Background: Assessment of the fetal nervous system - both in its anatomical structure and functional behaviour - has long been a challenge in perinatal medicine. Recent advances in ultrasound technology, especially 3D and 4D ultrasound, now allow detailed real-time observation of fetal anatomy and behavior. The development and maturation of the fetal brain in utero (and its continuity into extrauterine life) is a complex dynamic process: fetal neurobehavior is thought to follow a reproducible, gestational-age–dependent pattern that reflects neurological integrity. If normative fetal neurodevelopmental stages could be recognized and standardized, then deviations - abnormal neurobehaviors - could be identified, enabling prompt prenatal diagnosis of nervous-system pathology. Objective: The aim of this study was to emphasize the potential of 4D ultrasound–based fetal neurobehavioral evaluation (specifically with the Kurjak Antenatal Neurodevelopmental Test, KANET) in detecting abnormal neurobehavior prenatally, and to underline how this method may allow early identification of fetuses at risk for neurodevelopmental impairment. Methods: Review of the concept of fetal neurobehavioral assessment using 4D ultrasound. The KANET test applies 4D ultrasound to observe fetal behavior (movements, facial expressions, general/isolated movements) across gestation, akin to how neonates are neurologically assessed postnatally. By standardizing a scoring system for fetal behaviors relative to gestational age, KANET distinguishes between normal, borderline, and abnormal fetal neurobehavior. Evidence from multicenter studies and clinical/practice settings is considered to assess the feasibility and predictive value of KANET. Results: a) 4D ultrasound makes it possible to observe a wide repertoire of fetal behaviors (limb movements, facial expressions, mouth movements, hand-to-face, general movements), with increasing complexity and organization through gestation - reflecting central nervous system (CNS) maturation. PubMed+2De Gruyter Brill+2; b) Application of KANET in both low-risk and high-risk pregnancies (including growth-restricted and diabetic pregnancies) has shown significant differences in fetal behavior patterns. PubMed+2journaljammr.com+2; c) Postnatal follow-up in some studies found that fetuses with abnormal prenatal KANET scores indeed displayed adverse neurological outcomes - suggesting KANET’s potential as a predictive tool. PubMed+2PubMed+2; d) A recent systematic review (2025) found consistent evidence that behaviors observed via 4D ultrasound (e.g., yawning, hand-to-face, startle, general movements) increase in complexity between approx. 24–34 weeks gestation, coinciding with known neurodevelopmental milestones (e.g., thalamocortical connectivity). PubMed+1; e) However, despite growing evidence for structured fetal behavior as a marker of neural integration, the review cautions that such behaviors cannot yet be equated with consciousness or subjective awareness. PubMed+1.- Conclusion: The advent of 3D/4D ultrasound - and standardized tools like KANET - enables non-invasive prenatal assessment not only of fetal anatomy but also of functional neurodevelopment. Observing and scoring fetal behavior provides a promising avenue for early detection of neurodevelopmental abnormalities. While current evidence supports the use of KANET in clinical practice to identify fetuses at risk for neurodevelopmental impairment, interpretation should remain cautious: observed behaviors likely reflect maturation and neural integration but do not equate to consciousness. Further large-scale, long-term follow-up studies are needed to solidify the predictive validity and clinical utility of prenatal neurobehavioral assessment.

The functional performance and in-service quality of products are strongly influenced by surface roughness, which is a direct outcome of material removal processes. In general, surface roughness is function by the input parameters of the machining process and the extent of tool wear, the increase of which leads to an increase cutting forces, torque, acoustic emission level, vibrations, and temperature. Finding the dependence between machining parameters, tool wear indicators, and surface roughness parameters enables real-time prediction of surface quality and contributes to appropriate processing quality. In this study, based on data obtained through experiment conducted using the Taguchi design of experiment, predictive models were developed using multiple regression analysis and artificial neural networks (ANN). These models establish a relationship between input drilling parameters, axial drilling force, and the maximum height of the surface roughness profile.

This paper examines the implementation of Industry 4.0 elements in enhancing the quality of cables and connectors in the automotive industry, with a focus on meeting ISO 16949 requirements. Modern quality control solutions are presented, including smart sensors, digital twins, and predictive analytics. Special emphasis is placed on multi-stage testing methods and process digitalization for quality monitoring. Through a case study from the company Leoni, the impact of QRQC, Q4.0, and Q-Loop systems on defect reduction in the production of BMW components is analyzed. The paper demonstrates how the integration of Industry 4.0 technologies enhances reliability, efficiency, and compliance with automotive industry standards.

Background: To gain insight into the role and relevance of inflammatory and immunological markers in the comprehensive assessment of a patient's immune response to surgical procedures. This study focused on investigating preoperative and postoperative serum levels dynamics of SAA, CRP and proportion of HLA-DR CD14 monocytes, CD14 monocytes, and pro-inflammatory monocytes CD16 T CD14 T in patients who underwent heart surgery using extracorporeal circulation (on-pump). Methods: An observational, prospective study was conducted at the Heart Center of the Clinical Center of the University of Sarajevo on 53 patients divided into 3 age groups: 50-59, 60-69, and 70-80. The serum levels of CRP and SAA were quantitatively determined by immunonephelometry. At the same time, flow cytometry technology was applied to measure the proportion of CD14 monocytes, HLA-DR CD14 monocytes, and pro-inflammatory CD16 CD14 monocytes. Results: Measured values of CRP; SAA, proportion of monocytes CD14, and proportion of pro-inflammatory monocytes CD16 CD14 are significantly increased postoperatively compared to the preoperative values (p < 0.05). The proportion of HLA-DR CD14 monocytes is lower postoperatively compared to preoperative values (p < 0.001). Furthermore, there are no significant gender differences in the preoperative or postoperative parameters (p > 0.05), with the notable exception of the preoperative proportion of CD14 monocytes (p < 0.05). The analysis of age-related differences indicates no significant changes in the observed preoperative and postoperative parameters among the defined age groups (p >0.05). Conclusions: Early monitoring of inflammatory and immunological markers in the postoperative phase could be valuable for healthcare professionals to implement prompt interventions to mitigate negative outcomes.

Today’s accelerated construction of buildings generates a enormous number of reinforced concrete rooms in which people live and in which an increasing number of various electrical devices are installed. Since buildings are characteristic of urban areas, mostly polluted air, consisting of particulate and gaseous pollutants, gets inside them. The electrical devices generate an electromagnetic field in their environment that multiplies with the number of these devices. The electromagnetic field cannot leave the reinforced concrete construction of buildings because of the so-called Faraday cage. The electromagnetic field generator in this analysis is focused on the electric foil heating floor. In addition, polluted air has a deficit of negative oxygen ions, which is further reduced near electronic devices since they generate positive ions. Due to their extremely high mobility, ultrafine and fine particles quickly reach from the streets even to the highest floors of buildings. The triple synergistic impact caused by the generation of electromagnetic fields, positive ions and fine particles inside closed spaces is the subject of experimental analysis carried out in this paper. The conducted analysis is carried out when varying the working parameters within one room as a research polygon.

The imperatively excellent performance of wavelength-division multiplexing (WDM) transmission over a fiber optic link, demands flat, i.e. not wavelength-selective transfer function. This implies that, mostly during installation and commissioning of a WDM-aimed fiber link, it is of interest to measure its frequency response, by complex stimulus-response tests using a tunable laser source coupled with an optical spectrum analyzer. On the contrary, a simple and practically costless alternative that we propose here, is testing in time domain by means of the ubiquitous optical time-domain reflectometer (OTDR), considering its distinctly reflective trace pattern as approximation of the fiber channel two-way power-delay profile, whose rms delay spread is the straightforward indicator of the fiber attenuation vs. wavelength characteristics’ unflatness qualifying the fiber as either appropriate for WDM transport, or requiring piecewise “flattening” of the transfer function by applying coherent optical orthogonal frequency-division multiplexing (CO-OFDM). Specifically, the proposed OTDR – aided WDM suitability fiber test model applied on the exemplar traces, showed significant peak-to-peak DWDM spectrum unflatness, i.e. the pronounced frequency selectivity strongly indicating the need for introducing CO-OFDM on top of WDM. This was found to be monotonically tracked by the WDM transmission performance – the bit-error rate (BER) values in particular, measured with and without the CO-OFDM applied.

The aim was to investigate sex differences regarding shooting position, shooting technique, and shot placement preceding open-play goal scoring in the Swedish Super League (SSL) in floorball. Video recordings of 3751 goals were analysed to determine the goal scorers’ positions on the pitch when they took the shots and which type of shots they used. In addition, the placement of the ball when it entered the goal was determined. The proportion of goals from the playing zone closest to the goal was higher for women (P < 0.001), whereas the relative number of goals from the playing zones to the left of the goal and from the central playing zone farthest from the goal was higher for men (all P < 0.001). Women used wrist shots and backhand shots more frequently to score goals than men (both P < 0.01); conversely, the proportion of goals scored using slap shots and volley shots was higher for men (both P < 0.001). In terms of shot placement, the percentage of goals scored in top-left corner was higher for male players (P < 0.05). Hence, there are sex-related goal-scoring differences in SSL and the findings may inform coaches in refining tactics and training. Keywords: Sex difference, video analysis, unihockey, shooting technique.

Background: HLA-A gene is one of the most polymorphic loci in human genome and its variants influence disease susceptibility and immune checkpoint inhibitor (ICI) therapy response. HLA-A*03 allele has been identified as a biomarker associated with poor ICI response. Objective: This study aimed to characterize HLA-A allele and genotype frequencies in the Bosnian population, assess sex specific differences, and evaluate the prevalence of HLA-A*03. Methods: Blood samples from 75 individuals were analyzed. Genomic DNA was isolated using the Miller method, and HLA-A typing was performed using PCR with sequence specific primers (PCR-SSP). Polymorphism parameters were calculated using PowerMarker v3.25. Differences between males and females were assessed using chi square and Fisher’s exact tests. Results: Twelve HLA-A allelic groups and 28 genotypes were identified. The most frequent alleles were HLA-A*02 (33.33%), A*01 (16.67%), A*24 (11.33%), A*03 (10%), and A*11 (8%). The most common genotypes were HLA-A*01/*02 (12%), A*02/*02 (12%), and A*02/*03 (8%). Females showed significantly higher frequencies of HLA-A*02, A*03, and A*31, as well as genotypes HLA-A*02/*03, A*02/*11, and A*02/*31. The population exhibited high polymorphism (heterozygosity 0.8667; gene diversity 0.8232; PIC 0.8054). Strong similarity with European and Western groups and substantial divergence from East Asian and African populations were detected. Conclusion: The Bosnian population demonstrates high HLA-A polymorphism, with HLA-A*02 as the most common allele. Females more frequently carry the HLA-A*03 allele and several related genotypes, suggesting potential sex specific implications for ICI therapy response. These findings provide a foundation for future studies investigating the clinical relevance of HLA-A variation in Bosnian cancer patients undergoing immunotherapy.

The numerical simulation of friction stir welded T-joints made of AA2024 T3is investigated. Analysis of heat generation due to friction and plastic workis performed, as well as of the reaction force in the normal direction duringthe plunge stage of the friction stir welding. The effect of joint geometry isstudied for butt joints and T-joints produced from the same material.Different tool rotation speeds and tool pin lengths were considered forT-joint FSW welding. It was shown that the temperature at the root of theweld below the tool pin is lower in the T-joint than in the butt joint, due tothe efficient conduction of the heat produced through the normal plate. Also,the reaction force was higher for the T-joint than for the butt joint; so, heatproduction by friction was more intense in comparison with the heatproduced by plastic deformation. The reaction force was moderatelyincreased for the tool with a shorter pin, increasing both components of theheat produced. An increase in the tool rotation speed decreased theresistance to the tool plunging into the T-joint, increasing the frictional heatand decreasing the amount of heat generated by plastic deformation.

Cryptogenic stroke is an ischemic stroke of unknown cause after a comprehensive diagnostic workup and accounts for a significant percentage of all strokes. This paper presents the case of a 37-year-old female patient with recurrent ischemic strokes, in whom a patent foramen ovale (PFO) was diagnosed and subsequently closed via catheter-based intervention. Despite this therapeutic procedure, further recurrences occurred. During electrophysiological evaluation and ablation of paroxysmal supraventricular tachycardia, paroxysms of atrial fibrillation were detected, leading to the initiation of anticoagulant therapy. During follow-up, the patient remained free of symptomatic recurrences. This case highlights the importance of prolonged monitoring for the detection of atrial fibrillation in patients with cryptogenic strokes, which can significantly influence therapeutic strategies and recurrence prevention.

Background. Patent foramen ovales are very common in the population. Thrombus entrapped in a patent foramen ovale is very rare and can cause paradoxical embolism with a high mortality rate. We present the case of a patient diagnosed with a massive pulmonary embolism and a huge thrombus stuck over the interatrial septum. Case presentation. An 83-year-old female patient was admitted to our Coronary care unit with the diagnosis of massive pulmonary embolism confirmed by contrast-enhanced chest CT scan. At admission, the patient complained of chest pain and shortness of breath for the last 24 hours. Transthoracic echocardiography (TTE) showed the presence of a thrombus entrapped in a patent foramen ovale and floating in both atria. Transesophageal echocardiography was done as well to confirm the diagnosis. Deep vein thrombosis was diagnosed by duplex ultrasonography. After discussing the risks and benefits of surgical versus medical treatment, the patient was treated with unfractionated heparin during hospitalization and rivaroxaban on discharge. Seven days later, follow-up TTE showed no clot in the heart. Conclusion. Although rare, the thrombus stuck in patent foramen ovale presents a clinical emergency so early diagnosis and treatment is mandatory.

Acute myocardial infarction with ST elevation (STEMI) is a disease of the elderly, rarely of people younger than 40 years, predominantly men with comorbidities. The incidence of STEMI infarction in the general population in women younger than 40 years is very low. This paper presents the case of a young woman who was admitted with a diagnosis of STEMI infarction, which was understood as SCAD after coronary angiography. Repeated invasive diagnostics with intracoronary imaging determined that it was a classic infarction with plaque rupture/erosion and a large intraluminal thrombotic mass that partially embolized with occlusion of the apical part of the anterior descending artery (LAD). She was treated during hospitalization with dual antiplatelet therapy (DAPT) using a potent P2Y12 inhibitor and low molecular weight heparin, high dose of statins. Control coronary angiography revealed insignificant narrowing of the distal part of the main trunk of the left coronary artery (LM) and the proximal segment of the LAD with almost complete resolution of the thrombus. DAPT treatment was continued without stent implantation.

Introduction. When considering revascularization modalities, for patients with stable presentation, with appropriate coronary anatomy suitable for both PCI and CABG and low predicted surgical mortality, the recommendations are specifically focused on patients with main stem stenosis. In these cases, patients should be individually assessed according to the complexity of the anatomical disease, as determined by the anatomical SYNTAX score. In the last few years, the results of four randomized studies have been published comparing PCI with newer-generation DES and CABG in patients with left-main stenosis. The latest 2024 ESC guidelines for the management of chronic coronary syndromes recommend CABG over PCI when the anatomical SYNTAX score exceeds 22, as indicated by recent trials. The aim of this study was to examine whether the indications for CABG or PCI, as determined by the well-informed intuitive judgment of PCI operators in everyday clinical practice, align with the treatment recommendations outlined in the recently published ESC guidelines. Methods. Between January 1, 2023, and December 31, 2023, patients were recruited from the University Clinical Centre of the Republic of Srpska in Banja Luka, Bosnia and Herzegovina, utilizing the hospital information system. The study included consecutive patients diagnosed with significant unprotected left main coronary artery disease (≥50% diameter stenosis) confirmed through angiography, who did not exhibit major hemodynamic instability and received PCI at our facility. Patients were divided into two groups, based on the anatomical SYNTAX score i.e. those with SYNTAX ≤ 22 and those with SYNTAX > 22. Results. Following inclusion criteria, a total number of 38 patients were included in the analysis. The included patients had either previously diagnosed coronary artery disease or a high suspicion of coronary artery disease. The majority of the participants were male, with an average age of 65.6 years, with the youngest participant being 31 years old and the oldest 83 years old. A large majority of both sexes suffered from arterial hypertension, dyslipidemia, and type 2 diabetes. Participants in whom SYNTAX score was ≤ 22 were younger (p=0.049) and had less complex coronary artery disease i.e. fewer MEDINA 1,1,1 (p< 0.001) with less stents implanted (p=0.040). Over the course of one year of follow-up, three patients passed away, two of whom had a SYNTAX score exceeding 22. Additionally, two patients were lost to follow-up. Conclusion. The present study demonstrates that an intuitive decision-making process by experienced interventional cardiologists for choosing the optimal myocardial revascularization method for the individual patient with left main stenosis led to a discordance of the definitely chosen methods vs. the recommended method based on the SYNTAX score and ESC guidelines. This discordance between the recommended and the finally performed revascularization strategy led to a higher shortterm mortality.

This study aimed to evaluate the potential of non-conventional techniques in extracting phenolic compounds from tobacco agro-industrial waste. Two fractions of tobacco waste obtained from Virovitički Duhani dd (solid waste and dust) were subjected to ultrasound and subcritical water in a wide temperature range, treatment times and various liquid-solid ratios to determine the changes in the content of phenolic compounds and antiradical activity. Analysis of extracts was performed using high-performance liquid chromatography and spectrophotometric methods. Results showed that UAE is preferable in phenolic compound separation. In contrast, phenolic compounds (chlorogenic acid and rutin) were degraded during SWE, which may have increased the amount of undesirable breakdown products or beneficial simple phenolic compounds.