This work demonstrates the design, implementation, and experimental results of a low-cost disposable flexible sensor system capable of both impact localization and measurement. The proposed flexible sensor structure utilizes a special series of Bristol paper as the main fabrication material, which is coated with electric paint graphite paste and silver paste. The implemented sensor system uses a planar absolute encoder-like sensing topology to locate the impact and has a low-cost and quick manufacturing process. The size of the structure is <inline-formula> <tex-math notation="LaTeX">${210}\times {18}.{56}$ </tex-math></inline-formula> mm with a thickness of approximately 340 <inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula>. It has an electronic read-out consisting of three identical Wheatstone bridge circuits and instrumentation amplifiers for each bit. It can detect the external forces in the range of 0.6N to 12N with a spatial resolution of 2.4 cm and 0.55 cm in horizontal and vertical axes, respectively. The proposed sensor structure is tested in a series of experiments using a robotic setup consisted of a pantograph mechanism and a direct drive linear motor. The experiments illustrate the results with measurement sensitivity as small as 1N and proper fatigue resilience against repetitive loads.

To achieve the highest possible agricultural production, it is necessary to procure the appropriate agricultural machinery. A tractor is the most useful machine in agriculture that performs various functions. Therefore, the selection of a tractor is one of the key decisions in the agriculture-production process. This study aims to evaluate heavy tractors for agricultural production in Bosnia and Herzegovina. Since this is a selection between different tractors, which are evaluated using several criteria, the methods of multi-criteria analysis (MCDA) were used in this study. Five different methods were used to determine the weight of the criteria, of which a modified standard-deviation method is a new method used in practice, while the tractor ranking was performed using the CRADIS (compromise ranking of alternatives from distance to ideal solution) method. The results showed that the best-ranked tractor is A4, while the most deviations from the ranking occur when the entropy method is used. The contribution of this study is in the systematization of the methods for the objective determination of the criteria weights and the development of new methods to facilitate decision-making in agriculture and other industries.

Purpose Treatment of distal vessel occlusions causing incomplete reperfusion after mechanical thrombectomy (MT) is debated. We hypothesized that pretreatment with intravenous thrombolysis (IVT) may facilitate delayed reperfusion (DR) of residual vessel occlusions causing incomplete reperfusion after MT. Methods Retrospective analysis of patients with incomplete reperfusion after MT, defined as extended thrombolysis in cerebral infarction (eTICI) 2a–2c, and available perfusion follow-up imaging at 24 ± 12 h after MT. DR was defined as absence of any perfusion deficit on time-sensitive perfusion maps, indicating the absence of any residual occlusion. The association of IVT with the occurrence of DR was evaluated using a logistic regression analysis adjusted for confounders. Sensitivity analyses based on IVT timing (time between IVT start and the occurrence incomplete reperfusion following MT) were performed. Results In 368 included patients (median age 73.7 years, 51.1% female), DR occurred in 225 (61.1%). Atrial fibrillation, higher eTICI grade, better collateral status and longer intervention-to-follow-up time were all associated with DR. IVT did not show an association with the occurrence of DR (aOR 0.80, 95% CI 0.44–1.46, even in time-sensitive strata, aOR 2.28 [95% CI 0.65–9.23] and aOR 1.53 [95% CI 0.52–4.73] for IVT to incomplete reperfusion following MT timing <80 and <100 min, respectively). Conclusion A DR occurred in 60% of patients with incomplete MT at ~24 h and did not seem to occur more often in patients receiving pretreatment IVT. Further research on potential associations of IVT and DR after MT is required.

Cilj ovog rada bio je ispitati utjecaj termičke obrade kuhanjem na sadržaj željeza (Fe), cinka (Zn), bakra (Cu) i magnezija (Mg) u mišićnom tkivu i jetri junadi u ovisnosti od sustava tova iz kojeg životinje potječu. Istraživanje je provedeno na uzorcima mišićnog tkiva (but i plećka) i jetre junadi u dobi od 9 do 12 mjeseci koja su tovljena ekstenzivno (n=12) ili intenzivno (n=12). Svaki uzorak je podijeljen na dva jednaka dijela od kojih je jedan analiziran u sirovom stanju, a drugi nakon termičke obrade kuhanjem u vodi na 100°C. Rezultati su iskazani u apsolutno suhoj tvari mesa. Sadržaj pepela (mineralnog ostataka) u termički obrađenim uzorcima bio je smanjen u odnosu na sirove uzorke, ali to nije bilo praćeno značajmeso junadi, termička obrada, minerali nim promjenama u sadržaju Fe, Zn i Cu u mišićnom tkivu, niti promjenama Zn i Cu u jetri. Termička obrada dovela je do smanjenja sadržaja Mg u svim ispitivanim partijama mesa (za 40-50%), a do smanjenja sadržaja Fe došlo je samo u jetri (za 25-42 %). Učinak termičke obrade na sadržaj ispitivanih minerala u mišićnom tkivu i jetri bio je neovisan od sustava tova, iako su razlike po sustavu tova bile evidentne kod svih ispitivanih minerala, osim kod Fe. Sadržaj Zn u mišićnom tkivu buta junadi iz ekstenzivnog tova bio je manji, a sadržaj Cu veći u odnosu na uzorke buta iz intenzivnog sustava tova. Suprotno od buta, u jetri je sadržaj Cu bio veći kod junadi iz intenzivnog tova. U svim ispitivanim partijama mesa iz ekstenzivnog tova sadržaj Mg je bio značajno veći nego kod junadi iz intenzivnog tova.

Neprekidni rast broja stanovnika u urbanim područjima ograničavajući je faktor u uzgoju bilja u gradskim i van gradskim područjima, a rješenje se može pronaći u urbanoj poljoprivredi. Budući da se hortiterapija veoma često provodi u urbanoj sredini logično je da predstavlja oblik urbane poljoprivrede. Pored značaja urbane poljoprivrede u radu se razmatra i nivo (udio) njene zastupljenosti. Kroz cilj rada utvrđen je i značaj hortiterapije u liječenju. Cilj rada bio je istražiti koliko su građani Mostara upoznati s urbanom poljoprivredom i hortiterapijom te dobrobitima koje ona pruža. Rezultat su pokazali da građani Mostara imaju tek dovoljna do osrednja znanja o urbanoj poljoprivredi i hortiterapiji. Mišljenja o zadovoljavajućoj zastupljenosti uzgoja poljoprivrednih kultura i ukrasnog bilja u privatnim dvorištima, gradskim zelenim površinama, gradskim vrtovima i slično propagira većina ispitanika. Najveći broj ispitanika samostalno, ali tek ponekad u okviru obiteljskih, gradskih vrtova te balkona i terasa uzgaja različite poljoprivredne kulture i ukrasno bilje. Građani se u većoj mjeri nezadovoljavaju s gospodarskom koristi od uzgoja bilja u urbanoj sredini. Rad s biljkama na njih ima pozitivne zdravstveno-psihičke uticaje u zadovoljavajućoj mjeri. Također, više od polovine ispitanika posjeduje stav kako urbana poljoprivreda ipak pozitivno utiče na poboljšanje društvenih odnosa u Mostaru. Većina ispitanika uzgaja bilje po ekološkim principima u zadovoljavajućoj mjeri. Razvojem urbane poljoprivrede i hortiterapije poboljšava se zdravstveno-psihičko stanje pojedinaca te se unapređuje gospodarsko stanje, društveni odnosi, okoliš i slično.

A graph convolutional network (GCN) is employed in the deep energy method (DEM) model to solve the momentum balance equation in three‐dimensional space for the deformation of linear elastic and hyperelastic materials due to its ability to handle irregular domains over the traditional DEM method based on a multilayer perceptron (MLP) network. The method's accuracy and solution time are compared to the DEM model based on a MLP network. We demonstrate that the GCN‐based model delivers similar accuracy while having a shorter run time through numerical examples. Two different spatial gradient computation techniques, one based on automatic differentiation (AD) and the other based on shape function (SF) gradients, are also accessed. We provide a simple example to demonstrate the strain localization instability associated with the AD‐based gradient computation and show that the instability exists in more general cases by four numerical examples. The SF‐based gradient computation is shown to be more robust and delivers an accurate solution even at severe deformations. Therefore, the combination of the GCN‐based DEM model and SF‐based gradient computation is potentially a promising candidate for solving problems involving severe material and geometric nonlinearities.

Corpus-based activities (CBAs) have been used in FLT in recent decades, especially in countries where educational systems are well developed. However, this is not the case in Bosnia and Herzegovina. That is why a case study was conducted in a primary school in Bosnia and Herzegovina including 48 7th grade students divided into an experimental and a control group to investigate the effect of the use of corpus-based activities on vocabulary acquisition. In both groups blended learning methods were applied due to COVID restrictions. The aim was also to determine whether the use of CBAs had any impact on the students' motivation for participating in vocabulary learning activities. The students' results achieved in the pre- and post-tests which included new vocabulary items were analyzed and compared. The students' responses in the five-point Likert scale motivation questionnaires completed prior to and after the use of CBAs were also compared and discussed. Statistical analysis of the results confirmed that there was a positive effect of the use of CBAs on vocabulary acquisition of A1 – A2 level seventh graders, as well as on their motivation for participating in such activities. Contrary to statistically significant improvement in vocabulary acquisition, there is no statistically significant increase in the motivation to learn new vocabulary items in either of the groups, for which some possible explanations are also discussed in the paper.  Article visualizations:

Body mass index (BMI) and body image (BI) are constructs worth examining in the context of physical activity (PA), and they are both related to quality of life (QoL). PA, BMI, and BI should all be considered as associated parameters, and their effect on QoL should be examined and understood. This study aimed to determine the moderating role of PA in the relationship of BMI and BI with QoL. The sample of examinees consisted of 500 respondents (307 women; aged 39 ± 6 years). A physical activity self-evaluation questionnaire (IPAQ-SF) was used to estimate PA; BI was evaluated by using the Body Image Dimensional Assessment (BIDA) questionnaire, while QoL was determined with the WHOQOL-BREF questionnaire. The results showed that vigorous PA moderates the relationship between BMI and social relationships in adults (Sig. = 0.000). Walking and vigorous PA affect the relationship between BMI and environmental health (Sig. = 0.017 and Sig. = 0.049, respectively). Both walking (Sig. = 0.035) and moderate PA (Sig. = 0.032) alternate the relationships between BI and social relationships. Walking (Sig. = 0.000) and vigorous PA (Sig. = 0.016) moderate the relationship between BI and environmental health. The influence of PA on the moderation of the relationship of BMI and BI with physical and psychological health in the working population was not statistically significant.

Fatty acid hydroxylase-associated neurodegeneration (FAHN) is a rare childhood onset neurodegenerative disease caused by mutations in the FA2H gene. Patients display abnormal myelination, cerebellar atrophy and some have iron deposition in the central nervous system. Here we describe the generation of AKOSi010-A, a human induced pluripotent stem cell (hiPSC) line derived from fibroblasts of a female patient carrying the compound heterozygous p.Gly45Arg/p.His319Arg, using non-integrating Sendai virus. The generated iPSCs express pluripotency markers, can differentiate into cell types of the three germ layers and show a normal karyotype. This cell line displays a unique source to study the pathophysiology of FAHN.

ABSTRACT

On ITER, plasma start-up will be performed in limiter configuration on the inboard equatorial beryllium first wall panels (FWP). In contrast to most present tokamaks, however, this ramp-up phase will be comparatively long (∼10 s) and the use of actively cooled components means that power flux management is key if FWP lifetime is not to be compromised. Shaping of the FWPs is mandatory to ensure that leading edges do not appear between neighbouring units. For the ITER inboard panels, this has been optimized to account for the discovery in recent years on current devices of narrow scrape-off layer power flux channels for inner wall limited plasmas. However, the shaping results in power densities which are particularly sensitive to the overall ‘longwave’ (LW) alignment of the central column FWP ring with the structure of the toroidal magnetic field (TF), placing tight constraints on the target alignment. This target is currently based on a pure n = 1 LW alignment, but simulations of TF coil (TFC) locking upon energization show that, depending on the initial configuration of the gaps between the TFC inner legs, the field structure can be more complex. Although the TFC manufacture and machine assembly strategy is to make every effort possible to approach the ideal TF structure, an NMR sensor-based TF mapping diagnostic will be implemented to measure the field structure during the first plasma and engineering operation phase. An analytic framework has been developed and verified against numerical simulations to assess the capability for measurements from a set of discrete sensors located on the vacuum vessel inner column to be used to reconstruct the field structure at the FWP locations, a further ∼60 cm radially inward. In parallel with the alignment optimization and TF mapping strategies, modified ramp-up scenarios are also being designed which may be used to reduce inner wall limiter power fluxes if this proves to be necessary during operation.

Introduction In one third of all patients with epilepsy, seizure freedom is not achieved through anti-seizure medication (ASM). These patients have an increased risk of earlier death, poorer cognitive development, and reduced quality of life. Cenobamate (CNB) has recently been approved as a promising novel ASM drug for the treatment of adults with focal-onset epilepsy. However, there is little experience for its application in pediatric patients. Methods In a multicenter study we evaluated retrospectively the outcome of 16 pediatric patients treated “off label” with CNB. Results In 16 patients with a mean age of 15.38 years, CNB was started at an age of 15.05 years due to DRE. Prior to initiation of therapy, an average of 10.56 (range 3–20) ASM were prescribed. At initiation, patients were taking 2.63 (range 1–4) ASM. CNB was increased by 0.47 ± 0.27mg/kg/d every 2 weeks with a mean maximum dosage of 3.1 mg/kg/d (range 0.89–7) and total daily dose of 182.81 mg (range 50–400 mg). Seizure freedom was achieved in 31.3% and a significant seizure reduction of >50% in 37.5%. Adverse events occurred in 10 patients with fatigue/somnolence as the most common. CNB is taken with high adherence in all but three patients with a median follow-up of 168.5 days Conclusion Cenobamate is an effective ASM for pediatric patients suffering from drug-resistant epilepsy. In addition to excellent seizure reduction or freedom, it is well-tolerated. Cenobamate should be considered as a novel treatment for DRE in pediatric patients.