Given the ongoing "arms race" in cybersecurity, the shortage of skilled professionals in this field is one of the strongest in computer science. The currently unmet staffing demand in cybersecurity is estimated at over 3 million jobs worldwide. Furthermore, the qualifications of the existing workforce are largely believed to be insufficient. We attempt to gain deeper insights into the nature of the current skill gap in cybersecurity. To this end, we correlate data from job ads and academic curricula using two kinds of skill characterizations: manual definitions from established skill frameworks as well as "skill topics" automatically derived by text mining tools. Our analysis shows a strong agreement between these two analysis techniques and reveals a substantial undersupply in several crucial skill categories, e.g., software and application security, security management, requirements engineering, compliance and certification. Based on the results of our analysis, we provide recommendations for future curricula development in cybersecurity so as to decrease the identified skill gaps.

OCT is a well-established antiseptic molecule routinely used in a large field of clinical applications. Since the spread of antimicrobial resistance has restricted the use of antibiotics worldwide, topically applied antiseptics like OCT, with a broad spectrum of antimicrobial activity and high safety profile, gain increasing importance for effective infection prevention and therapy. ABSTRACT The antimicrobial killing mechanism of octenidine (OCT), a well-known antiseptic is poorly understood. We recently reported its interaction with Gram-negative bacteria by insertion of OCT into the outer and cytoplasmic membrane of Escherichia coli, resulting in a chaotic lipid rearrangement and rapid disruption of the cell envelope. Its action primarily disturbs the packing order of the hydrophobic moiety of a lipid, which consequently might result in a cascade of multiple effects at a cellular level. Here, we investigated OCT’s impact on two different Gram-positive bacteria, Enterococcus hirae and Bacillus subtilis, and their respective model membranes. In accordance with our previous results, OCT induced membrane disorder in all investigated model systems. Electron and fluorescence microscopy clearly demonstrated changes in cellular structure and membrane integrity. These changes were accompanied by neutralization of the surface charge in both E. hirae and B. subtilis and membrane disturbances associated with permeabilization. Similar permeabilization and disordering of the lipid bilayer was also observed in model membranes. Furthermore, experiments performed on strongly versus partly anionic membranes showed that the lipid disordering effect induced by OCT is a result of maximized hydrophobic over electrostatic forces without distinct neutralization of the surface charge or discrimination between the lipid head groups. Indeed, mutants lacking specific lipid head groups were also susceptible to OCT to a similar extent as the wild type. The observed unspecific mode of action of OCT underlines its broad antimicrobial profile and renders the development of bacterial resistance to this molecule less likely. IMPORTANCE OCT is a well-established antiseptic molecule routinely used in a large field of clinical applications. Since the spread of antimicrobial resistance has restricted the use of antibiotics worldwide, topically applied antiseptics like OCT, with a broad spectrum of antimicrobial activity and high safety profile, gain increasing importance for effective infection prevention and therapy. To eliminate a wide spectrum of disease-causing microorganisms, a compound’s antiseptic activity should be unspecific or multitarget. Our results demonstrate an unspecific mechanism of action for OCT, which remained largely unknown for years. OCT disturbs the barrier function of a bacterial cell, a function that is absolutely fundamental for survival. Because OCT does not distinguish between lipids, the building blocks of bacterial membranes, its mode of action might be attributed to all bacteria, including (multi)drug-resistant isolates. Our results underpin OCT’s potent antiseptic activity for successful patient outcome.

Najvažniji zahtjev vladavine prava je da ljudi na pozicijama vlasti treba da vrše svoju vlast unutar ograničavajućeg okvira dobro ustanovljenih javnih normi, umjesto na proizvoljan, ad hoc ili čisto diskrecioni način. Vladavina prava se utjelovljuje stabilnim ustavom koji se sastoji od formalnih pravila putem kojih se ograničavaju upravljačka ovlašćenja na osnovu zakonu. Pored sudova, za vladavinu prava je važno i obezbjeđenje poštovanja zakona i podsticanje izvršenja sudskih odluka od strane vladinih službenika. Upravo zbog toga, zakonodavstva u razvijenim demokratijama propisuju krivično djelo „Neizvršenje sudske odluke“ prema kojim se kažnjivim ponašanjem smatraju radnje odgovornog službenika koji odbije da izvrši pravnosnažnu presudu. Nezavisnost pravosuđa je kičma vladavine prava, dok nezavisnost sudija štiti nezavisnost pravosuđa u cjelini. Nepristrasnosti u odlučivanju sudije znači da je neophodno da sudije djeluju bez bilo kakvih ograničenja, nedoličnog uticaja, pritiska, prijetnje ili miješanja, neposrednog ili posrednog, od strane bilo kog autoriteta, uključujući autoritete unutar pravosuđa. Međutim, finansijska nezavisnost pravosuđa je još uvijek ograničena i uslovljena postupkom odobravanja budžetskih sredstava dodijeljenih pravosuđu od strane ministarstava finansija, što pravosudne organe čini zavisnim od vladajućih politika i omogućava korupciju u pravosuđu ili uticaj politike na rad pravosuđa. Reforma pravosudnog sistema moguća je samo ukoliko građani osjećaju njene benefite i pokazuju zadovoljstvo postignutim rezultatima. Sudeći prema percepciji građana, korupcija je najdominatnija u sistemu zdravstva i među političkim partijama, zbog čega Agencija za borbu protiv korupcije BiH treba pojačati svoje napore budući da je sprječavanje korupcije na visokom nivou direktno pod njenom nadležnošću. Upravo zbog toga, u namjeri da se predstavi negiranje vladavine prava u Bosni i Hercegovini, koristiće se studije slučaja koji predstavljaju sekundarnu viktimizaciju žrtava i ukazati na indikatore postojanja vladavine prava, a to su: poštovanje zakona, nezavisnost pravosuđa i odsustvo korupcije.

Since December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far. In the present review, we analyzed the PubMed indexed literature published between December 2019 and January 2022 to understand this relationship from various points of view, such as susceptibility, severity and heritability. Based on our knowledge, this is the first comprehensive review on COVID-19 and its associations with various congenital anomalies and genetic diseases. According to reported studies, some congenital disorders present high-risk for developing severe COVID-19 since these disorders already include some comorbidities related to the structure and function of the respiratory and cardiovascular systems, leading to severe pneumonia. Other congenital disorders rather cause psychological burdens to patients and are not considered high-risk for the development of severe COVID-19 infection.

The prevalence of English as a global language has been mirrored in various domains of life. The latest testimony to its pervasive influence on other languages is finely portrayed through the case of coronavirus that blindsided the world recently. The disease has led to certain English words being used so often that they have become an integral part of everyday vocabulary in many languages and thus in the Bosnian language. The present quantitative research paper considers the frequency of usage and knowledge of the original form and meaning of English words related to the current pandemic used as Anglicisms in the Bosnian language. Respondents of different demographic backgrounds have reported infrequent use of these Anglicisms during and before the pandemic. Moreover, it has been reported that their knowledge of the English written form of these Anglicisms is more significant than their knowledge of their Bosnian translations/synonyms. The results indicated that Covid-19-related Anglicisms are characteristic of speakers of all ages, genders, and English-proficiency backgrounds.

Background We aimed to determine the diagnostic yield of transthoracic (TTE) and transesophageal echocardiography (TEE) in patients with ischemic stroke and transient ischemic attack with established indications for direct oral anticoagulants before the index event. Methods and Results This was a retrospective cohort study of consecutive patients with preceding established indications for long‐term therapeutic direct oral anticoagulants presenting to a single comprehensive stroke center with ischemic stroke or transient ischemic attack. Choice of echocardiography modality was based on expert recommendations. The primary outcome was a composite of prespecified management‐relevant high‐risk findings adjudicated by an expert panel, based on TTE and TEE reports according to evidence‐based recommendations. Explorative analyses were performed to identify biomarkers associated with the primary outcome. Of 424 patients included (median [interquartile range] age, 78 [70–84] years; 175 [41%] women; National Institutes of Health Stroke Scale, 4 [1–12]; 67% atrial fibrillation), 292 (69%) underwent echocardiography, while 132 (31%) did not. Modality was TTE in 191 (45%) and TEE in 101 (24%). Median time from index event to echocardiography was 2 (1–3) days. TTE identified 26 of 191 (14%) patients with 35 management‐relevant pathologies. TEE identified 16 of 101(16%) patients with 20 management‐relevant pathologies. Most management‐relevant findings represented indicated coronary artery disease and valvular pathologies. In a further 3 of 191 (2%) patients with TTE and 4 of 101 (4%) patients with TEE, other relevant findings were identified. Variables associated with management‐relevant high‐risk pathologies included more severe stroke, diabetes, and laboratory biomarkers (NT‐proBNP [N‐terminal pro‐B‐type natriuretic peptide], C‐reactive protein, d‐dimer, and troponin levels). Conclusions In patients with established indications for long‐term direct oral anticoagulant therapy and stroke who received echocardiography, both TTE and TEE identified a relevant and similar proportion of management‐relevant high‐risk pathologies and predictive biomarkers could help to guide diagnostic workup in such patients.

c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is implicated in several physiological processes, including pigmentation, hematopoiesis, and gut movement. Accumulating evidence suggests that dysregulated c-KIT function, caused by either overexpression or mutations in c-kit, promotes tumor development and progression in various human cancers. In this review, we discuss the most important structural and biological features of c-KIT, as well as insights into the activation of intracellular signaling pathways following SCF binding to this RTK. We then illustrate how different c-kit alterations are associated with specific human cancers and describe recent studies that highlight the contribution of c-KIT to cancer stemness, epithelial-mesenchymal transition and progression to metastatic disease in different experimental models. The impact of tyrosine kinase inhibitors in treating c-KIT-positive tumors and limitations due to their propensity to develop drug resistance are summarized. Finally, we appraise the potential of novel therapeutic approaches targeting c-KIT more selectively while minimizing toxicity to normal tissue.

As the quest for marine-derived compounds with pharmacological and biotechnological potential upsurges, the importance of following regulations and applying Responsible Research and Innovation (RRI) also increases. This article aims at: (1) presenting an overview of regulations and policies at the international and EU level, while demonstrating a variability in their implementation; (2) highlighting the importance of RRI in biodiscovery; and (3) identifying gaps and providing recommendations on how to improve the market acceptability and compliance of novel Blue Biotechnology compounds. This article is the result of the work of the Working Group 4 “Legal aspects, IPR and Ethics” of the COST Action CA18238 Ocean4Biotech, a network of more than 130 Marine Biotechnology scientists and practitioners from 37 countries. Three qualitative surveys (“Understanding of the Responsible Research and Innovation concept”, “Application of the Nagoya Protocol in Your Research”, and “Brief Survey about the experiences regarding the Nagoya Protocol”) indicate awareness and application gaps of RRI, the Nagoya Protocol, and the current status of EU policies relating to Blue Biotechnology. The article categorises the identified gaps into five main categories (awareness, understanding, education, implementation, and enforcement of the Nagoya Protocol) and provides recommendations for mitigating them at the European, national, and organisational level.

The paper present results of the investigations on the prehistoric sites in the vicinity of the city of Zenica conducted during 2018 and 2019. Based on the cooperation between the Austrian Archaeological Institute of the Austrian Academy of Sciences and City Museum of Zenica we applied geophysical prospection, air-borne laser scanning and excavations in order to get a better understanding of the Bronze and Iron Age developments in this specific part of the central Bosnia along the Bosna River. This research is emebeded within the project “Visualizing the unknown Balkans, supported by the Innovation Fond of the Austrian Academy of Sciences.Apart from previously known and to smaller extent excavated hillfort Kopilo, our work also focused on the sites situated on the ridge above Gradišće in the northern part of the Zenica Basin. What appears to be indicative of this micro-region are high attitudes (600-900 m a.s.l.) of the identified Bronze and Iron Ages settlements in comparison to the situation in the neighboring valleys and basins of the central Bosnia. Such position provided mutual visual contact between the sites and an excellent control of the entry and exit from the Zenica Basin. Our work also brought evidences of prehistoric stone mounds on the ridge above Gradišče. The numerous archeological finds indicatate the importance and a long continuity of the hillforts such as Kopilo that obviuolsy lasted unti the advanced La Téne Period.

This work presents the synthesis of heat-integrated water networks (HIWNs) by using mathematical programming. A new superstructure is synthesised by combining a water network and a modified heat exchanger network. Based on the proposed superstructure, a mixed-integer nonlinear programming (MINLP) model is developed. The model is solved by using a one-step solution strategy enabling different initialisations and the generation of multiple solutions, from which the best one is chosen. The results show that the proposed model can be effectively used for solving HIWN problems of different complexities, including large-scale problems.

In addition to a historical overview of development of stećak tombstones, this paper also includes their overview in a catalog form, containing individual descriptions with photographs. Stećak tombstones located in the National Museum were declared a movable property by the Decision of the Commission to Preserve National Monuments of Bosnia and Herzegovina, adopted at its 30th session, held on June 26, 2019, entitled: Collection of Ancient and Medieval Stone Monuments at the National Museum of Bosnia and Herzegovina, Sarajevo.

The infection with SARS-CoV-2 virus in cats and dogs raised issue of human-to-animal transmission of SARS-CoV-2 in domestic pets in close contacts with their owners. Our study was designed to research this in the framework of Bosnia and Herzegovina. Using ELISA, AFIAS fluorescent immunoassay, RT-qPCR and WGS on Nanopore MinION platform with ARTIC Network Amplicon sequencing protocol for SARS-CoV-2, we showed that three out of thirteen dogs and one out of five cats from the households with confirmed human cases of COVID-19 in Bosnia-Herzegovina were infected with SARS-CoV-2. The high viral RNA load was detected in samples collected from a 4-year-old male Havanese (Ct = 12.52), a 6-year-old German Shepherd (Ct = 21.36) and a 9-year-old female American Staffordshire terrier (Ct = 25.74). The antibody response in dogs and one cat was observed. The viral genetic sequences from dogs were identical to the sequences detected in the owners suggesting the human-to-animal transmission of the virus. These findings, especially the low initial Ct values detected, from the public health perspective additionally stress the need for precautionary measures to protect both humans and animals.