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<abstract> <p>Newton's identities of an infinite polynomial with complex-conjugate roots <italic>n</italic>^{<italic>−(</italic>σ+<italic>it</italic>)} and <italic>n</italic>^{<italic>−(</italic>σ<italic>−it</italic>)} are multiple zeta functions for <italic>n</italic>∈[1, ∞), σ∈R and <italic>t</italic>∈R. All Newton's identities can be represented by Macdonald determinants. In a special case of the Riemann hypothesis, the multiple zeta function of the first order is equal to zero, ζ(σ+<italic>it</italic>)+ζ(σ−<italic>it</italic>) = 0. The special case includes all non-trivial zeros. The value of the last, infinite multiple zeta function, in the special case, changes the structure of the determinant that can be calculated. The result is the reciprocal of the factorial value (<italic>n</italic>!)⁻¹. The general value of the infinite multiple zeta function is calculated based on Vieta's rules and is equal to (<italic>n</italic>!)^−2σ. The identity based on the relation of the special case and the general case (<italic>n</italic>!)⁻¹ = (<italic>n</italic>!)^−2σ is reduced to the equation −1 = −2σ. The value of the critical line for all non-trivial zeros is singular, σ = ½.</p> </abstract>

Functional appliances are key to success in early orthodontic therapy. Their application is most useful in the period of a pre-puberty and pubertal growth spurt, in order to achieve facial aesthetics and improve the patient's health. The aim of treatment with functional appliances is to act on the muscles and ligaments, thereby influencing the movement and growth of the lower jaw forward, when it comes to the distal bite. The devices are used to correct malocclusions in all three spatial planes: sagittal, vertical, and transferal. In the sagittal dimension, the distal bite is corrected and Angle class I occlusion is established. In the transferal dimension, appliances are used to expand the dental arches. In the vertical dimension, appliances are used to correct an open or deep bite. Most often, mobile functional appliances are used, which consist of special upper and lower parts, such as the Twin block and the "M" block. Other types of functional devices have been used for many years, they consist of one part and their disadvantage is discomfort for patients and the impossibility of use in the presence of septal deviation or any other airway obstruction (activator and all its modifications, as well as Bionator). Recently, fixed functional appliances are also used, the advantage of which is that they do not depend on the cooperation of the patient and that they hold the mandible in an anterior position for 24 hours, achieved on the basis of an adequately taken construction bite. Their application is not conditioned by the puberty growth spurt but can be used by post-adolescents and young adults. In the production of functional appliances, the most important thing is to take a good construction bite, which determines how the muscle power will be transferred to the tissues, teeth, and jawbone. They determine the course of treatment and its duration. Muscle activation is performed in sagittal, transverse, and vertical directions, individually for each patient depending on the type of device.

The authors analyse the peculiarities of contracting in the business of vessel leasing in the Republic of Croatia and its relation to other movable properties. General business conditions as part of the vessel leasing contract are the focus of this research. In the paper, the authors examine different approaches of leasing companies in relation to the specifics of the vessel, as an object of leasing, which, through the general conditions of business, determine the specific rights and obligations of the leasing provider and receiver. A critical review is given of the various solutions that are prescribed by leasing companies in the Republic of Croatia through the general terms of business. For a complete analysis of the scope of the parties in the contracting process, the legal framework of the leasing contract is analysed beforehand.

The discussion about whether the internet addiction disorder should be considered a primary addiction disorder or a secondary disorder due to other psychiatric illnesses is a very current topic. Although the term "addiction" has historically been associated with the pathological use of psychoactive substances, research over the past few decades indicates that various behaviors are also part of the spectrum of addiction. Accordingly, addictions to psychoactive substances and behavioral addictions overlap in several segments, but there are also certain differences between them. Taking into account these statements, the subject of this research was the analysis of the personality structure of Internet addicted adolescents, aimed at identifying if there are specific differences in certain personality dimensions between adolescents addicted to the Internet (reference group) and adolescents who abuse psychoactive substances, as well as in adolescents from the non-clinical population. The methodology was applied to a sample consisting of 125 respondents of both genders, aged 13 to 24, of whom 27 were from the clinical group of Internet addicts, 24 from the clinical group of psychoactive substance addicts, and 74 from the non-clinical population. A questionnaire was used for assessing Internet addiction (Internet Addiction Test) and a questionnaire for assessing the personality of adolescents (Belgrade Personality Inventory of Adolescents). The results indicate that we cannot talk about a specific profile that distinguishes respondents who are addicted to the Internet. However, despite the limitations, significant differences in certain dimensions indicate certain deviations between groups of adolescents with Internet addiction, addiction to psychoactive substances and the non-clinical population. Low research curiosity, poorly developed perseverance and goal orientation play a significant role in the aetiopathogenesis of Internet addicts. We conclude that the obtained results can have a significant role in solving the current dilemma whether Internet addiction disorder should be considered a primary addiction disorder or a secondary disorder due to other psychiatric diseases.

Eating disorders affect both the physical health, but also the psychological and social aspects of life of the people who suffer from them. The World Health Organization (WHO) uses the term "quality of life" to define the individuals' perception of their position in life in the context of their culture and values, and in relation to their goals, expectations, standards and concerns, to express a wide range of changes in the life of a person. Some of these changes are either caused or affected by eating habits that often present in a form of eating disorders. In recent decades, there has been growing interest in finding adequate questionnaires to help identify and measure the severity of eating disorders, as well as the quality of life of these patients. Several studies have been conducted on this topic, and scientific evolution and progress will be discussed in detail below to identify the most appropriate questionnaire to assist clinicians in their therapeutic practices. The primary objective is the detailed identification and classification of eating disorders in line with the most recent findings. The secondary objective is identification and classification of the questionnaires for testing eating disorders and quality of life. We conducted a review of the current research into developing the possibility of detecting eating disorders and potential health risks in untreated patients. The following index data bases were digitally searched: PubMed-Medline, Web of Science, Scopus, Cochrane database of systematic reviews, Embase, Epistemonikos, all searched up to August 2022. The combination of keywords revised in the list of medical subject headings (MeSH) was used to select relevant articles: (eating disorders) and (tests and/or questionnaires for eating disorders and quality of life). The analysis included meta-analyses, systematic reviews and original scientific articles. Special attention was paid to the discussion on identifying and providing insight into eating disorders in line with the latest findings, as well as to the examination and description of questionnaires for exploring eating disorders and quality of life. Among the first questionnaires used in practice to assess the quality of life of patients with eating disorders were Short Form-36 (SF-36) and the Eating Disorder Examination Questionnaire (EDE-K). Although generic questionnaires were applied and had produced good results, there is still no specific questionnaire on the quality of life of persons with eating disorders. New discoveries emerge as the search continues for highly specialized and sensitive questionnaires. Several instruments and questionnaires are used to get a final result in several studies investigating the connection between the intensity of symptoms caused by eating disorders and the quality of life, which shall be discussed below. Great progress has been made in evaluating and designing appropriate questionnaires to help clinicians and researchers in diagnostics, developing treatment strategies and providing prognoses for eating disorders, as well as in assessing the quality of life of these patients. Most studies and research come to the conclusion that a combination of multiple questionnaires simultaneously is the best choice for detection and prevention of deterioration in the quality of life of patients with eating disorders, as well as for considering the predictive factors that pertain to the quality of life. It is important to emphasize frequent comorbidity of other mental illnesses, such as depression and anxiety, meaning that it is important to use instruments that help in early detection of these comorbidities during examination.

227 Наше писмо уреднику анализира сазнања о интензитету и учесталости паралелног појављивања вазомоторних, соматских и психолошких симптома у климактеријуму, менопаузи и понеких у постменопаузи. Написан је да подстакне стручну и научну јавност да критички анализира питања и да предложи одређени правац деловања унутар могућности репродуктивне ендокринологије, менталног здравља и методологија расположивих за примену опција лечења. Писмо уреднику такође пружа најновију перспективу сазнања која служи сврси и покреће контроверзну тему у нади да ће се боље разумети концепт (симптома и третмана).

Background: Pulmonary Embolism (PE) represents a life-threatening medical emergency that, given the serious complications, requires urgent application of anticoagulant therapy. In addition to other factors that are taken into account when choosing a therapy for treatment of PE, the anatomical distribution of thrombi is also considered–whether it is a central, lobar, segmental or subsegmental PE. D-dimer is an intermediate product of degradation of fibrin molecules and its values in the plasma are increased in the case of PE, but also in other diseases. Objective: To determine whether there is a difference in D-dimer values in subjects with different anatomical distribution of PE. Methods: The study included 100 subjects with diagnosed PE by using MSCT and/or V/P SPECT and with measured values of D-dimer. Results: Out of 100 subjects, PE was not diagnosed in 37 subjects, while 63 subjects PE was diagnosed. All subjects with diagnosed PE were divided into 3 groups regarding the anatomical localization of thrombus: lobar, segmental or subsegmental. Average D-dimer values were calculated for all 3 groups. Statistical analysis showed that there was no significant difference in D-dimer values between subjects with different anatomical distribution of PE. Conclusion: There is no significant difference in D-dimer values between subjects with different anatomical distribution od PE–lobar, segmental and subsegmental PE.

Background: Increasing evidence indicates that COVID-19 may result in cardiac issues in certain individuals, such as myocarditis, arrhythmias, and heart failure. Ongoing research on echocardiographic manifestations is still limited. Objective: To investigate the incidence and patterns of left and right ventricular dysfunction in COVID-19 patients. Methods: This study retrospectively observed COVID-19 patients admitted to the Clinical Center of University of Sarajevo during the third wave, with a particular focus on cardiac evaluations. Results. Our patients, predominantely male 155 (72.4%), with a mean age of 66.2±11.4, having hypertension 86 (40.1%), diabetes mellitus 61 (28.5%), hyperlipidemia 144 (67.3%), were active smokers 87 (40.6%), had family history of cardiovascular diseases 123 (57.5%) and were COVID-19 positive 95 (44.4%), presented because of chest pain 78 (36.4%), dyspnea 103 (48.1%), palpitations 67 (31.3%), fatigue 106 (49.5%) and peripheral oedema 30 (14.0%). COVID-19 patients reported much higher symptoms of dyspnea (65 (68.4%) vs 38 (31.9%)) and fatigue (73 (76.8%) vs 33 (27.7%)) than COVID-19 negative patients. On the initial laboratory report, COVID-19 patients had a significantly (p<0.05) higher mean score of C-reactive protein (24.0±4.8 vs. 6.0±2.1), D-dimer (1.6±2.5 vs 0.8±0.6), ALT (94.8±17.2 vs 36.5±19.9) and creatinine (128.0±80.8 vs. 93.4±40.1) when compared to COVID-19 negative patients. COVID-19 patients had enlarged left atrium diametes (31.6±5.6 vs 27.5±5.3), enlarged left ventricular diameter both in systole (27.9±18.1 vs 23.3±16.3) and diastole (39.3±24.1 vs 34.9±22.7), reduced left ventricular ejection fraction (53.5±9.2 vs 59.8±4.3) and elevated right ventricular systolic pressure (37.0±16.4 vs 35.1±8.6). Conclusion. COVID-19 patients had enlarged left atrium, enlarged systolic and diastolic left ventricular diameter, reduced left ventricular ejection fraction and elevated right ventricular systolic pressure.

Smoking is a global public health problem, and control measures should be implemented in the community so as to reduce the number of smoking-related diseases and healthcare costs. Community pharmacies are ideal places for providing tobacco cessation counselling as a type of public health service, because they are the most accessible health facilities with direct contact with patients. We aimed to examine attitudes towards the implementation of such services, conducting surveys on a sample of pharmacy students (N=300), community pharmacists (N=383) and the general public (N=987) in the Republic of Serbia. The introduction of smoking cessation services at pharmacies was supported by pharmacy students (59.7%), pharmacists (49.2%), and the general public (36.7%). No difference was found between pharmacistsàttitudes in terms of their gender, age, level of education and years of experience. We found evidence that pharmacists as public health practitioners were recognized mostly by students (94.3%). The majority of them (86.3%) recognized the need for additional education in order to implement new services, and every third pharmacist recognized a gap in their education. The data indicate the need for directed research in order to explore the educational needs and competences for practicing pharmacists and enable them to perform services such as smoking cessation in the future.

Background: The development of medicine and pharmacy in the Bosnia and Herzegovina was marked by different historical periods–first they were settled by the Illyrians and Delmatians, and after them came the Romans, the Ottoman Empire and the Austro-Hungarian Monarchy. Objective: The aims of this article are to show, based on the available literature: a) The development of medicine and pharmacy in Bosnia and Herzegovina from the medieval period until the Second World War; b) The most significant historical events that marked the development of medicine and pharmacy in the areas of Bosnia and Herzegovina; c) Methods of treatment, medicinal forms and preparations that were used in the mentioned period. Methods: The subject of this study was the development of medicine and pharmacy in the areas of Bosnia and Herzegovina from the 14th century until the Second World War. In order to achieve the set goals, a) Retreival of professional and scientific literature and b) Search of scientific databases and web pages on the Internet that offer adequate and relevant data and historical facts related to the subject of studies were carried out. Most of the facts are covered in previously published articles by the author and deposited in the PubMed and PubMed Central databases, as well as in books and monographs by the author of this text. Results and Discussion: In the Middle Ages, folk medicine was present, in which herbalists looked for medicines in certain plant and animal species. In the 13th century, Bosnia was settled by the Franciscans, who permanently marked the development of medicine and pharmacy. They are educated at prestigious universities abroad, from where they bring their knowledge, skills and recipes and write them in books, which are called ljekaruse (medicine books). Every historical period brought some changes for medicine and pharmacy, so the Ottoman Empire brought customs of frequent cleaning, public fountains and hammams were built. During the reign of the Austro-Hungarian Monarchy, the first hospitals and pharmacies were established, and laws on pharmacy activity were introduced. Written documents on the history of the medicine and pharmacy development in Bosnia and Herzegovina are mostly found in the libraries of monasteries, and a significant number of them are also in the libraries of madrasas, and the National and University Librarie in Sarajevo and the library of former Institute of Hygiene in Sarajevo. Conclusion: In connection with the medical and pharmacy practice of the Bosnian Franciscans, the question of the various medical records that they created, which helped them in their health efforts, stands out. First of all, we are talking about numerous medicinal books, so called ”ljekaruse”. On the soil of Bosnia and Herzegovina, there were many such “ljekarusa” who mostly grew up at the sources of national experience. In those books, the recipes are mostly based on the use of medicinal herbs. Historians of medicine believe that these medicinal books represent the cultural and historical significance of our regions.