Semantičke razlike između sinonima (ar. al-furūq al-luġawiyya - الفروق اللغوية) su naučna disciplina u arapskom jeziku koja istražuje razlike između pojedinih riječi koje, na prvi pogled, imaju identična značenja.Značaj izučavanja ove teme se ogleda u što preciznijem tumačenju i shvatanju sakralnih tekstova (Kurʼana i riječi Muhammeda, s.a.v.s.,), zatim čuvanju bogate arapske leksike, kao i trganju od zaborava izraza koji imaju preciznija značenja.U prvom periodu stasanja arapske leksikografije, autori koji su pisali djela iz ove naučne discipline su dali veliki doprinos njenom bogaćenju, a jedno od najpoznatijih djela je Al-Furūq al-luġawiyya (الفروق اللغوية) ʼAbū Hilāla al-‘Askariyya (395/1005).

The string-matching paradigm is applied in every computer science and science branch in general. The existence of a plethora of string-matching algorithms makes it hard to choose the best one for any particular case. Expressing, measuring, and testing algorithm efficiency is a challenging task with many potential pitfalls. Algorithm efficiency can be measured based on the usage of different resources. In software engineering, algorithmic productivity is a property of an algorithm execution identified with the computational resources the algorithm consumes. Resource usage in algorithm execution could be determined, and for maximum efficiency, the goal is to minimize resource usage. Guided by the fact that standard measures of algorithm efficiency, such as execution time, directly depend on the number of executed actions. Without touching the problematics of computer power consumption or memory, which also depends on the algorithm type and the techniques used in algorithm development, we have developed a methodology which enables the researchers to choose an efficient algorithm for a specific domain. String searching algorithms efficiency is usually observed independently from the domain texts being searched. This research paper aims to present the idea that algorithm efficiency depends on the properties of searched string and properties of the texts being searched, accompanied by the theoretical analysis of the proposed approach. In the proposed methodology, algorithm efficiency is expressed through character comparison count metrics. The character comparison count metrics is a formal quantitative measure independent of algorithm implementation subtleties and computer platform differences. The model is developed for a particular problem domain by using appropriate domain data (patterns and texts) and provides for a specific domain the ranking of algorithms according to the patterns’ entropy. The proposed approach is limited to on-line exact string-matching problems based on information entropy for a search pattern. Meticulous empirical testing depicts the methodology implementation and purports soundness of the methodology.

Abstract Introduction. Present study was performed to verify red blood cell distribution width-to-platelet ratio (RPR) level in rheumatoid arthritis (RA) patients and to examine its correlation with clinical and biochemical indicators of disease activity status. Methods. In this cross-sectional analytical study, 67 patients with RA and 34 age- and gender-matched healthy control subjects were enrolled. Based on the disease activity score 28-ESR (DAS28-ESR), RA patients were divided into subgroups: low disease activity (n = 20), moderate disease activity (n = 22) and high disease activity (n = 25). Laboratory tests included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) concentration, platelet count (PLT), red blood cells count (RBC), red blood cells distribution width (RDW) and fibrinogen concentration. Statistical analyses were carried out using SPSS 13 software. Statistical significance was set at a p-value less than 0.05. Results. There was statistically significant difference (p = 0.006) between RPR in RA patients with different stages of disease activity, with higher values in patients with low disease activity. The RPR showed statistically significant negative correlations with ESR (rho = –0.309; p = 0.012), CRP (rho = –0.421; p = 0.001), swollen joint count – SJC (rho = –0.368; p = 0.002) and tender joint count – TJC (rho = –0.355; p = 0.003), DAS28-ESR (rho = –0.409; p = 0.001), DAS28-CRP (rho = –0.422; p < 0.0005) and Visual analogue scale – VAS (rho = –0.260; p = 0.033) in RA patients. Conclusion. The present study provided evidence that the lower RPR values in RA patients are significantly associated with the disease activity indicators.

Melanomacrophages of fish are commonly explored as biomarkers of water pollution and are considered to be sensitive albeit non-specific health indicators in water ecosystems. Sharks as long living marine species are good sentinel species. This study presents morphometric data for splenic and hepatic melanomacrophages (MMC), and observed histopathology in ten lesser-spotted catsharks, Scyliorhinus canicula (L.), one of the most abundant shark species in the eastern Adriatic Sea. At necropsy, we collected random tissue samples from liver, brain, gallblader, pancreas, spleen, kidney, gills, entire digestive system, thyroid gland, rectal gland, entire urogenital (male samples) and genital system (female samples). Collected tissue samples were routinely processed and stained with hematoxylin-eosin, Periodic Acid-Schiff, and Masson Trichrome for microscopic examinations and morphometry. There was a minimal number of histopathological lesions in the examined sharks, but morphometric values reported herein were three folds higher than in previous studies in free-ranging sharks. Studies on larger numbers of sharks are needed to elucidate the biological significance of our finding in the context of population decline of the lesser-spotted catshark.

Konformizam se obično posmatra kao oblik socijalnog utjecaja gdje se pojedinac prilagođava grupi, odnosno, gdje pojedinac mijenja svoje stavove i ponašanja i prilagođava ih stavovima i ponašanjima grupe kojoj pripada ili kojoj želi da pripada. Cilj ovog rada jeste naglašavanje potrebe da se konformiranje grupi razlikuje od pokornosti grupi. Konformiranje grupi prati želja da se bude što sličniji većini, da se prisvoje grupne vrijednosti ili saznanja, pri čemu pojedinac sam bira da li će se prikloniti grupi ili većini.

Ljudi o sebi vole misliti kao samostalnima, kriticki svjesnima, individuama koje nisu pijuni i koje imaju stav, ne pokoravajuci se vecini, imuni su na socijalne zaraze. Ipak, svakodnevno smo izloženi socijalnom utjecaju drugih. Sklonost da cinimo osnovnu atribucijsku gresku, odnosno, da vlastito i tuđe ponasanje objasnjavamo iskljucivo osobinama licnosti, podcjenjuje snagu i važnost tog utjecaja. Kako bi sacuvao svoje samopostovanje i, istovremeno, bio ravnopravnim dijelom grupe, covjek se pokorava socijalnom utjecaju, težeci da pronađe savrsenu ravnotežu između onog sto sam želi i ocekivanja grupe kojoj pripada.Naucno proucavanje vrijednosnih orijentacija, kao i vrijednosti uopce, ima veliki naucni, ali i drustveni znacaj, jer se radi o proucavanju faktora koji pokrecu i usmjeravaju ponasanje pojedinca i grupe. Ispitivanje preferencija konformizma i aktivizma – opceg i drustvenog – kao vrijednosnih orijentacija urađeno je na uzorku od 106 odraslih osoba s podrucja Bosanske krajine. Uzorak je cinilo 60 žena (56.6%), a starost ispitanika bila je između 19 i 77 godina.Dobiveni rezultati pokazuju kako prisutnost konformizma te opceg i drustvenog aktivizma kao vrijednosnih orijentacija u tradicionalnom drustvu nije visoka te se može ocekivati da je danas, u XXI stoljecu, i u tradicionalnim sredinama ojacan individiualizam, a da se napusta kolektivizam i održavanje grupne kohezije kao tradicionalne vrijednosti.

Public health strategies to contain the pandemic continue to vary markedly across the world. In Sweden, compared to most advanced economies, social restrictions have primarily relied upon voluntary adherence to a set of recommendations and strict lockdowns have not been enforced. To better understand the development of humoral immunity to SARS-CoV-2 in the Stockholm population before the start of mass vaccinations, healthy blood donors and pregnant women (n=4,100) were sampled at random between 14th March-11th December 2020. All individuals (n=200/sampling week) were screened for anti-SARS-CoV-2 spike (S) trimer- and RBD-specific IgG responses with highly sensitive and specific ELISA assays, and the results were compared with those from historical controls (n=595). Data were modelled using a probabilistic Bayesian framework that considered individual responses to both antigens. We found that after a steep rise at the start of the pandemic, the seroprevalence trajectory increased steadily in approach to the winter second-wave of infections, approaching 15% of all individuals surveyed by 11th December. In agreement with the high transmission rate observed in the Stockholm area, seroprevalence in this cohort of active adults increased during the 9 months from the start of the outbreak, but was far from that required for herd immunity at the end of 2020.

Applying conceptual blending theory, the paper analyses the construction of the meaning of a satirical text ridiculing the language employed by politicians to frame the debate on current political and social issues. In particular, it focuses on the language used by Donald Trump in explaining his anti-immigration stances through a poem based on the fable about the farmer and the viper, and a satirical text providing a new version of the poem, which criticizes Trump’s immigration policy. The paper examines the creation of the humorous meaning of the text in conceptual blending. The humorous meaning is created in the blended space due to the unusual combination of related structures, which results in incongruity (Coulson 2002; Marín-Arrese 2003). Furthermore, as blending can be used as a rhetorical tool influencing the audience to change the reality and even act upon it (Coulson 2006; Coulson & Oakley 2006; Coulson & Pascual 2006; Oakley & Coulson 2008), the analysis of the construction of the meaning of the satirical text as a product of conceptual blending can reveal rhetorical and argumentative goals in political discourse.

Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic proteins that are involved in canonical and non-canonical Wnt signaling pathway during embryonic development. The role of DVL proteins in the placental tissue remains mostly unknown. In the current study, we explored the role of Dishevelled proteins in naturally invasive tissue, trophoblast. Formalin-fixed paraffin-embedded samples of 15 term placentas from physiologic term pregnancies and 15 term placentas from pregnancies complicated with intrauterine growth restrictions (IUGR) were used for the study. Expression levels of mRNA for DVL1, DVL2, and DVL3 in placentas were analyzed by quantitative real-time PCR (qRT-PCR). DVL1, DVL2, and DVL3 protein expression were semi-quantitatively analyzed using immunohistochemistry. The expression of DVL3 protein was significantly higher in trophoblasts and endothelial cells in placental villi from IUGR pregnancies compared with the control group of term placentas, while DVL2 protein expression was significantly higher in trophoblasts in placental villi from IUGR pregnancies compared with normal term placentas. The observed differences at protein levels between normal and IUGR placentas were not confirmed at the mRNA levels of DVL genes. Our data indicate the active involvement of DVL proteins in IUGR-related placentas. No significant changes were observed in DVL mRNA levels between the two groups of placentas. Further studies are required to explore the clinical relevance of these observations.

Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic proteins that are involved in canonical and non-canonical Wnt signaling pathway during embryonic development. The role of DVL proteins in the placental tissue remains mostly unknown. In the current study, we explored the role of Dishevelled proteins in naturally invasive tissue, trophoblast. Formalin-fixed paraffin-embedded samples of 15 term placentas from physiologic term pregnancies and 15 term placentas from pregnancies complicated with intrauterine growth restrictions (IUGR) were used for the study. Expression levels of mRNA for DVL1, DVL2, and DVL3 in placentas were analyzed by quantitative real-time PCR (qRTPCR). DVL1, DVL2, and DVL3 protein expression were semi-quantitatively analyzed using immunohistochemistry. The expression of DVL2 and DVL3 proteins was significantly higher in trophoblasts in placental villi from IUGR pregnancies compared with the control group of term placentas. In contrast, DVL3 protein expression was significantly higher in endothelial cells in placental villi from IUGR pregnancies compared with normal term placentas. The observed differences at protein levels between normal and IUGR placentas were not confirmed at the mRNA levels of DVL genes. Our data indicate the active involvement of DVL proteins in IUGR-related placentas. No significant changes were observed in DVL mRNA levels between the two groups of placentas. Further studies are required to explore the clinical relevance of these observations.

Applying conceptual blending theory, the paper analyses the construction of the meaning of a satirical text ridiculing the language employed by politicians to frame the debate on current political and social issues. In particular, it focuses on the language used by Donald Trump in explaining his anti-immigration stances through a poem based on the fable about the farmer and the viper, and a satirical text providing a new version of the poem, which criticizes Trump’s immigration policy. The paper examines the creation of the humorous meaning of the text in conceptual blending. The humorous meaning is created in the blended space due to the unusual combination of related structures, which results in incongruity (Coulson 2002; Marín-Arrese 2003). Furthermore, as blending can be used as a rhetorical tool influencing the audience to change the reality and even act upon it (Coulson 2006; Coulson & Oakley 2006; Coulson & Pascual 2006; Oakley & Coulson 2008), the analysis of the construction of the meaning of the satirical text as a product of conceptual blending can reveal rhetorical and argumentative goals in political discourse.

Glaucoma is considered to be one of the biggest health problems in the world. It is the main cause of preventable blindness due to its asymptomatic nature in the early stages on the one hand and patients’ non-adherence on the other. There are several approaches in glaucoma treatment, whereby this has to be individually designed for each patient. The first-line treatment is medication therapy. However, taking into account numerous disadvantages of conventional ophthalmic dosage forms, intensive work has been carried out on the development of novel drug delivery systems for glaucoma. This review aims to provide an overview of formulation solutions and strategies in the development of in situ gel systems, nanosystems, ocular inserts, contact lenses, collagen corneal shields, ocular implants, microneedles, and iontophoretic devices. The results of studies confirming the effectiveness of the aforementioned drug delivery systems were also briefly presented.

We address several problems of coordination and consensus on and that can be formulated as minimization problems on these Lie groups. Then, gradient descent methods for minimization of the corresponding functions provide distributed algorithms for coordination and consensus in a multi-agent system. We point out main differences in convergence of algorithms on the two groups. We discuss advantages and effects of representing 3D rotations by quaternions and applications to the coordinated motion in space. In some situations (and depending on the concrete problem and goals) it is advantageous to run algorithms on and map trajectories onto via the double cover map , instead of working directly on .

Introduction: Adolescence is characterised as a period of further development and maturation of higher executive functions (EF). It is well established that EF play an important role in social skills and academic competence of typically developing adolescents. Purpose: The goal of this study was to examine the relationship between executive functions (EF) and academic competency and social skills in adolescents with a mild intellectual disability. In particular, we were interested to examine which EF have the greatest impact on social skills and academic competency. Methods: EF were measured with the Behaviour Rating Inventory of Executive Functions (BRIEF), and social and academic competences were measured with the Social Skills Rating System (SSRS). The sample for this study consisted of 44 adolescents with mild intellectual disability aged 15-18 years old (mean age 16.7 years, SD1.4). Results: The results of this study clearly pointed to the strong relationship between these constructs. Of all EF, planning had the strongest impact on academic success, and monitoring had the strongest impact on social skills. Conclusion: EF are susceptible to training effects, we thus propose early interventions in these domains in order to increase the social and academic competence of persons with an intellectual disability.