Abstract The athlete's ability to achieve the maximum amplitude of movement in certain sports can be crucial for achieving a top result. Most theorists consider flexibility to be one of the essential motor skills of humans. Flexibility is defined as the ability of the locomotor apparatus to realize movements of optimal amplitude in a certain joint. The goal of this research was to determine the differences in flexibility between football players and karate practitioners (karateka) between the ages of 12 and 14 years, in chronological order. The purpose of this paper is to determine the differences in flexibility between football players and karateka based on the obtained results, and to further determine whether and within which variables of flexibility karateka are more dominant than football players. This research will complete the findings and fill the knowledge gaps that exist about flexibility. The importance of this research is reflected in that it will gather relevant information about the status and differences in flexibility between football players and karateka within the specified age group. The research was carried out on a sample of 40 respondents who make up two subsamples, football players (n=20; age 12.70 ± 0.86) and karateka (n=20; age 12.95 ± 0.82). Tests were applied to determine height and body mass, as well as to determine flexibility (10 variables). The obtained results were processed in the program package IBM SPSS Statistics 26.0. Descriptive parameters were calculated for all collected data, normality of distribution was determined, while differences in tests were determined by T-test for independent samples. The results showed that in terms of body height and mass, there are no statistically significant differences between young football players and karateka, nor in the ability to lower a stick behind the back (MFLISK). In all other flexibility tests (deep front bend off an elevated platform/block, deep bend with legs apart, side split, active straight leg raise while lying on the back (degrees) for both legs, leg raises while lying on the chest, leg raise while lying on the side) a statistically significant difference was obtained at the significance level of .99% (p ≤ 0.01), and all in favor of karateka. We can conclude that the level of flexibility is higher in karate practitioners compared to football players, which was to be expected. The main discovery of this study is the existence of statistically significant differences in almost all flexibility variables, where better values were shown in favor of karatekas, except for the back stick raise test, where no statistically significant difference was found between football players and karateka. The research can serve other researchers who will deal with similar issues, and the findings of this research will complete the mosaic of research regarding flexibility in karate and football. The obtained results will benefit sports teams, researchers, trainers and physical education professors, as a relevant indicator of the importance and significance of flexibility development and flexibility training in sports. Key words: flexibility, football, karate,

Abstract This study investigates emigration patterns among healthcare professionals in Bosnia and Herzegovina, examining the underlying reasons for emigration and proposing actionable solutions to curb this trend. A mixed-methods approach is employed, combining quantitative data from surveys administered to medical and health studies students with qualitative insights from interviews with governmental officials, language educators, and statistical agencies. The findings reveal significant dissatisfaction with socio-economic and political conditions, prompting healthcare professionals to seek opportunities abroad. Major reasons for going abroad include political instability, low wages, and poor working conditions, while better pay and career opportunities are attracting factors. While the study is limited by the lack of comprehensive official statistics on emigration, the implications of this research emphasize the need for policy interventions aiming to improve local working conditions and reform educational systems. The study provides valuable insights for policymakers and stakeholders to effectively address the issue of brain drain.

Abstract The aim of the work was to determine the connection between morphological characteristics and the effectiveness of the throwing technique by kicking the legs from behind from the program of Special Physical Education (SPE). The sample of respondents consisted of 84 students (male), first year of the Faculty of Security Sciences from Banja Luka. The variable sample was composed of 17 tests for the evaluation of morphological characteristics, which were the independent variables and the dependent variable OSOTOG, which was the average grade of the performance of the kicking technique from the SPE program. The regression analysis did not establish a statistically significant connection between the efficiency of performing the throwing technique by striking the landing leg from behind and the selected set of predictor variables for the assessment of morphological characteristics. Only the elbow diameter variable (ADIJLA) gave a statistically significant contribution to the explanation of the criteria variable OSOTOG. Based on the value of the Beta coefficients, we can see that the variables: body weight (ATETJ) and leg length (ADUZNO) have significant positive partial correlations with the criterion variable, while negative correlations were achieved by the variables: elbow diameter (ADIJLA), body height (AVISTJ) and length hands (ADUZRU). The obtained results could be used in terms of improving the quality of the performance of certain program contents of the SPE, when choosing the appropriate technique within the motor program when solving certain problem situations from the SPE program. Keywords: students, interconnection, morphological characteristics, throwing by kicking out the leg from behind

Background and Objectives: The aim of this study was to determine the role of physicians in the intensive intervention and education regarding the smoking cessation of patients undergoing elective surgery under general anaesthesia. Materials and Methods: A randomised prospective study was conducted in family physicians’ clinics in which smokers of both sexes, aged 21–65 years, without cognitive impairments, and who were not addicted to psychoactive substances voluntarily participated. Four weeks preoperatively, 120 smokers were randomised into two equal groups; the intervention group (IG) underwent an intervention for the purpose of smoking cessation and the control group (CG) underwent no intervention. Biochemical tests were performed in order to determine the smoking status of the participants in the phase of randomisation, one week preoperatively, as well as 40, 120, and 180 days and 12 months postoperatively. The examinees of the IG talked to the physician five times and received 140 telephone messages, leaflets, and motivational letters along with the pharmacotherapy, while the participants in the CG received little or no advice on smoking cessation. Results: The results of this study confirmed a significant influence of the intervention and education on the smoking abstinence in the IG compared to the CG (p < 0.001). The smokers in the IG had 7.31 (95% CI: 2.32–23.04) times greater odds of abstinence upon the 12-month follow-up than the smokers in the CG. The smokers in the IG who did not stop smoking had a lower degree of dependence and smoked fewer cigarettes (p < 0.0001) compared to those in the CG, as well as a multiple times higher prevalence of short- and long-term abstinence. Conclusions: It can be concluded that the intensive intervention and education can motivate patients preparing for elective surgery to stop smoking in the short- and long term.

Diabetes mellitus is a complex, multifactorial, progressive condition with a variety of approved therapeutic options. The purpose of this study was to offer an overview of the authorized antidiabetic medicines (excluding insulin) compared with marketed products in seven European countries. Data were obtained from primary sources, including the websites of national authorities and directly from specialists in the countries of interest. The range of marketed medicines compared with the authorized group was assessed in terms of active pharmaceutical ingredients (>60% in Bulgaria, France, Serbia), brand names (>70% in Bulgaria, the Czech Republic, Romania, Serbia, Spain), pharmaceutical forms (>60% in all countries), strengths (>60% in Bulgaria, the Czech Republic, Romania, Serbia, Spain), marketing authorization holder (≥50% in all countries) and the status of medicine. Spain was found to have the highest number of products based on most of these attributes. Over 90% of authorized medicines had a pharmacy price in Serbia. Regarding the newer class of GLP-1 receptor agonists, a retail price for all approved substances was available in Bulgaria, Romania, Serbia, and Spain. Only one brand name with one concentration was found available for some agents, being susceptible to drug shortages: glibenclamide (Romania, Serbia, Spain), glipizide (the Czech Republic, Poland, Romania, Spain), glisentide (Spain), acarbose (the Czech Republic), sitagliptin (Bulgaria, Poland), vildagliptin (the Czech Republic, Poland) and saxagliptin (the Czech Republic, France, Romania, Serbia). An overview of the national and international therapeutic options may allow competent authorities and health professionals to take rapid measures in case of supply problems or health crises.

Bioeconomy is becoming a more interesting field for investments in the Republic of Croatia, especially in its small regions and local administrative units. Vukovar-Srijem county is one such unit in eastern Croatia with noticeable potential for development in a circular, carbon-neutral, and sustainable bioeconomy. Due to the nature potential represented by one of the largest forest reservoirs in Europe-Spačva basin, forestry is one of the most important county branches. Aiming to provide more inputs on the wood biomass management, the study on the biomass flow of Vukovar -Srijem c ounty was conducted in 2020 by collecting data from local stakeholders and official reports. The study results have shown that Vukovar-Srijem county has the potential to increase the efficiency level of biomass use, but specific actions on the value-chain strengthening, finalisation of wood products, and innovative ecosystem establishment are still needed. The results highlight the predominant use of sawdust for heating purposes in the VSC region, suggesting potential for optimizing its utilization towards a circular, carbon-neutral, and sustainable bioeconomy, thus offering novel insights for future research and initiatives aiming to maximize economic and environmental benefits from wood biomass residues.

The tumor suppressor proteins are key transcription factors involved in the regulation of various cellular processes, such as apoptosis, DNA repair, cell cycle, senescence, and metabolism. The tumor suppressor protein p53 responds to different type of stress signaling, such as hypoxia, DNA damage, nutrient deprivation, oncogene activation, by activating or repressing the expression of different genes that target processes mentioned earlier. p53 has the ability to modulate the activity of many other proteins and signaling pathway through protein-protein interaction, post-translational modifications, or non-coding RNAs. In many cancers the p53 is found to be mutated or inactivated, resulting in the loss of its tumor suppressor function and acquisition of new oncogenic properties. The tumor suppressor protein p53 also plays a role in the development of other metabolic disorders such as diabetes, obesity, and fatty liver disease. In this review, we will summarize the current data and knowledge on the molecular mechanisms and the functions of p53 in different pathways and processes at the cellular level and discuss the its implications for human health and disease.

Physical literacy (PL) is considered an important determinant of physical activity level (PAL), but studies have rarely examined the associations between PL and PAL in preadolescents. This study aimed to evaluate associatios between PL, PAL and sedentary behavior (SB) in preadolescents from southeastern Europe. The participants were 9- to 11-year-old children from Croatia and Bosnia and Herzegovina (n=333, 52% girls) who were tested for PL, PAL and SB. The PLAYself questionnaire was used for the evaluation of PL, while PAL was estimated by data provided throughout the Physical Activity Questionnaire for Children (PAQ-C). Pearson’s correlations and multiple regressions were calculated to identify the associations between study variables. The results revealed a significant correlation between PL and PAL in the total sample (16% of the common variance) among boys (10% of the common variance) and girls (25% of the common variance), which was additionally confirmed by multiple regression calculated between the PL subdomains and PAL (R2=0.23, 0.15, and 0.31 for total sample, boys and girls, respectively). The SB was not significantly correlated with PL (<2% of the common variance; p>0.05) or with PAL (<1% of the common variance; p>0.05). The results indicated a stronger association between PL and PAL in girls than in boys, indicating the possible influence of the types of physically demanding activities children are involved in on the studied associations. To explore causality more specifically, intervention studies are warranted.

Abstract The preschool years are characterized by additional physical development changes, enhanced motor abilities, and strengthened movement apparatus in the kid. The feet undergo morpho-functional changes at that period, particularly between the ages of 3 and 6, which result in the development of their longitudinal and transverse arches. The aim of this study was to evaluate the actual causes of foot deformity and its degree of severity in preschool-aged children, as well as the distinction in deformity representation between the sexes. The "Institution for preschool education" kindergarten "Aladin" in Tuzla is the focus of this study, which involves 74 children of both sexes, ages 3-6, were measured in 2023. Foot deformities are equally present in girls and boys. Deformities in boys are particularly pronounced: pedes recti 21 (56.8%), pedes planovalgi 6 (16.2%), while in girls: pedes recti 20 (54.1%), pedes excavati 8 (21.6%). With the Chi-square test, we determined the statistical significance of the presence of foot deformities between the sexes. By looking at the size of the chi-square (Pearson Chi-Square) 5.964a and Asymp. Sig. (2-sided) .544 tells us that there is no statistically significant difference in the representation of foot deformities between the sexes and that these deformities are equally represented. Because foot deviations can lead to problems kindergarten kids' foot arches need to be continuously monitored. This allows for timely intervention and the adoption of suitable treatment procedures to avoid the development of deformities. Keywords: children, preschool strature, foot, deformity, gender.

Abstract OBJECTIVES To overcome some of the challenges of endoscopic minimally invasive valve surgery, an automated annular suturing device has been used in aortic and mitral valve replacement surgeries. The current study investigates early clinical outcomes of patients who received aortic or mitral valve replacement with the help of the RAM® device as first experiences in minimally invasive valve surgery. METHODS Between September 2020 and June 2023, 66 consecutive patients (mean age 61.8 ± 11 years) underwent endoscopic minimally invasive aortic or mitral valve replacement through right anterior mini-thoracotomy at 2 cardiac surgery referral centres in Germany. The RAM® device was used in all Patients. 3.5 and 5.0 sizes were used in 16.7% and 83.3% of patients, respectively. Aortic, mitral and double valve surgery was performed in 81.8%, 15.2% and 1.5% of patients, respectively. Clinical data were prospectively entered into our institutional database. RESULTS Cardiopulmonary bypass time and cross-clamping time were 97.9 ± 20.9 and 66 ± 15.7 min, respectively. Intensive care unit and hospital stays were 1 [1–2] and 9 [7–13] days, respectively. No paravalvular leak and no other intraoperative complications occurred. 30-day and in-hospital mortality were zero. Conversion to sternotomy occurred in 1 (1.5%) patient due to bleeding. CONCLUSIONS The usage of the RAM® device is a safe, feasible and effective approach to the endoscopic implantation of aortic or mitral valves and yield excellent early outcomes. Larger size studies are needed to evaluate the efficacy and safety of RAM® device.

Abstract This paper presents a detailed model of low-frequency oscillations and their damping within the Electric Power System (EPS) of Bosnia and Herzegovina (B&H). The system is modeled using MATLAB software, analysing the steady state and dynamic responses. This research highlights the challenges and impacts of integrating renewable energy sources, such as wind farms, on grid stability and oscillation damping. The paper utilizes eigenvalue analysis to investigate the dynamic characteristics of the system, emphasizing the need for efficient damping strategies to maintain system stability. The methodology includes a comprehensive review of existing literature, the creation of a detailed EPS model of B&H, and the application of eigenvalue and oscillation amplitude analysis to determine damping ratios. The dynamic responses of hydro power plants, HPP Mostar and HPP Jablanica, to transient disturbances are analysed to validate the model and refine damping strategies. The results indicate that the B&H EPS is well-damped, with all eigenvalues possessing negative real parts, and demonstrate the system’s resilience to small disturbances. The results are compared with the technical report on the integration of the wind power plant WPP Podveležje. This comparative analysis shows consistent patterns between the modeled calculations and empirical data, confirming the robustness of the EPS model. This alignment underscores the effectiveness of current damping mechanisms and provides a foundational strategy for enhancing system stability with increasing renewable energy penetration. The findings highlight the importance of developing advanced control strategies to sustain system stability as the integration of variable renewable energy sources continues to grow.

Background: Severe coagulation abnormalities are common in patients with COVID-19 infection. We aimed to investigate the relationship between pro-inflammatory cytokines and coagulation parameters concerning socio-demographic, clinical, and laboratory characteristics. Methods: Our study included patients hospitalized during the second wave of COVID-19 in the Republic of Serbia. We collected socio-demographic, clinical, and blood-sample data for all patients. Cytokine levels were measured using flow cytometry. Results: We analyzed data from 113 COVID-19 patients with an average age of 58.15 years, of whom 79 (69.9%) were male. Longer duration of COVID-19 symptoms before hospitalization (B = 69.672; p = 0.002) and use of meropenem (B = 1237.220; p = 0.014) were predictive of higher D-dimer values. Among cytokines, higher IL-5 values significantly predicted higher INR values (B = 0.152; p = 0.040) and longer prothrombin times (B = 0.412; p = 0.043), and higher IL-6 (B = 0.137; p = 0.003) predicted longer prothrombin times. Lower IL-17F concentrations at admission (B = 0.024; p = 0.050) were predictive of higher INR values, and lower IFN-γ values (B = −0.306; p = 0.017) were predictive of higher aPTT values. Conclusions: Our findings indicate a significant correlation between pro-inflammatory cytokines and coagulation-related parameters. Factors such as the patient’s level of education, gender, oxygen-therapy use, symptom duration before hospitalization, meropenem use, and serum concentrations of IL-5, IL-6, IL-17F, and IFN-γ were associated with worse coagulation-related parameters.