Uvod. Tireoglosalna cista predstavlja najcescu kongenitalnu anomaliju vrata i javlja se kod oko 7% ukupne populacije. Nastaje kao posljedica izostanka obliteracije ductus thyreoglossus-a za vrijeme tireoidne migracije tokom embrionalnog razvoja. Najcesce se dijagnostikuje u prvoj deceniji života, a dijagnoza se postavlja klinickim pregledom, ehosonografijom, multislajsnom kompjuterizovanom tomografijom (MSCT) i/ili magnetnom rezonancom (MRI) glave i vrata, finom iglenom aspiracijom (FNA) i citoloskom analizom punktata. Terapija je hirurska, operacijom po Sistrunk-u. Prikaz bolesnika. Cetrdesetogodisnji pacijent je hospitalizovan radi dijagnostike i lijecenja tumora podvilicne i podbradne regije i usne supljine, sa dislokacijom jezika, otežanim gutanjem, i govorom. Pacijent je u ranom djetinjstvu uocio potkožnu izraslinu ispod brade koja je postepeno rasla. Klinickim pregledom vidi se potkožna tumorska masa koja zahvata submentalnu i obje submandibularne regije predominantno lijevo uz intraoralnu prezentaciju submukoznog tumora koja u potpunosti ispunjava orofarinks i dislocira jezik udesno. MSCT poda usta i vrata ukazuje na nepravilno ovalni tumor velicine 120 x 95 x 90 mm, koji gornjim polom doseže do tvrdog nepca, zauzima usnu supljinu te se spusta anterolateralno i vise lijevo u regiju vrata do hioidne kosti, udesno dislocirajuci jezik, jednjak i strukture farinksa i larinksa. Citoloska analiza sadržaja ciste dobijenog FNA pokazuje da sadržaj odgovara tireoglosalnoj cisti. U uslovima opste nazotrahealne anestezije uradi se operacija po Sistrunk-u sa odstranjenjem cisticnog tumora i srednjeg dijela hioidne kosti uz repozicioniranje jezika. Postoperativni tok protekao uredno. Funkcije govora i gutanja u potpunosti rehabilitovane. Patohistoloski nalaz je potvrdio da se radi o tireoglosalnoj cisti. Zakljucak. Tireoglosalne ciste su najcesce kongenitalne anomalije vrata i uspjesno se lijece operativnim zahvatom sa zadovoljavajucim ishodom, niskom stopom komplikacija i malim procentom recidiva.

In this study, novel hexa coordinated ruthenium(III) complex of the type Na[RuCl2L2)] (where L = monobasic bidentate Schiff base derived from the condensation of 5-nitrosalicyladehyde with aniline) has been synthesized and characterized by electrospray ionization time-of-flight mass spectrometry, infrared spectroscopy and ultraviolet/visible spectrophotometry. Schiff base N-phenyl-5-nitrosalicylideneimine is coordinated to the ruthenium via imine nitrogen and phenolic oxygen. Mass spectra showed molecular ion (M-) at m/z 653.9641 which corresponds to [C26H18Cl2N4O6Ru]. The in vitro antimicrobial properties of the Schiff base and the complex were tested by micro-dilution technique and agar plate assay for determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The compounds showed a higher antibacterial activity against tested Gram-positive bacteria (Staphylococcus aureus ATCC 33591 and ATCC 29213), whereas against the Gram-negative bacteria (Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603) were ineffective. The genotoxic effects of Ru(III) complex were investigated using the Cytokinesis Block Micronucleus (CBMN) assay in human lymphocytes cultures. The cell culture treated with the complex at a concentration of 3.7 μg/mL exhibit the most prominent effect of decreasing the frequency of micronucleus for 44%, while at the concentrations of 1.5 and 7.4 μg/mL effect is slightly lower (40%), compared to the control cell culture.

To alleviate the problem of scarce spectrum resources and meet the ever-increasing of mobile broadband data traffic demands, Licensed Assisted Access (LAA)-Long Term Evolution (LTE), operating in the unlicensed spectrum, is a promising solution. Considering that the unlicensed spectrum is shared by a few incumbent systems, such as IEEE 802.11 (i.e., WiFi), one main target is to guarantee the friendly and harmonious coexistence of LTE with other wireless systems in the unlicensed spectrum. Both listen-before-talk (LBT) and duty cycle methods are regarded as effective ways to solve the coexistence problem in academia and industry so far. Although there are a large number of theoretical researches on LTE in unlicensed spectrum (LTE-U), field trail results are still lacking. In this paper, an experimental testing platform is deployed to model the realistic environment. This paper focuses on three aspects. First, a typical indoor field trial scenario in 5.8 GHz unlicensed bands is deployed, and the performance of LTE-U and WiFi, including coverage and capacity, is evaluated. Specifically, a methodology to determine the proper clear channel assessment energy detection (CCA-ED) threshold for LTE-U is proposed to implement the friendly coexistence between LTE-U and WiFi systems. Second, supplementary downlink (SDL) and Cell ON/OFF mechanisms are investigated to verify the fair coexistence between LAA and WiFi in the unlicensed spectrum. Third, the Enhanced Cell ON/OFF scheme, which introduces Clear to Send (CTS)-to-Self (CTS2S) message, is discussed and evaluated. Based on the built testbed, we obtain threefold conclusions. First of all, introducing LTE into unlicensed spectrums can greatly improve the spectrum efficiency and optimize wireless resources. Furthermore, test results and analyses show that a proper CCA-ED threshold is necessary for coexisting friendly and fairly among different systems, and experiments are also provided to validate the feasibility of the suggested method in various scenarios. Second, experimental results show that SDL mechanism guarantees relatively friendly and harmonious coexistence between LAA and WiFi only in the sparse scenario, while basic Cell ON/OFF mechanism is more effective to ensure coexistence between LAA and WiFi than the SDL. Finally, with the introduction of CTS2S message, the Enhanced Cell ON/OFF scheme is able to achieve more peaceful coexistence between LTE and WiFi users employed in the same bands compared with the Basic Cell ON/OFF scheme.