Hercegovine potvrđuje nalaz prethodnih istraživanja da u našoj državi ne postoji jedinstven ili barem harmonizovan i efikasan inovacioni sistem, primjeren potrebama razvoja društva i ekonomije znanja. Prvi koraci u utvrđivanju razloga ovakvog stanja su SWOT analize položaja i uloge inovacionog sistema u okviru opšteg strateškog planiranja i sektorskog planiranja istraživanja i transfera tehnologije. Najvažniji rezultati dobiveni iz tih matrica su diskutovani u radu. Oni su potom uspoređeni sa rezultatima naših najnovijih istraživanja. Prvi rezultat je sažeta SWOT matrica inovacionog sistema. Rezultate razrade pojedinih faktora smo prikazali u detaljnoj SWOT matrici zasnovanoj na elementima snage. I ova matrica je pokazala da je ujednačeno i stabilizirano visoko obrazovanje najvažniji element snage inovacionog sistema. Zbog toga su obilježja univerziteta kao subjekta inovacionog sistema posebno razmotrena.

UDK: 630*232:582.475(497.6) It is well known that mechanical damage to trees, caused by felling and removal of timber from the forest, has multiple negative effects on the quality of the stock and the health of the forests as well as the volume increment. In Bosnia and Herzegovina there were no significant analises of volume increment loss due to bark damage of the trees. In this paper, a direct relationship between the significant damage to the bark of the stem and the size of the volume increment of individual trees was determined. Original data recorded during the Second National Forest Inventory in Bosnia and Herzegovina (2006-2009), within the accesible high economical forests was used. These forests cover a total area of 1.329.500 ha. Data on measured trees was taken from every fourth sample plot (one from cluster). 18.546 trees were selected, on which the 10-year increment of brest diameter (DBH) was measured and significant mechanical damage was recorded (LOJO et al., 2008). Of the total number of selected trees, 2.635 or 14.21% were mechanically damaged. The results of the study showed that the volume increment of trees, with significant bark damage of all tree species and thickness, was lower from 4,9% to 19,4% in average, compared to undamaged trees. Based on registered damage the bark of the stem, during second NFI BiH and determined the average losses increment on individual trees, it was estimated how much these losses are on an annual basis in, productive high forests in Bosnia and Herzegovina. The volume increment of mechanically damaged trees is statistically significantly lower compare to the increment of undamaged trees, resulting in a total loss of about 200.000 m3 / year / 1.329.500 ha.

UDK: 630*232:582.475(497.6) Provenance experiments with forest trees provide valuable information about the growth and adaptability of population, often transferred from remote geographical regions and various climate conditions. This study researches the growth of nine provenances of silver fir from the area of its natural distribution in Bosnia and Herzegovina. The experiment was established in the year 1991 in the form of a random block system with 5 repetitions. For planting, we used five-year-old seedlings (2/3), and planting spacing was 2x2 m. Each Silver fir provenance was included with 320 plants. Measurement results in the 28th year of age show the existence of variations between silver fir provenances in characteristics; mean height, mean diameter and average tree volume. Silver fir provenance from Bosanski Petrovac showed the best results. The mean height of this Silver fir provenance at the age of 28 was 9.1 m, while the mean diameter was 11.9 cm. Provenances that show the lowest growth (8.1 m) were from Pale, Olovo-Klis and Konjic. Silver fir provenance from Konjic has the lowest mean diameter (10.7 cm). In all provenances, we have had a culmination of height increment in age between 20 and 25 years. Variation between tested silver fir provenances for examined characteristic “mean height” was larger (four groups of population) compared to examined characteristic “mean diameter” (two groups of population). Volume of mean tree (0.062m3) and assortment (111.33 m3/ha) in Bosanski Petrovac provenance was larger than spreadsheet values for the first yield class for Central Europe conditions. The trial shows that silver fir in Bosnia and Herzegovina is variable on the local level due to specific micro-habitual conditions in which it grows.

Highlights • From 42 sampling areas (municipalities) distributed throughout the country 6 193 tick samples were collected from the ixoidae family.• I.ricinus was the most common tick species found, however with decreasing contribution to overall tick population compared to earlier studies.• Dermacentor marginatus as second most common species found had doubled its presence compared to earlier studies.• Changes is tick species distribution were discussed in light of increase of average annual temperature and rainfall, changes of land management and land use.

Introduction: Having in mind the importance of providing continuous pediatric dental services during the COVID-19 pandemic and the fact that children have similar viral loads to adults, the potential to spread the virus to others, and with variable clinical presentation of COVID-19 infection, this study aimed to analyze the impact of COVID-19 outbreak on pediatric dentistry service provision, risks, and preventive measures before and during dental treatment. Method: Structured and closed epidemiological cross-sectional survey involved seven Southeastern European countries. The questionnaire was developed using the modified Delphi method, pretested, and tested in North Italy during April 2020. The sample consisted of licensed dental professionals reached via national dental chambers and social media using the best strategies according to the national setting. Results: A total of 3227 dentists participated in the survey, and we included 643 specialists in this study—among them, 164 were pediatric dentists. Most pediatric dentists worked in the public sector (61.0%) and provided emergency (64.6%) and routine dental treatment (18.3%) during the outbreak. One-third of pediatric dentists were COVID-19 tested, statistically significantly more than other specialties, and 3.0% tested COVID-19 positive. In addition, significantly more pediatric dentists (13.4%) reported the presence of at least one symptom related to COVID-19 compared to other specialists (6.1%). None of the pediatric dentists reported PPE shortage. However, 26.2% of all specialists stated that they lacked clear step by step professional guidance in a national language. Similarly, in both groups, around 10% of specialists attended education on coronavirus. Conclusions: Considering that most pediatric dentists provided dental treatment during lockdown in their countries in public health centers and that they will continue to work during pandemic, our results suggest that pediatric dentists might be at higher risk of COVID-19 infection. Further research should focus on finding better ways to promote and adapt preventive, protective measures and PPE in the pediatric dental setting to be behaviorally acceptable. Moreover, additional efforts should be invested in dental education regarding COVID-19 in the mother tongue.

Flotation collector O-isopropyl N-ethylthionocarbamate (IPETC) is widely used for separation of sulfide ores. Its removal from water by several oxidation processes was studied. Photocatalytic oxidation with air in the presence of iron salts, utilizing solar irradiation or artificial UV-A light is very efficient. Oxidation leads through the formation of O-isopropyl N-ethylcarbamate and several other reaction intermediates to total decomposition of organic compound in the final stage in 1 day. Similar results were obtained with a Fenton type oxidation with hydrogen peroxide and iron salts. Treatment with sodium hypochlorite yields mainly O-isopropyl N-ethylcarbamate. The formation of this compound in wastewaters can be of concern, since simple alkyl carbamates are cancer suspect agents.

Introduction : The value of intravenous thrombolysis (IVT) in patients eligible for mechanical thrombectomy (MT) remains unclear. We hypothesized that pre‐treatment with and/or ongoing IVT may facilitate reperfusion of distal vessel occlusion after incomplete MT. We evaluated this potential association using follow‐up perfusion imaging. Methods : Retrospective observational analysis of our institution`s stroke registry included patients with incomplete reperfusion after MT, admitted between February 1, 2015 and December 8, 2020. Delayed reperfusion (DR) was defined as the absence of a persistent perfusion deficit on contrast‐enhanced perfusion imaging ⁓24h±12h after the intervention. The association between baseline parameters and the occurrence of DR was evaluated using a logistic regression analyses. To account for possible time‐dependent associations of IVT with DR, additional stratification sets were made based on different time windows between IVT start time and final angiography runs. Results : Among the 378 included patients (median age 73.5, 50.8% female), DR occurred in 226 (59.8%). Atrial fibrillation (aOR 2.53 [95% CI 1.34 ‐ 4.90]), eTICI score (aOR 3.79 [95% CI 2.71 ‐ 5.48] per TICI grade increase), and intervention‐to‐follow‐up time (aOR 1.08 [95% CI 1.04 ‐ 1.13] per hour delay) were associated with DR. Dichotomized IVT strata showed no association with DR (aOR 0.75 [95% CI 0.42 ‐ 1.33]), whereas shorter intervals between IVT start and end of the procedure showed a borderline significant association with DR (OR 2.24 [95% CI 0.98 ‐ 5.43, and OR 2.07 [95% 1.06 – 4.31], for 80 and 100 minutes respectively). Patients with DR had higher rates of functional independence (modified Rankin scale 0–2 at 90 days, DR: 63.3% vs PPD: 38.8%; p<0.01) and longer survival time (at 3 years, DR: 69.2% vs PPD: 45.8%; p = 0.001). Conclusions : There is weak evidence that IVT may favor DR after incomplete MT if the time interval between IVT administration and end of the procedure is short. In general, perfusion follow‐up imaging may constitute a suitable surrogate parameter for evaluating medical rescue strategies after incomplete MT, because a considerable proportion of patients do not experience DR, and there seems to be a close correlation with clinical outcomes.

The construction of smooth interpolation trajectories in different non-Euclidean spaces finds application in robotics, computer graphics, and many other engineering fields. This paper proposes a method for generating interpolation trajectories on the special orthogonal group SO(3), called the rotation group. Our method is based on a high-dimensional generalization of the Kuramoto model which is a well-known mathematical description of self-organization in large populations of coupled oscillators. We present the method through several simulations and visualize each simulation as trajectories on unit spheres S2. In addition, we applied our method to the specific problem of object rotation interpolation.

The primary function of the university, in addition to education, is scientific research. At Bosnia and Herzegovina universities, the scientific research has been neglected. There are two basic reasons for that. The first is insufficient financial investment in science and research, and the second is an underdeveloped awareness of the importance of scientific research work, both in the society of Bosnia and Herzegovina and in universities themselves. This paper indicates what needs to be done to overcome this latter difficulty. In addition, the possibilities for improving science and shaping the science system at universities in Bosnia and Herzegovina to make them research universities were analysed. Scientific research work builds on research and development work, technological development, cooperation with the economy and the development of science and technology parks. These activities are even less represented at universities in Bosnia and Herzegovina than scientific research work. This paper shows the ways how to overcome these difficulties, so that research universities become carriers of the technological development of Bosnia and Herzegovina.