Endometriosis is a common gynecological hurting disorder in which tissue is similar to the tissue that normally lines the inner layer of the uterus. It often causes fertility problems. Unfortunately, effective treatments are limited. Therefore it's important to explore an imperative and easily accessible treatment to alleviate the probable pathologies and preserve fertility in endometriosis. Consequently, we aimed to investigate the effects of metformin, letrozole, and atorvastatin on inflammation and apoptosis in experimentally induced ovarian and peritoneal endometriosis in rat models. In the present study, 35 rats were randomly divided into five groups. Group 1: sham-operated control group. Group 2: untreated endometriosis group. Group 3: given 100 mg/kg/day of oral metformin. Group 4: given 0.1 mg/kg/day of oral letrozole. Group 5: given 2.5 mg/kg/day of oral atorvastatin. At the end of the 28 days, we examined Ki67, Bax and Bcl-2 immunoexpressions in ovarian and peritoneal tissues, and IL-6, IL-8, and TNF-α levels were evaluated from the peritoneal fluid. All medical treatment groups showed a significant decrease in Ki67 expression. A significant increase in Bax expression was also observed in all samples from all medical treatment groups (other than the untreated endometriosis groups). Further, a significant decrease in Bcl-2 expression was found in all medical treatment groups. IL-6, IL-8, and TNF-α levels were significantly lower in all medical treatment groups than in the endometriosis groups. In conclusion; Metformin, letrozole, and atorvastatin showed apoptosis induction and anti-inflammatory effects on both ovarian and peritoneal endometriosis in experimental models.

Genomic data leaks are irreversible. Leaked DNA cannot be changed, stays disclosed indefinitely, and affects the owner's family members as well. The recent large-scale genomic data collections [1], [2] render the traditional privacy protection mechanisms, like the Health Insurance Portability and Accountability Act (HIPAA), inadequate for protection against the novel security attacks [3]. On the other hand, data access restrictions hinder important clinical research that requires large datasets to operate [4]. These concerns can be naturally addressed by the employment of privacy-enhancing technologies, such as a secure multiparty computation (MPC) [5]–[10]. Secure MPC enables computation on data without disclosing the data itself by dividing the data and computation between multiple computing parties in a distributed manner to prevent individual computing parties from accessing raw data. MPC systems are being increasingly adopted in fields that operate on sensitive datasets [11]–[13], such as computational genomics and biomedical research [14]–[22].

All processes in the production and distribution of material goods, which include material and interactive information flows, are united by the term “Logistics” and are realized within the logistics processes. Logistics processes hide large technological and economic reserves that need to be identified, located and used. At the EU level, a new philosophy of realization of quality logistics processes has been created in the past decades, and it is increasingly including the environmental aspect by introducing the term Green Logistics, which highlights the demand for a healthy environment. The level of logistics process technology is still far below the level of development of material production technology, which is the main reason for giving strategic importance to the rationalization and optimization of logistics processes at the global level in order at reducing the costs of all participants in the implementation of the process, and especially in the direction of raising the quality of services and meeting the increasingly stringent requirements of service users.

Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) share common culprit foods and potential pathophysiological factors. However, how diet may contribute to disease course and whether this differs between both entities is unclear. We therefore investigated the association of dietary indices with intestinal inflammation and gastrointestinal symptoms in both IBD and IBS patients. Food frequency questionnaires from 238 IBD, 261 IBS and 195 healthy controls (HC) were available to calculate the overall diet quality by the Dutch Healthy Diet-Index 2015 (DHD-2015) and its inflammatory potential by the Adapted Dietary Inflammatory Index (ADII). Intestinal inflammation and symptoms were evaluated by faecal calprotectin and the Gastrointestinal Symptom Rating Scale, respectively. The DHD-2015 was lower in IBD and IBS versus HC (p < 0.001), being associated with calprotectin levels in IBD (b = −4.009, p = 0.006), and with abdominal pain (b = −0.012, p = 0.023) and reflux syndrome (b = −0.016, p = 0.004) in IBS. ADII scores were comparable between groups and were only associated with abdominal pain in IBD (b = 0.194, p = 0.004). In this side-by-side comparison, we found a lower diet quality that was differentially associated with disease characteristics in IBD versus IBS patients. Longitudinal studies are needed to further investigate the role of dietary factors in the development of flares and predominant symptoms.

Simple Summary Boar spermatozoa can be exposed to many harmful factors. The low antioxidant capacity of spermatozoa makes them susceptible to reactive oxygen species. The protection of spermatozoa from these harmful effects lies in the seminal plasma, which is enriched by antioxidant enzymes. This study aimed to measure the antioxidant status of boar seminal plasma, and to determine spermatozoa DNA status, and the total number of motile spermatozoa after the concurrent joint application in the boars’ diet of two commercial products with antioxidative potential. Abstract The study was conducted on a commercial pig farm located in Serbia. Thirty Duroc or Landrace breed boars were randomly selected for this study. The experimental group was fed a compound feed with added organic selenium and Oxynat 3D. The antioxidant status parameters of boar seminal plasma were evaluated using a biochemical analyzer and commercial Randox kits. The sperm chromatin structure assay (SCSA) using flow cytometry (FC) provided information about spermatozoa’s DNA status. Additionally, the total number of motile spermatozoa and spermatozoa kinematic parameters were measured using the computer-assisted sperm analysis (CASA) system. The aim of this study was to improve the parameters of semen by combining two preparations that have a potential antioxidant effect, but also to establish the level of various antioxidant enzymes in native sperm. There was no statistically significant difference in total antioxidant capacity and glutathione peroxidase activity in the seminal plasma obtained from the experimental and control groups of boars. Regarding the superoxide dismutase activity, the research results showed a difference in the control group compared to the experimental one. Moreover, spermatozoa DNA fragmentation and the total number of motile spermatozoa showed statistically significant lower and higher values, respectively, in experimental compared to the control groups. The combination of these two preparations shows significantly enhanced vital parameters of semen. To the best of our knowledge, this study is the first in which the ejaculate parameters were examined after the application of a combination of these two antioxidant supplements.