Manifold calculus of functors has in recent years been successfully used in the study of the topology of various spaces of embeddings of one manifold in another. Given a space of embeddings, the theory produces a Taylor tower whose purpose is to approximate this space in a suitable sense. Central to the story are deep theorems about the convergence of this tower. We provide an exposition of the convergence results in the special case of embeddings into $\mathbb R^n$, which has been the case of primary interest in applications. We try to use as little machinery as possible and give several improvements and restatements of existing arguments used in the proofs of the main results.

Abstract: The paper’s practical objective is to provide those developing community-scale food systems with an implementable model. Its theoretical objective is to examine the ways to effectively design post-capitalist models for food systems. In providing a testable model for food systems design, the paper advances concept formation in the field. The case study approach recognizes that local food systems design cannot depend on abstract, formalized models due to the specificity of each project. The crucial role for designers include the involvement of end-users in everyday life in the research process, experimentation in everyday life, building relationships, as well as prototyping, policy making and implementation of services to be delivered by public agencies. People-led food systems can engage agencies and citizens in a co-production process whereby users design and implement their own service program that can be enabled by public agencies. Design-led food strategies illustrate an approach to create eco-acupuncture points that will ultimately start to change the dominant industrial agriculture system into a new social and economic paradigm.

Abstract The most popular measure of the National Rural Development Programme in Romania for 2007-2013 was the measure 121 addressing the support for modernisation of agriculture While the success at the level of the Programme is measured by the achievement level of the assumed indicators the present analysis is focused on differences between the volumes of proposed, selected, contracted and concluded projects. These differences as observations and findings contribute as learning points to the further use of public support for investments in agriculture by three main categories of users: the administration with the procedural enhancement in programme implementation, the beneficiaries improving their approach and readiness for applications/projects and the consultants in perfecting their tools and work to support and smoothen the resources transfer in the process.

Summary Premature loss of teeth in children may lead to both functional and esthetic problems. Missing teeth in both anterior and posterior regions may cause malfunctions in mastication and proper pronunciation. If the missing teeth are not replaced, further complications may occur, including adjacent tooth migration, loss of alveolar bone, and irregular occlusion. Considering the sensitive nature of children, loss of teeth may cause the development of insecurities and low self esteem problems. Due to dynamic nature of growth in children and adolescents, prosthetic appliances must not hinder development of orofacial system, and must meet adequate esthetic and functional standards. Dental prosthetic appliances in paediatrics must be planned with respect to the special conditions that led to tooth loss or damage. Multi-disciplinary approach is needed, under constant supervision of paediatric dentist and orthodontist, as well as regular checkups with clinical and radiographical examinations.

Background: Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique that is designed to remove substances with a large molecular weight. The TPE procedure includes removal of antibodies, alloantibodies, immune complexes, monoclonal protein, toxins or cytokines, and involves the replenishment of a specific plasma factor. The aim of the study was to describe the clinical response to TPE in various neurological patients, and to assess the clinical response to this therapy. Methods: The study was retrospective. We analyzed the medical records of 77 patients who were treated at the Department of Neurology, University Clinical Center (UCC) Tuzla from 2011 to 2016. Results: 83 therapeutic plasma exchanges were performed in the 77 patients. There was a slight predominance of male patients (54.5%), with an average age of 51±15.9 years. The most common underlying neurological diseases were Guillain–Barré syndrome (GBS) (37.7%), then chronic inflammatory demyelinating polyneuropathy (CIDP) (23.4%), multiple sclerosis (MS) (11.7%) and myasthenia gravis (10.4%). Less frequent neurological diseases that were encountered were paraneoplastic polyneuropathies (5.2%), neuromyelitis optica (also known as Devic’s disease) (3.9%), motor neuron disease (3.9%), polymyositis (2.6%) and multifocal motor neuropathy (1.2%). Conclusions: Six years experience of therapeutic plasma exchange in neurological patients in our department have shown that, following evidence-based guidelines for plasmapheresis, the procedure was most effective in patients with GBS, CIDP and myasthenia gravis.

Abstract Objectives SB2 is a biosimilar to the reference infliximab (INF). Similar efficacy, safety and immunogenicity between SB2 and INF up to 30 weeks were previously reported. This report investigates such clinical similarity up to 54 weeks, including structural joint damage. Methods In this phase III, double-blind, parallel-group, multicentre study, patients with moderate to severe RA despite MTX were randomized (1:1) to receive 3 mg/kg of either SB2 or INF at 0, 2, 6 and every 8 weeks thereafter. Dose escalation by 1.5 mg/kg up to a maximum dose of 7.5 mg/kg was allowed after week 30. Efficacy, safety and immunogenicity were measured at each visit up to week 54. Radiographic damage evaluated by modified total Sharp score was measured at baseline and week 54. Results A total of 584 patients were randomized to receive SB2 (n = 291) or INF (n = 293). The rate of radiographic progression was comparable between SB2 and INF (mean modified total Sharp score difference: SB2, 0.38; INF, 0.37) at 1 year. ACR responses, 28-joint DAS, Clinical Disease Activity Index and Simplified Disease Activity Index were comparable between SB2 and INF up to week 54. The incidence of treatment-emergent adverse events and anti-drug antibodies were comparable between treatment groups. Such comparable trends of efficacy, safety and immunogenicity were consistent from baseline up to 54 weeks. The pattern of dose increment was also comparable between SB2 and INF. Conclusion SB2 maintained similar efficacy, safety and immunogenicity with INF up to 54 weeks in patients with moderate to severe RA. Radiographic progression was comparable at 1 year. Trial registration ClinicalTrials.gov (http://clinicaltrials.gov; NCT01936181) and EudraCT (https://www.clinicaltrialsregister.eu; 2012-005733-37)

Partial wave amplitudes of meson photoproduction reactions are an important source of information in baryon spectroscopy. We investigate a new approach in single-energy partial wave analyses of these reactions. Instead of using a constraint to theoretical models in order to achieve solutions which are continuous in energy, we enforce the analyticity of the amplitudes at fixed values of the Mandelstam variable $t$. We present an iterative procedure with successive fixed-$t$ amplitude analyses which constrain the single-energy partial wave analyses and apply this method to the $\gamma p \to \eta p$ reaction. We use pseudo data, generated by the EtaMAID model, to test the method and to analyze ambiguities. Finally, we present an analytically constrained partial wave analysis using experimental data for four polarization observables recently measured at MAMI and GRAAL in the energy range from threshold to $\sqrt{s}=1.85$ GeV.