The purpose of this paper is to present the results of archaeological research carried out in 2022 at the site of Baričko brdo – Lug near Lukavac. Having above mentioned in mind, the methodology used during the two phases of archaeological research and the flow of work in the field is first briefly described. Next, the condition of the site prior to the fieldwork is described, followed by a description of previous archaeological research. What follows is a presentation of the results of archaeological excavations carried out during all the phases of archaeological research and geophysical surveys carried out during 2022.

Angiogenesis is the process of forming new blood capillaries from pre-existing vessels. Even though it is essential during normal development, it plays a major role in cancer progression. Neratinib is a pan-human epidermal growth factor receptor (HER) inhibitor that has recently been approved for the treatment of HER2-positive breast cancer. However, its effects on angiogenesis and embryogenesis remain unknown. This study examined the antiangiogenic effects of neratinib using the chorioallantoic membrane (CAM) of chicken embryos. We also evaluated neratinib’s toxicity during the early stages of normal development using the chicken embryos, primary embryonic fibroblasts (EFBs), and human umbilical vein endothelial cells (HUVEC). Our findings revealed that neratinib significantly inhibited the CAM angiogenesis compared to controls by reducing vessel percentage area and the average vessel length. Furthermore, neratinib downregulated vascular endothelial growth factor (VEGF), a key mediator of angiogenesis. At lower concentrations, neratinib was well-tolerated during early stages of normal development. Additionally, EFBs treated with neratinib showed no morphological or viability changes when compared to controls. However, at the highest concentration tested, neratinib treatment reduced HUVEC cell viability. This effect may be associated with the dysregulation of key apoptotic genes, including caspase-3, caspase-8, caspase-9, and the B-cell lymphoma 2 (Bcl2) gene. Our findings indicate a novel potential application of neratinib as an antiangiogenic agent, exhibiting tolerable toxicity in the early stages of embryogenesis.

Bosnia and Herzegovina (BiH), a country rich in history and culture, has for centuries been at the crossroads between the West and the East, which has resulted in quite a mixture of cross-cultural elements that pose many obstacles for translators. As the issues of tourism-language translation have been relatively underexplored in BiH, this article attempts to investigate the extent to which the translators of tourism-related content available online succeeded in making the local color of architecture-related terms accessible to foreign visitors. The article also examines whether the issue of accessibility of local color was addressed adequately by local translators. Many formal and informal online sources were used for the selection of prominent cultural terms and their English translations, which were analyzed in terms of lexis and semantics. We identified many examples where the cultural content was made accessible to the target audience, as well as examples where the transfer of the cultural content was done less successfully. In cases where translators experienced difficulty while transferring cultural terms, we attempted to draw prospective translators’ attention to potential pitfalls in the process of cultural mediation in translation from BiH’s official languages into English. Keywords: Bosnia and Herzegovina, tourism online, mediation, (in)accessibility, local color, translation, architecture

Rad na evidenciji i obradi stećaka Bosne i Hercegovine, koji se kontinuirano provodi putem usvajanja Odluka Komisije za očuvanje nacionalnih spomenika o proglašenju određenih lokaliteta nacionalnim spomenicima Bosne i Hercegovine, redovno rezultira pronalaženjem većeg broja stećaka i ukrasa zastupljenih na njima, kao i stećaka s natpisima pisanim srednjovjekovnom bosanskom epigrafskom ćirilicom. Nekropolu sa stećcima na lokalitetu Pitomi brijeg, na Morinama, u Nevesinju, pronašao je Gordan Čahtarević i evidentirao postojanje natpisa na pet stećaka, koji se u ovom radu prvi put objavljuju. Godine 2018. u mjesecu septembru i decembru izvršili smo opservaciju lokaliteta te utvrdili postojanje još dva natpisa. U ovom radu predstavljeno je dosadašnje čitanje Semoradovih natpisa s Boljuna te priređeno čitanje natpisa s lokaliteta Pitomi brijeg na Morinama u Nevesinju i lokaliteta Bojičića do na planini Crvanj u općini Kalinovik.

<p>Diabetic retinopathy (DR) is a chronic microvascular complication of diabetes. Due to the dramatic increase in the number of diabetes cases, the prevalence of DR has also risen, making it the leading cause of blindness among the working-age population worldwide, despite the availability of screenings and modern therapeutic options. Risk factors for the development and progression of DR (duration of diabetes, hypertension, hyperglycemia, dyslipidemia, and genetic factors) have been investigated in numerous epidemiological studies and clinical researches, but the research results were not consistent. In recent years, there has been considerable interest in the study of dyslipidemia in diabetes as one of the factors that could influence the onset and progression of DR, as well as apolipoproteins as potentially better biomarkers for DR. The results of our research also point in that direction. Identifying the risk factors for DR is crucial for enabling adequate prevention and raising awareness among individuals with diabetes about the importance of taking appropriate measures to prevent this microvascular complication.</p>

<p><strong>Introduction. </strong>Long-term care is series of health and social care services provided at home or in an institutional environment to people with reduced functional capacity. Even though it is known that the quality of life (QoL) of elderly is on a lower level when compared to younger people, there is a small amount of information about QoL of long-term health care patients. The aim of our study was to determine the difference in QoL, depression, anxiety and stress of longterm health care users placed in and outside the institution.</p> <p><strong>Methods.</strong> This cross-sectional study included 100 long-term healthcare users, divided in two groups. First group consisted of 50 respondents from primary level of health care and second group consisted of 50 residents of nursing home. The research was conducted in the period from June to July 2022. A general socio-demographic questionnaire, SF-36 health questionnaire for estimating the QoL and the scale of depression, anxiety and stress (DASS-21) were used as instruments in this study.</p> <p><strong>Results. </strong>Respondents who were institutionalized had significantly lower values of domains and summary scores of QoL compared to respondents whose health care took place outside of institutions, where the difference was observed in physical health summary score (37.67&plusmn;6.20% vs. 50.39&plusmn;10.74%, p&lt;0.001), and the mental health summary score (44.87&plusmn;11.82% vs. 51.83&plusmn;16.01%, p =0.015). Respondents who received long-term health care institutionally had significantly (p=0.011) more mild anxiety (12%) and moderate anxiety (34%) compared to respondents who received long-term health care outside the institution (4% vs. 14%).</p> <p><strong>Conclusion. </strong>Our results showed that residents of nursing home had significantly worse physical and mental functioning, as well as more frequent occurrence of anxiety symptoms compared to users of longterm health care placed outside institutions, in home environment.</p>

<p><strong>Introduction.</strong> Denture-induced fibrous hyperplasia (DFH) is a reactive lesion that occurs as a result of chronic trauma caused by the denture on the oral mucosa.</p> <p><strong>Case report.</strong> A female patient, 56 years old, reported to the Specialist Center for Dentistry at the Faculty of Medicine in Foča for the fabrication of complete dentures. She wore previous complete dentures for about 25 years and complained about their age and discoloration. Clinically, both dentures were poorly retained and stabilized by short wings, with pronounced signs of wear. Denture hygiene was poor. Multiple folds of hyperplasic connective tissue were observed in oral cavity upper vestibule mucosa. The lesion folds were pink and firm, corresponding to denture edges. Based on the anamnesis and clinical examination, a temporary diagnosis of denture-induced hyperplasia was made. The patient was informed about clinical condition assessment as well as possible therapeutic procedures and gave written consent to accept the offered therapeutic procedures. She was advised not to wear dentures for four weeks and to maintain proper oral hygiene. After that, the hyperplasia was surgically removed under local anesthesia. A tissue sample was sent for pathohistological analysis. A new pair of total dentures was made. Removed tissue pathohistological examination confirmed the diagnosis: &ldquo;Epulis fissuratum&rdquo;.</p> <p><strong>Conclusion.</strong> Education and regular check-ups are essential for the prevention of DFH. Patients should be given detailed oral and written instructions on oral and denture hygiene maintenance, with special reference to possible changes in oral tissues and the importance of regular follow-ups.</p>

Vines in Bosnia and Herzegovina are traditionally grown in the Herzegovina region, where, in addition to many international varieties, indigenous and domesticated varieties are also successfully grown. The most important varieties are Žilavka and Blatina, while others are found in a much smaller area. One of these is the Radovača variety, which is preserved in only one micro-locality in Herzegovina region. The paper presents the results of a two-year analysis (2017 - 2018) of the qualitative characteristics of grapes and wines of the Radovača variety. The average cluster weight ranged from 195,50 to 308,97g, and the weight of 10 berries ranged from 23,67g to 29,79g. A favorable proportion of the weight of berries in the cluster weight (96,63 - 97,86 g/100 gcluster) compared to the proportion of petioles (2,14 - 3,37 g/100 g cluster) was observed. The year had a significant impact on the observed characteristics, considering that the analyzed parameters had a slightly higher value during 2017. Oscillations in the value of TSS consequently caused oscillations in the alcohol content of the wine (13,88 - 8,19 %v/v). The values ​​of TTA in grape juice and TA of wine in the years of research were quite uniform, which may also indicate the genetic specificity of this variety in this respect. The content of phenolic compounds in grapes was also significant, especially in seeds (428,74 - 977,27 mg/kg). Regardless of the fluctuations in the years of research, the Radovača variety has a certain oenological potential, which is especially important considering that it is an indigenous grape variety.

The times of social distancing and movement restrictions caused by Covid-19 have been marked by significant changes in all aspects of life. Due to preventive pandemic measures direct access of audiences to cultural institutions was unabled and performative arts moved to an online, virtual environment physicaly distancing performers from the audience. In this paper, we discuss adaptations that took place in the domain of culture and arts offering a virtual, technologically mediated experience, deprived from some dimensions of senses, emotional engagement, interaction and communication in vivo. Our research, therefore aims to inform on audiances’ aesthetic experience which was on the one hand devoided of bodily, situated performances, or on the other hand taking place with reduced number of spectators in an open space sites during the social distancing times. Key issues we focus on are transformations of performing arts in terms of audience participation and similar kinds of modifications that were not merely an answer to a current crisis, but a shift towards the new hybrid models of digital culture overcoming classic conceptual oppositions such as real-virtual, individual-collective and mass-elite. Our insights on performative arts and new media spheres hybridisation process as well as audiences’ altered position during social distancing times are based on literature in the field of sociology of culture and arts, esthetics and mediology.

The article is devoted to the actual issues of individual labor dispute resolution. In particular, the author draws attention to the fact that in connection with the armed aggression of the Russian Federation, quite a large number of workers found themselves in a situation of forced migration, and some enterprises remained in temporarily occupied territories or faced the problem of the impossibility of relocation, which causes problems in the normal development of labor relations between the employee and the employer. An analysis of the current labor legislation and the existing approaches in the legal literature regarding the procedure for resolving individual labor disputes was carried out. The author highlighted the following reasons for labor disputes, including reduction of the main staff, changes in existing working conditions, dissatisfaction of the employee with the existing level of remuneration and others, in particular, and the martial law, which caused a number of reasons that impact on the occurrence of labor disputes - suspension of labor relations, the relocation of enterprises from the occupied territories and the impossibility of ensuring the safety of workers, downtime. These obstacles cause the problems in the relationship between the employer and the employee, resulting in the employees being forced to defend their rights. Conclusions were made by the author that, to date, the labor legislation of Ukraine ensures the implementation of the right to protect the rights of employees in individual labor relations in the pre­trial (commissions on labor disputes and through mediation) and the judicial procedure. It should be noted that an attempt was made by the legislator to regulate labor relations during the legal regime of martial law by adopting the Law of Ukraine «On the Organization of Labor Relations in the Conditions of Martial Law», but it did not define the issues related to the resolution of individual labor disputes, as well as the practice of its application provisions to date is ambiguous, which is confirmed by a number of court cases.

This study was conducted to investigate the relationship between vertical jump height and negative block performance of elite male volleyball players in the positions of spiker and middle player. Twenty-two players, 10 middle players and 12 spikers, aged 25-30 years, playing in professional volleyball league in Turkey participated in the study. During 15 training matches, vertical jump distances were recorded with VERT belt and negative block performances (-) ineffective block and (=) erroneous block percentages) were recorded with Data Volley4 software. Since the data did not show normal distribution as a result of normality analysis performed in SPSS 25 program, the relationship between the variables was determined by Spearman correlation analysis. As a result of the analysis, there was no correlation between the average jump height of the middle players and their block error percentages, while there was a strong positive significant correlation in ineffective block percentages. There was a strong positive correlation between the vertical jump height of the spikers and their ineffective block percentage, while there was a strong negative correlation in their block error percentage. As the vertical jump height of the middle players and spikers increased, ineffective block percentage increased. It can be said that as the vertical jump height of the spikers increases, the block error percentage decreases, while the vertical jump height of the middle players does not affect the block error percentage.

Osvrt na knjigu The Height of Prophet Adam: At the Crossroads of Science & Scripture Muntasira Zamana

Physical inactivity and obesity are growing concerns, negatively impacting the general population. Moderate physical activity is known to have a beneficial anti-inflammatory effect. N-glycosylation of immunoglobulin G (IgG) reflects changes in the inflammatory potential of IgG. In this study, GlycanAge index of biological age (GlycanAge), one of the first commercially used biomarkers of aging, was employed to assess effects of exercise intensity in three different groups of athletes: professional competing athletes, regularly moderate active individuals and newly involved recreational individuals, compared to the group of inactive individuals. GlycanAge was significantly lower in the active group compared to the inactive group (β = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (β = 7.546, p = 3.20E-02). Competing female athletes had significantly higher GlycanAge comparing to active females exercising moderately (β = 20.206, p.adj = 2.71E-02), while the latter had significantly lower GlycanAge when compared with the inactive counterparts (β = -9.762, p.adj = 4.68E-02). Regular, life-long moderate exercise has an anti-inflammatory effect in both female and male population, demonstrated by lower GlycanAge index, and it has great potential to mitigate growing issues related to obesity and a sedentary lifestyle, which are relentlessly increasing world-wide.

Introduction: A bone fracture is a break in the continuity of bone tissue, caused by the action of an external or internal force on the bone. Ankle sprains are one of the most common injuries among athletes. Physically active people who participate in activities that require jumping, changing direction, and turning have an increased risk of ankle sprains. Ankle sprains and the repetitive trauma often associated with this condition can lead to long-term disability, lost time from activity, and financial burdens for athletes. Methods: The work is non-experimental (qualitative research), i.e. a review of scientific literature. The search included an overview of the relevant databases: Medline, PubMed, Google Scholar, Research Gate. The literature review includes 4 randomized clinical trials and 1 randomized single-blind trial. The mentioned databases were searched with the help of keywords: athletes, injury, ankle joint, rehabilitation. Results: Through a scientific review of the literature, the results of the significance and productivity of the application of rehabilitation in athletes with an ankle injury are presented. The results include the presentation and analysis of five published scientific papers in the period 2018-2020. The studies used for this review were published in India, Saudi Arabia, Iran, United States, Austria. Conclusion: By reviewing the scientific literature, it can be concluded that there are improvements in the quality of life of athletes after an ankle injury. The greatest improvements were noted in strength, balance and functional task performance. The application of the rehabilitation program plays an important role in reducing pain and stabilizing the knee joint.

A research study was conducted on a sample of 110 male and female participants aged 11 and 12 years (±1.2 years) to compare two different methods for identifying spinal deformities. The aim was to determine which of the two methods is better and more applicable in practical school conditions. The methods compared were Napoleon Wolanski's method with 8 variables and the 3D method from Contemplas GmbH TEMPLO General Motion, assessed with a total of 11 variables. By analyzing the table of central dispersion parameters of body posture according to Napoleon Wolanski's method, the participants were classified into 5 groups based on the results. Participants with scores up to 8 points were considered to have good posture, while those with scores from 9 to 16 points were treated as having poor posture. The research revealed that a total of 66 out of 110 participants had poor posture, accounting for 60%. Results from the Contemplas method showed deviations from proper posture in almost all variables. The analysis indicated significant deviations in shoulder rotation, pelvic rotation, sagittal distances, and flexion/extension variables. Overall, the results demonstrated a high prevalence of body deformities in 11- and 12-year-old students. Analyzing the results of both methods for determining body deformities, it can be confidently stated that the frequency of body deformities in students aged 11 and 12 is significantly high. Napoleon Wolanski's method identified that 60% of participants had some form of spinal deformity, while the Contemplas method showed more pronounced results, with some variables indicating deformations in 80-85% of participants. Despite providing more detailed information about students' posture, the Contemplas method is less applicable in practical school conditions due to its significant cost. Therefore, Napoleon Wolanski's method remains indispensable in school settings.