Local producers constitute a crucial segment of the local economy, playing a pivotal role in driving rural development and the progress of tourism. Their avenues for showcasing products extend beyond markets, bazaars, or food events, often being integrated into a destination’s tourism offerings. Moreover, they contribute to the culinary progress within tourism. Originating from wider rural areas or nearby villages, local producers significantly impact everyday migrations, services, and financial transactions in relationships spanning suburban–urban, village–town, and cross-border cooperation. This study aims to scrutinize the social facets of the organization and work of local producers, offering insights into contemporary market processes. It also serves to illustrate cross-border cooperation and the role of culinary tourism in local business. Through qualitative data processing, we will delve into the outcomes of cross-border projects, emphasizing ethical and sustainable values rooted in territory, landscape, local culture, authenticity, and the application of culinary elements in tourism. The results will shed light on the economic, social, and cultural ramifications on markets in border regions, influencing daily life and the economy. This study will define key aspects of rural development. These research findings can inform local governments, the economy, and communities in future strategic planning for developing this market segment. Tourism, especially in hospitality, will empower rural communities to enhance financial inflow and create local employment opportunities, such as roles for vineyard tour guides or local chefs. Simultaneously, it will bolster other sectors of the local economy, such as agriculture.

Appendiceal neoplasms are quite uncommon. They are detected in fewer than 0.5 percent of appendectomies and less than 0.5 percent of all gastrointestinal neoplasms. Similar to a colonic adenoma, an appendiceal adenoma is neoplasm with precancerous nature. A rare case of appendiceal adenoma is presented here in a 65-year-old female patient, incidentally discovered at the orifice of the appendix, during the screening analysis. The patient felt well. Abdominal examination and laboratory analysis were regular. Due to the inaccessibility of the lesion by colonoscopy, surgical treatment was recommended. A laparoscopic appendectomy was performed. On pathological examination, diagnosis of tubulovillous adenoma was performed. Endoscopic screening analysis of precancerous appendiceal neoplasm is very important. The method of choice for any appendiceal neoplasm is surgical removal i.e. appendectomy, preferably with a clean caecal margin, which requires stapling of the cecum. Early detection can prevent complications and decrease the risk of consequential appendiceal or colorectal carcinoma.

Introduction: Globally, the most common mental disorders in the elderly include dementia (5% - 8%), depression (7%), anxiety disorder (4%), and substance abuse (1%). Moreover, 25% of suicide deaths occur among the elderly. Whether the prevalence rate of psychiatric disorders increases in later life is currently debated in the literature. During the previous two decades of their lives, older adults in Bosnia and Herzegovina have experienced many specific psychosocial circumstances. The experience of war aggression on our country, and the post-war period with a very complex socioeconomic environment of the current socio-political climate, were accompanied by special challenges for the mental health of this population. Motivated by a large number of questions and dilemmas related to the state of mental health of this population, we conducted research at the Department of Psychiatry at the University Clinical Center Tuzla.Objective: Our objective was to investigate psychiatric morbidity and comorbidity in people over 55 years of age.Methods: The research sample consisted of all patients older than 55 years treated at the Department for Psychiatry during 2018 (N=281), divided into four age categories. To obtain data, we used medical documentation, i.e., medical records, and we constructed a special questionnaire for research purposes.Results: Diagnoses by ICD-10 groups: 33.4% of patients in the entire sample had affective disorders (F30.0-F39.0): "young" (39.2%), "middle" (43.3%), "older "(75%) (p<0.001); women had significantly more affective disorders (61.8%) than men (26.8%) (p<0.001). Men had significantly more organic mental disorders (F00.0-F09.0) (63.3%) than women (22.6%) (p<0.001).Hypertensio arterialis was the most common comorbid dg. of the entire sample, without significant differences according to age groups and sex (p>0.05). Diabetes mellitus was the second comorbid dg. By frequency in the total sample (19.6%) without significant differences according to age groups and according to sex (p>0.05).Conclusion: In the entire sample, the most common diagnoses are from the affective disorders group; the most common somatic comorbidities are hypertensio arterialis and diabetes mellitus.

PURPOSE When carrying out prosthetic rehabilitation of edentulous and partially edentulous patients, great attention is paid to the personal attitude of the patients, their satisfaction with oral health and psychosocial interaction due to tooth loss, as well as the treatment of the resulting disorders. This attention has led to the development of various instruments for examining the quality of life related to oral health. The aim of this study was to develop and validate a reliable instrument in the Serbian language suitable for measuring oral health-related quality of life in patients who have been rehabilitated with complete or partial dentures. Мaterials and Methods: The study was unicentric and cross-sectional, and assessed the reliability and validity of a newly developed instrument for measuring the oral health-related quality of life in denture wearers (OHRQoL-DW). It was conducted on a sample of 200 adults from Serbia, wearers of various types of dentures, with a mean age 66.9 ± 10.3 years and male/female ratio of 86/114 (43%/57%). RESULTS The definitive version of the OHRQoL-DW scale with 28 items showed very good reliability, with Cronbach's alpha = 0.938. Good temporal stability of the questionnaire was demonstrated, and satisfactory results were obtained for divergent and convergent validity tests. Exploratory factorial analysis revealed four domains of oral health-related quality of life in denture wearers: physical, psychosocial, environmental and aesthetic. CONCLUSIONS The OHRQoL-DW scale is a reliable and valid generic instrument for measuring the oral health-related quality of life in patients wearing dentures, which is one of the most important outcomes of oral health in prosthetic treatment.

The decrease in overall inertia in power systems due to the shift from synchronous generator production to renewable energy sources (RESs) presents a significant challenge. This transition affects the system’s stable frequency response, making it highly sensitive to imbalances between production and consumption, particularly during large disturbances. To address this issue, this paper introduces a novel approach using Multivariate Empirical Mode Decomposition (MEMD) for the accurate estimation of power system inertia. This approach involves applying MEMD, a complex signal processing technique, to power system frequency signals. The study utilizes PMU (Phasor Measurement Unit) data and simulated disturbances in the IEEE 39 bus test system to conduct this analysis. MEMD offers substantial advantages in analyzing multivariate data and frequency signals during disturbances, providing accurate estimations of system inertia. This approach enhances the understanding of power system dynamics in the context of renewable energy integration. However, the complexity of this methodology and the requirement for precise data collection are challenges that need to be addressed. The results from this approach show high accuracy in estimating the rate of change of frequency (RoCoF) and system inertia, with minimal deviation from actual values. The findings highlight the significant impact of renewable energy integration on system inertia and emphasize the necessity of accurate inertia estimation in modern power systems.

Introduction: The positive effects of static stretching exercises (SS) on physical fitness and rehabilitation are well established, but the effect on general health and physical fitness, including muscle function, flexibility, and activities of daily living at the individual level are less well understood. The objective of this systematic review was to compile the latest research on the effects of SS on general health and different occupational groups with regards to improving or maintaining general health. Material and methods: This review followed PRISMA guidelines. PubMed, Web of Science, Scopus, MEDLINEOnline medical articles, and Science Direct databased were searched from 2010 to 2022 (including 2022) using the search string ‘static stretching effects OR muscle stretching exercises AND rehabilitation AND injury prevention’. Results: Th e database search yielded 799 articles of which 20 remained after elimination according to the selection criteria. The articles found that the effect of SS, regardless of the protocol used or whether it is active or passive, has a positive effect on the health status of the subjects. SS can reduce work-related musculoskeletal disorders (WMSD), improve respiratory muscle function in patients after a stroke with hemiparesis, improve lung function in patients with chronic obstructive pulmonary disease (COPD), and can be used in pregnancy to reduce the risk or pre-eclampsia. Conclusion: SS is an effective and safe method for improving flexibility and ROM, preventing muscle atrophy, enhancing physical functioning, and improving quality of life with minimal risk of injury.

Idiopathic multicentric Castleman disease (iMCD) is a rare hematologic disorder with heterogeneous presentations ranging from moderate constitutional symptoms to life-threatening multiorgan system involvement. There are vastly different clinical subtypes, with some patients demonstrating thrombocytopenia, anasarca, fever/elevated C-reactive protein, reticulin fibrosis/renal failure, and organomegaly (TAFRO) and others having milder/more moderate symptoms with potential for severe disease (not otherwise specified, NOS). Due to its rarity and heterogeneity, the natural history and long-term burden of iMCD are poorly understood. We investigated real-world medical data from ACCELERATE, a large natural history registry of patients with Castleman disease, to better characterize the long-term disease burden experienced by these patients. We found that iMCD-TAFRO patients face a significant hospitalization burden, requiring more time in the hospital than iMCD-NOS patients during the year surrounding diagnosis (median [interquartile range]: 36 [18-61] days vs. 0 [0-4] days; P<0.001). In addition, we found life-sustaining interventions, such as mechanical ventilation (17%) and dialysis (27%), were required among iMCD patients, predominantly those with iMCD-TAFRO. iMCD-NOS patients, however, spent a significantly greater proportion of time following disease onset in a state of disease flare (median 52.3% vs. 18.9%; P=0.004). Lastly, we observed severe iMCD-related morbidities, such as acute renal failure, sepsis and pneumonia, among others, arising after iMCD diagnosis, impairing the patients’ quality of life. These data demonstrate a substantial disease burden experienced by iMCD patients and emphasize the importance of ongoing research into iMCD to aid disease control.

Natural clay minerals, because of their physical and chemical characteristics are good adsorbents of metals. Among metals we often investigate heavy metals, but redox-sensitive metals are getting more and more attention. Redox-sensitive elements were measured in clay pit samples from clay mine in Bosnia and Herzegovina. For the purpose of analysis, a 23 m deep clay pit core sample was taken. From this sample 45 clay pit subsamples from different depths were used. The pH, electrical conductivity (EC), oxidation-reduction potential (ORP) and redox-sensitive elements content were measured. Amounts of redox-sensitive metals and aluminum were measured with an ICP-OES instrument. For statistical evaluation, maximum, minimum, average, median, correlation, correlation applying Al normalization and clr transformation were calculated. When justified PCA analysis was performed. The results are showing acidic pH, and oxidative ORP. The EC varied significantly through the sediment. The element concentrations lie in the sequence: Fe>Ti>V>As. There is a significant change in correlations with and without Al-normalization. The highest difference in was found in case of titanium and vanadium (r value ranging from -0.553 to 0.835). Correlations and PCA after clr transformation showed mainly strong negative correlations, meaning that redox sensitive elements behave differently in clay samples. Supplementary material: https://doi.org/10.6084/m9.figshare.c.7014329

Due to the natural energy sources used in constructed wetlands, minimal energy and chemicals are required for wastewater treatment. For the successful wastewater treatment via constructed wetlands, adequate pretreatment and a sufficient amount of oxygen are crucial. Constructed wetlands can be used to treat industrial wastewater, such as wastewater from the dairy industry, with prior degreasing. This study was conducted on a horizontal flow pilot constructed wetland located on a plot of land used by the Biotechnical Faculty in Bihać. The constructed wetland consisted of two fields planted with rushes (Typha latifolia) and reeds (Phragmites australis). The substrate and plants were not changed during the experimental period. We monitored the efficiency of industrial wastewater treatment (wastewater from the dairy industry) by season, varying the flow rate as well as the hydraulic retention time of the water in the device. The quality of the influent and effluent was monitored by determining analytical parameters. The constructed wetland showed the highest efficiency in the summer period, with a hydraulic retention time of 6 days, with removal efficiencies of 98.03% for ammonia, 98.19% for total nitrogen, 95.27% for total phosphorous, 94.50% for COD and 97.73% for BOD5. The organic substance removal efficiency across all four seasons was 94.68%.