User Name

Zerina Sakić

Društvene mreže:

N. Srabović, Monika Rustemović Čorbić, E. Dautović, A. Smajlović, A. Softič, Anida Delimehić, Jasmina Grapkić Aličić, Damir Terzić, Emina Hodžić et al.

Introduction: Statins are lipid lowering medications, used for the prevention of cardiovascular diseases (CVD), but have shown to increase the risk of Type 2 diabetes mellitus. The aim of this study was to investigate the effects of high-potency statins, atorvastatin, and rosuvastatin on fasting glucose (FG) and hemoglobin A1c (HbA1c) in CVD patients. Methods: The case–control study included 123 patients from Tuzla Canton, Bosnia, and Herzegovina, with a diagnosis of CVD, treated in three health centers: Public Health Center Gračanica, Banovići, and Čelić. Of total patients, 84 were statin users (39 atorvastatin users and 45 rosuvastatin users) and 39 were not. Demographic data, diagnosis, and data of the therapy were taken from the medical records, as well as data of the FG and HbA1c, measured before or within 3 months of the statin therapy introduction. For the same patients, FG and HbA1c were also measured at least 3 months after the introduction of therapy. Results: Obtained results have shown a significant increase of FG in CVD patients on statin therapy in relation to control (p = 0.034). Comparing the diabetogenic effects of atrovastatin and rosuvastatin, it was found that the HbA1c in patients on atorvastatin therapy was significantly higher comparing to those on rosuvastatain therapy (p = 0.028). The FG was significantly increased (p = 0.027) after atrovastatin therapy. Similar results were obtained in diabetogenic CVD patients, where HbA1c on atorvastatin therapy was significantly higher comparing to HbA1c in those on rosuvastatain therapy (p = 0.039). A significant correlation was found between the increase in FG and HbA1c with the duration of atorvastatin therapy (p = 0.001 and p = 0.033), and between the increase in HbA1c and the duration of rosuvastatin therapy (p = 0.001). Conclusion: Long-term therapy with high-potency statins, atorvastatin, and rosuvastatin, may increase levels of FG and HbA1c in patients with CVD, where atorvastatin shows more significant effects.

This study deals with the unfolded quantities based on the time intervals between successive neutron events from the aspect of the power law. Neutrons from spontaneous fission in special nuclear material induce fission in most cases. In this study, it was demonstrated that the inverse value of the number of induced neutrons decreases following a power function with the increasing radius of a plutonium metal sphere. In addition, it was considered an increase in the neutron background level with increasing altitudes. The inverse value of the mean neutron counting rate depending on altitudes can be described with a power function merely for higher elevations. A linear relationship was obtained by plotting the quantities on logarithmic axes against each other indicating generally a power law relationship for both investigated phenomena. The results of this study showed a connection between two seemingly unrelated neutron phenomena through power laws based on the distributions of time intervals between successive neutron counts. The empirical evidence implies that a connection between the observed quantities in a log-log plot is unchanged except for a multiplicative constant.


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