Abstract Islanded microgrids with low-inertia distributed energy resources (DERs) are prone to frequency fluctuations. With the increasing integration of DERs in microgrids, the complexity of control and stability has also increased. Moreover, the integration of DERs into microgrids may result in a power imbalance between energy supply and demand during sudden changes in load or energy generation. This can cause frequency variations in the microgrid, which could have disastrous consequences such as equipment damage or even blackouts. This paper proposes a control strategy to ensure the efficient operation of an islanded hybrid microgrid consisting of a PV generator, battery energy storage system (BESS), and emergency diesel generator. According to Energy Exchange Model proposed in this paper, the hybrid system presented operates independently without being connected to the electrical grid, where the PV system and BESS act as the main energy sources, while the emergency diesel generator provides active power backup with voltage and frequency regulation. The novel in this paper is also that DER aids in frequency regulation during active power transients by delivering and absorbing active power in accordance with the inverter's suggested P droop control strategy. In this way inverter droop control decreases system frequency nadir emulating so called “synthetic inertia”. To design both the islanded hybrid system and the proposed control strategy, the MATLAB/Simulink environment is utilized. Based on the results, it can be concluded that the analyzed microgrid system is capable of maintaining stability and operating efficiently in a range of operating conditions.

The focus of the authors’ interest is the criminal offense of embezzlement in the service, which we classify in the catalogue of corrupt criminal offences, by its nature, operationalization method, consequences and other specificities. In addition, it is a criminal offense from the catalogue of premeditated criminal offenses, so the paper pays due attention to the interconnection and cumulative conditionality of objective and subjective elements, that is, the action of execution and the subjective component. Special attention is directed to the discovery of the existence of this criminal offense, i.e. the realistic discovery possibilities and capacities, then the objectivesubjective concept based on the legal description of this criminal offense, and the aspect of gathering the necessary evidence in connection with establishing the existence of the criminal offense and guilt, considering the restrictive legal requirements. The complexity of discovering and proving this criminal offense arises from the very nature of this criminal offense and certain specificities that are directly related to the way it is operationalized. The criminal law autonomy and independence, as well as the clear differentiation of this criminal offense in relation to other related criminal offences, are emphasized in order to avoid (possible) wrong identifications, and with the aim of a better and more comprehensive understanding of the very nature of this criminal offence

Uvod: Heterogena priroda akutne mijeloične leukemije (AML) iziskuje primjenu specifičnih i pouzdanih laboratorijskih testova pri postavljanju dijagnoze. Istraživanja ukazuju na određene nedostatke konvencionalnih morfoloških i imunofenotipskih metoda, ali i potrebu za imple-mentacijom kompleksnog dijagnostičkog algoritma koji uz navedene metode inkorporira citogenetičke i molekularno-genetičke analize u integrirani dijagnostički pristup. Cilj: Predstaviti prednosti i nedostatke integriranog dijagnostičkog pristupa u dijagnostici akutne mijeloične leukemije. Metode: Za potrebe neeksperimentalnog kvalitativnog istraživanja, pretražene su relevantne baze podataka (PubMed, Scopus i Web of Science). Pretraga baza u širem opsegu provedena je uz pomoć ključnih riječi acute myeloid leukemia, cytomorphology, flow cytometry, cytogenetic abnormalities i molecular diagnostics. Za konačnu analizu, odabrani su naučni radovi koji zadovoljavaju kriterije relevantnosti i povezanosti s postavljenim ciljem i temom istraživanja. Rezultati: Integracija dijagnostičkih modaliteta u AML predstavlja veliki izazov zbog kontinuriane složenosti i opterećenja za zdravstvene profesionalce. Kao značajne prednosti izdvajaju se mogućnost umrežavanja rezultata različitih dijagnostičkih modaliteta, te detekcija nespecifičnih i izazovnih slučajeva AML. Prijavljeni nedostaci se odnose na potrebu za jedinstvenim protokolima, nepredvidiv turnaround time, validaciju i potrebu za visoko specija-liziranim osobljem. Danas se sve više pažnje pridaje AI (engl. artifical intelligence) i njenoj sposobnosti da obradi podatke s ciljem pružanja brzih i preciznih dijagnostičkih i prognostičkih informacija što predstavlja obećavajući koncept u AML-u. Usvajanje ove paradigme znatno bi olakšalo trenutne pristupe i unaprijedilo koncept zdravstvene zaštite. Zaključak: Integrirani dijagnostički pristup ima za cilj poboljšati kvalitet pojedinačnih metoda primjenom dosadašnjih saznanja i paralelnim testiranjem novih mogućnosti. S razvojem precizne medicine, ovaj dijagnostički model će u budućnosti dobiti dodatni značaj. Neovisno od utvrđenih prednosti i nedostatka, dostupna istraživanja ukazuju na nužnost dodatnih napora i primjenu AI za uspostavljanje standardiziranog integriranog pristupa na globalnom nivou.

Uvod: Biotin, vitamin H ili vitamin B7, je topiv u vodi i neophodan je za reakcije karboksilacije, glukoneogenezu i metabolizam aminokiselina. Preporučena doza za odrasle je 0,03-0,06 mg/dan. Terapija visokim dozama biotina medicinski je indicirana za urođene pogreške metabolizma (nedostatak biotinidaze) i određene oblike alopecije, obično u dozama 5-10 mg/dan. U kliničkom ispitivanju je primjena biotina u dozi od 300 mg/dan kao tretman za progresivnu multiplu sklerozu. Materijal i metode: Streptavidin i manjim dijelom avidin nekovalentno se vežu za biotin s posebno jakim afinitetom, a trajnost te interakcije iskorištava se u laboratorijskim tehnikama kao što su western blot, protočna citometrija, imunohistokemija i imunohemijski testovi. Prema trenutačnim istraživanjima, poznato je da biotin uzrokuje interferencije u imunohemijskim testovima. Biotin ima sposobnost vezanja na različite molekule (biotinilacija) uz minimalne promjene u funkcionalnih ili antigenskih svojstava. Interferencije sa biotinom uključuju brojne imunohemijske testove kao što su proteini i steroidni hormoni, tumorski markeri, mikronutrijenti i lijekovi. Rezultati: Biotin može lažno povećati ili smanjiti rezultate u kompetitivnome i nekompetitivnome “sendvič” imunohemijskom testu. Niža povećanja vrijednosti obično se čine manje značajnima u usporedbi s visokim odstupanjima kod povišenih koncentracija biotina, ali mogu biti od terapijske i dijagnostičke važnosti. Osobito za procjenu hormona štitnjače (T3, T4, fT3, fT4), steroidnih hormona (kortizol, progesteron, testosteron i estradiol) kao i vitamina B12 i folne kiseline u slučaju postojeće interferencije biotina teško će se razlikovati deficit, referentna vrijednost odnosno povećanje. Interferencija sa biotinom mogla bi se ukloniti sa serijskim razblaženjem uzorka, ponavljanjem analize na drugoj metodi koja ne koristi biotin, utvrđivanjem koncentracije biotina i uklanjanjem biotina prije nego što se uzorak testira. Zaključak: Preporuka je da pacijent prestane sa terapijom biotina 3 dana prije uzorkovanja krvi odnosno 14 dana ako se koriste visoke doze biotina.

Introduction: Laboratory professionals (LP) are exposed to various hazards in the workplace, whose direct and/or cumulative effects can lead to the development of health disorders of varying severity. Our study aims to assess the level of occupational risk in biomedical laboratories. Subjects and methods: A cross-sectional study was conducted between November 2020 and February 2021. The study included LP of all profiles in Europe, and the territorial affiliation of the respondents formed the basis for the formation of the groups studied. A validated questionnaire used for data collection was distributed online through the networks of professional associations. Based on the type of agent, frequency of exposure, characteristics of the workplace and work process, and individual factors, an occupational risk assessment matrix was created in categories ranging from low to very high. Descriptive and inferential statistical methods with a statistical significance threshold of 5% (p ≤ 0.05) were used for the statistical analysis. Results: Significant differences in risk categorization were found between the groups studied (p < 0.001). Overall, 81.2% of LP in the European Union fall into the medium risk category, while more than half (52.1%) of LP and 1.7% of LP in Bosnia and Herzegovina fall into the high and very high risk categories. Higher education, service longer than 21 years, public sector, and biochemistry laboratory were identified as predictors of high risk, while predictors of very high risk were higher education, service of 21 to 30 years, public sector, and histopathology and molecular laboratories. Conclusions: Lack of equipment, organizational issues and working conditions were identified as weak points that directly correlate with risk levels in biomedical laboratory workplaces. Additional efforts to control exposure in biomedical laboratories are needed to maintain the health of LP.

The Aether-Scalar-Tensor (AeST) theory is an extension of General Relativity (GR) which can support Modified Newtonian Dynamics (MOND) behaviour in its static weak-field limit, and cosmological evolution resembling ΛCDM. We consider static spherically symmetric weak-field solutions in this theory and show that the resulting equations can be reduced to a single equation for the gravitational potential. The reduced equation has apparent isolated singularities at the zeros of the derivative of the potential and we show how these are removed by evolving, instead, the canonical momentum of the corresponding Hamiltonian system that we find. We construct solutions in three cases: (i) in vacuum outside a bounded spherical object, (ii) within an extended prescribed source, and (iii) for an isothermal gas in hydrostatic equilibrium, serving as a simplified model for galaxy clusters. We show that the oscillatory regime that follows the Newtonian and MOND regimes, obtained in previous works in the vacuum case, also persists for isothermal spheres, and we show that the gas density profiles in AeST can become more compressed than their Newtonian or MOND counterparts. We construct the Radial Acceleration Relation (RAR) in AeST for isothermal spheres and find that it can display a peak, an enhancement with respect to the MOND RAR, at an acceleration range determined by the value of the AeST weak-field mass parameter, the mass of the system and the boundary value of the gravitational potential. For lower accelerations, the AeST RAR drops below the MOND expectation, as if there is a negative mass density. Similar observational features of the galaxy cluster RAR have been reported. This illustrates the potential of AeST to address the shortcomings of MOND in galaxy clusters, but a full quantitative comparison with observations will require going beyond the isothermal case.

Kultura sigurnosti je set vrijednosti, znanja, vještina, stavova i prakse na individualnom i institucionalnom nivou organizacije radioterapijskog procesa koji uspostavlja način rada u kojem sigurnost i zaštita zdravlja predstavljaju prioritet prilikom obavljanja radnih zadataka. Razvoj kulture sigurnosti na individualnom i institucionalnom nivou postalo je jedno od ključnih sigurnosnih pitanja u savremenoj radioterapiji. Cilj ovog istraživanja je procijeniti mogućnost upotrebe elektronskog sistema za prijavljivanje incidenata u razvoju kulture sigurnosti kod zdravstvenih profesionalaca u radioterapiji i mogućnost izgradnje sistemske primjene seta vrijednosti koji omogućava obavljanje svih radnih zadataka u radioterapiji uz davanje maksimalnog priorieta sigurnosti. Kao instrument istraživanja korišten je elektronski sistem za prijavljivanje incidentata u formi strukturiranog kompjuterskog intervjua prema ROSEIS metodologiji. Na osnovu informacija prikupljenih pomoću sistema napravljena je procjena razvijenosti različitih segmenata kulture sigurnosti, predložene mjere na njenom razvoju i poboljšanju, te data pocjena njihove efikasnosti u unaprijeđenju sigurnosti u radioteapiji. Razvijena kultura sigurnosti u radioterapijskom radnom okruženju može značajno unaprijediti kvalitet radioterapijskog tretmana, reducirati pojavu incidenata, poboljšati efikasnost i efektivnost radioterapijskog tretmana. Razvoj kulture sigurnosti ne podrazumijeva samo uspostavu standardnog seta pravila, nego i promjenu stavova, ponašanja i profesionalne prakse na individualnom i institucionalnom nivou.

Pravilnom pripremom hrane moguće je spriječiti većinu hranom prenosivih bolesti. Značajni napori uloženi u usaglašavanje legislative na širim geografskim područjima, rezultovali su formiranjem općeprihvaćenog stava da je većina kupljenih namirnica sigurna za konzumiranje. Međutim, neophodno je da potrošači nastave dobre prakse rukovanja, pripremanja i čuvanja namirnica u domaćinstvima. Ovo istraživanje je provedeno kao presječna, deskriptivno-analitička i eksperimentalna studija u periodu novembar 2020. – juli 2021. godine. Mikrobiološka analiza briseva je provedena u akreditovanoj laboratoriji Odjela za mikrobiološku analizu namirnica, voda i predmeta opšte upotrebe pri Zavodu za javno zdravstvo Federacije Bosne i Hercegovine. U domaćinstvima je uzorkovano po 7 briseva radnih površina i pribora u kuhinjama (n = 2681) u skladu sa smjernicama standardne metode BAS EN ISO 18593:2019 – Horizontalne metode za uzimanje uzoraka sa površine. U više od polovine domaćinstava (61,5%) izolovane su ciljane bakterije u vrijednostima iznad referentnih. Najveća odstupanja u bakteriološkoj ispravnosti utvrđena su na radnim površinama u kuhinjama (45,8%), daskama za rezanje (34,1%) i slavinama (34,1%). Staphylococcus aureus je izolovan u 153, Enterobacteriacea u 151, a aerobne bakterije u 286 domaćinstava. Prema kategorizaciji ukupnog rizika, 17% domaćinstava na području Kantona Sarajevo spada u kategoriju visokog rizika od hranom prenosivih bolesti u svojim domaćinstvima. Obzirom da javnost nije upoznata sa rizikom u kojem se nalazi, smatramo da je što hitnije potrebno poduzeti korake u podizanju kolektivne svijesti o javno-zdravstvenom značaju sigurnosti hrane u domaćinstvima.

Introduction: Hypothyroidism is a common disorder of the endocrine system caused by insufficient biologically active hormones at the tissue level or the inability of the tissue to utilize thyroid hormones. Iron plays a crucial role in the synthesis and metabolism of thyroid hormones, and it is stored in the body as ferritin. We aimed to evaluate the correlation between serum ferritin (SF) levels and thyroid hormone panel levels in both hypothyroid and euthyroid subjects. Methods: In 2022, a matched case–control study was conducted. The study involved participants with hypothyroidism and a control group (n = 53). The levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and SF were measured using the chemiluminescence immunoassay on a Mindray Cl 900-i analyzer (Shenzhen Mindray Bio-Medical Electronics Co., China). Results: The hypothyroid group had TSH levels that were significantly higher (10.76 [8.54-18.76] vs. 1.76 [1.26-2.58]; p < 0.001) and SF concentrations that were significantly lower (39.08 [21.15-45.70] vs. 54.09 [41.41-71.82]; p < 0.001) compared to the control group. In both male and female subjects of the hypothyroid group, a strong negative correlation was found between SF concentration and TSH levels ([Rho = −0.855,p < 0.01]; [Rho = −0.747; p < 0.01]). In female subjects of the hypothyroid group, a weak positive correlation was found between SF concentration and fT3 (Rho = 0.488; p < 0.05). In the euthyroid group, a correlation of the same strength and direction was found for fT4 (Rho = 0.366; p < 0.05). Conclusion: Research results indicate a correlation between lower SF concentrations and hypothyroidism, which is of particular importance for understanding the etiopathogenesis, diagnosis, monitoring, and treatment modalities of patients with hypothyroidism.

Background. The management of breast cancer treatments within the limitations of family, social, and professional life is emotionally burdening and negatively affects physical, psychological, and social well-being, reducing the overall quality of life of patients and their families. Methods: This cross-sectional descriptive–analytical study was conducted from March to August 2023 at the “Dr. Radivoj Simonović” General Hospital in Sombor. A total of 236 breast cancer patients participated in this study. The research was conducted using the following instruments: a questionnaire on sociodemographic and clinical characteristics of patients, the Berlin Social-Support Scales—for assessing social support—and the Connor–Davidson Resilience Scale—for assessing resilience. This study aimed to determine the predictors and levels of social support and resilience of breast cancer patients. We also wanted to examine whether resilience is a mediator between patients’ sociodemographic and clinical characteristics and levels of social support. Results: The total average value of social support was 3.51 ± 0.63, while on the resilience scale, the respondents achieved a total average score of 52.2 ± 9.63. Perceived and actually received social support of breast cancer patients were positively correlated with resilience [p < 0.01], while no statistically significant correlations were found for the need for support and satisfaction. The sets of predictors can significantly predict their effects on all types of perceived social support (emotional social support: 9%; perceived instrumental social support: 9%) and all types of received social support (actually received emotional social support: 8%; actually received instrumental social support: 7%; actually received informational social support: 8%). There is a potential mediating role of resilience in relation to sociodemographic factors, clinical characteristics, and the need for support. Conclusion: This study confirms that a strong connection exists between social support and resilience. However, the analysis did not confirm the mediating role of resilience between the sociodemographic and clinical characteristics on the one hand and social support on the other.

Abstract Background  Many recent studies show that exoscopes are safe and effective alternatives to operating microscopes (OM). Developments of robotics and automation are present in neurosurgery with the appearance of a newer device such as RoboticScope (RS) exoscope with a digital three-dimensional (3D) image and a head-mounted display. The body of the RS is connected to a six-axis robotic arm that contains two video cameras, and serves as stereovision. This robotic arm allows accurate 3D camera motions over the field of view, giving the user a great degree of freedom in viewpoint selection. The surgeons may specify the direction and speed of the robotic arm using simple head movements when the foot pedal is pressed. Since its development in 2020, the RS has occasionally been used in neurosurgery for a multitude of procedures. Methods  This study showcases vessel microanastomosis training on chicken legs using the RS. The aim of this study is to demonstrate the feasibility of the RS without a comparative analysis of the standard OM. The study was conducted in 2023 during a month-long trial period of the device at the Department of Neurosurgery of the Clinical Center of the University of Sarajevo. All procedures including RS-assisted anastomosis were performed by a neurosurgeon in anastomosis training (A.A.) supervised by a senior vascular neurosurgeon (E.B.). For the purpose of the study, we evaluated occlusion time in minutes, bypass patency with iodine, and overall satisfaction of the trainee in terms of light intensity, precision of automatic focus, mobility of the device, ergonomics, and convenience of the helmet. Results  Ten RS-assisted microanastomoses were performed by interrupted suturing technique with 10.0 nylon thread. Bypass training included seven “end-to-side,” two “end-to-end,” and one “side-to-side” microanastomoses. The smallest vessel diameter was 1 mm. Occlusion time improved by training from 50 to 24 minutes, with contrast patency of the anastomoses in all cases without notable leakage of the contrast, except one case. Complete satisfaction of the trainee was achieved in 7 out of 10 cases. During this period, we also performed different RS-assisted surgeries including a single indirect bypass, convexity brain tumor resection, and microdiscectomies. Conclusion  RS provides a new concept for microanastomosis training as an alternative or adjunct to the standard microscope. We found a full-time hands-on microsuturing without the need for manual readjustment of the device as an advantage as well as instant depth at automatic zooming and precise transposition of the focus via head movements. However, it takes time to adapt and get used to the digital image. With the evolution of the device helmet's shortcomings, the RS could represent a cutting-edge method in vessel microanastomosis in the future. Nevertheless, this article represents one of the first written reports on microanastomosis training on an animal model with the above-mentioned device.