The World Health Organization (WHO) released guidelines for physical activity (PA), sedentary behavior, and sleep for children under 5 years of age in 2019, but there are no reports on the adherence to the guidelines in southeastern Europe. This study aimed to: (i) determine the proportion of preschool children (aged 3-5 years) who met the WHO guidelines and examine the feasibility of the proposed protocol for the SUNRISE study in Bosnia and Herzegovina (B&H), and (ii) define sex-, and urban/rural-living-specifics in movement-behaviors, anthropometrics, gross-motor-skills, fine-motor- skills, and cognitive-skills. The sample comprised 115 preschool children (63 girls and 52 boys), residing in urban (n = 66) and rural areas (n = 49) from B&H. Participants were tested on movement behaviors (PA, sleep time, screen time) by accelerometry and comprehensive questionnaires. Body height, weight, body mass index, executive function, fine-, and gross-motor skill, and cognitive function were also measured. The results showed that PA-, sleep duration-, and screen time guidelines were met by 64%, 74% and 53% of children, respectively, while only 23% of the children met all three guidelines on movement behaviors. Boys exhibited higher PA than girls, but no differences in gross- and fine motor skills and cognitive functioning were recorded between the sexes. Children living in urban and rural environments did not differ in any of the studied variables. Results evidenced preschool children from B&H being in line with other samples globally about study variables. Although PA was higher in boys than in girls it was not translated to differences in motor skills. Further studies on larger samples and other environments are warranted.

Forensic obstetrics attracts much attention from forensic experts and the public owing to the professional, legal, public health, and not inconsiderable social-emotional aspects and directly correlates with maternal, fetoneonatal, and iatrogenic risk factors. Modern obstetrics and fetomaternal medicine must not be quantified and qualified based only on perinatal disease but also according to current obstetric problems that burden forensic obstetrics. Therefore, high-risk obstetrics as a significant medico-legal problem should be viewed from the point of view of the entire perinatal period with possible long-term consequences, hence the monitoring of complete perinatal and infant morbidity is of immediate importance for quality control and risk control in the profession. The task of forensic obstetrics is to assess the impact of risk factors on the occurrence of an adverse event and to assess whether it is an obstetric complication or obstetric malpractice. Acknowledging the mentioned facts is the only way we will develop high obstetric awareness, and we and pregnant women, birth attendants, midwives and patients, fetuses, and newborns will have professional safety with imminent but controlled obstetric risk and controlled expected complications. On the other hand, the fact that the statistics of perinatal (obstetrical) malpractice globally is not abating requires a change in obstetrical philosophy, especially the unreasonable epidemic increase of cesarean sections with a significant percentage of cesarean sections without medical indication and complications. It is necessary to introduce and maintain solid professionalism and bioethical norms in obstetrics with constant training of skills, which is emphasized by numerous authors and with which we fully agree. Forensic obstetrics is based on the principles of good clinical practice, professional guidelines of modern obstetrics, and ethical and deontological principles. It clearly shows the perfection and imperfection of biological systems that we can and cannot influence. However, we must act according to the rules of the clinical profession, deontological rules, and health laws to reduce clinical risk to the smallest possible extent. Attention should certainly be focused on reducing the disproportion between iatrogenic and maternal-fetoneonatal risk factors, which is the most common reason for litigation today.

This study examines the relationships between societal cultures and preferred leadership behaviors across seven Slavic nations: Bosnia and Herzegovina, Croatia, the Czech Republic, North Macedonia, Poland, Russia (in two regions), and Serbia. The results depict variations in the associations between cultural dimensions and leadership behaviors within the Slavic context, revealing both consistent patterns and intriguing differences across countries, underscoring their cultural diversity. The obtained results contribute to the field of cross-cultural leadership and provide deeper insights into leadership dynamics within Central and Eastern European countries.

This study explores relationships between societal culture value dimensions and preferred leader behavior in Bosnia and Herzegovina (BIH). It is one of the first studies that provide an overview of the dimension of Monumentalism in BIH and bring together all seven cultural dimensions, thus contributing to their overall understanding. Data in two observed regions (region Bosnia, region Herzegovina) have not yielded significant differences in preferred leader behavior across regions, and regarding cultural dimensions, significant differences among regions were found only for Individualism and Masculinity, implicating relatively homogenous culture in BIH. While Power Distance has no significant correlations with any of the preferred leadership behaviors, significant correlations were found for other cultural dimensions. The study’s results contribute to a deeper understanding among leaders and employees and enhance managerial effectiveness.

Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint inflammation and destruction, leading to significant pain and disability. Adenosine deaminase (ADA) is identified as a biomarker for RA’s inflammatory process. This study aims to investigate the potential of flavonoids and phenolic acids to inhibit ADA activity (in silico) and evaluate their anti-inflammatory effects in a RA model (in vivo). Methods: The molecular docking study was conducted using YASARA Structure 19.12.14. software following the Auto Dock 4.2 protocol. A rat model with pristane-induced arthritis was used to test the anti-inflammatory effect of selected polyphenols. The consistency of the development of the rat model was evaluated through the following indicators artistic score, paw volume, and body weight. Quercetin was administered intragastrically at doses of 150 and 400 mg/kg over 15 days. The C-reactive protein (CRP) level in serum was measured with an automatic biochemical analyzer. Statistical analyses were performed using SPSS 29.0.2.0. Results: Molecular docking simulations showed flavonoids inhibited ADA activity with inhibition constants ranging from 0.012 mM to 0.190 mM. In the in vivo RA model, quercetin significantly reduced joint inflammation and serum CRP levels at a higher dose of 400 mg/kg. Conclusion: Quercetin shows promise as an anti-inflammatory agent for RA by targeting ADA, suggesting that flavonoid-rich plant extracts could enhance RA treatment.

Metamaterials, synthetic materials with customized properties, have emerged as a promising field due to advancements in additive manufacturing. These materials derive unique mechanical properties from their internal lattice structures, which are often composed of multiple materials that repeat geometric patterns. While traditional inverse design approaches have shown potential, they struggle to map nonlinear material behavior to multiple possible structural configurations. This paper presents a novel framework leveraging video diffusion models, a type of generative artificial Intelligence (AI), for inverse multi-material design based on nonlinear stress-strain responses. Our approach consists of two key components: (1) a fields generator using a video diffusion model to create solution fields based on target nonlinear stress-strain responses, and (2) a structure identifier employing two UNet models to determine the corresponding multi-material 2D design. By incorporating multiple materials, plasticity, and large deformation, our innovative design method allows for enhanced control over the highly nonlinear mechanical behavior of metamaterials commonly seen in real-world applications. It offers a promising solution for generating next-generation metamaterials with finely tuned mechanical characteristics.

Background - Organ donation and organ transplantation refer to a medical treatment approach that involves substituting a diseased or damaged organ or tissue in the human body with a healthy one. Progress in surgical techniques, immunology, and medical science has facilitated the advancement of transplant procedures. Nowadays, a wide range of organs, organ parts, and tissues can be successfully transplanted. Depending on the part of the body in question, the organs that are donated can come from a deceased donor or from a living person. Factors that influence the individual in a positive direction in terms of donating their organs have been presented in previous studies as the socio-economic status of informants, education level, being young, gender, donation to family members and social support. Aim - of this study is to synthesize qualitative and quantitative research on individuals' attitudes and decisions regarding organ donation, as well as the factors influencing these matters. Materials and Methods - A systematic search was conducted on the PubMed, Embase, CINAHL, and Web of Science databases for qualitative and quantitative literature regarding factors influencing an individual to donate their organs to other individuals. An inductive thematic analysis was conducted to generate themes and supporting subthemes. Fifteen studies were included. Results - The three main themes were: socioeconomic and cultural factors, dissatisfaction with, and mistrust of the healthcare system. Unspecified donors demonstrated a deep sense of different factors that influenced the individual to donate their organs to other individuals. Religious factors, fear and prejudices, gender differences, the influence of family members and not being treated well by healthcare professionals were only a few of the factors that were stated in the present study. Conclusion - The results of the present study show that there were many different factors that influenced an individual to decide whether to donate organs. Even though the individuals belong to different religions, come from different cultures, look at family relationships differently and have different degrees of knowledge, the opinions and factors that influence their decision regarding organ donation are the same. Healthcare should work more actively to inform and increase knowledge and consciousness about organ donation among people who are prospective donors. This can mean more information in several different languages, as well as where different religions stand on organ donation. Key words: Organ donation, transplantation, influence, factors, decision, review.

Research suggests that serious games can be used as supplementary training tools for young people with complex mental health needs. This study aimed to co-produce a mobile-accessible serious game, ReGoal, in collaboration with young people (11 – 16 years) and an interdisciplinary team of academic experts and practitioners. ReGoal is aimed to serve as a supplementary tool for improving emotion regulation, goal-orientation, and executive functioning skills. This study consisted of three interlinked co-production phases. First, 122 participants, of which 34% had moderate to high conduct problems, completed an online survey about the role of gaming in managing their emotions. During the second phase, 16 young people attended three focus groups in which their lived experiences shaped the narrative of ReGoal. In the third phase, an online user survey gathered feedback from 72 young people playing the most recent prototype of ReGoal. The key fi ndings suggest that young people valued playing ReGoal as a supplementary aid to improving their mood, increasing empathy towards peers and family, reducing anxiety, anger, and impulsivity, and understanding other people ’ s emotions. Future research should test the applicability and feasibility of ReGoal in reducing behavioural problems with clinical and non-clinical samples.

Metamaterials, synthetic materials with customized properties, have emerged as a promising field due to advancements in additive manufacturing. These materials derive unique mechanical properties from their internal lattice structures, which are often composed of multiple materials that repeat geometric patterns. While traditional inverse design approaches have shown potential, they struggle to map nonlinear material behavior to multiple possible structural configurations. This paper presents a novel framework leveraging video diffusion models, a type of generative artificial Intelligence (AI), for inverse multi-material design based on nonlinear stress-strain responses. Our approach consists of two key components: (1) a fields generator using a video diffusion model to create solution fields based on target nonlinear stress-strain responses, and (2) a structure identifier employing two UNet models to determine the corresponding multi-material 2D design. By incorporating multiple materials, plasticity, and large deformation, our innovative design method allows for enhanced control over the highly nonlinear mechanical behavior of metamaterials commonly seen in real-world applications. It offers a promising solution for generating next-generation metamaterials with finely tuned mechanical characteristics.

Avoidable disasters are both saddening and baffling. In 2022, 159 people, mostly in their 20s, and 30s were crushed to death in Itaewon's narrow alleyway amid South Korea's first pandemic-restrictions-free Halloween celebration. What is particularly sobering about this tragedy is that although many people called police hotlines as crowds became cramped and static, their calls went unheeded for hours. Rather than order independent investigations into the catastrophe (as of January 2024), the President of South Korea at the time focused on superficial issues such as asking the public to refer to the disaster as an "accident" (which it was not, it was an avoidable disaster) and the casualties as "the dead" (who are casualties indeed, instead of victims of a preventable tragedy). In this paper, we examine how officials' complacency about public health and safety dangers, ineffective disaster prevention, and preparedness systems, as well as the government's chronic lack of prioritization of public health and safety may have contributed to the disaster. Furthermore, we discuss the importance of creating integrated public health and safety protection systems to prevent similar tragedies from happening.