Traditional pear cultivars are increasingly in demand by consumers because of their excellent taste, the possibility of use in sustainable food production systems, convenience as raw materials for obtaining products of high nutritional quality, and perceived health benefits. In this study, individual sugars, organic acids, and polyphenols in the fruits of nine traditional and one commercial pear cultivar during two growing seasons were determined by HPLC. A significant influence of cultivars, growing years, and their interaction on the content of analyzed primary and secondary metabolites was determined. The commercial pear cultivar ‘Président Drouard’ and traditional cultivars ‘Dolokrahan’, ‘Budaljača’, and ‘Krakača’ had a lower content of all analyzed sugars. Overall, traditional pear cultivars had higher total polyphenols in the peel and pulp than ‘Président Drouard’, with the exception ‘Takiša’ and ‘Ahmetova’. High polyphenol content detected in ‘Budaljača’, ‘Dolokrahan’, and ‘Krakača’ shows the utilization value of traditional pear germplasm. The obtained data can serve as practical supporting data for the use of traditional pears in the neutraceutical, pharmaceutical, and food industries.

Contouring, planning and dose calculation in treatment planning systems (TPS) are based on computedtomography (CT) images. Therefore, it is important to have developed, optimized and adapted scanning protocolsfor specific anatomic regions and special radiotherapy modalities such as stereotactic radiosurgery (SRS). The aimof this study was to determine influence of tube voltage, field of view size (FOV) and reconstruction kernels on CTnumbers and the resulting radiotherapy (RT) dose calculation.This study was performed at Clinic of Oncology, Clinical Center University of Sarajevo. Verification electrondensity and CT number values was performed using CIRS Thorax 002LFC phantom, while anthropomorphic CIRS038 phantom for stereotactic end-to-end verification was used for the purpose of dose plan calculation analysis withlarge bore CT simulator Canon Aquillion LB.The significant correlation between the tube voltage and the measuredvalues of CT numbers is significant for all materials (p < 0.05), except for water (p = 0.310). No significantcorrelation between FOV and obtained values of CT numbers was found in any of the evaluated tissue equivalentmaterials. Evaluating the impact of reconstruction kernels on Hounsfield units (HU), significant deviations werefound for the FC62, FC68 and FC07 reconstruction kernels. Also, analyzing the influence of reconstruction kernelson the RT dose calculation, the extreme values are associated with Dmin/D in PTV for kernels FC41 and FC68, wheredeviations from the values obtained using the baseline scanning parameters were -1.3% and -1.9%. For deviation of1 HU in muscle tissue of CIRS 002LFC, the calculated Dmin/D in PTV of CIRS STEEV phantom will reduce by0.79%. Similarly, the reduction of D₉₈ and D₂ would be 6.8 cGy and 3.03 cGy for 1 HU, respectively. Change of thereconstruction kernels caused differences of 0.4% in Dmin/D calculation in clinical target volume (CTV).CT scanning and reconstruction parameters may affect Hounsfield units, which could have an impact on dosecalculations in RT plan. Hence, it is recommended to standardize the scanning protocol used in calibration curvegeneration for TPS. One should avoid use of different tube voltages and kernels, while according to this study, thechange of FOV will have no impact on dose calculations

Cellular death, aging, and tissue damage trigger inflammation that leads to enzymatic and non-enzymatic lipid peroxidation of polyunsaturated fatty acids present on cellular membranes and lipoproteins. This results in the generation of highly reactive degradation products, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), that covalently modify free amino groups of proteins and lipids in their vicinity. These newly generated neoepitopes represent a unique set of damage-associated molecular patterns (DAMPs) associated with oxidative stress termed oxidation-specific epitopes (OSEs). OSEs are enriched on oxidized lipoproteins, microvesicles, and dying cells, and can trigger sterile inflammation. Therefore, prompt recognition and removal of OSEs is required to maintain the homeostatic balance. This is partially achieved by various humoral components of the innate immune system, such as natural IgM antibodies, pentraxins and complement components that not only bind OSEs but in some cases modulate their pro-inflammatory potential. Natural IgM antibodies are potent complement activators, and 30% of them recognize OSEs such as oxidized phosphocholine (OxPC-), 4-HNE-, and MDA-epitopes. Furthermore, OxPC-epitopes can bind the complement-activating pentraxin C-reactive protein, while MDA-epitopes are bound by C1q, C3a, complement factor H (CFH), and complement factor H-related proteins 1, 3, 5 (FHR-1, FHR-3, FHR-5). In addition, CFH and FHR-3 are recruited to 2-(ω-carboxyethyl)pyrrole (CEP), and full-length CFH also possesses the ability to attenuate 4-HNE-induced oxidative stress. Consequently, alterations in the innate humoral defense against OSEs predispose to the development of diseases associated with oxidative stress, as shown for the prototypical OSE, MDA-epitopes. In this mini-review, we focus on the mechanisms of the accumulation of OSEs, the pathophysiological consequences, and the interactions between different OSEs and complement components. Additionally, we will discuss the clinical potential of genetic variants in OSE-recognizing complement proteins – the OSE complotype - in the risk estimation of diseases associated with oxidative stress.

Over the past decades, recognised importance of prompt and valid pain recognition and quantification in veterinary medicine significantly increased interest in investigating attitudes and self-rated abilities of veterinarians towards pain assessment. However, giving that the owners are the ones who decide when to call the veterinarian, it is also essential to investigate their attitudes and knowledge regarding pain recognition and management. This is the first research investigating horse owners’ attitudes and self-rated abilities towards pain assessment and management in Bosnia and Herzegovina. The participants were invited via email or social media with attached link to online questionnaire created using the Google Forms platform. Surveyed population included adult sport or pleasure horse owners, and horse caretakers in Bosnia and Herzegovina. Study response rate was 33.33% (40 respondents). The questionnaire consisted of sections asking about respondents’ demographic data, general pain assessment and management, and attitudes towards pain assessment done by veterinarians compared with theirs. Study respondents considered their abilities for pain recognition and quantification as sufficient and sufficient/moderate, even though most of them were unfamiliar with pain scales, and only negligible number use them. This study indicates the need and importance of owners' education concerning pain recognition and quantification in horses, and their more effective communication with veterinarians.

Duhan je biljna kultura koja se ističe brzinom i količinom apsorpcije teških metala iz tla, a naročito kadmija. Konzumiranjem duhana, teški metali se akumuliraju u organizmu ljudi, bez mogućnosti da se iz njega odstrane na bilo koji način, za razliku od nekih drugih biljnih kultura (npr. rajčica) kod kojih se ti metali mogu odstraniti iz organizma putem probavnog trakta. Autohtone hercegovačke sorte duhana (Ravnjak, VH i VH32) dugo su bile tretirane kao jedne od najkvalitetnijih, a za čiji rast i razvoj su potrebni specifični agroekološki uvjeti koji su karakteristični isključivo za Hercegovinu. U ovom istraživanju se prati translokacija Cd u sustavu tlo-duhan-dimni kondenzat kod duhana koji se danas uzgajaju na području BiH. Kako ovakvo ili slično istraživanje nije nikada prije rađeno na hercegovačkim duhanima, to su dobiveni rezultati uspoređivani s rezultatima dobivenim kod sorti Virdžinija i Berlej, koje su također bile predmetom istraživanja, a za koje postoje i literaturni podaci uzeti iz predhodnih svjetskih istraživanja. Uzorci tla i duhana uzeti su s 16 lokacija s područja cijele BiH, tj. sa svih lokaliteta na kojima se danas uzgaja duhan u BiH. Od najkvalitetnijih srednjih insercija, ručno su pravljene cigarete koje su kasnije popušene na pušačkom stroju. Na sadržaj Cd ispitivani su uzorci tla, duhana i dimnog kondenzata, a iz statističke analize dobivenih rezultata, može se zaključiti da postoji značajno kretanje kadmija iz tla preko biljke u dimni kondenzat.

Thermal transport properties of solid Bi-Cu alloys have been investigated over a wide composition range and temperature range ranging from 25 to 250 °C. The flash method was used to determine thermal diffusivity. Thermal diffusivity was discovered to decrease continuously with increasing temperature and bismuth content. The indirect Archimedean method was used to determine the density of the Bi-Cu alloys at 25 °C. The obtained results show that the density of the studied alloys decreases slightly as the copper content increases. Thermal conductivity of the alloys was calculated using measured diffusivity, density, and a calculated specific heat capacity. The thermal conductivity of the studied Bi-Cu alloys decreases with increasing temperature and bismuth content, similar to thermal diffusivity. SEM with energy dispersive X-ray spectrometry (EDS) and differential scanning calorimetry (DSC) were used to examine the microstructure and melting behavior of Bi-Cu alloys, respectively. The eutectic temperature was measured to be 269.9±0.1 °C, and the measured phase transition temperatures and heat effects were compared to thermodynamic calculations using the CALPHAD method.

Writing is an integral part of linguistic education of deaf persons which, due to the lack of auditorysensors, has an insurmountable difficulty achieving, so this shortcoming is directly reflected in the general literacyof deaf children. Many detailed studies in the world suggest that in order to become literate, a deaf child must learnthe language of the community. Je/she must first learn the letters and learn to write. About 50% of young deafpeople after high school read and write worse than a ten-year-old hearing child. The aim of this research is toexamine the usage, reading, writing, and comprehension in deaf children of the adverbial clause of place in writtenform and to determine the statistical significance of differences between deaf and hearing children. The study wasconducted on a sample of 140 respondents. The first subsample of subjects, the experimental group consisted of 70deaf students, and the second subsample, a control group of 70 hearing students, of the same chronological age. Themeasurement instrument “Test of writing, and comprehension of an adverbial clause of place” was applied. Thefrequencies and percentages of respondents' responses to the variables were calculated. The F (Fisher) test was usedto determine the statistical significance of the differences between deaf and hearing subjects. The results showed that1.40 % of deaf children are completely successful in reading and writing priloske odredbe, and thaat 90 % of deafchildren use prislocke odredbe partially successfully. The percentage of children that do not use priloske odredbe inany form in their written communication is 8.60%. The order of use of adverbial clause of place by frequency is asfollows: "in", "on", "below", "behind", "next to", and "between". The largest number of deaf children use theadverbial clause of place "in" in their written expression, 65.70% of them. Then, the adverbial clause of place "on"51.14%, the adverbial clause of place "below" 47.14%, the adverbial clause of place "behind" 31.43%, the adverbialclause of place "beside" 30%, and the adverbial clause of place "between" 22.85%.There is a statistically significant difference between deaf and hearing children in the use of the adverbial clause ofplace at the level of statistical significance of p=0.000.

Celiac disease is a chronic gastroenterological disease, and a lifelong gluten-free diet is a needed andnecessary therapy, which implies the exclusion of products containing gluten from the diet. The declaration ofgluten-free products is often unclear and ambiguous. The purpose of this paper was to examine celiac diseasepatients' attitudes and experiences with gluten-free diet declarations. 95 respondents from the area of HNŽ with adiagnosis of celiac disease were included in this quantitative research. The anonymous survey was conducted usingthe Google Forms tool. An anonymous survey examined sociodemographic data (age, gender, education, duration ofillness), experiences and attitudes with declarations about gluten-free diet. In this research, more than half of therespondents are extremely careful about what they consume, without exception. Participants who have beendiagnosed with celiac disease for a longer period of time completely disagree to a greater extent that they do notknow what products they can consume. Individuals with gluten sensitivity may rely more on the 'gluten-free' claimfor information about the gluten content of a product. Individuals with celiac disease, on the other hand, may bemore experienced readers of food labels and may rely more on the ingredient list. Consumer expectations havedriven the food industry to continuously adapt and improve the formulations and processing techniques used in theproduction of gluten-free products.

Radiology is integral to cancer care. Compared to molecular assays, imaging has its advantages. Imaging as a noninvasive tool can assess the entirety of tumor unbiased by sampling error and is routinely acquired at multiple time points in oncological practice. Imaging data can be digitally post-processed for quantitative assessment. The ever-increasing application of Artificial intelligence (AI) to clinical imaging is challenging radiology to become a discipline with competence in data science, which plays an important role in modern oncology. Beyond streamlining certain clinical tasks, the power of AI lies in its ability to reveal previously undetected or even imperceptible radiographic patterns that may be difficult to ascertain by the human sensory system. Here, we provide a narrative review of the emerging AI applications relevant to the oncological imaging spectrum and elaborate on emerging paradigms and opportunities. We envision that these technical advances will change radiology in the coming years, leading to the optimization of imaging acquisition and discovery of clinically relevant biomarkers for cancer diagnosis, staging, and treatment monitoring. Together, they pave the road for future clinical translation in precision oncology.

The Weibull distribution, with shape parameter $k>0$ and scale parameter $\lambda>0$, is one of the most popular parametric distributions in survival analysis with complete or censored data. Although inference of the parameters of the Weibull distribution is commonly done through maximum likelihood, it is well established that the maximum likelihood estimate of the shape parameter is inadequate due to the associated large bias when the sample size is small or the proportion of censored data is large. This manuscript demonstrates how the Bayesian information-theoretic minimum message length principle coupled with a suitable choice of weakly informative prior distributions, can be used to infer Weibull distribution parameters given complete data or data with type I censoring. Empirical experiments show that the proposed minimum message length estimate of the shape parameter is superior to the maximum likelihood estimate and appears superior to other recently proposed modified maximum likelihood estimates in terms of Kullback-Leibler risk. Lastly, we derive an extension of the proposed method to data with type II censoring.

In this short note, we derive a new bias adjusted maximum likelihood estimate for the shape parameter of the Weibull distribution with complete data and type I censored data. The proposed estimate of the shape parameter is significantly less biased and more efficient than the corresponding maximum likelihood estimate, while being simple to compute using existing maximum likelihood software procedures.

The aim of this manuscript is to introduce the Bayesian minimum message length principle of inductive inference to a general statistical audience that may not be familiar with information theoretic statistics. We describe two key minimum message length inference approaches and demonstrate how the principle can be used to develop a new Bayesian alternative to the frequentist $t$-test as well as new approaches to hypothesis testing for the correlation coefficient. Lastly, we compare the minimum message length approach to the closely related minimum description length principle and discuss similarities and differences between both approaches to inference.