Introduction: Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these oncoviruses and their crosstalk in breast cancer is still unclear. Methods: We explored the co-presence of high-risk HPVs, EBV, and MMTV-like virus in 74 breast cancer samples from Qatar using PCR. Results: We found the presence of HPV and EBV in 65% and 49% of our cancer sample cohorts; 47% of the samples are positive for both oncoviruses. The MMTV-like virus alone was detected in 15% of the samples with no significant association with clinicopathological features. The three oncoviruses were co-present in 14% of the cases; no significant association was noted between the co-presence of these viruses and the clinicopathological features. Conclusion: Despite the presence of the oncoviruses, additional studies are necessary to understand their interactions in human breast carcinogenesis.

The main objective of the study is to empirically investigate the impact of the Conventional stock market index on the Islamic stock market index and the comparative performance of the two stock market indexes. For the purpose of the study, daily observations of Dow Jones Islamic Market US Titans 50 (DJUS50) and Dow Jones Composite Index (DJA) spanning a period from January 2015 until December 2021 are obtained from the Investing.com database. Risk-adjusted performance, VAR model, granger-causality test, generalized impulse response functions, and Johansen cointegration tests are used to investigate the behavior and performance of the Islamic market index empirically. Results based on risk-adjusted performance indicate that the Islamic market index performs better than the Conventional market index. Furthermore, the results suggest no long-run association between the indexes, while there is short-run bidirectional causality. This study will contribute both to the literature and practice. It will contribute to the already existing literature through the usage of the newest data, while the practical implication will help investors to better understand the behavior of the Islamic stock market index.

En-bloc tumor resection is the standard treatment for locally advanced colorectal cancer (CRC). An extensive histopathological assessment is necessary to evaluate the metastatic spread and adjuvant therapy. Sentinel lymph node biopsy decreases the histopathological burden when only sentinel lymph nodes (SLNs) are examined. This study aims to evaluate the spread of a magnetic tracer throughout the lymphatic system after ex vivo injection in en-bloc resected specimens of patients with CRC. To achieve this, lymph nodes (LNs) were quantified using a new magnetic detection method. Fifteen patients with CRC diagnosed with clinically negative LNs were included in this study and received 2–4 ex vivo magnetic tracer injections (total volume of 2[Formula: see text]mL). Magnetic sample series were acquired to create a look-up table for magnetic tracer quantification. In 80% of the patients, at least one magnetic LN was detected. A total of 33 LNs were marked as magnetic, containing an average of 8.1[Formula: see text][Formula: see text]g iron. In 71% of the patients, metastases were found in nonmagnetic LNs. Ex vivo injection leads to sub-optimal tracer spread and therefore inaccurate diagnosis. This study presents a novel magnetic detection method to quantify magnetic tracer in lymph nodes. Detecting the SLNs in en-bloc resected specimens and involving only these LNs in histopathological investigation enable a decrease in healthcare costs or an increased diagnostic potential.

<p>Reading is an extremely important language skill both in educational process and out of it.<br />Unfortunately, in many foreign language classrooms, particularly in our country, the significance of this<br />skill is not completely recognized and the most attention is still paid to grammar. Namely, reading is often<br />seen as a mere capacity of decoding written language signs and the parallel processes of reading<br />comprehension and interpretation are not sufficiently addressed. The paper deals with the several issues,<br />such as significance of reading skills, the strategies needed for their development and the strategic role of<br />the reading skill in the environment of content and language integrated learning (CLIL). Most of the<br />contemporary research done in this field of the applied linguistics highlights the role of reading skills in<br />facilitating an easier acquisition of the content matter, which is one of the focuses of the CLIL approach<br />in general.</p>

<p>The paper focuses on the role of language in a specific socio-political context. It offers a critical<br />approach regarding the representation of political actors in Bosnia-Herzegovina (BiH) in press releases<br />of the Office of the High Representative in BiH, for the period 2006 - 2011. The aim of the linguistic<br />examination is to analyse the notion of the power imbalance between different actors and ideology which<br />is subtly interwoven in the investigated discourse. There are three stages of analysis in the process of<br />linguistic investigation. In the first stage of analysis, the linguistic investigation is carried out by the means<br />of language tools provided by systemic functional grammar. At this stage, the text is analysed at three<br />different levels: ideational, interpersonal, and textual. In the second stage, the logogentic patterns, which<br />emerge as a result of the lexico-grammatical investigation, are further sifted by the analytical framework<br />of critical discourse analysis. In the final stage of the investigation, the text, which is comprehended as a<br />structure realized by clauses, undergoes a pragmatic investigation of presuppositions. The paper shows<br />that the proposed threefold investigation of the text enables the deconstruction of the meaning of the text<br />and at the same time provides an insight into the nature of the relationship between different actors<br />involved in the discourse.</p>

<p>Svjedoci smo pojave sve većeg broja informacionih sistema. Informacioni sistemi se kreiraju u<br />cilju olak&scaron;anja procesa koji su podrazumijevani u okviru nekog servisa. U slučaju ovog rada,<br />informacioni sistem je sproveden u vidu desktop aplikacije, kreirane u programskom jeziku Java,<br />kori&scaron;tenjem JFrame formi. JFrame forme predstavljaju izuzetno jednostavan i efikasan način<br />dizajniranja aplikacija, gdje je, uz pomoć NetBeans okruženja, moguće upravljanje elementima u<br />prozoru &bdquo;klikom mi&scaron;a&ldquo;, &scaron;to uključuje njihovo pozicioniranje na ekranu, funkcionalnost koju okidaju<br />nakon određenog event-a (događaja) i sl. Za bazu podataka kori&scaron;ten je MySQL, u sklopu WampServera.</p>

Introduction: Sexual satisfaction is the pleasure an individual feels both physically and psychologically, and is the result of erotic experiences, thoughts, dreams, and autoeroticism. Purpose: The purpose of the study is to present the determinants of sexual satisfaction among Bosnian and Herzegovinian women. Methods: The survey was conducted on 387 Bosnian and Herzegovinian women via online questionnaire that consisted of demographic data and 17 statements. The validated questionnaire was used with some adaptations and contained a 5-point Likert scale for each statement, ranging from “not at all satisfied” to “extremely satisfied.” The inclusion criteria were: (a) Age 18–60 years; and (b) completion of the questionnaire as personal consent. Data were analyzed using SPSS 26.0 statistical software. Results: Data collection was conducted from July 2020 to September 2020. The realization rate of the sample was 24.19%. Most of the participants have a high school diploma, most are between 18 and 24 years old and most are currently married. Thirty-five percent of women sometimes experience pain during intercourse (less than half the time). The lower half of the vagina (from the vaginal entrance to the half of the vagina) and the lower part of the abdomen are usually most affected. A relationship was found between the number of children and sexual satisfaction. Women without children were the most satisfied with their sexual life, followed by women who had only one or two children. Conclusions: Every woman has the right to feel sexual satisfaction. The complexity of sexual satisfaction is reflected in many determinants and factors that can influence it positively and negatively.

Circular peptides are attractive lead compounds for drug development; this study investigates the immunomodulatory effects of defined root powder extracts and isolated peptides (called cyclotides) from Carapichea ipecacuanha (Brot.) L. Andersson (‘ipecac’). Changes in the viability, proliferation and function of activated human primary T cells were analysed using flow cytometry-based assays. Three distinct peptide-enriched extracts of pulverised ipecac root material were prepared via C18 solid-phase extraction and analysed by reversed-phase HPLC and mass spectrometry. These extracts induced caspase 3/7 dependent apoptosis, thus leading to a suppressed proliferation of activated T cells and a reduction of the number of cells in the G2 phase. Furthermore, the stimulated T cells had a lower activation potential and a reduced degranulation capacity after treatment with ipecac extracts. Six different cyclotides were isolated from C. ipecacuanha and an T cell proliferation inhibiting effect was determined. Furthermore, the degranulation capacity of the T cells was diminished specifically by some cyclotides. In contrast to kalata B1 and its analog T20K, secretion of IL-2 and IFN- γ was not affected by any of the caripe cyclotides. The findings add to our increased understanding of the immunomodulating effects of cyclotides, and may provide a basis for the use of ipecac extracts for immunomodulation in conditions associated with an exessive immune responses.

– This paper considers controlled scalar systems relying on a lossy wireless feedback channel. In contrast with the existing literature, the focus is not on the system controller but on the wireless transmit power controller that is implemented at the system side for reporting the state to the controller. Such a problem may be of interest, e.g. , for the remote control of drones, where communication costs may have to be considered. Determining the power control policy that minimizes the combination of the dynamical system cost and the wireless transmission energy is shown to be a non-trivial optimization problem. It turns out that the recursive structure of the problem can be exploited to determine the optimal power control policy. As illustrated in the numerical performance analysis, in the scenario of a dynamics without perturbations, the optimal power control policy consists in decreasing the transmit power at the right pace. This allows a significant performance gain compared to conventional policies such as the full transmit power policy or the open-loop policy.

Background: The aim of the study was to find out what happens to erythrocytes and their forms during life and after death as a result of high water temperature.Methods: Heat stress was used on a rat model.to investigate the effects of different temperature intensities (37°C and 44°C) and exposure time (20 min and until the time of death) on erythrocyte morphology. Total of 23 Wistar rats were divided into two groups: 37°C as control group and 44°C as trial groups. The trial groups were classified into antemortem the exposure time of 20 min and postmortem groups exposure time until fatal outcome. The anaesthetised rats were exposed to preheated water using the water bath. May-Grünwald-Giemsa colouring technique was applied on blood samples taken from the abdominal aorta. Results: Exposure of Wistar rats to water temperature in groups KG37 and G44 led to a significant changes in core temperature. In the control group, the thermoregulatory mechanism established normothermia, and in G44 hyperthermia was detected during 20 minutes of exposure. The frequency of heat stroke in group G44 was 43.8%. Target cells and anulocytes were predominant in antemortem group at 44°C, while anulocytes and spherocytes in postmortem groups 44°C, respectively. Dacryocytes with spherocytes were significantly higher in postmortem group 44°C than in antemortem group 44°C (p=0.002, p=0.017, respectively).Conclusions: Poikilocytosis is associated with the exposure length and temperature intensity. Following a fatal outcome dacryocytes with spherocytes at 44°C were significantly more than in corresponding antemortem groups.

Denial of Service attacks and the distributed variant of this type of attack called DDoS are attack types which are easy to start but hard to stop especially in the DDoS case. The significance of this type of attack is that attackers use a large number of packets usually created with programs and scripts for creating specially crafted types of packets for different types of attack such as SYN flood, ICMP smurf, etc. These packets have similar or identical attributes such as length of packets, interval time, destination port, TCP flags etc. Skilled engineers and researchers use these packet attributes as indicators to detect anomalous packets in network traffic. For fast detection of anomalous packets in legitimate traffic we proposed Interactive Data Extraction and Analysis with Newcombe-Benford power law which is able to detect matching first occurrences of leading digits – size of each packet that indicate usage of automated scripts for attack purposes. Power law can be used to detect the same first two, three, or second digits, last one or two digits in data set etc. We used own data set, and real devices.

In this paper we proved the existence and local stability of prime period-two solutions for the equation 𝐱𝐧􀬾𝟏 􀵌 𝛂𝐱𝐧 𝟐 􀬾𝛃𝐱𝐧􀬾𝛄𝐱𝐧􀰷𝟏 𝐀𝐱𝐧 𝟐 􀬾𝐁𝐱𝐧􀬾𝐂𝐱𝐧􀰷𝟏 , for certain values of parameters ,,,A,B,C0, where ++>0 , A+B+C>0, and where the initial conditions x₋₁, x₀>0 are arbitrary real numbers such that at least one is strictly positive. For the obtained periodic solutions, it is possible to be locally asymptotically stable, saddle points or nonhyperbolic points. The existence of repeller points is not possible.

Pomegranate peel extract (PoPEx) has been shown to have antioxidant and anti-inflammatory properties, but its effect on the adaptive immune system has not been sufficiently investigated. In this study, the treatment of human peripheral blood mononuclear cells (PBMC) with PoPEx (range 6.25–400 µg/mL) resulted in cytotoxicity at concentrations of 100 µg/mL and higher, due to the induction of apoptosis and oxidative stress, whereas autophagy was reduced. At non-cytotoxic concentrations, the opposite effect on these processes was observed simultaneously with the inhibition of PHA-induced PBMC proliferation and a significant decrease in the expression of CD4. PoPEx differently modulated the expression of activation markers (CD69, CD25, ICOS) and PD1 (inhibitory marker), depending on the dose and T-cell subsets. PoPEx (starting from 12.5 µg/mL) suppressed the production of Th1 (IFN-γ), Th17 (IL-17A, IL-17F, and IL-22), Th9 (IL-9), and proinflammatory cytokines (TNF-α and IL-6) in culture supernatants. Lower concentrations upregulated Th2 (IL-5 and IL-13) and Treg (IL-10) responses as well as CD4+CD25hiFoxp3+ cell frequency. Higher concentrations of PoPEx increased the frequency of IL-10- and TGF-β-producing T-cells (much higher in the CD4+ subset). In conclusion, our study suggested for the first time complex immunoregulatory effects of PoPEx on T cells, which could assist in the suppression of chronic inflammatory and autoimmune diseases.