The 5th edition of the World Health Organisation Blue Book was published recently and includes a comprehensive update on testicular tumours. This builds upon the work of the 4th edition, retaining its structure and main nomenclature, including the use of the term ‘germ cell neoplasia in situ’ (GCNIS) for the pre‐invasive lesion of most germ cell tumours and division from those not derived from GCNIS. While there have been important developments in understanding the molecular underpinnings of testicular cancer, this updated classification paradigm and approach remains rooted in morphology. Nomenclature changes include replacement of the term ‘primitive neuroectodermal tumour’ by ‘embryonic neuroectodermal tumour’ based on the non‐specificity of the former term and to separate these tumours clearly from Ewing sarcoma. Seminoma is placed in a germinoma family of tumours emphasising relation to those tumours at other sites. Criteria for the diagnosis of ‘teratoma with somatic transformation’ have been modified to not include variable field size assessments. The word ‘carcinoid’ has been changed to ‘neuroendocrine tumour’, with most examples in the testis now classified as ‘prepubertal type testicular neuroendocrine tumour’. For sex cord‐stromal tumours, the use of mitotic counts per high‐power field has been changed to per mm2 for malignancy assessments, and the new entities, ‘signet ring stromal tumour’ and ‘myoid gonadal stromal tumour’, are defined. Well‐differentiated papillary mesothelial tumour has now been defined as tumour type with a favourable prognosis. Sertoliform cystadenoma has been removed as an entity from testicular adnexal tumours and placed with Sertoli cell tumours.
The Cooperative Intelligent Transportation System (C-ITS) testbed or simplified called the Smart Highway (Antwerp, Belgium) is designed to facilitate research in the area of distributed/edge computing and vehicular communications. The Smart Highway testbed deploys the Cooperative Awareness Basic Service to exchange Cooperative Awareness Messages (CAMs) between road C-ITS entities, e.g., C-ITS vehicles and Road-Side Units (RSUs). CAMs support vehicular safety and traffic efficiency applications by providing them with the continuous status information of relevant C-ITS entities. Therefore, it is important that those messages are delivered with low latency, especially the CAMs that originate from special vehicles, e.g., emergency vehicles, police cars, and fire trucks. In this paper, we research the impact of CAM messages configuration on the communication latency among vehicles. Moreover, we have performed the practical experimentation to evaluate the aforementioned impact, using ITSG5 and LTE-V2X system under realistic vehicular conditions, on the Smart Highway testbed located in Antwerp.
Along with an increased interest for connected vehicles and autonomous driving, the Cooperative Intelligent Transportation Systems (C-ITS) are being investigated and validated through the use of C-ITS messages, such as Cooperative Awareness Messages (CAMs). In this paper we demonstrate a tool to support research on CAMs, since C-ITS deploy the Cooperative Awareness Basic Service to exchange CAMs among road C-ITS entities, e.g., vehicles and roadside units (RSUs). These messages provide awareness of traffic information in the Non-line-of-sight (NLOS) of the vehicle (e.g., speed, location, heading), and are an enabler of improving safety in vehicles. Therefore, it is important that those messages are received at the receiving C-ITS vehicle with low latency. In this demo, we showcase how the size of a particular CAM that carries information about the vehicle and surrounding infrastructure affects the latency. In order to demonstrate this effect, we use two leading technologies that support the first generation V2X communication respectively ITS-G5 (IEEE 802.11p) and LTE-V2X (3GGP). We have tested our proposal in a real life C-ITS testbed, at the Smart Highway located in Antwerp, Belgium.
The paper presents a new approach to the treatment of uncertainty and subjectivity in the decision-making process based on the modification of Multi-Attributive Border Approximation area Comparison (MABAC) and an Objective–Subjective (OS) model by applying Linguistic Neutrosophic Numbers (LNN) instead of traditional numerical values. By integrating these models with LNN it was shown that it is possible to a significant extent to eliminate subjective qualitative assessments and assumptions by decision makers in complex decision-making conditions. On this basis, a new hybrid LNN–OS–MABAC model was formed. This model was tested and validated on a case-study in which the optimal unmanned aircraft were selected to combat forest fires. After defining the criteria and their attributes, they were prioritized using the LNN–OS model, in which the weights of the criteria and their attributes are a combination of the objective values obtained by the method of maximum deviation and the subjective values of the criteria obtained by expert examination using LNN. The ranking and selection of the optimal unmanned aircraft from those on offer with similar characteristics was carried out using the LNN–MABAC model. Testing of the model showed that the proposed model based on LNN provides an objective expert evaluation by eliminating subjective assessments when determining the numerical values of criteria. A sensitivity analysis of the LNN–OS–MABAC model, carried out through 54 scenarios of changes in the weight coefficients, showed a high degree of stability in the solutions obtained when the alternatives were ranked. The results were validated by comparison with LNN extensions of the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) model.
In this original scientific paper, the content of crude fiber and total sugars in three different fruit products (cherry compote, rosehip marmalade and plum jam) in correlation with the production process and storage time was examined. All tests were conducted in the Laboratory of Food Technology, Faculty of Technology, University of Tuzla. The test results showed that in all fruit products a higher content of non-reducing sugars than reducing and sucrose was recorded. Also, the highest content of crude fiber was obtained in the S5 sample for rosehip marmalade and was 1.11%, while the lowest was recorded in the S1 sample for cherry compote and was 0.011%.
Digital transformation is unstoppable and ongoing process that affects all segments of our everyday lives such as healthcare, banking and finance systems, public administration, or postal and logistics systems. One of the main engines of this process, among many, is the use of cryptocurrencies. Both of these concepts are usually addressed from the firm perspective, but they should be considered from the individual’s perspective as well. Cryptocurrencies recently face increased cyber security threats, thereby affecting the digital transformation and posing additional challenges to it. Therefore, this paper gives a brief overview of security threats and challenges characteristic for cryptocurrency technology today and discusses what can be expected tomorrow. We provide insight how these challenges can affect digital transformation process and propose ways to increase the level of protection for both individuals and organizations.
The fifth generation of mobile telecommunications (5G) is one of the most important novelties of our times due to its influence on the economy and society. The advent of 5G networks and services expands the security threats landscape and requires the implementation of adequate countermeasures. This paper presents a brief overview of 5G security threats and countermeasures from operators’ perspective. The aim is to contribute to the 5G cybersecurity knowledge collection and dissemination by summarizing the key findings and identifying next steps.
Abstract This study explores the mechanism of influence of total quality management (TQM) practices on a company’s financial performance (FP), considering innovation performance (IP) as a mediator variable. In addition, the proposed model seeks to determine whether the competition intensity (CI) moderates the relationship between TQM practices and FP. Based on the sample of 593 companies from various sectors in Bosnia and Herzegovina, structural equation modeling is used to analyze the relationships between the variables in the model. The results of this paper reveal the implicit and often omitted impact of IP on FP taking into account TQM practices, suggesting that the impact of TQM practices is manifested through full mediation of IP. The moderating effect of CI in the relationship between TQM practices and FP was not supported. The results indicate the role and the importance of IP in the mechanism of influence of TQM practices.
Brucellosis is one of the most common zoonotic diseases worldwide that is endemic to Bosnia and Herzegovina (B&H) and remains an emerging public and animal health concern in this country. Diagnostic testing of brucellosis in ruminants in B&H relies exclusively on serological methods. The present study was conducted to determine the presence of Brucella spp. in clinical samples of seropositive ruminants by Real-time PCR assay. Of the 135 samples tested, 37% were positive by Real-time PCR. The frequency of detection of Brucella-DNA in the samples collected from aborted animals (n = 20/20; 100%) was significantly higher (P < 0.00001) when compared to asymptomatic animals (n = 30/115; 26%). Among asymptomatic animals, 31.1% of cattle were positive for Brucella-DNA, followed by sheep (23.4%) and goats (16.6%). The results of this research underline the limitations of the current control policy and indicate the need for additional diagnostic methods required for more effective brucellosis control program.
A UAV (Unmanned Aerial Vehicle) is an unmanned aerial vehicle or aircraft that can be monitored remotely or flown independently using a pre-programmed flight plan. Simply, a drone is a selfpropelled vehicle heavier than air. From their beginnings and first forms to modern drones as we know them today, people have discovered many areas for their application. As the power and carrying capacity of drones has grown, so does the possibility of using them for different purposes such as logistics and postal services. The main advantage of drones in urban areas is the independence from road infrastructure and fast delivery, but several challenges need to be addressed for this type of delivery to be competitive with other modes. Many projects have dealt with this topic, but none of them has widespread use to this day. In this paper, we will present the basic challenges that arise in the use of drones for shipment delivery. The paper will present activities that should be prioritized to make a competitive type of service. The paper will present also the advantages over other types of shipment delivery and the current limitation with a future possible research area.
Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent resistance to various environmental conditions. It is used as an ornamental plant and is recognized as a medicinal plant in both traditional and Western medicine. Its bioactive potential is associated with the presence of flavonoids and terpene trilactones, but many other compounds may also have synergistic effects. Flavonoid dimers—biflavonoids—are important constituents of ginkgophytopharmaceuticals. Currently, the presence of 13 biflavonoids has been reported in ginkgo, of which amentoflavone, bilobetin, sciadopitysin, ginkgetin and isoginkgetin are the most common. Their role in plants remains unknown, but their bioactivity and potential role in the management of human health are better investigated. In this review, we have provided an overview of the chemistry, diversity and biological factors that influence the presence of biflavonoids in ginkgo, as well as their bioactive and health-related properties. We have focused on their antioxidant, anticancer, antiviral, antibacterial, antifungal and anti-inflammatory activities as well as their potential role in the treatment of cardiovascular, metabolic and neurodegenerative diseases. We also highlighted their potential toxicity and pointed out further research directions.
Deregulation of TGF‐β family signalling underlies some serious human diseases, including cancer, the Marfan syndromes, and other connective tissue disorders. Recent work in my lab has focused on working out how mutations in key components of TGF‐β family signalling pathways cause these diseases.
Nema pronađenih rezultata, molimo da izmjenite uslove pretrage i pokušate ponovo!
Ova stranica koristi kolačiće da bi vam pružila najbolje iskustvo
Saznaj više