The measured forward-backward asymmetry in the tt production at the Tevatron might be explained by the additional exchange of a colored weak singlet scalar. Such state appears in some of the grand unified theories, and its interactions with the up-quarks are purely antisymmetric in flavor space. We systematically investigate the resulting impact on charm and top quark physics. The constraints on the relevant Yukawa couplings come from the experimentally measured observables related to D{sup 0}-D{sup 0} oscillations, as well as dijet and single-top production measurements at the Tevatron. After fully constraining the relevant Yukawa couplings, we predict possible signatures of this model in rare top quark decays. In a class of grand unified models we demonstrate how the obtained information enables to constrain the Yukawa couplings of the up-quarks at very high energy scale.

Diazepam is one of most frequently prescribed benzodiazepines. It is classified as a class I substance according to the Biopharmaceutics Classification Scheme (BCS). Diazepam tablets were prepared using different API rawmaterials. Before the formulation, we measured particle size distribution on Malvern Instruments Ltd Mastersizer 2000. The tablets were prepared by employing conventional wet granulation. The formulations were evaluated for hardness, friability, content uniformity, in vitro disintegration time (DT), release profiles. The dissolution profile testing is performed on the two formulations with different particles size distribution. Test parameters were: medium 0.1 mol / l hydrochloric acid, 900 ml, temperature 37°C ± 0.5°C, Mixing Speed 100 rpm, Number of tested tablets 12, Testing Cycle 10, 15, 20, 25 and 30 min. Instrument: Varian Van Kel VK7025, Varian Cary 50. We used the spectrophotometric method with absorbance measuring on 242 nm for quantification. Results for particle size distribution for first Diazepam API particle distribution were d (0.10): 88.743 μm; d (0.50): 305.231 μm; d (0.90): 655.911 μm, and for the second raw-material of API was d (0.10):1.998 μm; d (0.50): 4.419 μm; d (0.90): 8.845 μm. The results of diazepam dissolution for two formulations and f2 value with reference drug are presented in Table 1:

Metoprolol is a cardioselective β-blocker that is classified as a class I substance according to the Biopharmaceutics Classification Scheme BCS, meaning that it is highly soluble and highly permeable. [...]

Amlodipine is a long-acting calcium channel blocker used in the treatment of hypertension and angina pectoris. [...]

Onychomycoses, fungal nail infections, are responsible for 50% of all nail disorders affecting up to 18% of general population in some countries [1]. [...]

The separation of solids in adhesive contact, or the fracture of solid bodies, often results in the emission of high-energy photons, e.g., visible light and X-rays. This is believed to be related to charge separation. We propose that the emission of high-energy photons involves surface roughness and surface diffusion of ions or electrons, resulting in the concentration of charge at the tips of high asperities, and to electric-field enhancement, which facilitate the discharging process which result in the high-energy photons. If the surface diffusion is too fast, or the separation of the solid surfaces too slow, discharging starts at small interfacial separation resulting in low-energy photons.