Abstract Service Startups and Creative Communities can be seen as two sides of the same coin. They are both organizations that adopt service dominant logic to create innovative services. These service models are a double-edged sword as they can facilitate the transition towards sustainability or they can support an unjust, neoliberal ‘gig economy’ that commodifies work and further elongates social inequalities. Understanding the similarities and differences of these organizations reveals a wider issue: the conflict of values between eco-modernist and radical approaches to sustainability. Reviewing the two antithetical positions of this spectrum would allow designers to make informed design choices. Finally, such a review provides a philosophical springboard for further debates in the field of design.

Introduction:Total hip endoprosthesis is one of the most frequent and effective methods that are used in the treatment of progressive degenerative hip changes. After the implantation of total hip endoprosthesis, patients perception on their postoperative improvement and health has big role in their contentment and thus in the success of the surgical procedure. The aim of this survey is to examine whether there are differences in the quality of life of people in third age before and after the implantation of total hip endoprosthesis.Material and methods:The survey included 100 examinees in the third age, above 65 years, of both genders, with the disease of hip joint that had been treated at the Clinics for orthopaedics and traumatology of UKCS by implanting the total endoprosthesis. The examinees were questioned before the surgery and after implanting the total hip endoprosthesis. The survey has covered the period from 1st January 2014 till 31st December 2016. As an instrument tool in the survey well validated SF-36 questionnaire for the estimation of life quality and total health status was used. Results: Evaluating all the elements in SF-36 questionnaire it was determined that statistically significant improvement of all the life quality elements that this questionnaire measured was detected, after the conducted surgery compared to the state before the surgery, p=0.001. Statistically biggest improvement has been detected in limitations that happened because of physical and emotional issues, and then in those that were related to physical and social functioning (p=0.001). Body pains and vitality are also statistically significantly better after the conducted surgery (p=0.001). Conclusion:Out of the results of the survey it derives that the quality of life of the people in third age is significantly better after the surgery of implanting the total hip endoprosthesis.

BACKGROUND Prefabricated myofunctional appliances (PMAs) are widely advocated for correcting Class II division I malocclusion. However, their effectiveness is associated with a high amount of uncertainty within contemporary literature. OBJECTIVES The aim of this review was to systematically examine the available literature regarding the effectiveness of PMAs in treating Class II division 1 malocclusion in children and adolescents. SEARCH METHODS Comprehensive unrestricted electronic searches in multiple databases as well as manual searches were conducted up to August 2018. SELECTION CRITERIA Randomized controlled trials (RCTs) and non-randomized studies (NRS) matching the eligibility criteria. DATA COLLECTION AND ANALYSIS Two independent review authors were directly involved in study selection, data extraction, and bias assessment. The Cochrane risk of bias tool and the ROBINS-I tool were used for assessing the risk of bias. Quantitative pooling of the data was undertaken with a random-effects model with its 95% confidence interval (CI). RESULTS Three RCTs comparing PMAs to activators and three NRS comparing PMAs to untreated controls met the inclusion criteria. On a short-term basis, exploratory quantitative synthesis indicated that the activators were more effective than the PMAs in correcting overjet with a mean difference of (1.1 mm; 95% CI: 0.44 to 1.77). On a long-term basis, there were no significant differences between the two appliances. Qualitative synthesis indicated less favorable soft tissue changes as well as patient experiences and compliance with the PMAs when compared to the activators. However, PMAs were associated with reduced costs compared to customized activators and modest changes when compared to untreated controls. CONCLUSIONS On a short-term basis, low quality of evidence suggests that PMAs were generally less effective than the activators in treating Class II division 1 malocclusion. The main advantage of PMAs seems to be their reduced costs. These results should be viewed with caution, as a definitive need for high-quality long-term research into this area is required. REGISTRATION PROSPERO (CRD42018108564).

ABSTRACT Background: Risk of cardiovascular disease (CVD) has been associated with stress from serving in a war, but it has not been established whether children who experience war-related stress are at increased CVD risk. Objective: This study aimed to compare CVD risk factors in young adults according to whether they experienced traumatic events as children during the 1990–1995 war in Bosnia and Herzegovina, and whether those exposed to trauma have evidence of subclinical atherosclerosis. Method: We examined 372 first-year medical students who were preschool children during the war (1990–1995) (average age 19.5 ± 1.7 years, 67% female) in 2007–2010. They completed the Semi-Structured Interview for Survivors of War. CVD risk factors and carotid intima–media thickness (CIMT) measurements were obtained and compared in individuals with and without trauma. We also examined whether increased CIMT was independently associated with trauma after adjustment for other risk factors. Results: From multiple logistic regression, only elevated triglycerides (> 1.7 mmol/l) were associated with a 5.2 greater odds of having experienced trauma. The mean CIMT of subjects with trauma was greater than that of non-trauma-exposed subjects (0.53 mm vs 0.50 mm, p = 0.07). Moreover, trauma was independently associated with higher CIMT (difference = 0.036 mm, p = 0.024) after adjustment for CVD risk factors. Conclusions: We show that most CVD risk factors are associated with post-war trauma in young adults, and, if present, such trauma is associated with higher triglycerides and higher levels of CIMT in multivariable analysis. HIGHLIGHTS • Our investigation was to examine whether there are differences in cardiovascular risk factors and subclinical atherosclerosis in persons previously exposed compared to not exposed to trauma during the war in Bosnia and Herzegovina.• We demonstrated that while traditional risk factors are not strongly related to the presence of post-war trauma in young adults, those with greater CIMT appear to have been more likely to have had been prevoiusly exposed to trauma.

The paper focuses on the analysis of multi‐agent systems interacting over directed and time‐varying networks in presence of parametric uncertainty on the interaction weights. We assume that agents reach a consensus, and the main goal of this work is to characterize the contribution that each agent has to the consensus value. This information is important for network intervention applications such as targeted advertising over social networks. Indeed, for an advertising campaign to be efficient, it has to take into account the influence power of each agent in the graph (ie, the contribution of each agent to the final consensus value). In our first results, we analytically describe the trajectory of the overall network, and we provide lower and upper bounds on the corresponding consensus value. We show that under appropriate assumptions, the contribution of each agent to the consensus value is smooth both in time and in the variation of the uncertainty parameter. This allows approximating the contribution of each agent when small perturbations affect the influence of each agent on its neighbors. Finally, we provide a numerical example to illustrate how our theoretical results apply in the context of network intervention.

The main circulatory medium of echinoderms is the coelomic fluid. Biochemistry of coelomic fluid is very complex and slightly different from seawater. The main aim of this research was to analyse concentration of electrolytes (potassium, calcium, magnesium, chlorine and sodium), heavy metals (lead, chromium, cadmium and cobalt) and iron in coelomic fluid of sea urchin, Arbacia lixula as an indirect indicator of seawater contamination. After precise statistical evaluation it was observed that electrolyte concentrations were; Na 189.20±11.41 mmol/l, Cl 134.06±37.08 mmol/l, Mg 4.24±1.08 mmol/l, Ca 3.04±0.84 mmol/l. Biochemical content of heavy metals in coelomic fluid was; Co 1.292±0.879 ppm, Pb 0.644±0.131 ppm, Cr 0.116±0.055 ppm, Cd 0.031±0.017 ppm and iron 0.259±0.058 ppm, and it depends on the potential accumulation level in the organism. The composition of electrolyte and heavy metal content varies depending on the composition of seawater. Obtained values are within the range of values most commonly found in low polluted areas of the Adriatic sea. Similar models may be applied for monitoring of heavy metal contamination in marine environment.

ABSTRACT This paper presented the quality of the treated surface, which is most often followed by roughness representing micro-geometric irregularities of the treated surface. The processing influence parameters behaviour of on the roughness of the treated wood surface was considered, where the results of measurements of the average deviation of the roughness profile of the surface of beech and maple wood from the area of Bosnia and Herzegovina after processing with orthogonal cutting on a four-sided shaper was studied, at different feed speed and cutting depth . The mathematical model of the influence parameters on the treated surface roughness of solid wood was also presented. The paper presented a sample example of how a process can be predicted before it goes into production, avoiding exploitation testing and increased costs of the process itself.

Aim Barrett’s esophagus (BE) is a predisposing factor of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma (ECA/GEJ Aca). BE patients are stratified and subsequently monitored according to the risk of malignant progression by the combination of endoscopy and biopsy. This study is to evaluate the maspin expression patterns as early diagnostic markers of malignancy in BE patients. Materials and methods Immunohistochemistry (IHC) staining was performed on 62 archival core biopsies from 35 patients, including BE without dysplasia (intestinal metaplasia, IM), BE with low grade dysplasia, BE with high grade dysplasia, carcinoma in situ, and well to poorly differentiated ECA/GEJ Aca (PD-ECA/GEJ Aca). The intensity and the subcellular distribution of immunoreactivity were evaluated microscopically. Statistical analysis was performed using the χ2 and Fisher exact tests. Results The level of epithelial-specific tumor suppressor maspin protein inversely correlated with the progression from IM to PD-ECA/GEJ Aca. Lesions of each pathological grade could be divided into subtypes that exhibited distinct maspin subcellular distribution patterns, including nuclear only (Nuc), combined nuclear and cytoplasmic (Nuc+Cyt), cytoplasmic only (Cyt) and overall negligible (Neg). The Cyt subtype, which was minor in both IM and dysplasia (approximately 10%), was predominant in ECA/GEJ Aca as early as well-differentiated lesions (more than 50%: p = 0.0092). In comparison, nuclear staining of the tumor suppressor TP53 was heterogeneous in dysplasia, and did not correlate with the differentiation grades of ECA/GEJ Aca. Conclusion The Cyt subtype of maspin expression pattern in core biopsies of BE patients may serve as a molecular marker for early diagnosis of ECA/GEJ Aca.

Uvod Informisanost o nivou treniranosti sportista, te uzrocima i posljedicama takvog stanja, bitna je za njihov uspjeh. Poznato je da fudbaleri u igri ostvare veći broj kratkih sprinteva, te da primjenjuju različite načine vođenja lopte, pravolinijski i sa promjenom smjera kretanja. Struktura agilnosti s loptom je mnogo složenija u odnosu na takvo kretanje bez lopte (Sporiš, Milanović, Trajković, & Joksimović, 2011). Brzina i eksplozivna snaga se smatraju preduslovom za uspjeh u omladinskom fudbalu (Reilly, Bangsbo, & Franks, 2000), naglašavajući pritom ubrzanja na kratkim udaljenostima. Visina i tjelesna težina su značajno povezane sa fi zičkom izvedbom u slučaju mladih fudbalera ( Mathisen & Petersen, 2015). Ipak se sa sigurnošću ne može izolovati neka osobinu ili sposobnost koja donosi odlučujuću prednost u utakmici. Fudbaleri su tjelesno lakši od osoba koje žive sedentarnim načinom života (Popović, Akpinar, Jaksic, Matic, & Bjelica, 2013), ali i niži u odnosu košarkaše, odbojkaše i rukometaše juniorske kategorije (Masanovic & Vukasevic, 2009; Masanovic, 2018). Međutim, u sportovima gdje se traži velika brzina kretanja, nagla promjena pravca u velikoj brzini kretanja, grubi sudari sa protivnikom (fudbal i hokej), tjelesna visina ne samo da nije dominantna, nego je u određenoj mjeri i nepovoljna (Bjelica & Fratrić, 2011). Međusobni odnos tjelesne visine i težine (body mass index), te udio masne komponente (% fat mass) u ukupnoj tjelesnoj masi, za trenere može biti važna informacija. Optimalne vrijednosti BMI-a mogu rezultirati u poboljšanju opšteg nivoa tjelesne i anaerobne snage (Nikolaidis, 2014). Fudbaleri imaju povoljan sadržaj mišića sa niskim nivoom tjelesnih masti (Popovic, Bjelica, Jaksic, & Hadzic, 2014). Ipak, višak tjelesnih masti stvara nepotreban teret i umanjuje učinkovitost u igri, te značajno narušava elemente tehnike mladih fudbalera (Nemčić, Fiorentini, & Sporiš, 2018). Vrijednosti tjelesnih masti za vrhunske fudbalere su u prosjeku 7-12%, te su niže nego u slučaju sedentarnih ljudi, ali su takođe više u odnosu na trkače u sportovima izdržljivosti (Shephard, 1999.). Pored optimalizacije voluminoznosti mišića, na količinu potkožnog masnog tkiva se može uticati dopunskim treningom (Conroy i Earle, 2000), i to djelovanjem u pravcu njene redukcije. S obzirom da se takmičenja omladinskih liga organizuju shodno hronološkoj, a ne biološkoj starosti, često se pojedinci Abstract

Walking is classified as the oldest transport mode with the least impact on the environment. It is frequently one of the intermediate transport modes. Generally, while designing exclusive walking transit areas or structures with high human traffic volumes and considering different scenarios, it is advantageous to be able to foresee the congestion conditions and the relative problems. The study of pedestrian trajectories, which are strictly related to the characteristics of the walkers, is necessary and preliminary for the purposes of an in-depth analysis linked to the habits of populations and cultures. Often areas crowded by tourists run, of limited size such as bridges, must be considered in advance for emergencies. This article focuses on an old footbridge of Mostar located in a confined area with an increasing tourist flow. The peculiarity of the bridge lies in the double-flight geometry with elements that generate discontinuity in the trajectory as well as the steps. This analysis was carried out obtaining the traffic data from video cameras and analyzing different scenarios on holidays and weekdays. Also, the possible presence of obstacles on the bridge was taken into account, such as some areas not walkable for temporary work or the presence of obstacles. These scenarios have been calibrated and simulated through the definition of O/D matrices, arcs and nodes (or areas) through the pedestrian simulation tool Viswalk. This comparison is useful for understanding the variation of LOS (Level of Service) during the daily or emergency situations and the results can provide help to local authorities to plan and design an appropriate action plan. Therefore, this research work aims to compare scenarios under critical flow conditions in the order to define preventively possible actions that can guarantee an optimal LOS value during the bridge crossing and the surrounding areas.

Aberrant lipid accumulation and marked changes in cellular lipid profiles are related to breast cancer metabolism and disease progression. In vitro, these phenomena are primarily studied using cells cultured in monolayers (2D). Here, we employ multicellular spheroids, generated using the MCF10A cell line series of increasing malignancy potential, to better recapitulate the 3D microenvironmental conditions that cells experience in vivo. Breast cancer cell lipid compositions were assessed in 2D and 3D culture models as a function of malignancy using liquid chromatography coupled with mass spectrometry. Further, the spatial distribution of lipids was examined using Raman chemical imaging and lipid staining. We show that with changes in the cellular microenvironment when moving from 2D to 3D cell cultures, total lipid amounts decrease significantly, while the ratio of acylglycerols to membrane lipids increases. This ratio increase could be associated with the formation of large lipid droplets (>10 μm) that are spatially evident throughout the spheroids but absent in 2D cultures. Additionally, we found a significant difference in lipid profiles between the more and less malignant spheroids, including changes that support de novo sphingolipid production and a reduction in ether-linked lipid fractions in the invasive spheroids. These differences in lipid profiles as a function of cell malignancy and microenvironment highlight the importance of coupled spatial and lipidomic studies to better understand the connections between lipid metabolism and cancer.

Ship accidents that entail flooding may lead to disastrous consequences which could be avoided or mitigated based on the knowledge of damaged ship dynamics. The dynamic behaviour of a damaged hull is a complex phenomenon involving the interaction of the flooded water and the ship motions. The presence of a damage opening allows water flow into and out from the compartment, which further complicates the mathematical description of the problem. A fast simulation method, based on the lumped mass approach, is developed and presented. The lumped mass path in space depends on free-surface inclinations that differ from the ship angles of the roll and pitch. The viscous effects in the floodwater dynamics are implemented based on the model for the dissipation of the energy of standing waves in rectangular rooms. The method applies to both the transient stage of flooding and to the dynamic behaviour of a flooded ship in regular waves. In the first case, viscous effects are implemented considering the water in the compartment variable with time. Several case studies are carried out on three different hull models: Transient stage of flooding, roll decay of the damaged hull, and steady state responses in waves are simulated and compared with available experimental data.