We consider the Arrow–Debreu exchange market model under the assumption that the agents’ demands satisfy the weak gross substitutes (WGS) property. We present a simple auction algorithm that obtains an approximate market equilibrium for WGS demands assuming the availability of a price update oracle. We exhibit specific implementations of such an oracle for WGS demands with bounded price elasticities and for Gale demand systems.

Angiotensin-converting enzyme inhibitors (ACEIs) reduce arterial stiffness beyond their antihypertensive effect. Studies showed that sulfhydryl ACEIs have the antioxidative potential to improve endothelial function, which might have a clinical effect on arterial distensibility. However, there are no studies that directly compare the effects of sulfhydryl (zofenopril) and non-sulfhydryl ACEIs (enalapril) on arterial stiffness. Therefore, this prospective study aims to compare the effects of enalapril and zofenopril on arterial stiffness and oxidative stress in both short- and long-term treatment of arterial hypertension (AH). Baseline and post-treatment peripheral and central arterial pressure indices, augmentation index (Aix), aortic pulse wave velocity (ao-PWV), serum levels of oxidized low-density cholesterol lipoprotein, LDL and uric acid (UA) were measured. The results showed that acute treatment with zofenopril, in contrast to enalapril, significantly decreased peripheral and central Aix (p < 0.001). Chronic treatment with zofenopril showed a superior effect over enalapril on the reduction of the peripheral systolic arterial pressure with reduction of ao-PWV (p = 0.004), as well as a reduction in peripheral Aix (p = 0.021) and central Aix (p = 0.021). Therefore, this study indicates that zofenopril has beneficial effects on the reduction of arterial stiffness compared to enalapril. It has potent clinical efficacy in AH treatment and further studies should compare its safety and long-term efficacy to other AH drugs that would aid clinicians in treating AH and other various cardiovascular diseases that have arterial stiffness as a common denominator.

Creativity at the tertiary level of education refers to analyzing creativity in higher education institutions through segments such as creativity among teachers and students and creativity in the business/functioning of the institution, which is one of the goals of this paper. A chapter on increasing the level of creativity in organizations/faculties was specially presented, with a special emphasis on increasing creativity with the help of creative techniques. The focus is also on the question of how management can encourage creativity in faculties, without excluding employees and their creative behavior in organizations. It tries to show the specificity of creativity in higher education institutions; do teachers and students use creative strategies in the teaching process and what is needed to encourage creativity in higher education institutions.

The paper investigates figurative construal of children’s excessive use of electronic devices in articles that tackle the issues of children’s media addiction, as well as concentration and attention span, which are considered to be affected by this excessive use of technology. In giving their opinion on the topic, authors of articles resort to the use conceptual metaphor – a cognitive device where more abstract concept (a target domain) is being understood through the use of another, more concrete concept (a source domain). Authentic language data reveal the use of metaphorical linguistic expressions such as ‘digital overdose’ and ‘electronic cocaine’, which send a disturbing message that children are ‘overdosing’. This detailed analysis aims to investigate: (a) the types of metaphor (according to Steen’s 2010 three-dimensional model of metaphor analysis) in articles on children’s media addiction; (b) whether ADDICTION metaphors are dominant and deliberate; (c) their communicative function – the rhetorical function intended by the authors, as well as their rhetorical effects on recipients (notably, parents);(d) the implications of their combination with other metaphors within a sentence or a paragraph; (e) the possibility of resorting to alternative metaphor use.

Aim: The aim of this study was to analyze all the factors (disease symptoms, sinthigraphic findings, biochemical parameters) that occur in patients with hyperparathyroidism, and since hyperparathyroidism itself is a common endocrine disorder. Methods: We analyzed 79 patients with primary, secondary, and tertiary hyperparathyroidism, who underwent surgery. We analyzed mean of age, male: female ratio, representation of different forms of hyperparathyroidism. In our study, we examined the indications for examination and surgery, as well as the most common symptoms and comorbidities. For localization PTG, scintigraphy was performed by a nuclear medicine specialist (at the Clinic of Radiology and Nuclear Medicine) preoperatively. Preoperative values of calcium (Ca), phosphorus (P), and parathyroid hormone (PTH) were determined in all patients, and the same values were measured postoperatively. We also analyzed correlation of dialysis length and parathyroid gland hyperplasia in patients with secondary hyperparathyroidism. Results: In our study mean of years was 51.13 ± 11.83 and most of the respondents were female. The most common operation was subtotal parathyroidectomy. The most common indication for examination of parathyroid glands (PTG) was renal failure. The most common comorbidity was arterial hypertension, which was found in 43 (53.2%) subjects, and the rarest gastrointestinal diseases and pancreatitis, in 1 (1.3%) patients. Scintigraphy showed an equal representation of enlarged lower parathyroid glands (both right and left). The mean values determined preoperatively for PTH were 796.24 pg/ml, Ca 2.58 mmol / l and P 1.35 mmol / l. The mean postoperative values for PTH were 222.33 pg/ml, Ca 2.06 mmol/l and P 1.17 mmol/l. We also showed that was a large correlation between dialysis length and hyperplasia. Conclusion: Hyperparathyroidism is a common endocrine disease, carrying potential complications of many organic systems. In most cases, regardless of the form (primary, secondary, or tertiary), it ultimately requires surgical treatment. For this reason, the clinical picture must be well known, the necessary preoperative diagnostic methods (which are complex), all with the aim of better effect of treatment of such patients.

The aim of this work was to investigate the qualitative characteristics of hearing aid users (satisfaction with the use of hearing aids in everyday life) and to determine if there are any differences compared to published research in the literature. The sample of respondents consisted of 50 users of hearing aids, aged from 20 to 88 years. The sample was chosen by random selection from a previously selected sample of 398 hearing aid users. A special questionnaire was constructed for the research. The first part of the questionnaire consisted of variables: gender, age, type of hearing impairment, percentage of hearing loss, degree of hearing impairment, time of hearing aid use, and brand of hearing aid. The second part consisted of variables for the assessment of satisfaction with the use of hearing aids, that is, 15 statements to which respondents had to express their views on satisfaction with the use of hearing aids. This part of the questionnaire was carried out by surveying. The results showed that the majority of hearing aid users wear the hearing aid regularly, they benefit significantly from the hearing aid and it helps them in communication. They have no significant problems when using and handling the hearing aid. The variables gender, age, and time of hearing aid use had no statistically significant correlations with the applied set of variables (claims). Attitudes of hearing aid users can be an important factor in determining benefit and satisfaction with hearing aids.

The aim of the study was to compare pre-treatment and post-treatment pure tone thresholds and tympanometric findings in preschool children with adenoid hypertrophy and hearing loss. This retrospective study included 63 children, 40 males (63.5%) and 23 females (36.5%), aged 4 to 6 years (mean age of 5.5±0.6 years). A total of 21 children (33.3%) had tympanostomy tube placement in addition to adenoidectomy or adenotonsillectomy. All children had mild conductive hearing loss. Pure tone average (PTA) was lower after adenoidectomy and adenotonsillectomy (p<0.0001). Type B tympanogram was predominant before treatment (62.7%), and type A tympanogram after treatment (81%). Preoperative mean PTA in children with adenoidectomy was 28 dB HL and in children with adenotonsillectomy was 27 dB HL. In both subgroups postoperative mean PTA was 16 dB HL. In children with adenoid hypertrophy and conductive hearing loss, hearing thresholds after adenoidectomy or adenotonsillectomy are significantly lower than preoperative hearing thresholds.

It seems completely impossible today to imagine life without mass media. The development of modern technologies has made mass media available to everyone. Mass media, in our case the press, sometimes try to interest and excite their users with their sensational headlines, sometimes make them think, and sometimes even entertain. However, it is very important to keep in mind that each medium shapes the message according to its own language, and an integral part of the languages of the mass media are usually different stylistic and linguistic means. Following earlier analyses of journalistic style, this paper will offer a stylistic-linguistic analysis exclusively of titles, as important and recognizable features of journalistic style, whose task is to be particularly effective in provoking the reader's attention and therefore can appear in the form of rhetorical questions, phrases, already established journalistic templates, etc. , which reflects their expressiveness. In addition, the analysis of the headlines of daily newspapers from the territory of bosnia and herzegovina (osloboenje, nezavisne novine and dnevni list) confirmed that on the phoneticphonological level, for example, there is a difference in writing foreign names, i. E. Names of clubs, awards, proper names, etc. Among these three newspapers, that on the morphological plan, verbs are most often used in the present and future, that the superlative forms of adjectives are often represented, that syntaxic, lexical-semantic figures are used that give the title a stronger, stylistically colored meaning - elliptical sentences, metaphor , metonymy with, of course, an unavoidable lexicon of foreign origin where anglicisms and latinisms dominate, along with some words of oriental origin, and among the dominant functions of the titles are referential (informative), popularistic, expressive and aesthetic.

Monitoring, evaluation and assessment of students' knowledge are inseparable processes that subject teachers apply almost daily in their educational work. Experiences from teaching practice point to the fact that the evaluation of student achievements is one of the most sensitive areas of a teacher's work. The processes of assessment, evaluation and reporting on student achievements are often in the focus of the professional public and as such are the subject of numerous discussions and misunderstandings. The biggest shortcomings of the evaluation system in the area of Herzegovina-Neretva Canton at the level of primary education are the absence of clear criteria according to which student achievements and the desired level of objectivity are evaluated, which leads to encouraging negative patterns of motivation and learning among students. Evaluating students in class is a complex process, and in that process teachers can help themselves and students only if they create an effective system of recording, monitoring and checking students’ knowledge and skills within their subject. The paper describes in detail the essential elements of the evaluation process, namely evaluation methods, sources used in the evaluation process, evaluation and assessment criteria. This paper presents the knowledge and thoughts of the authors, through clear presentations of concrete examples for improving the process of monitoring, checking and evaluating students’ knowledge in the teaching of Biology, Bosnian language and literature, and English language, based on modern reform requirements.

This paper performs a comparative evaluation of various generations of Controller Area Network (CAN), including the classical CAN, CAN Flexible Data-Rate (FD), and CAN Extra Long (XL). We utilize response-time analysis for the evaluation. In this regard, we identify that the state of the art lacks the response-time analysis for CAN XL. Hence, we discuss the worst-case transmission times calculations for CAN XL frames and incorporate them to the existing analysis for CAN to support response-time analysis of CAN XL frames. Using the extended analysis, we perform a comparative evaluation of the three generations of CAN by analyzing an automotive industrial use case. In crux, we show that using CAN FD is more advantageous than the classical CAN and CAN XL when using frames with payloads of up to 8 bytes, despite the fact that CAN XL supports higher bit rates. For frames with 12-64 bytes payloads, CAN FD performs better than CAN XL when running at the same bit rate, but CAN XL performs better when running at a higher bit rate. Additionally, we discovered that CAN XL performs better than the classical CAN and CAN FD when the frame payload is over 64 bytes, even if it runs at the same or higher bit rates than CAN FD.

Epilepsy is a life threatening neurological disorder. The person with epilepsy suffers from recurrent seizures. Sudden emission of electrical signal in the nerves of the human brain is called seizure event. The most widely used method for diagnosing epilepsy is analysing electroencephalogram signals in short called as EEG signals collected from the scalp of the patient. The EEG data are normally used for seizure detection. If the recurrent seizure signals are detected in the input EEG dataset, then it can be considered as the presence of epilepsy disorder. Manual inspection of seizure signals in the EEG data is a laborious process. An automated system is very crucial for the neurologists to identify seizures. In this paper, an automated seizure detection method is presented using deep learning method, pre‐trained convolutional neural network architecture. Freely available EEG dataset from Temple University Hospital database is used for the study. The pre‐trained CNN networks, VGGNet and ResNet are used for classifying the seizure activities from non‐seizure activities. CNNs are extremely good in learning the features of the input data. A very large dataset from TUH is provided as input to the multiple layers of CNN model. The same data is fed to VGGNet and ResNet models. The results of CNN, VGGNet and ResNet models are assessed using performance metrics accuracy, AUC, precision and recall. All the three models gave extremely good performance compared to state‐of‐the‐art works in the literature. In comparison VGGNet performed with little higher results giving 97% accuracy, 96% AUC, 97% precision and 79% recall.

The complexity of Industry 4.0 systems makes it challenging to manually synthesize and optimize architecture-level decisions, such as service deployment and composition. To address this challenge, we propose an approach that utilizes a satisfiability modulo theories (SMT) solver to (semi-)automate service deployment and composition synthesis. Thereby, we conceptualize, formalize and implement the complete workflow from input service workflows to valid and optimized service deployments and compositions. We demonstrate the practical application of our approach in an Industry 4.0 scenario, specifically the flexible production of new products. We evaluate the effectiveness of the proposed approach by investigating its benefits in terms of engineering effort, complexity of the resulting IEC 61499-based applications, and improvement of communication coupling quality attribute (QA).

Design of manufacturing system involves various architectural design decisions (ADDs), including software and hardware component allocation, production service composition, plant layout determination, and production planning. These ADDs gain significance in Industry 4.0 (I4.0) scenarios due to the frequent need for architecture synthesis to achieve adaptable and flexible production processes. Additionally, synthesizing ADDs in conjunction with each other increases the decisions’ impact on system quality attributes (QAs). The increasing importance of architecture synthesis and optimization (ASO) in I4.0 necessitates an overview of ADDs within this context. This paper expands on the previous work by creating a landscape of I4.0-related ADDs based on insights from the BaSys 4.0 research project series. The landscape describes relevant ADDs and their relationships, and suggests multi-dimensional ASO workflows. Mapping the ADD landscape to BaSys 4.0 research enhances idea generation and the exploration of existing solutions in ASO.

Graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation is a major cause of nonrelapse morbidity and mortality. Although ruxolitinib is now approved for the treatment of steroidrefractory GVHD, to date, no agent added to corticosteroids has been shown to improve outcomes compared with corticosteroids alone. In this issue of Blood Advances, Al Malki et al presented the results of a multicenter phase 2 study that tested whether the addition of natalizumab, a humanized antibody against the α4 subunit of α4β7 integrin, would improve the outcomes of new-onset acute GVHD. The primary end point was a complete response after 28 days, defined as the clinical resolution of GVHD in the target organs.