Introduction: Scoliosis is a spinal deformity that affects school-age children and adolescents the most. Excessive body weight, heavy school bags, improper sitting at school desks, and reduced physical activity are significant risk factors for the development of scoliosis in children. To prevent the occurrence of scoliosis of the spinal column, the focus of attention must be on early identification and education about scoliosis. The research aims to determine the presence of risk factors for scoliosis in sixth-grade elementary school students, assess knowledge about scoliosis of the spine, and determine whether the health system can respond. Research Method: From a total of 3.600 sixth-grade elementary school students in the Tuzla canton a cross-sectional study was conducted among 350 students using anthropometric measurements, full and empty school bag measurements, and the Nordic Musculoskeletal Questionnaire (NMQ). Data on the health system was collected using a retrospective method. Discussion: Obesity was recorded in 21.14% of the respondents. Based on the results obtained, in 39.43% of the respondents, the ratio of the weight of a full school bag to body weight was equal to or greater than 10%. Almost one-third of the respondents felt pain/discomfort when carrying a school bag, which indicates that only 38.57% of children carry the bag correctly. 42.86% of the respondents have the wrong posture when sitting. Based on the results collected, 52.86% of the respondents do not play sports. The results show insufficient knowledge about scoliosis among both school-age children and parents/guardians. The health system of the Tuzla Canton can respond to the presence of the risk of spinal deformity with the available resources. Conclusion: The results of the study have shown the presence of risk factors for the development of scoliosis, a low level of knowledge about scoliosis, and the unwillingness of the health system to provide treatment and prevention services. Mandatory screening examinations and education of students, parents, and teachers are necessary.

Summary Explosive energy can be used in metal forming processes, e.g. for bulk forming, sheet forming and for other processes. This paper presents the experimental research and numerical modelling of the process of sphere deformation by explosive forming. The assembly for forming a sphere with a diameter of 210 mm was welded from flat segments and annealed after welding. The material of the sphere was steel St12 according to DIN 1629/3. The thickness of the sheet metal was 2.0 mm. The sphere was modelled in the SolidWorks program and 3D-printed with the polylactic acid (PLA) material. The Poladyn 31ECO explosive was used for the experimental investigation into the process of deep drawing of the sphere by explosion, while the LS-DYNA hydrodynamic software was used for simulation. The pressure in the sphere was measured with a pair of copper crushers. It is shown that the simulation satisfactorily reproduces the experimentally measured pressure.

Background: T Measles is a viral, highly contagious disease from the group of rash fevers, which mainly affects children. Persons suffering from measles are considered contagious four days before and four days during the period of the appearance of measles, which favors its faster spread. Clinical observation and laboratory diagnostics are essential for monitoring the course of the disease in order to prevent complications. Objective: Our study aimed to analyze the significance and usefulness of laboratory tests on admission to hospital in pediatric patients with measles. Methods: This prospective study included children with confirmed measles infection who came accompanied by parents to the Infectious Disease Clinic of the Clinical Center of the University of Sarajevo during nine months. Data on age, sex, symptoms and results of laboratory analyzes (biochemical, hematological and coagulation) were recorded. Results: The study included a total of 302 subjects, including 122 healthy controls and 180 measles patients. Significantly lower values observed for aPTT, absolute number of eosinophils and basophils, RBC, hemoglobin, hematocrit, MCV, MCH, MCHC in measles patients. Significantly higher values were observed for fibrinogen, D-dimer, WBC, neutrophils, lymphocytes, monocytes, RDW and MPV in measles patients in contrast to controls. Significantly higher values were also observed for serum chloride, glucose, CRP, AST, ALT and LDH values. AST/ALT, NLR, PLR, NPR, LMR, LCR, SII and AISI also showed significant differences in measles patients compared to controls. Conclusion: The results of our study showed that laboratory tests have great significance and potential in measles in pediatric patients admitted to the hospital. Lymphocyte/C-reactive protein ratio also showed good diagnostic potential.

Background: Laryngeal squamous cell carcinoma (LSC) is the leading malignant tumour of the head and neck. Establishing new biomarkers is extremely important because they can be important for early diagnosis and prognosis of LSC. Objective: The aim of this study was to establish the significance of cytokeratin fragment antigen 21-1 (CYFRA 21-1) in the early diagnosis and prognosis of LSC. Methods: This was prospective research involving 35 patients of both sexes with pathohistologically confirmed LSC, who were treated in the period from 2022 to 2024. The control group consisted of 30 patients who underwent surgery for other non-malignant diseases and who had a normal indirect laryngoscopy findings. The levels of CYFRA 21-1 were determined for three time periods: preoperative, four weeks after surgery, and three months after radiotherapy or concomitant chemoradiotherapy. For the statistical analysis of data we used descriptive statistics methods, the Student T-test and the χ2 test to calculate the significance of the tested differences, where differences on the level of p<0.05 were considered to be statistically significant. Results: Statistically significantly higher mean serum levels of CYFRA 21-1 were found preoperatively in the experimental group in comparison with the control group (p<0.001). Statistically significant lower levels of CYFRA 21-1 were found four weeks after surgery in the experimental group in comparison with preoperative levels (p=0.004). A statistically significant decrease in serum levels of CYFRA 21-1 was also found three months after radiotherapy or concomitant chemoradiotherapy in comparison with the preoperative levels (p=0.001). The serum levels of CYFRA 21-1 were statistically significantly higher preoperatively in patients with stage III/IV of the disease in comparison with stage I/II (p<0.001). Conclusion: Increased levels of CYFRA 21-1 are a significant indication of the presence of LSC, especially in patients with advanced stages of the disease.

Background: Aortic stenosis (AS) is the most common form of valvular disease in the elderly population, with degenerative calcified valves remaining the primary cause of this condition. Due to the progressive nature of the disease, a significant reduction in aortic valve area leads to increased left ventricular (LV) pressure overload, resulting in adaptive but ultimately maladaptive concentric hypertrophy and progressive myocardial remodeling. Objective: The main objectives of the study were to assess the regression of left ventricular (LV) hypertrophy, Methods: This retrospective study included 150 patients who underwent surgical aortic valve replacement (AVR) with the Sorin Freedom Solo (SFS) stentless bioprosthesis and the St. Jude Regent (STJ) mechanical valve. Patients were divided into three groups based on follow-up duration: six months, one year, and two years. changes in transvalvular gradient, perioperative outcomes, and survival rates. Results: The results showed a significant reduction in the transvalvular gradient for both valves (p < 0.0001), with a more pronounced decrease in patients with the SFS valve. The thickness of the interventricular septum (IVS) continuously decreased in SFS patients across all groups, whereas a significant reduction was observed only in Group 2 for STJ valves. Left ventricular ejection fraction (LVEF) showed a significantly greater increase in patients with the SFS valve (p < 0.024), particularly in Group 2. Overall mortality was 5.30% for STJ valves and 6.66% for SFS valves, with no statistically significant differences in Kaplan–Meier survival analysis (p > 0.05). Conclusion: The SFS valve demonstrated superior hemodynamic performance and more pronounced LV hypertrophy regression, making it a suitable option for high-risk patients. The STJ valve ensures stable long-term function and remains the preferred choice for younger patients with acceptable operative risk. These findings highlight the importance of a personalized approach in selecting valvular prostheses.

The concept of decision making is considered as one of the key topics in the field of strategic management and related fields. According previous theoretical considerations and discussions of the main contributors, there is no single routine/path used by managers in strategic decision-making. Mintzberg, Raisinghani and Théorêt define strategic decisions with regard to the decision-making level as a combination of entrepreneurial activities and efficient use of resources. The process of making strategic decisions is often described as unstructured, non-routine associated with uncertainty, defining it as a set of activities, which includes the collection of information, the development of alternatives and their evaluation, and ultimately the selection of the best alternative. It is clear, therefore, that it is difficult to talk about strategic decision-making exclusively in the context of a logical sequence of activities by division makers. This type of presentation of strategic decision-making, based on the idea of rational action by top management, as the strategic management executives, is also shown in numerous management text books. In their editorial in a special issue of the prestigious Strategic Management Journal, Cyert and Williams synthesized the conclusions of the special issue contributors. Analysing the cause-and-effect relationship between strategy, strategic decision-making and the organization, emphasis is put on the importance of organizational learning. In the conditions of creating an economy based on information and knowledge, a connection is created between information, organizational structure and strategic decision-making. In complex systems, such as companies, one of the key problems that occurs when making decisions is to find out where the decision comes from and how it is realized. Strategic decisions are most often a collection of some individual decisions in the organization or a consequence of informal conversations or actions that lead to collective action. The focus of this paper is an attempt to identified a key theoretical underpinning, through an overview of relevant theories and strategic management schools. In so doing, this paper will use the concept of strategic management schools, presented by Mintzberg, Ahlstrand and Lampel in their popular book Strategic Safari.

Regardless of the geopolitical and economic challenges the world as well as the European Union (EU) face, it appears that these issues have not, in the slightest, affected the EU's commitment to the green transition. The European Commission continues to provide strong support to member countries in implementing reforms that encourage the green transition. In conditions of sluggish economic growth, the investments in the green transition are characterized as a significant driver of economic growth. This paper analyzes and evaluates the implications of the EU's green transformation on the economic development of the Western Balkans (WB), with a special focus on the Green Deal and climate neutrality. The Green Deal represents the EU's key strategy for achieving climate goals and transitioning to a sustainable, green economy. Through an analytical approach, the impacts of the green transformation and related policies on the economic, social, and environmental aspects of the region are explored, considering the global Green Economy Index. The research methodology includes cluster analysis and analysis of the green economy index to assess the correlation between factors of the green economy and economic development, considering financial, institutional, and legal aspects of the Green Deal. Additionally, a comparison of development according to the Green Economy Index is applied to identify the position, potential, but also limitations of the Western Balkans in this context. Key indicators of the green economy, such as investments in renewable energy sources, energy efficiency, and sustainable infrastructure, are analyzed in terms of their impact on macroeconomic indicators such as gross domestic product per capita, unemployment, etc., in the Western Balkans. The paper identifies a range of opportunities for economic development, including increasing investments in renewable energy sources and developing sustainable infrastructure projects, but at the same time recognizes limitations, such as a lack of capacity, financial resources and public sector support to implement sustainable policies. Furthermore, there is a risk of increasing economic and social inequalities in the process of green transformation, as well as potential negative environmental consequences if appropriate measures are not taken.

Background: Benign acute childhood myositis (BACM) is a rare complication of viral URTIs, usually occurring in winter. It is characterized by acute onset of bilateral calf pain and difficulty/refusal to walk. A prodromal phase precedes these manifestations, consisting of catarrhal and constitutional symptoms. These are associated with increased muscle-specific enzymes, usually normal inflammatory parameters, and leukopenia. Objective: Our study aimed to define the demographic, clinical, and laboratory characteristics of BACM patients and determine the etiology leading to their development. Methods: Medical charts for patients diagnosed with BACM from October to April 2023/2024 at the Pediatric Clinic Clinical Center University of Sarajevo, Department of Allergology, Rheumatology, and Immunology were reviewed retrospectively. Relevant medical information was collected for 20 patients. Statistical analysis was done in Microsoft Excel 2013. Results: Demographic analysis demonstrated male predominance (75%), with primarily school-aged children affected (median age 8.36). Most cases occurred in winter (60%). The majority of patients presented with bilateral calf pain (100%), difficulty walking (90%), and fever (100%). All cases demonstrated increased CK levels, with median values of 3779 U/L; a notable number had leukopenia (70%). The most commonly isolated pathogen was Influenza B virus (75%). Conclusion: BACM is relatively rare but presents acutely and leads to plenty of distress for both patients and their parents. A child with coryzal symptoms complicated by bilateral calf pain or difficulty/refusal to walk and an increase in CK levels should raise suspicion of BACM. The condition is self-limiting and usually resolves without complications.

BACKGROUND Non-ST segment elevation myocardial infarction (NSTEMI) poses significant challenges in clinical management due to its diverse outcomes. Understanding the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient care. AIM To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events (MACE) in NSTEMI patients, potentially improving clinical outcomes. METHODS A prospective, observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla, Bosnia and Herzegovina. The study included 170 patients with NSTEMI, who were divided into a group with MACE and a control group without MACE. Furthermore, the MACE group was subdivided into lethal and non-lethal groups for prognostic analysis. Alongside hematological parameters, an additional 13 hematological-derived ratios (HDRs) were monitored, and their prognostic role was investigated. RESULTS Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction (NSTEMI) patients with MACE and a control group at T1 and T2. However, significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes post-MACE. Notably, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were elevated in lethal outcomes. Furthermore, C-reactive protein-to-lymphocyte ratio (CRP/Ly) at T1 (> 4.737) demonstrated predictive value [odds ratio (OR): 3.690, P = 0.024]. Both NLR at T1 (> 4.076) and T2 (> 4.667) emerged as significant predictors, with NLR at T2 exhibiting the highest diagnostic performance, as indicated by an area under the curve of 0.811 (95%CI: 0.727-0.859) and OR of 4.915 (95%CI: 1.917-12.602, P = 0.001), emphasizing its important role as a prognostic marker. CONCLUSION This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI patients. During follow-up, NLR, PLR, and CRP/Ly offer important insights into the inflammatory processes underlying cardiovascular events.

Change in cytoarchitecture and reconnection of neurons in rats' brain under direct two months high frequency electromagnetic field (HFEMF) exposure has been found, supported with data and discussed. HFEMF used in the experiment had the following characteristics: 2.0 GHz frequency, 0.015 A/m intensity, electric field strength of 5.64 V/m, and SAR value was 2.5 W/kg. Rats were exposed for 6 hours a day for 6 days a week, during period of 60 days with experimental HFEMF. Six months after the treatment, histological and unbiased stereological analyses show that there is a reconnection of neurons in rats' brain, demonstrated by slight increase in their number and production of new dendrites. Effects of HFEMF on neuronal disconnection were detected via caspase, while the SNXS25 protein indicated their reconnection and regeneration. Immunohistochemical analysis of nervous tissue in this paper shows that HFEMF disrupt the work of proteins found on cell membranes and endocytic function of neurons and thus interrupts interneuron communication. The advantage of HFEMF over other methods of treating brain damage is in their controlled and very precise use, with specifically defined characteristics of HFEMF, without ionizing and mutagenic effect on neurons.

Forgone healthcare is a hot topic in the United States. One reason is that many Americans cannot afford healthcare or health insurance. This article examines whether there are statistically significant differences in cancer mortality between US states with low, medium, and high levels of forgone healthcare. The analysis revealed statistically significant differences in cancer mortality rates between US states. Evidence shows that the percentage of adults unable to access healthcare when needed due to cost, and the percentage of adults reporting fair or poor health, are associated with differences in cancer mortality rates. These findings have important policy implications, highlighting the need for state-specific measures to improve the health and wellbeing of the population.

Cancer is one of the leading causes of death, which emphasises the need for prevention, detection and treatment. This article aims to investigate whether there are statistically significant differences in gender-specific cancer incidence and mortality between countries with low, medium and high health expenditure (as a percentage of GDP). The results for the year 2022 indicate statistically significant differences in cancer incidence and mortality in men between countries with low and medium health expenditure and countries with low and high health expenditure; however, no such differences were found in women.

Artificial intelligence is rapidly transforming higher education, continually oscillating between its innovative potential and concerns over academic integrity. While universities are expected to develop policies addressing ethical and pedagogical challenges, many institutions have yet to implement clear guidelines. To extract the dimensions of students’ perceptions of generative AI, the authors primarily used exploratory factor analysis. By using the exploratory factor analysis three key dimensions were revealed, i.e. 1) awareness and familiarity with AI tools, shaped both by personal exposure and institutional practices 2) institutional engagement and guidance, emphasizing the degree to which professors integrate AI in teaching and the demand for clearer instructions on its use and 3) concerns ranging from perceived risks of misuse and violations of academic integrity to recognition of AI’s educational value. These findings imply the urgent need for universities to establish transparent AI policies and provide guidance, ensuring that students can engage with AI tools ethically and effectively.